• Journal of Astronomy and Space Sciences
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• v.33 no.3
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• pp.173-176
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• 2016

We report on a systematic analysis of the spin and superorbital modulations of the high-mass X-ray binary 4U 0114+650, which consists of the slowest spinning neutron star known. Utilizing dynamic power spectra, we found that the spin period varied dramatically during the RXTE ASM and Swift BAT observations. This variation consists of a long-term spin-up trend, and two ~1,000 day and one ~600 day random walk epochs previously, MJD 51,000, ~MJD 51,400-52,000, and ~MJD 55,100-56,100. We further found that the events appear together with depressions of superorbital modulation amplitude. This provides evidence of the existence of an accretion disk, although the physical mechanism of superorbital modulation remains unclear. Furthermore, the decrease of the superorbital modulation amplitude may be associated with the decrease of mass accretion rate from the disk, and may distribute the accretion torque of the neutron star randomly in time.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.1
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• pp.32.1-32.1
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• 2021

We present the magnetic field strengths of CTA 102 using multi-frequency data at 2.6-343.5 GHz in order to study the physical origins of radio flares. The observations at 22 and 43 GHz were conducted using the single-dish radio telescopes of the Korean VLBI Network (KVN) from December 2012 until May 2018 (MJD 56200-58400). We used multi-frequency data obtained from the Effelsberg 100-m, OVRO 40-m, Metsähovi 14-m, IRAM 30-m, SMA, ALMA, and VLBA telescopes. During the period of the observations, two major flares (R1 and R2) are seen clearly at 15 and 37 GHz during MJD 57500-57800 and MJD 58000-58300, respectively. The source shows typical variability with time-scales ranging from 20-161 days at 15 GHz. The variability Doppler factor is in the range of 11.51-31.23. The quasi-simultaneous radio data are used to investigate the synchrotron spectrum of the source, finding that the synchrotron radiation is self-absorbed. The turnover frequency and the peak flux density of the synchrotron self-absorption (SSA) spectra are in ranges of 38.06-167.86 GHz and 1.49-10.38 Jy, respectively. From the SSA spectra, magnetic field strengths are estimated to be < 10 mG. The equipartition magnetic field strengths are larger than the SSA magnetic field strengths by a factor of > 100. This indicates that the radio flares may be related to a particle energy-dominated emission region.

• Journal of The Korean Astronomical Society
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• v.56 no.2
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• pp.231-252
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• 2023

We present the analysis results of the simultaneous multifrequency observations of the blazar 4C +28.07. The observations were conducted by the Interferometric Monitoring of Gamma-ray Bright Active Galactic Nuclei (iMOGABA) program, which is a key science program of the Korean Very Long Baseline Interferometry (VLBI) Network (KVN). Observations of the iMOGABA program for 4C +28.07 were conducted from 16 January 2013 (MJD 56308) to 13 March 2020 (MJD 58921). We also used γ-ray data from the Fermi Large Array Telescope (Fermi-LAT) Light Curve Repository, covering the energy range from 100 MeV to 100 GeV. We divided the iMOGABA data and the Fermi-LAT data into five periods from 0 to 4, according to the prosody of the 22 GHz data and the presence or absence of the data. In order to investigate the characteristics of each period, the light curves were plotted and compared. However, a peak that formed a hill was observed earlier than the period of a strong γ-ray flare at 43-86 GHz in period 3 (MJD 57400-58100). Therefore, we assumed that the minimum total CLEANed flux density for each frequency was quiescent flux (S_q) in which the core of 4C +28.07 emitted the minimum, with the variable flux (S_var) obtained by subtracting S_q from the values of the total CLEANed flux density. We then compared the variability of the spectral indices (α) between adjacent frequencies through a spectral analysis. Most notably, α_22-43 showed optically thick spectra in the absence of a strong γ-ray flare, and when the flare appeared, α_22-43 became optically thinner. In order to find out the characteristics of the magnetic field in the variable region, the magnetic field strength in the synchrotron self-absorption (B_SSA) and the equipartition magnetic field strength (B_eq) were obtained. We found that B_SSA is largely consistent with B_eq within the uncertainty, implying that the SSA region in the source is not significantly deviated from the equipartition condition in the γ-ray quiescent periods.

