• Mass Spectrometry Letters
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• 제10권4호
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• pp.117-122
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• 2019

This study demonstrated the sensitivity of electron capture dissociation mass spectrometry (ECD-MS) to probe subtle conformational changes in gaseous melittin ions induced by the substitution of an amino acid. ECD-MS was performed for triply and quadruply-protonated melittin and its variants obtained by a single amino acid substitution, namely, D-Pro14, Pro14Ala, and Leu13Ala. Although native triply-protonted melittin showed only a few peptide backbone cleavage products, the D-Pro14 and Pro14Ala variants exhibited extensive backbone fragments, suggesting the occurrence of a significant structural or conformational change induced by a single amino acid substitution at Pro14. On the contrary, the substitution at Leu13, namely Leu13Ala (+3), did not cause significant changes in the ECD backbone fragmentation pattern. Thus, the sensitivity of ECD-MS is demonstrated to be good enough to probe the aforementioned conformational change in melittin.

• Journal of Magnetics
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• 제17권2호
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• pp.158-162
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• 2012

Although 3.0T magnetic resonance imaging (MRI) has the advantages of a higher signal to noise ratio (SNR) and contrast than 1.5T MRI, there are limitations on the contrast between white and grey matter because of the long T1 recovery time when T1 images are obtained using the Spin Echo Technique. To overcome this, T1 weighted images are obtained occasionally using the inversion recovery (IR) technique, which employs a relatively long TR. The aim of this study was to determine the optimal TI in a brain examination when a T1 weighted image is obtained using the IR technique. Eight participants (male: 7, female: 1, average age: $34{\pm}14.11$) with a normal diagnosis were targeted from February 18, 2012 to February 27, 2012, and the contrast between white and grey matter as well as the contrast to noise ratio (CNRs) in each participant were measured. The CNRs of white matter and grey matter were highest at TI = 600, 650, 750, 900, 1050 and 1100 ms when the TR was 1100, 1400, 1700, 2000, 2300 and 2600 ms, respectively. Therefore, as the TIs were $44.425{\pm}0.877%$ of the TRs in the TR range of 1400-2300 ms, the optimal T1 weighted images that describe the contrast between white and grey matter can be obtained if the TIs are compensated for with $44.425{\pm}0.877%$ of the TRs in the time of setting TIs.

• 대기
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• 제18권3호
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• pp.207-224
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• 2008

Severe downslope windstorms observed at Gangneung, Korea in the springtime during the last 30 years are studied to understand their generation mechanisms. 92 severe wind cases are selected for which the maximum instantaneous wind speeds exceed two standard deviation of total mean plus ($18.7ms^{-1}$). They are categorized into the three mechanisms (hydraulic jump, partial reflection, and critical-level reflection) proposed in previous studies based on the flow condition, which is calculated using the wind and temperature profile observed at one upstream rawinsonde station, Osan. Among the three, partial reflection is found to be the most frequent mechanism for the last 30 years (1976 - 2005). To understand the role of inversion in generating severe downslope windstorms, horizontal velocity perturbation was calculated analytically for the atmosphere with an inversion layer. It turned out that the intensity of downslope wind was increased by inversion layer of specific heights, which are well matched with the observations. For better understanding the generation mechanisms, two-dimensional numerical simulations are conducted for the 92 severe wind cases using the ARPS model. In most simulations, surface wind speed exceeds the value of the severe-wind criterion, and each simulated case can be explained by its own generation mechanism. However, in most simulations, the simulated surface wind speed is larger than the observed, due to ignoring the flow-splitting effect in the two-dimensional framework.

• Journal of Cardiovascular Imaging
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• 제31권2호
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• pp.71-82
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• 2023

BACKGROUND: Cardiac magnetic resonance fingerprinting (cMRF) enables simultaneous mapping of myocardial T1 and T2 with very short acquisition times. Breathing maneuvers have been utilized as a vasoactive stress test to dynamically characterize myocardial tissue in vivo. We tested the feasibility of sequential, rapid cMRF acquisitions during breathing maneuvers to quantify myocardial T1 and T2 changes. METHODS: We measured T1 and T2 values using conventional T1 and T2-mapping techniques (modified look locker inversion [MOLLI] and T2-prepared balanced-steady state free precession), and a 15 heartbeat (15-hb) and rapid 5-hb cMRF sequence in a phantom and in 9 healthy volunteers. The cMRF_5-hb sequence was also used to dynamically assess T1 and T2 changes over the course of a vasoactive combined breathing maneuver. RESULTS: In healthy volunteers, the mean myocardial T1 of the different mapping methodologies were: MOLLI 1,224 ± 81 ms, cMRF_15-hb 1,359 ± 97 ms, and cMRF_5-hb 1,357 ± 76 ms. The mean myocardial T2 measured with the conventional mapping technique was 41.7 ± 6.7 ms, while for cMRF_15-hb 29.6 ± 5.8 ms and cMRF_5-hb 30.5 ± 5.8 ms. T2 was reduced with vasoconstriction (post-hyperventilation compared to a baseline resting state) (30.15 ± 1.53 ms vs. 27.99 ± 2.07 ms, p = 0.02), while T1 did not change with hyperventilation. During the vasodilatory breath-hold, no significant change of myocardial T1 and T2 was observed. CONCLUSIONS: cMRF_5-hb enables simultaneous mapping of myocardial T1 and T2, and may be used to track dynamic changes of myocardial T1 and T2 during vasoactive combined breathing maneuvers.

