• Bulletin of the Korean Chemical Society
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• v.29 no.1
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• pp.51-56
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• 2008

The regioselective ring opening of epoxides using elemental iodine and bromine in the presence of methimazole (MMI, a anti-thyroid drug) and its metabolite methimazole-disulfide as new catalysts are studied. MMI easily converted in vitro to MMI-disulfide without any double activation presented in vivo. FT-Raman and UV spectroscopies are used to study the interaction of iodine with these catalysts. The results indicate that both catalysts are efficient in polyiodide formation, but MMI-disulfide can catalyze this reaction in higher yield and regioselectivity. The complex [(MMI-disulfide)I]+.I3- is considered to be formed initially which could be bulkier by addition of excess of iodine in the course of the reaction. These bulky nucleophiles have a fundamental role in the high regioselectivity by attacking the less sterically hindered epoxide carbon. In this study we suggest that MMI is readily converted to MMI-disulfide by interaction with iodine or activated iodine in thyroid gland, and this process is responsible for high anti-thyroid activity of MMI.

• The Journal of the Acoustical Society of Korea
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• v.38 no.5
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• pp.607-613
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• 2019

This paper proposes LF-MMI (Lattice Free Maximum Mutual Information)-based acoustic modeling using external knowledge for speech recognition. Note that an external knowledge refers to text data other than training data used in acoustic model. LF-MMI, objective function for optimization of training DNN (Deep Neural Network), has high performances in discriminative training. In LF-MMI, a phoneme probability as prior probability is used for predicting posterior probability of the DNN-based acoustic model. We propose using external knowledges for training the prior probability model to improve acoustic model based on DNN. It is measured to relative improvement 14 % as compared with the conventional LF-MMI-based model.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.2076-2088
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• 2010

MMI (Man Machine Interface) is the system that monitors the operating condition of the ATP/ATC/ATS systems and receives defined information from ATP/ATC/ATS systems through the interface with On-board systems. Based on the data from the ATP/ATC/ATS system, MMI can display the information and status of the train to secure safe operation. It is possible for the display mode and quantities of MMI to be improved by the customer's demand, and it can be designed as the same structure of existing devices for the driver. The ERTMS is Regular Safety Standards of high-speed railroad. It is fundamental structure of European Rail Control System which train control, safety and operate facilities. In this paper, I study requirements of ERTMS form which design function each section of MMI and application at ATP/ATC/ATS combined Train Constrol System.

• Nuclear Engineering and Technology
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• v.32 no.1
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• pp.88-98
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• 2000

More than half of all incidents in large complex technological systems, particularly in nuclear power or aviation industries, were attributable in some way to human erroneous actions. These incidents were largely due to the human engineering deficiencies of man-machine interface (MMI). In nuclear industry, advanced computer-based MMI designs are emerging as part of new reactor designs. The impact of advanced MMI technology on the operator performance, and as a result, on plant safety should be thoroughly evaluated before such technology is actually adopted in nuclear power plants. This paper discusses the applicability of human reliability analysis (HRA) to support the design review process. Both the first-generation and the second-generation HRA methods are considered focusing on a couple of promising HRA methods, i.e., ATHEANA and CREAM, with the potential to assist the design review process.

• International journal of thyroidology
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• v.10 no.1
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• pp.50-55
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• 2017

Sweet's syndrome, or acute febrile neutrophilic dermatosis, occurs in association with autoimmune diseases such as Hashimoto's thyroiditis but is rare in Graves' disease, in which all cases are induced by propylthiouracil (PTU). We report a case of Sweet's syndrome in a patient with Graves' disease treated with methimazole (MMI) during three weeks. A 34-year-old man presented with the acute onset of high fever, skin rashes on the whole body, arthralgia, and acroparesthesia. Laboratory results showed leukocytosis and elevated C-reactive protein. MMI first stopped and antibiotics and antihistamine therapy started, but his symptoms dramatically improved after oral prednisolone. Graves' disease has again been treated by MMI because of his aggravated ophthalmopathy. After one year of retreatment with MMI, there has been no recurrence of Sweet's syndrome, supporting that Sweet's syndrome in this case was not related to MMI exposure. To our knowledge, this is the first report of Sweet's syndrome associated with Graves' disease per se but not PTU or MMI use.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.11
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• pp.29-34
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• 2008

