• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제19권3호
• /
• pp.147-155
• /
• 2008

Objectives: The purpose of this study was to evaluate the efficacy and tolerability of osmotic release oral system-methylphenidate (OROS-MPH) in children with attention-deficit hyperactivity disorder (ADHD) and comorbid psychiatric disorders. Methods: This was an 8-week open label study of OROS-MPH monotherapy. The subjects were 113 children with ADHD aged 6-12 years. Outcome measures were the Korean version of the parent ADHD Rating Scale (K-ARS), Korean version of the Conners Parent Rating Scale (K-CPRS), Clinical Global Impression-Severity and Clinical Global Impression-Improvement. Side effects were monitored using Barkley's Side Effect Rating Scale. We compared the change-over-time in the mean scores of the outcome measure according to the comorbidity of disruptive behavior disorder, depressive disorder, anxiety disorder, and tic disorder. Results: The mean K-ARS and K-CPRS scores were significantly decreased, regardless of the comorbidity. The mean doses of OROS-MPH and dropout rate did not differ significantly according to comorbidity. The OROS-MPH was well tolerated, regardless of the comorbidity. However, children with tic disorder reported a higher frequency of tics or nervous movements between the $2^{nd}\;and\;8^{th}$ week than those without tic disorder. Conclusion: The OROS-MPH is effective for decreasing the symptoms of ADHD, and it is well tolerated, even by patients with comorbid psychiatric disorders.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제22권2호
• /
• pp.74-80
• /
• 2011

Attention-deficit hyperactivity disorder (ADHD) is a neurobehavioral disorder with an onset of symptoms before 7 years of age, often starting as early as the preschool years. The off-label use of methylphenidate (MPH) for 3- to 6-year-old preschool children with ADHD is being more common, although MPH is not licensed for use in children younger than age 6 years, in most countries. Despite the limited data, the review of the literature suggests that MPH meets evidence based criteria as beneficial and safe for carefully diagnosed ADHD preschool children. Carefully monitored administration of evidence-based psychotropic medication in preschool children with ADHD may be indicated if psychosocial treatments are ineffective.

• Journal of applied mathematics & informatics
• /
• 제14권1_2호
• /
• pp.405-413
• /
• 2004

Rational parameterization of curves and surfaces is one of the main topics in computer-aided geometric design because of their computational advantages. Pythagorean hodograph (PH) curves and Minkowski Pythagorean hodograph (MPH) curves have attracted many researcher's interest because they provide for rational representation of their offset curves in Euclidean space and Minkowski space, respectively. In [10], Kim presented the characterization of the PH curves in the Euclidean space and analyzed the relation between the class of PH curves and the class of rational curves. In this paper, we extend the characterization of PH curves in [10] into that of MPH curves in the general Minkowski space and consider some generalized MPH curves satisfying this characterization.

• 한국자동차공학회논문집
• /
• 제12권6호
• /
• pp.135-142
• /
• 2004

The severe frontal crash tests are NCAP with belted occupant at 35mph and FMVSS 208 with unbelted occupant at 25mph, This paper describes the design process of occupant protection systems, airbag and seat belt, under the two tests. In this study, NCAP simulations are performed by Monte Carlo search method and cluster analysis. The Monte Carlo search method is a global optimization technique and requires execution of a series of deterministic analyses, The procedure is as follows. 1) Define the region of interest 2) Perform Monte Carlo simulation with uniform distribution 3) Transform output to obtain points grouped around the local minima 4) Perform cluster analysis to obtain groups that are close to each other 5) Define the several feasible design ranges. The several feasible designs are acquired and checked under FMVSS 208 simulation with unbelted occupant at 25mph.