• Journal of Genetic Medicine
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• v.4 no.1
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• pp.84-87
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• 2007

Spinocerebellar Ataxia Type 3 (SCA 3) is a rare autosomal dominative disorder in which one of the neurodegenerative disorders is caused by a CAG repeat expansion on chromosome 14q32.1. The age at onset of disease is related to the size of the expanded CAG repeat. We present the prenatal diagnosis of SCA3 in a woman whose husband was known to carry an unstable CAG repeat expansion in the MJD gene. The diagnosis was made using PCR with a fluorescent probe for an expanded MJD allele. The normal ranges of (CAG)n of SCA3 are 14~38 repeats. The husband, who had a family history of SCA 3, has an expanded allele of 69 CAG repeats with a normal allele of 27 repeats. His wife had two normal alleles with 26 and 32 CAG repeats. The fetus had two normal alleles with 26 and 27 CAG repeats; consequently, the baby w as healthy. We report a case of prenatal diagnosis of SCA3 using a fluorescent PCR which is rapid and accurate.

• Journal of Microbiology and Biotechnology
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• v.8 no.6
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• pp.663-668
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• 1998

Several neurodegenerative diseases such as Huntington's disease, dentatorubralpallidoluysian atrophy, spinobulbar muscular atrophy, Machado-Joseph disease, and spinocerebellar ataxias type 1 are associated with the aggregation of expanded glutamine repeats within their proteins. Generally, in clinically affected individuals, the expansion of the polyglutamine sequences is beyond 40 residues. To address the length of polyglutamine that forms aggregation, we have constructed plasmids encoding glutathione S-transferase (GST) Machado-Joseph disease gene fusion proteins containing polyglutamine and investigated the formation of aggregates in E. coli. Surprisingly, even $(Gin)_8$, in the normal range as well as $(Gin)_{65}$ in the pathogenic range enhanced the formation of insoluble protein aggregates, whereas $(Ser)_8$, and $(Aia)_8$, did not form aggregates. Our results indicate that the formation of protein aggregates in GST-polyglutamine proteins is specifically mediated by the polyglutamine repeat sequence within their protein structure. Our study may contribute to the understanding of the molecular mechanism of the formation of protein aggregates in neurodegenerative disorders and the development of preventative strategies.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.22 no.6
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• pp.910-915
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• 2018

The precise time, which is an essential element of the Global Navigation Satellite System (GNSS), such as US GPS, GLONASS in Russia, Galileo in Europe, and Beidou in China, is an important foundation for various economic activities around the world. Communication systems, power grids, IoT, Cloud computing and financial networks operate based on the precise time not only for the operating principles, but also for the synchronization and operational efficiency between tasks. In this paper, we introduce the Atomium software for the first time in South Korea. Atomium was developed by ORB in Belgium to calculate the clock error(clock solution) with GNSS signal observation data based on PPP method. The observation data is provided by Korea Research Institute of Standards and Science(KRISS). The results of MJD57106 with Atomium software are presented.

• Journal of the Korean Association of Geographic Information Studies
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• v.11 no.4
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• pp.1-9
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• 2008

It is restricted on CPU ability, memory, display size and networking to process GIS data on ubiquitous-based terminal. For that reason, we tried to improve the cadastral electronic file to solve these problems in this paper. The format of old cadastral electronic files is not efficient because it is made of file structure. So, it has inconvenience to let us read whole file, displaying on the screen and connecting to geographic objects by adding index file like database for connecting to geographic object and displaying on the screen. The file size was decreased to 27.6% of original file size through converting format.

• Clinical and Experimental Pediatrics
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• v.48 no.4
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• pp.425-432
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• 2005

Purpose : Polyglutamine diseases are a group of diseases caused by the expansion of a polyglutamine tract in the protein. The present study was performed to verify if polyglutamine disease transgenic Drosophila models show similar dysfunctions as are seen in human patients. Methods : Polyglutamine disease transgenic Drosophila were tested for their climbing ability. And using genetic methods, the effects of anti-apoptotic gene bcl-2 and chemical chaperones on neurodegeneration were observed. Also, spinocerebellar ataxia 2 (SCA2) transgenic Drosophila lines were generated for future studies. Results : Expanded forms of spinocerebellar ataxia 3 (SCA3) transgenic protein causes characteristic locomotor dysfunction when expressed in the nervous system of Drosophila but the anti-apoptotic gene bcl-2 shows no evidence of ameliorating the deleterious effect of the expanded protein. However, Glycerol, a chemical chaperone, seemed to reduce the toxicity, at least in the eyes of the transgenic flies. The level SCA2 expression is too weak in the transgenic SCA2 Drosophila for evaluation. Conclusion : SCA3 transgenic Drosophila show ataxic behavior as observed in human patients. Chemical chaperones such as glycerol may prove beneficial in this class of genetic disease, which has no current method of cure.