• Proceedings of the Safety Management and Science Conference
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• 2012.04a
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• pp.535-545
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• 2012

국내의 많은 기업들은 품질경영시스템인 ISO 9000 시리즈와 식스시그마 등 기업의 품질 및 제품에 대한 품질을 높이기 위해 품질관리, 품질경영에 많은 시간과 비용을 들여왔다. 하지만 품질인증제도와는 달리 제품의 신뢰성에 관한 경영시스템인증을 받으려고 하는 기업은 거의 없는 실정이다. 부품 소재나 제품의 신뢰성을 확보하기 위한 방안으로써 신뢰성경영시스템에 대한 인증은 필수적이라 할 수 있다. 신뢰성 관련 기법들을 표준화하고, 효율적인 경영시스템을 도입하여 운영하고, 여기에 세계적으로 통용되는 기술체계를 도입하여 기업의 신뢰성경영시스템을 발전시킨다면 우리산업이 당면한 수출 경쟁력 확보 등의 현안문제 해결에도 도움이 될 수 있다. 본 연구에서는 신뢰성 경영시스템 인증제도 수립에 있어 국제 표준인 신뢰성경영시스템 IEC 60300에 대해 소개하고, 신뢰성 경영시스템 평가방법을 활용한 MIR기법과 AHP기법을 분석 비교하고, 개선방향을 제시하고자 한다.

• Proceedings of the Safety Management and Science Conference
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• 2004.05a
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• pp.161-167
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• 2004

IEC 60300 series, the international standards on reliability management system are newly developed and introduced rapidly worldwide. In order to meet this fast-changing situation, it is necessary to apply them to the Korean industries effectively. It includes the establishment of the infrastructure such as documentation of Korean Standards, introduction of test equipments and test manuals, accreditation of the certification body and training of the specialists etc. IEC 60300 is upgraded management system of the ISO 9000 and ISO 14000. In this regard, the Korean companies which was certified with the ISO 9000 or 14000 should endeavor to find new strategies and methods to be certified with ISO 60300. This paper introduces a quantitative method of estimating the level of the reliability management system by applying the MIR(Maturity Index on Reliability) technique. This enables the estimation of the operation level of the system and can upgrade the maturity level of it.

• Proceedings of the KSR Conference
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• 2005.11a
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• pp.21-26
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• 2005

The recent developments in the field of reliability and safety is the realisation that these aspects are not only a function of the product but also of the organisation realising this product. Comparing with old DIN 0801 and new method IEC61508, quantitative analysis is required at not only product's quality but also organization's level. Product's life cycle also should be evaluated by analyzing relevant or maturity of business processes. This paper shows the necessity for an analysis on all aspects in a safety certification process, and presents an overview of the available tools and techniques for the various quadrants. Especially, tools and techniques for IEC61508 quadrant C are unavailable currently. Therefore, this paper propose the method which improves the maturity of an organization on reliability management.

• Biomedical Science Letters
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• v.23 no.2
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• pp.133-137
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• 2017

Periodontitis is the major causation of tooth loss in the elderly population. Multiple risk factors include oral microorganisms, smoking, metabolic syndrome, and genetic factors influence periodontitis development. In this study, we conducted a replication study of using previous Korean GWAS results by examining an independent population. The study population was recruited from Mir Dental Clinic, Daegu, Korea. In total, 93 samples were evaluated from July 2016 to January 2017. The sample groups include relatively older patients (>60 years) with no periodontitis (n = 31) and relatively younger patients (range 40~60 years) with severe periodontitis (n = 62). A total of seven markers which were previously reported to be associated with periodontitis were genotyped. Among the seven SNPs, rs16846206 and rs2392510 showed a significant association by logistic regression analysis and Chi square test, respectively. The former SNP showed significant association with severe periodontitis, whereas this study also showed same tendency in which individuals with the minor allele are significantly more frequent in cases than those in controls. The SNP is located on a coding gene (SLC9C2), where the alanine residue 505 is replaced by glycine (Ala505Gly). The later SNP was significant when differed between case and control groups, but there was no significance by logistic regression analysis when controlled for age and sex as covariant. Although the study population size examined in the current study was relatively smaller compared to previous studies, our results implicated that at least the two SNPs (rs16846206 and rs2392510) might be important candidates for the further genetic study.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.1
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• pp.65.2-65.2
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• 2018