The propagation characteristics of novel grating-assisted multimode interference (GA-MMI) coupler are explicitly and theoretically investigated by using longitudinal modal transmission-line theory (L-MTLT). The coupling efficiency of GA-MMI coupler is evaluated along the variation of grating thickness and duty cycle, and the spectrum is analyzed numerically. The numerical results reveal that the coupling length and the efficiency of $2{\times}2$ GA-MMI coupler along the variation of grating structure have low tolerance and the bandwidth varies dramatically along the output states.

• Journal of the Earthquake Engineering Society of Korea
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• v.13 no.6
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• pp.11-25
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• 2009

A method of instrumentally estimating the seismic intensity (MMI) based on Fourier Acceleration Spectrum, which is the so-called 'FAS MMI method' of Sokolov and Wald (2002), was considered for its applicability to Korea. In order to implement the FAS MMI method, the empirical models of mean (m) and standard deviation (${\sigma}$) for Korea were derived for MMI ${\leq}$ IV according to individual seismic intensity by using the site-consistent horizontal FAS of 580 records from 65 isoseismal maps prepared based on the reported MMI of Korea Meteorological Administration. The site-consistent FAS at a site were obtained by correcting the observed FAS for the difference of the site amplification function relative to that of the target site of Class D station (Yun and Suh, 2007) which was evaluated to be a representative site for the generic soil profile of Korea. The FAS m model for MMI ${\leq}$ IV follows the overall linear relation in log space according to seismic intensities, featuring the FAS mean model for MMI = IV similar to that of the global model of Sokolov and Wald (2002). The ${\sigma}$-values of the FAS model are found to be greater than those of the global model for MMI ${\geq}$ V, while significantly lower than those of the global model for MMI = IV.

• 제어로봇시스템학회:학술대회논문집
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• 1990.10a
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• pp.107-112
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• 1990

It is necessary to develop graphic MMI (Man-Machine Interface) for the maximum utilization of our installed ADS (Automated Distribution System) for which an operator types and executes string commands. Considering the restrictions and characteristics of the installed ADS and the data for modelled distribution lines, we calculated the time of periodic data acquisition for large number of points. And we presented the performance and characteristics of the graphic MMI system which will be developed and which will facilitate SCADA(Supervisory Control And Data Acquisition) functions.

• Proceedings of the KSR Conference
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• 2011.10a
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• pp.2782-2786
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• 2011

In this paper a protocol design for bus network communication between onboard signalling system and MMI(Man Machine Interface) will be presented and illustrated. Recently, many onboard signailling systems adopt hot standby for safety reasons. Hot standby is a method of redundancy in which the primary and secondary systems run simultaneously. It is convenient to use bus network(bus topology) in a hot standby system for communication between onboard signalling system and MMI. Because bus network is the simplest way to connect multiple clients such as onboard signalling system, MMI and etc. However, there are many problems when two clients want to transmit at the same time on the same bus. A effective protocol is necessary to solve that problems. We will describes protocol design which is useful when onboard signalling systems and MMIs are connected via RS485(Bus Network).

• ETRI Journal
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• v.25 no.2
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• pp.81-88
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• 2003

We designed a multimode interference (MMI) coupler to use in vertical coupling of double layered polymeric waveguides and analyzed the coupling characteristics by comparing our experimental and simulation results. We found that our proposed new structure, a stepped MMI coupler, is effective in vertical coupling between waveguide layers with a short length of MMI and has a high tolerance for the variation in the structure of an MMI coupler that can be induced as errors in the fabrication process.