• Journal of Chest Surgery
• /
• v.31 no.4
• /
• pp.353-361
• /
• 1998

Hypothermia is widely acknowledged as fundamental component of myocardial protection during cardiac operations. Although it prolongs the period of ischemic arrest by reducing oxygen demands, hypothermia is associated with a number of major disadvantages, including its detrimental effects on enzymatic function, energy generation, and cellular integrity. The ideal way to rotect the heart is to electromechanically arrest it and perfus it with blood that is aerobic arrest. However alternative technique has been developed, based on the principles of electromechanical arrest and normothermic aerobic perfusion using continuous warm blood cardioplegia. To determine if continuous warm blood cardioplegia was beneficial in clinical practice during valvular surgery, we studied two groups of patients matched by numbers and clinical characteristics. Group included is 31 patients undergoing valvular surgery who received intermittent cold crystalloid cardioplegia. Group II included 30 patients undergoing valvular surgery who received continuous warm blood cardioplegia. Our results suggest that the heartbeat in 100% of patients treated with continuous warm blood cardioplegia converted to normal sinus rhythm spontaneously after the removal of the aortic cross-clamp, compared to only 31% of the cold cardioplegia group. After operation, pericardial closure rate was 90% area in the warm group, compared to 35% area in the cold group. 12 hours after the operation, the total amount of urine output in the warm group was greater than that in the cold group(2863${\pm}$127 ml versus 2257${\pm}$127 ml; p<0.05). After the operation, left diaphragmatic elevation developed in 55% of the cold group but in 0% of the warm group. CK-MB level in the warm group was significantly lower than cold group(2.28${\pm}$0.62 versus 9.96${\pm}$2.12; p<0.01) 1 hour after operation and CK-MB level in the warm group was significantly lower than cold group(1.80${\pm}$1.01 versus 6.00${\pm}$1.74; p<0.05) 12hours after operation. Continuous warm blood cardioplegia is at least as safe and effective as hypothermic technique in patients undergoing cardiac valvular surgery. Conceptually, this represents a new approach to the problem of maintaining myocardial preservation during cardiac operations.

• 한국신재생에너지학회:학술대회논문집
• /
• 2010.06a
• /
• pp.227.1-227.1
• /
• 2010

본 연구는 자외선 영역의 흡수로 전자 정공의 전하쌍을 생성함으로써 광전압 및 전류를 일으키는 티타니아 물질을 금속지지체 표면에 양극산화로 튜브형 $TiO_2$(anodized tubular $TiO_2$; ATT)로 제조한 후 나노크기의 금속 혹은 $WO_3$입자를 담지하여 광감응 재료로 활용하였다. 이는 기존의 입자나 콜로이드 형태로 광촉매 물질을 고정화하여 사용한 재료의 탈리현상 및 효율저하를 극복하기 위함이다. ATT는 전해질 내에 전기화학적 에칭율과 화학적 용해율의 비율에 의해 나노튜브 길이 성장에 영향을 미치는데 이를 유기 전해질과 불산 전해질을 사용하여 정전압 혹은 정전류의 조건에서 다양한 길이의 $TiO_2$ 나노튜브를 제조하였다. 여기에 전기분해담지(electrolytic deposition; ELD)를 통하여 정전류 조건에서 다양한 금속(Pt, Pd, Ru)을 나노크기의 형태로 담지하여 광촉매 내 생성된 전자 정공의 재결합을 줄이고자 하였고 $WO_3$의 담지를 통하여 가시광 감응을 높이고자 하였다. 제조된 여러 조건의 시료는 SEM과 EDAX를 통하여 형태와 길이, 담지량을 확인 하고 XRD를 이용하여 열처리 온도에 따른 결정화상태를 확인하였으며 광전류 측정 및 Cr(VI)의 광환원과 MB의 광분해를 통하여 광효율을 관찰하였다. 금속이 도핑되었을 경우 순수 ATT보다 보통 3배의 흡착률과 UV광원 아래 2배의 광효율을 관찰할 수 있었는데 이 중 Pt의 담지가 가장 효율이 좋았으며 흡착률에서는 담지량의 증가에 따른 증가선을 관찰 할 수 있었으나 광원 사용시 3%담지율에서 최적을 확인 할 수 있었다. 또한 $TiO_2$외 가시광감응 활성을 높이기 위한 다양한 광촉매제조가 진행 중에 있다.

