• Journal of Korean Society on Water Environment
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• v.25 no.5
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• pp.778-784
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• 2009

The purpose of this study is to figure out the differences of the inflow rates of Sewage Treatment Plants (STP), invested by public fund or public-private partnership (PPP). This paper finds that the average ratio of sewage inflow according to facility capacities (medium and small scale STP) was either nearly below 30% or above 100% in the first year. As the size of STP increased, there was decrease in the accuracy of demand assumption. This was because the operation time when the ratio of sewage inflow was uniform was different according to the size of STP, whereby the time was short when the STP were small. The design average ratio of sewage inflow was 10% larger than the real average ratio; this was considered overdesigned. In the case of a plant built by the PPP scheme, the average ratio of inflow of the STP before an abolition of MRG was larger than after the abolition of MRG. This may be explained by moral hazard from too much reliance on MRG. After the abolition of MRG, the demand risk of PPP was shifted from a PPP project to a conventional project.

• Journal of Korean Society of Transportation
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• v.25 no.1 s.94
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• pp.49-59
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• 2007

This study has examined the allocation of risk in Korea's private provided Infrastructure(PPI) with the following contents (1) Developing a quantitative risk allocation model for Korea's PPI and (2) examining the implication of changes in the minimum revenue guarantees (MRG) clause of government legislation using the developed empirical model. The model of this study adopts and extends H. Yamaguchi's model developed in 2002. To investigate Korea's actual risk allocation deals, the author incorporated the MRG framework. The payment related to the MRG is indeterminable. Hence. the average MRG rate was calculated using probabilistic risk analysis. The risk allocation model is applied to the two eases to validate the model and evaluate the project's VFM(Value for Money). As the revenue guarantee rate is lowered, the government subsidies are increased. This in turn worsens VFM. The same relationship is true when the revenue guarantee Period is shortened.

• Korean Journal of Microbiology
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• v.25 no.1
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• pp.57-66
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• 1987

Mutants of E. coli which showed increased sensitivity to MMS(methylmethane sulfonate)were isolated by MNNG mutagenesis and characterized by enzymatic assay, survival of simple alkylating agents and host-cell reactivation. E.coli mutant, 5-62, which showed absolute deficiency in 3-methyladenine DNA glycosylase II activity and had low capability of reactivating MMS-treated phage charon 35 was very sensitive to MMS and MNNG. NNS gene which confered resistance to the lethal effects of MMS was cloned in 5-62 strain. 5-62 mutants carrying recombinant plasmid, pMRG 1, which acquired resistance to the lethal effects of MMS had normal sensitivity to MNNG. Resistance to MMS was somewhat increased after they were treated with 0.5.$\mu$g MNNG/ml for 2 hours at $37^{\circ}C$. Although recombinant plasmid, pMRG 1, did not complement alk A mutation in 5-62 and ada mutation in 1-27 mutnat, mutnats transformed with this plasmid showed more capability of reactivating MMS treated phage than mutants.

• Journal of Korean Neurosurgical Society
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• v.62 no.6
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• pp.712-722
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• 2019

Objective : Although magnetic resonance guided focused ultrasound (MRgFUS) has been used as minimally invasive and effective neurosurgical treatment, it exhibits some limitations, mainly related to acoustic properties of the skull barrier. This study was undertaken to identify skull characteristics that contribute to optimal ultrasonic energy transmission for MRgFUS procedures. Methods : For ex vivo skull experiments, various acoustic fields were measured under different conditions, using five non-embalmed cadaver skulls. For clinical skull analyses, brain computed tomography data of 46 patients who underwent MRgFUS ablations (18 unilateral thalamotomy, nine unilateral pallidotomy, and 19 bilateral capsulotomy) were retrospectively reviewed. Patients' skull factors and sonication parameters were comparatively analyzed with respect to the cadaveric skulls. Results : Skull experiments identified three important factors related skull penetration of ultrasound, including skull density ratio (SDR), skull volume, and incidence angle of the acoustic rays against the skull surface. In clinical results, SDR and skull volume correlated with maximal temperature (Tmax) and energy requirement to achieve Tmax (p<0.05). In addition, considering the incidence angle determined by brain target location, less energy was required to reach Tmax in the central, rather than lateral targets particularly when compared between thalamotomy and capsulotomy (p<0.05). Conclusion : This study reconfirmed previously identified skull factors, including SDR and skull volume, for successful MRgFUS; it identified an additional factor, incidence angle of acoustic rays against the skull surface. To guarantee successful transcranial MRgFUS treatment without suffering these various skull issues, further technical improvements are required.