• 한국해양바이오학회지
• /
• 제7권2호
• /
• pp.58-70
• /
• 2015

Injectable RGD-bioconjugated Mussel Adhesive Proteins (RGD-MAPs) composite hydroxypropyl methylcellulose (HPMC) hydrogels provide local periodontal tissue for bone filling in periodontal surgery. Previously we developed a novel type of injectable self-supported hydrogel (2 mg/ml of RGD-MAPs/HPMC) based porcine nano hydroxyapatite (MPH) for dental graft, which could good handling property, biodegradation or biocompatibility with the hydrogel disassembly and provided efficient cell adhesion activity and no inflammatory responses. Herein, the aim of this work was to evaluate bone formation following implantation of MPH and collagen membrane in rabbit calvarial defects. Eight male New Zealand rabbits were used and four circular calvarial defects were created on each animal. Defects were filled with different graft materials: 1) collagen membrane, 2) collagen membrane with MPH, 3) collagen membrane with bovine bone hydroxyapatite (BBH), and 4) control. The animals were sacrificed after 2 and 8 weeks of healing periods for histologic analysis. Both sites receiving MPH and BBH showed statistically increased augmented volume and new bone formation (p < 0.05). However, there was no statistical difference in new bone formation between the MPH, BBH and collagen membrane group at all healing periods. Within the limits of this study, collagen membrane with MPH was an effective material for bone formation and space maintaining in rabbit calvarial defects.

• 한국항만학회지
• /
• 제14권1호
• /
• pp.66-75
• /
• 2000

From the traffic analysis, and model constructions and verifications for speed prediction on the freeway ramp junctions with 70mph speed limit, the following results were obtained : ⅰ) The traffic flow distribution showed a big difference depending on the time periods. Especially, more traffic flows were concentrated on the freeway junctions in the morning peak period when compared with the afternoon peak period. ⅱ) The occupancy distribution was also shown to be varied by a big difference depending on the time periods. Especially, the occupancy in the morning peak period showed over 100% increase when compared with the 24hours average occupancy, and the occupancy in the afternoon peak period over 25% increase when compared with the same occupancy. ⅲ) The speed distribution was not shown to have a big difference depending on the time periods. Especially, the speed in the morning peak period showed 10mph decrease when compared with the 24hours'average speed, but the speed did not show a big difference in the afternoon peak period. ⅳ) The analyses of variance showed a high explanatory power between the speed predictive models(SPM) constructed and the variables used, especially the upstream speed. ⅴ) The analysis of correlation for verifying the speed predictive models(SPM) constructed on the ramp junctions were shown to have a high correlation between observed data and predicted data. Especially, the correlation coefficients showed over 0.95 excluding the unstable condition on the diverge section. ⅵ) Speed predictive models constructed were shown to have the better results than the HCM models, even if the speed limits on the freeway were different between the HCM models and speed predictive models constructed.

• 한국항해항만학회:학술대회논문집
• /
• 한국항해항만학회 1999년도 추계학술대회논문집
• /
• pp.111-121
• /
• 1999

From the traffic analyses, and model constructions and verifications for speed prediction on the freeway ramp junctions with 70mph speed limit, the following results obtained: ⅰ) The traffic flow distribution showed a big difference depending on the time periods. Especially, more traffic flows were concentrated on the freeway junctions in the morning peak period when compared with the afternoon peak period. ⅱ) The occupancy distribution was also shown to be varied by a big difference depending on the time periods. Especially, the occupancy in the morning peak period showed over 100% increase when compared with the 24hours average occupancy, and the occupancy in the afternoon peak period over 25% increase when compared with the same occupancy.ⅲ) The speed distribution was not shown to have a big difference depending on the time periods. Especially, the speed in the morning peak period shown 10mph decrease when compared with the 24hours' average speed, but the speed did not show a big difference in the afternoon peak period.ⅳ) The analyses of variance showed a high explanatory power between the speed predictive models(SPM) constructed and the variables used, especially the upstream speed. ⅴ) The analysis of correlation for verifying the speed predictive models(SPM) constructed on the ramp junctions were shown to have a high correlation between observed data and predicted data. Especially, the correlation coefficients showed over 0.95 excluding the unstable condition on the diverge sectionⅵ) Speed predictive models constructed were shown to have the better results than the HCM models, even if the speed limits on the freeway were different between the HCM models and speed predictive models constructed.

