• The Korean Journal of Physiology and Pharmacology
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• v.5 no.2
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• pp.107-122
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• 2001

A function of the kidney is elimination of a variety of xenobiotics ingested and wasted endogenous compounds from the body. Organic anion and cation transport systems play important roles to protect the body from harmful substances. The renal proximal tubule is the primary site of carrier-mediated transport from blood into urine. During the last decade, molecular cloning has identified several families of multispecific organic anion and cation transporters, such as organic anion transporter (OAT), organic cation transporter (OCT), and organic anion-transporting polypeptide (oatp). Additional findings also suggested ATP-dependent organic ion transporters such as MDR1/P-glycoprotein and the multidrug resistance-associated protein (MRP) as efflux pump. The substrate specificity of these transporters is multispecific. These transporters also play an important role as drug transporters. Studies on their functional properties and localization provide information in renal handling of drugs. This review summarizes the latest knowledge on molecular properties and pharmacological significance of renal organic ion transporters.

• IE interfaces
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• v.15 no.1
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• pp.99-106
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• 2002

A recently developed alternative to traditional production planning and control systems such as material requirement planning(MRP) and just-in-time(JIT) is the drum-buffer-rope(DBR). The DBR now being implemented in growing number of manufacturing organizations enables better scheduling and decision making on the shop floor. In implementing the DBR, however, an information system is usually needed to transmit the signal that runs from the constraint to material release. In this paper we propose a different mechanism to transmit the signal in the case that the demand of product is stable, which uses the well-known Kanban system. To improve the reality, this paper shows and example of the Kanban format, its operation, and calculation of the number of Kanbans.

• ICROS
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• v.1 no.2
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• pp.55-62
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• 1995

보통 제조기업을 움직이는 기능을 제품개발기능, 생산기능, 영업기능, 경영관리기능 등으로 나눌 수 있는데, 경영관리기능은 하위 3가지 기능에서 제공되는 정보를 기반으로 운영되는 특징이 있다. 최근 CIM 개념 도입에 의해 기업의 기본기능시스템에 많은 변화를 가져 오고, 이러한 변화는 필연적으로 새로운 형태의 경영관리시스템을 요구하게 될 것으로 전망된다. 즉 CIM이 구축된 상황에서는 생산현장의 모든 데이타를 Real Time으로 포착하고, 이러한 데이타는 공간제약 없이 어느 곳으로도 전송, 공유되며 컴퓨터 계산능력의 향상으로 많은 데이타를 쉽게 추출할 수 있게 된 것이다. 이러한 환경을 충분히 반영한 새로운 경영관리시스템의 재구축은 향후 기업 경쟁력을 결정짓는 주요 요인이 될 것으로 예상된다. 또한 정보시스템의 기능과 구조는 개별기업별로 상이하고 경영환경변화 및 정보기술의 발전에 따라 다르게 구축될 것이므로 여러 기업에 공통적으로 적용가능한 비즈니스 참조모델을 개발함으로써 많은 비용의 재투자 없이 필요한 소프트웨어를 재생산하는 체제의 구축이 필요하다.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4635-4639
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• 2013

Multi-drug resistance (MDR) is an essential aspect of human lung cancer chemotherapy failure. Recent studies have shown that vinorelbine is involved in underlying processes in human tumors, reversing the MDR inseveral types of cancer cells. However, the roles and potential mechanism are not fully clear. In this study, we explored effects of vinorelbine in multi-drug resistance reversal of human lung cancer A549/DDP cells. We found that vinorelbine increased drug sensitivity to cisplatin and intracellular accumulation of rhodamine-123, while decreasing expression of P-glycoprotein (P-gp), multi-drug resistance-associated protein (MRP1) and glutathione-S-transferase ${\pi}$ (GST-${\pi}$) in A549/DDP cells. At the same time, we also established downregulation of p-Akt and decreased transcriptional activation of NF-${\kappa}B$ and twist after vinorelbine treatment. The results indicated that vinorelbine might be used as a potential therapeutic strategy in human lung cancer.

• International Journal of Aeronautical and Space Sciences
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• v.1 no.2
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• pp.68-74
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• 2000

A comparative wind tunnel testing of an airplane model was performed at the Korea Aerospace Research Institute Low Speed Wind tunnel(KARI LSWT). The model used for the comparative test was a seaplane model from the Glenn L. Martin Wind(GLM) Tunnel of University of Maryland, U.S.A. The 6-component external balance used in force and moment measurement is pyramidal type, which is a precision device that has strain gauge-type load cell inside of balance and the virtual center of the balance coincides with the tunnel centerline. Image method is adopted to eliminate the tare and interference of the model support, and to correct the flow angularity to the model also. Test results from KARI LSWT were compared with the results from GLM tunnel.

• Journal of Microbiology
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• v.43 no.6
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• pp.569-571
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• 2005

White-rot fungi have the following enzyme systems for lignin degradation: laccase, lignin peroxidase and manganese peroxidase. There are other types of peroxidases related to lignin degradation, one of which we have cloned a cDNA gene of manganese-repressed peroxidase (MrP) in Trametes versicolor isolated in South Korea. The mrp transcript level has been decreased by $1{\mu}M\;of\;Mn^{2+}$.