Through MIRIS $Pa{\alpha}$ Galactic plane survey, a lot of $Pa{\alpha}$ blobs were detected along the plane. To reveal their characteristics, we are planning to collect NIR high-resolution spectroscopic data for them by using Immersion GRating INfrared Spectrograph (IGRINS). Here, we present the preliminary results of the IGRINS observations for a Herbig Be star, MWC 1080, which is one of the $Pa{\alpha}$ blobs detected in Cepheus. This Herbig Be star is known to possess a lot of young stellar objects (YSOs) and bright MIR ($10-20{\mu}m$) nebulosity in its vicinity. From IPHAS $H{\alpha}$ data, we revealed large extended $H{\alpha}$ features that correlate well with MIR and 13CO morphologies around MWC 1080. A part of the $H{\alpha}$ features shows a bow shock shape to the northeast of the primary star MWC 1080A, which seems to be due to an outflow from MWC 1080A. Through IGRINS observations, we detected faint [Fe II] ${\lambda}1.644{\mu}m$ and H2 1-0 S(1) ${\lambda}2.122{\mu}m$ emission lines around the bow shock feature. Interestingly, to the east region of MWC 1080A, we also detected strong [Fe II] and H2 emission lines with a couple of velocity components, which suggests the detection of a new outflow from another YSO. Broad $Br{\gamma}$ ${\lambda}2.1662{\mu}m$ line and H2 lines with various velocity components were detected around the bright MIR and $H{\alpha}$ nebulosity as well.

• Journal of Korean Neurosurgical Society
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• v.65 no.5
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• pp.697-709
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• 2022

Objective : The present study aimed to identify the function of ischemic stroke (IS) patients' peripheral blood and its role in IS, explore the pathogenesis, and provide direction for clinical research progress by comprehensive bioinformatics analysis. Methods : Two datasets, including GSE58294 and GSE22255, were downloaded from Gene Expression Omnibus database. GEO2R was utilized to obtain differentially expressed genes (DEGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs were performed using the database annotation, visualization and integrated discovery database. The protein-protein interaction (PPI) network of DEGs was constructed by search tool of searching interactive gene and visualized by Cytoscape software, and then the Hub gene was identified by degree analysis. The microRNA (miRNA) and miRNA target genes closely related to the onset of stroke were obtained through the miRNA gene regulatory network. Results : In total, 36 DEGs, containing 27 up-regulated and nine down-regulated DEGs, were identified. GO functional analysis showed that these DEGs were involved in regulation of apoptotic process, cytoplasm, protein binding and other biological processes. KEGG enrichment analysis showed that these DEGs mediated signaling pathways, including human T-cell lymphotropic virus (HTLV)-I infection and microRNAs in cancer. The results of PPI network and cytohubba showed that there was a relationship between DEGs, and five hub genes related to stroke were obtained : SOCS3, KRAS, PTGS2, EGR1, and DUSP1. Combined with the visualization of DEG-miRNAs, hsa-mir-16-5p, hsa-mir-181a-5p and hsa-mir-124-3p were predicted to be the key miRNAs in stroke, and three miRNAs were related to hub gene. Conclusion : Thirty-six DEGs, five Hub genes, and three miRNA were obtained from bioinformatics analysis of IS microarray data, which might provide potential targets for diagnosis and treatment of IS.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.1
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• pp.57-57
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• 2010

We report the discovery of a bright mid-infrared (MIR) source with prominent crystalline silicate emission using the space telescope AKARI and Spitzer. This source, IRAS 15099-5856, has a spectacular morphology with a bright central compact source (CCS) surrounded by knots, spurs, and several extended (~4') arc-like filaments. The source is seen only in infrared at ${\geq}10{\mu}m$. The Spitzer MIR spectrum of the CCS shows prominent emission features from Mg-rich crystalline silicates and strong [Ne II] 12.88 ${\mu}m$ and several other faint ionic lines. We model the MIR spectrum as thermal emission from several independent dust components and compare their properties to those of the Herbig Be star HD 100546 which shows very similar MIR spectrum. Our molecular line observations reveal two molecular clouds around the source, but no associated dense molecular cores. We discuss two possible origins for IRAS 15099-5856; a deeply embedded massive young stellar object on the other side of the Galaxy and a disrupted, protoplanetary disk being photoevaporated by the UV radiation from the nearby O star Muzzio 10.