• Nutrition Research and Practice
• /
• 제17권2호
• /
• pp.316-329
• /
• 2023

BACKGROUND/OBJECTIVES: This study investigated the association between dietary quality based on the Korean Healthy Eating Index (KHEI), and the prevalence of chronic conditions among middle-aged individuals (40-60 yrs of age) living alone. MATERIALS/METHODS: The participants were selected (1,517 men and 2,596 women) from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016-2018 and classified into single-person households (SPH) and multi-person households (MPH). Nutrient intake, KHEI, and the prevalence of chronic conditions were compared according to household size. The odds ratios (ORs) of chronic conditions were analyzed according to the tertile levels of KHEI by gender within each household size category. RESULTS: Men in SPH had a significantly lower total KHEI score (P < 0.0001) and a lower prevalence of obesity (OR, 0.576) than those in MPH. For men, the adjusted ORs for obesity, hypertension, and hypertriglyceridemia in the first tertile (T1) of KHEI scores within SPH compared with the third tertile (T3) were 4.625, 3.790, and 4.333, respectively. Moreover, the adjusted OR for hypertriglyceridemia in the T1 group compared to the T3 group within the MPH was 1.556. For women, the adjusted ORs for obesity and hypertriglyceridemia in T1 compared to T3 within the SPH were 3.223 and 7.134, respectively, and 1.573 and 1.373 for obesity and hypertension, respectively, within MPH. CONCLUSIONS: A healthy eating index was associated with a reduced risk of chronic conditions in middle-aged adults. Greater adherence to a healthy eating index could lower the risk of chronic conditions in middle-aged adults living alone.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제21권2호
• /
• pp.63-71
• /
• 2010

Objectives : The aim of this study was to investigate the effect of the clinical and demographic variables such as body weight, dosage, family history of attention-deficit hyperactivity disorder (ADHD), and psychiatric co-morbidity on the side-effects of OROS-Methylphenidate (OROS-MPH), and to evaluate the relationship between drug response and side effect severity. Methods : A total of 144 children (ages 6-18) with diagnosed ADHD were treated with OROS-MPH. Children were examined at baseline and after 1, 3, 6, 9, and 12 weeks of each treatment condition. The stimulant drug side effect rating scale (SERS), pulse rate, systolic blood pressure, diastolic blood pressure, and electrocardiogram (ECG) were evaluated to assess side effect profiles. Changes in these parameters from baseline were examined and analyzed. Results : Anorexia (30.95%) and insomnia (13.10%) were the most commonly reported side effects during this study. Insomnia and loss of appetite score increased at one week follow-up, but was sustained or decreased as treatment progressed. Small but significant increases in pulse rate and diastolic blood pressure were observed during treatment ; however, no clinically meaningful changes in ECG parameters were noted during the study. Low body weight, high dosage of OROS-MPH, and family history of ADHD were associated with cardiovascular side effect. In contrast, there was no significant relationship between OROS-MPH treatment response and the severity of side effect and no difference resulted between the responder and non-responder groups with respect to OROS-MPH dosage in the 12 weeks of follow-up. Conclusion : To the best of our knowledge, this study is the first Korean study to investigate comprehensive side effect profiles and their correlates in OROS-MPH treatment for ADHD children. OROS-MPH was well tolerated with no clinically significant side effects during the treatment period. In conclusion, low body weight, high dosage of OROSMPH, and family history of ADHD could be used as predictive factors in increasing pulse rate and blood pressure.

• 대한한방소아과학회지
• /
• 제24권3호
• /
• pp.138-149
• /
• 2010

Objectives: The purpose of this study is to estimate genetic and environmental factors which can effect growth, and predict final height using this factors. Methods: Correlation analysis and regression analysis were conducted between measurements of height and Genetic & environmental factors through survey from 1352 child & adolescent patients. Results: Factors which have correlation with height percentile are MPH(Mid-Parental Height), NBW(Neonatal body weight), anorexia, dyspepsia, atopic dermatitis, frequency of breakfast and quality of sleeping time. MPH has moderate relation, NBW and anorexia have fair relation, and other factors have linear but poor relation. Regression equation from factors which have correlation and height percentile has 26.9% of predictive power. Regression equation considering only genetic factor has 20.4%. MPH has the most effect on height percentile. Anorexia has more effect than NBW. Other factors also have small and similar effect. Conclusions: Height of parents has the most effect on growth, anorexia, dyspepsia, atopic dermatitis, frequency of breakfast and quality of sleeping time also has effect.