• JOURNAL OF ELECTRICAL WORLD
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• no.9 s.105
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• pp.83-91
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• 1985

''생산관리''라고 하면 보통 공장에서 생산에 종사하는 기술자로서 무엇인가 이질적인 것 같은 느낌이 없었는지, 생산기술에 대하여 이것은 사무계산에 불과하다든지 매일 변화하는 생산현장에 대하여 이것은 정형화된 사무처리에 불과하다든지 하는 극단적인 생각은 아닐지라도 ''생산관리가 공장의 생산성 향상에 기여하고 있는가''에 대해서는 별로 인식가치가 되고 있지 않는 것 같다. 생산관리란 ''생산이 과학적인 계획과 통제''이므로 그 목적은 생산성의 향상에 있는데 지금까지는 생산설비나 생산기술자, 워커 등과의 연결이 비교적 적었다. 컴퓨터가 대대량적인 수의를 아우트푸트하는데 이들과의 직접적인 연결은 별로 없다. 공장의 생산 시스템을 피라밋형으로 시행하면 생산관리는 상위에 있고 생산설비나 사람은 하위에 있으며 그 사이에는 왠지 갭이 있었다. 화학, 시멘트, 은, 지 등으로 대표되는 프로세스에서는 설비의 자동화가 ''프로세스오토메이션''으로서 일찍이 개발되어 이 갭이 서서히 메꾸어져 왔다. 한편 전기, 기계 등의 프로세스에서도 근년에 ''펙트리오트메이션''의 이름 아래 설비의 자동화, 라인화, 생산의 시스템화의 혁신이 이루어지고있으며 피라밋의 중앙에 가로 놓인 갭을 apRN는 요구가 강해지고 있다(그림1 참조) 여기서는 생산관리의 본체로서의 MRP는 간단하게 설명하고 이 갭을 메꾸는 시스템(여기서는 이것을 ‘생산관리’라고 한다.)를 중심으로 설명한다.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5619-5625
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• 2012

Gastric carcinoma is a leading cause of cancer death in the world and multi-drug resistance (MDR) is an essential aspect of gastric carcinoma chemotherapy failure. Recent studies have shown that integrin-linked kinase (ILK) is involved in metastasis of human tumors, expression silencing of ILK inhibiting the metastasis of several types of cultured human cancer cells. However, the role and potential mechanism of ILK to reverse the multi-drug resistance in human gastric carcinoma is not fully clear. In this report, we focused on roles of expression silencing of ILK in multi-drug resistance reversal of human gastric carcinoma SGC7901/DDP cells, including increased drug sensitivity to cisplatin, cell apoptosis rates, and intracellular accumulation of Rhodamine-123, and decreased mRNA and protein expression of multi-drug resistance gene (MDR1), multi-drug resistance-associated protein (MRP1), excision repair cross-complementing gene 1 (ERCC1), glutathione S-transferase -${\pi}$ (GST-${\pi}$) and RhoE, and transcriptional activation of AP-1 and NF-${\kappa}B$ in ILK silenced SGC7901/DDP cells. We also found that there was a decreased level of p-Akt and p-ERK. The results indicated that ILK might be used as a potential therapeutic strategy to combat multi-drug resistance through blocking PI3K-Akt and MAPK-ERK pathways in human gastric carcinoma.

• The Korean Journal of Food & Health Convergence
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• v.5 no.2
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• pp.27-34
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• 2019

RNases plays a pivotal role in biological system and different RNases are known for their various functions like angiogenesis, immunological response, antiviral, antitumour activity and apoptosis. In which anti tumour activity of RNase is proved to improve genome stability in normal cells up to some extent. RNases like RNase L shows antiviral and antitumour activities against virus infected cells and cancer cells through 2'-5' oligo adenylate pathway and induces RNaseL dependent apoptosis where as RNase A modulates various proliferative pathways like MAP kinase, JNK, TGF-${\beta}$ and activates apoptosis in cancer cells and promotes immunological response through processing of Ags. IRE1 RNase acts as both tumour suppressor gene and oncogene in normal and cancer cells and involved in both antitumour and tumorigenic activities. RNase III upregulates miRNA in cancer cells there by acting via posttranscriptional level and proven to be effective against colorectal adeno carcinoma. In addition to this IRE1 RNase is a double edged sword through RIDD pathway in ER (18). To some of the cancers expressing c-myc IRE1 acts as tumour suppressor where as in cancers where myc is downregulated IRE1 acts as tumour provoking through RIDD pathway (18). Thus RNases play vital role in regulating the genome stability.

• Journal of Society of Preventive Korean Medicine
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• v.13 no.2
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• pp.51-64
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• 2009

Objective : This research was aimed to investigate the anti-tumor effect, safety, mechanism and metabolizing enzyme of Agrimonia pilosa LEDEB(APL) in female C57B/L mouse. Methods : At first, to evaluate the anti-tumor activity of APL, we divided into four groups, normal, control, APL100(100mg/kg), APL150(150mg/kg). LLC obtained American Type Culture Collection was used. LLC had been inoculated to induce tumor. To measure the anti-tumor effect of APL, we calibrate tumor size and weight. To study for mechanism of anti-tumor in APL, we used western blotting and to know metabolizing enzyme in APL we used to real-time PCR. Results : APL100, APL150 inhibited tumor growth after medicine injected. APL did not only induced caspase-dependent apoptosis in LLC-bearing mouse tumor. In APL100, it were decreased 72% in CYP3A11. In APL150, it were decreased 62%, 75% in CYP3A11 and MRP1a respectively. Conclusion : These results suggests that APL has some anti-tumor effects in female C57B/L mouse tumor. APL should be careful use with other drugs related with CYP3A11 or MRP1a.