• Proceedings of the Korea Water Resources Association Conference
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• 2009.05a
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• pp.1197-1201
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• 2009

본 논문에서는 각각의 시점에서의 변화확률을 산정하여 변화시점을 추정하는 Barry와 Hartigan(BH)의 베이지안 변화시점 추정 방법(Bayesian changing points estimation method)을 이용하여 측우기 관측자료계열(CWK)과 근대우량계 관측자료계열(MRG)간의 변화에 대한 상대확률적 절점의 발생여부를 분석하였다. 각 강우특성별로 상대확률적인 변화시점 분석을 통하여 CWK와 MRG 간의 동질성 분석을 실시하였다. 분석 결과, CWK의 정성적인(본질적인) 통계적 특성은 MRG와 큰 차이가 없어 보인다. 다만, 관측정밀도의 한계로 인한 정량적인 차이가 존재하는 것으로 판단되었다.

• Journal of Applied Biological Chemistry
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• v.65 no.4
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• pp.447-451
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• 2022

Phytoestrogenic S-equol production in human gut exclusively depends on the biotransformation of daidzein to dihydrodaidzein (DHD). With a growing demand for the DHD enriched biomaterials, the commercial soybean hypocotyl extract (SHE) was chosen as a substrate for the microbial DHD production by human gut bacterium MRG-1, anaerobic DHD producer. To optimize the production of DHD, anaerobic fermentation conditions, including sterilization time, growth stage of inoculum, and growth media, were investigated. Maximum DHD production (1.2 g/L) was achieved after 48 h incubation when 1% (w/v) of SHE in the 20-min-sterilized Gifu Anaeboic Medium media was inoculated with OD₆₀₀ 0.3-0.4 of MRG-1. This is the first report that crude soy biomaterial, instead of pure compounds, such as daidzin and daidzein, is utilized for the production of the DHD enriched biomaterial.

• Journal of Korea Water Resources Association
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• v.42 no.10
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• pp.795-807
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• 2009

In this study, homogeneity analysis was performed between rainfall observation data set of Chukwooki (CWK) and rainfall observation data set of modern rain gage (MRG) using Bootstrap method. Since traditional statistical homogeneity test method are validated only when distribution of their population is known, meteorological data which their statistical distributions of population are complicated were difficult to verify the homogeneity and there were plenty of room for doubt for their statistical significance using historical method. In this reason, in this study homogeneity test was evaluated between two data sets using bootstrap method which is not necessary to infer distribution of population. The test results show that there was an statistical homogeneity between CWK and MRG except for slight impact of climatical trend.

• Korean Journal of Construction Engineering and Management
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• v.13 no.5
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• pp.53-63
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• 2012

Korean Public-Private Partnership, mainly implemented using BTO (Build-Transfer-Operate) and BTL (Build-Transfer-Lease) methods, has contributed in increasing benefits of the people by providing the needed public services in a timely and efficient manner. It has also induced flexible national fiscal management. However, in addition to the repeal of the Minimum Revenue Guarantee (MRG) program in 2009, changes in business environment including recent financial crisis aggravated financial situation in pursing PPPs, resulting in significant contraction of BTO projects. Therefore, the new methods are to be suggested and applied to overcome this situation. This paper seeks to find ways to apply "Mixed Model," characterized as the compound of BTO and BTL, two different implementation methods of PPPs, as an enhanced burden-sharing mechanism.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2008.11a
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• pp.606-609
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• 2008

Traditionally, the feasibility of the private investment is determined by NPV(Net Presented Value) based on DCF(Discounted Cash Flow) and the volume of government's subsidiary without quantifying the effect of overturn share ratio and MRG(Minimum Revenue Guarantee), these variables which can seriously effect on the economic feasibility. One of the most important reasons why these variables are not underestimated is that the quantifying methods are insufficiently or so complicatedly studied to apply practically the real project. Therefore, this study suggests the modified binominal option model to estimate the overturn share ratio and MRG and estimates how much these variables impact the private investment. Also, these results are helpful to estimate how much the government's subsidiary can be reduced.

• Progress in Medical Physics
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• v.30 no.4
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• pp.104-111
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• 2019

Purpose: Online magnetic resonance-guided adaptive radiotherapy (MRgART), an emerging technique, is used to address the change in anatomical structures, such as treatment target region, during the treatment period. However, the electron density map used for dose calculation differs from that for daily treatment, owing to the variation in organ location and, notably, air pockets. In this study, we evaluate the dosimetric effect of electron density override on air pockets during online ART for pancreatic cancer cases. Methods: Five pancreatic cancer patients, who were treated with MRgART at the Seoul National University Hospital, were enrolled in the study. Intensity modulated radiation therapy plans were generated for each patient with 60Co beams on a ViewrayTM system, with a 45 Gy prescription dose for stereotactic body radiation therapy. During the treatment, the electron density map was modified based on the daily MR image. We recalculated the dose distribution on the plan, and the dosimetric parameters were obtained from the dose volume histograms of the planning target volume (PTV) and organs at risk. Results: The average dose difference in the PTV was 0.86Gy, and the observed difference at the maximum dose was up to 2.07 Gy. The variation in air pockets during treatment resulted in an under- or overdose in the PTV. Conclusions: We recommend the re-contouring of the air pockets to deliver an accurate radiation dose to the target in MRgART, even though it is a time-consuming method.