• Journal of Periodontal and Implant Science
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• v.37 no.4
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• pp.825-838
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• 2007

Endosseous implants are used in the treatment of various types of tooth loss, and numerous long-term studies have demonstrated the excellent reliability of this method of treatment. However, the increase of implant failure are associated with inadequate quality and/or height of bone. At the end of the 1980s, Wide(>3.75mm) implants were initially used for managing these difficult bone situations. The recommended indications for its use included poor bone quality, inadequate bone height. immediate placement in fresh extraction sockets, and immediate replacement of failed implants. At the 2000s, wider implants(6.0mm and 6.5mm) were used in a few studies. Although good clinical outcomes have been reported in recent years, there is still a controversy on this topic. Therefore, the purpose of this study was to estimate the survival rate of wide implants($6.0{\sim}8.0mm$) in molar regions, evaluating the clinical outcome. In this study, 1135 RBM surfaced wide implants($Rescue^{TM}$, MEGAZEN Co., Korea/595 maxillary, 540 mandibular) were placed in 650 patients(403 male, 247 female/age mean: $51.2{\pm}11.1$ years, range 20 to 83 years). Of the total, 68.3% were used to treat fully or partially edentulous situations, including single-tooth losses and 31.7% were placed immediately after teeth extraction or removal of failed implants, of which all were in the molar regions. Implant diameter and length ranged from 6.0 to 8.0mm and from 5.0 to 10.0mm respectively. The implants were followed for up to 42 months (mean: $14.6{\pm}9.5$ months). Of 1135 placed implants, 58 implants were lost. Among them, 53 implants were lost within 12 months after implant placement. The survival rate was 93.6% in the maxilla and 96.3% in the mandible, yielding an overall survival rate of 94.9%, for up to 42 months. As the result of Cox regression model, prosthetic type, sinus graft, and patient gender have an statistical significance on the implant survival rate in this study. This study suggests that the use of wide implants($6.0{\sim}8.0mm$) would provide a predictable treatment alternative in posterior areas.

• Journal of the Korean Magnetics Society
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• v.17 no.3
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• pp.141-146
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• 2007

A new class of LC-resonator for micro magnetic sensor device was invented and fabricated by means of MEMS technique. The micro LC-resonator consists of a solenoidal micro-inductor with a bundle of soft magnetic microwire cores and a capacitor connected in parallel to the micro-inductor. The core magnetic material is a tiny glass coated $Co_{83.2}B_{3.3}Si_{5.9}Mn_{7.6}$ microwire fabricated by a glasscoated melt spinning technique. The core materials were annealed at various temperatures $150^{\circ}C,\;200^{\circ}C\;,250^{\circ}C\;,$ and $300^{\circ}C$ for 1 hour in a vacuum to improve soft magnetic properties. The solenoidal micro-inductors fabricated by MEMS technique were $500{\sim}1,000{\mu}m$ in length with $10{\sim}20$ turns. The changes of inductance as a function of external magnetic field in micro-inductors with properly annealed microwire cores were varied as much as 370%. Since the permeability of ultra soft magnetic microwire is changing rapidly as a function of external magnetic field. The inductance ratio as well as magnetoimpedance ratio (MIR) in a LC-resonator was varied drastically as a function of external magnetic field. The MIR curves can be tuned very precisely to obtain maximum sensitivity. A prototype magnetic sensor device consisting of the developed microinductors with a multivibrator circuit was test successfully.

• Journal of the Korean Chemical Society
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• v.52 no.6
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• pp.649-656
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• 2008