• 대기
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• 제23권4호
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• pp.519-526
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• 2013

This study aims to analyze the vertical distribution of Asian dust measured by LIDARs at three weather stations in Baengnyeongdo (BND), Munsan (MS), and Gunsan (GS) during 10~11 May 2010, and thereby investigate their effectiveness. Asian dust passed through from central to south-western part of Korea. Although dust particles were detected over the surface in MS and GS, LIDAR data showed that the Asian dust with non-spherical particles was observed in all of the three regions. It seems that the naked-eye observation could not detect dust over the surface of BND due to the temperature inversion below a height of 0.45 km. During the Asian dust events, the duration time of dust presented 9.5 hr (BND), 19.5 hr (MS), and 24.5 hr (GS), respectively with the longest time in GS, whereas dust altitudes ranged from 0.4 to 1.3 km (BND), 0.1 to 2.8 km and 4.1 to 4.2 km (MS), and 0.2 to 2.0 km (GS), respectively, while showing the highest altitude in MS. Aerosol optical thickness (AOT) retrieved by LIDAR and skyradiometer (SR), located close to the LIDAR sites, was compared. MS (LIDAR) and Seoul (SR) attained the AOT of 0.64 and 0.50, and GS (LIDAR) and Gongju (SR) attained the AOT of 0.38 and 0.54, respectively. As SR-derived angstrom exponents (AE) during the time period determined as Asian dust by LIDAR data were 0.17 in Seoul (near MS) and 0.30 in Gongju (near GS), it can be said that the characteristics of dust particles were appeared. During the study period, depolarization ratio could serve as a useful indicator to determine dust aerosol. But, it still seems essential to conduct further investigation with longer period of data to better describe the discrepancy of AOT between LIDARs and SR.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2004년도 Asia Display / IMID 04
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• pp.26-29
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• 2004

S-PVA is a new technology which enables screen quality advantages over S-IPS and MVA, including high transmittance, >1000:1 contrast ratio, sub-10ms response time, and wide angle of view with no off-axis image inversion and undetectable gamma distortion. This new technology will be described in detail. This paper also addresses the other remaining performance issues facing LCD-TV, including Samsung's plans for addressing these challenges. For example, until recently, inter-gray response time and associated motion blur were significant issues for achieving LCD-TV images quality. Samsung has invented DCC-II technology to achieve sub-10ms response time, and this achievement is described herein. Other technology advancements, including next-generation color performance and ultra-low black performance and improvement of off axis image quality are also discussed in this paper.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2003년도 춘계학술대회 논문집
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• pp.660-663
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• 2003

This paper proposes a systematic approach for an accurate control of the Terfenol-D actuator taking into account hysteresis, modeled by applying the classical Preisach operator with memory curve. A desired input displacement is calculated by using the hysteresis inverter, which is fed into the actuator. Then the PI compensator corrects the error between the commanded and actual displacements. Experiments with the step responses show that the PI controller settles in 70 ms and the hybrid controller in 20 ms. It means that the concurrent application of two control schemes is effective to control the actuator.

• Journal of Magnetics
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• 제17권2호
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• pp.153-157
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• 2012

This study evaluated the ability of Diffusion-Weight Image (DWI), which is one of pulse sequences used in MRI based on the T2 weighted images, to detect samples placed within phantoms according to their size. Two identically sized phantoms, which could be inserted into the breast coil bilaterally, were prepared. Five samples with different sizes were placed in the phantoms, and the T2 weighted images and DWI were obtained. The Breast 2 channel coil of SIEMENS MAGNETOM Avanto 1.5 Tesla equipment was used for the experiments. 2D T2 weighted images were obtained using the following parameters: TR/TE = 6700/74 msec, Thickness/gap = 5/1 mm, Inversion Time (TI) = 130 ms, and matrix = $224{\times}448$. The parameters of DWI were that TR/TE = 8100/90 msec, Thickness/gap = 5/1 mm, matrix = $128{\times}128$, Inversion Time = 185 ms, and b-value = 0, 100, 300, 600, 1000 s/mm. The ratio of the sample volume on DWI compared to the T2 weighted images, which show excellent ability to detect lesions on MR images, was presented as the mean b-value. The measured b-value of the samples was obtained: 0.5${\times}$0.5 cm=0.33/0.34 square ${\times}$ cm (103%), 1${\times}$1 cm=1.28/1.25 square ${\times}$ cm (102.4%), 1.5${\times}$1.5 cm = 2.28/2.67 square ${\times}$ cm (85.39%), 2${\times}$2 cm=3.56/4.08 square ${\times}$ cm (87.25%), and 2.5${\times}$2.5 cm=7.53/8.77 square ${\times}$ cm (85.86%). In conclusion, the detection ability by the size of a sample was measured to be over 85% compared to T2 weighted image, but the detection ability of DWI was relatively lower than that of T2 weighted image.

• Investigative Magnetic Resonance Imaging
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• 제20권2호
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• pp.88-94
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• 2016

Purpose: Fluid-attenuated inversion recovery (FLAIR) imaging can be obtained faster with shorter repletion time (TR), but it gets noisier. We hypothesized that shorter-TR FLAIR obtained at 3 tesla (3T) with a 32-channel coil may be comparable to conventional FLAIR. The aim of this study was to compare the diagnostic value between conventional FLAIR (TR = 9000 ms, FLAIR9000) and shorter-TR FLAIR (TR = 6000 ms, FLAIR6000) at 3T in terms of diffusion-weighted imaging-FLAIR mismatch. Materials and Methods: We recruited 184 patients with acute ischemic stroke (28 patients < 4.5 hours) who had undergone 5-mm diffusion-weighted imaging (DWI) and two successive 5-mm FLAIR images (no gap; in-plane resolution, $0.9{\times}0.9mm$) at 3T with a 32-channel coil. The acquisition times for FLAIR9000 and FLAIR6000 were 108 seconds (generalized autocalibrating partially parallel acquisitions [GRAPPA] = 2) and 60 seconds (GRAPPA = 3), respectively. Two radiologists independently assessed the paired imaging sets (DWI-FLAIR9000 and DWI-FLAIR6000) for the presence of matched hyperintense lesions on each FLAIR imaging. The signal intensity ratios (area of DWI lesion to contralateral normal-appearing region) on both FLAIR imaging sets were compared. Results: DWI-FLAIR9000 mismatch was present in 39 of 184 (21.2%) patients, which was perfectly the same on FLAIR6000. Three of 145 patients (2%) with DWI-matched lesions on FLAIR9000 had discrepancy on FLAIR6000, showing no significant difference (P > 0.05). Interobserver agreement was excellent for both DWI-FLAIR9000 and DWI-FLAIR6000 (k = 0.904 and 0.883, respectively). Between the two FLAIR imaging sets, there was no significant difference of signal intensity ratio (mean, standard deviation; $1.25{\pm}0.20$; $1.24{\pm}0.20$, respectively) (P > 0.05). Conclusion: For the determination of mismatch or match between DWI and FLAIR imaging, there is no significant difference between FLAIR9000 and FLAIR6000 at 3T with a 32-channel coil.

• 지구물리
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• 제9권1호
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• pp.37-45
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• 2006

풍암분지 내에 위치한 140 m 깊이 시험시추공 주변에서 지표 굴절법 및 원거리 수직탄성파 자료의 초동주시를 토모그래피방식으로 동시에 역산하여 시추공 주변의 속도구조를 구하였다 . 지진총으로 발생시킨 지진파는 시추공을 중심으로 N20°E 방향과 이에 수직인 측선을 따라 3 m 간격의 42개 지표 측점과 공내 71 m 깊이에서 수신하였다 . 는 시추공으로부터의 수평거리 -19.5∼+19.5 m인 지표 측점에서 5 kg 해머로 발생시켰으며 , 1∼2 m 간격의 깊이 9∼99 m 구간에서 3성분으로 204 ms 동안 기록하였다 . 지연시간 보정 후 , 이 자료를 지진총으로 기록한 지표 기록자료 초동주시와 동시에 SIRT 방식으로 역산하여 속도 토모그램을 작성하였다 . 속도 토모그램은 평균 1.5 m 두께의 속도 500 m/s 표토층이 속도 3,067∼5,717 m/s의 속도를 갖는 기반암 위에 분포하고 있음을 보여 준다 . 기반암 내부에는 깊이 30∼44 m 구간과 71 m 하부에 속도가 5,130 m/s 이상 되는 매우 단단한 암층이 존재하며 , 이는 코아분석 자료와 비교할 때 사암 및 이암층에 협재하는 역암층의 영향으로 판단된다 . 시추공 주변 조사범위 내에서 대규모 파쇄대나 단층 존재의 증거는 발견되지 않는다 .