• Asian-Australasian Journal of Animal Sciences
• /
• v.24 no.12
• /
• pp.1660-1665
• /
• 2011

This study presents a linkage disequilibrium (LD) analysis and effective population size ($N_e$) for the entire Hanwoo Korean cattle genome, which is the first LD map and effective population size estimate ever calculated for this breed. A panel of 4,525 markers was used in the final LD analysis. The pairwise $r^2$ statistic of SNPs up to 50 Mb apart across the genome was estimated. A mean value of $r^2$ = 0.23 was observed in pairwise distances of <25 kb and dropped to 0.1 at 40 to 60 kb, which is similar to the average intermarker distance used in this study. The proportion of SNPs in useful LD ($r^2{\geq}0.25$) was 20% for the distance of 10 and 20 kb between SNPs. Analyses of past effective population size estimates based on direct estimates of recombination rates from SNP data demonstrated that a decline in effective population size to $N_e$ = 98.1 occurred up to three generations ago.

• Journal of Ginseng Research
• /
• v.39 no.3
• /
• pp.206-212
• /
• 2015

Background: Ginseng total saponin (GTS) contains various ginsenosides. These ginsenosides are widely used for treating cardiovascular diseases in Asian communities. The aim of this study was to study the effects of GTS on cardiac injury after global ischemia and reperfusion (I/R) in isolated guinea pig hearts. Methods: Animals were subjected to normothermic ischemia for 60 minutes, followed by 120 minutes of reperfusion. GTS significantly increased aortic flow, coronary flow, and cardiac output. Moreover, GTS significantly increased left ventricular systolic pressure and the maximal rate of contraction ($+dP/dt_{max}$) and relaxation ($-dP/dt_{max}$). In addition, GTS has been shown to ameliorate electrocardiographic changes such as the QRS complex, QT interval, and RR interval. Results: GTS significantly suppressed the biochemical parameters (i.e., lactate dehydrogenase, creatine kinase-MB fraction, and cardiac troponin I levels) and normalized the oxidative stress markers (i.e., malondialdehyde, glutathione, and nitrite). In addition, GTS also markedly inhibits the expression of interleukin-$1{\beta}$ (IL-$1{\beta}$), IL-6, and nuclear factor-${\kappa}B$, and improves the expression of IL-10 in cardiac tissue. Conclusion: These data indicate that GTS mitigates myocardial damage by modulating the biochemical and oxidative stress related to cardiac I/R injury.

• JSTS:Journal of Semiconductor Technology and Science
• /
• v.1 no.2
• /
• pp.125-131
• /
• 2001

When the program voltage is applied to a word line, a part of the boosted channel charge in inhibited bit lines is lost due to the coupling between the string select line (SSL) and the adjacent word line. This phenomenon causes the program disturbance in the cells connected to the inhibited bit lines. This program disturbance becomes more serious, as the word line pitch is decreased. To reduce the word line coupling, the rising edge of the word-line voltage waveform was changed from a pulse step into a ramp waveform with a controlled slope. The word-line ramping circuit was composed of a timer, a decoder, a 8 b D/A converter, a comparator, and a high voltage switch pump (HVSP). The ramping voltage was generated by using a stepping waveform. The rising time and the stepping number of the word-line voltage for programming were set to $\mutextrm{m}-$ and 8, respectively,. The ramping circuit was used in a 512Mb NAND flash memory fabricated with a $0.15-\mutextrm{m}$ CMOS technology, reducing the SSL coupling voltage from 1.4V into a value below 0.4V.

• Genomics & Informatics
• /
• v.14 no.4
• /
• pp.230-233
• /
• 2016

Linkage disequilibrium (LD) is the non-random association between the loci and it could give us a preliminary insight into the genetic history of the population. In the present study LD patterns and effective population size (Ne) of three Korean cattle breeds along with Chinese, Japanese and Mongolian cattle were compared using the bovine Illumina SNP50 panel. The effective population size (Ne) is the number of breeding individuals in a population and is particularly important as it determines the rate at which genetic variation is lost. The genotype data in our study comprised a total of 129 samples, varying from 4 to 39 samples. After quality control there were ~29,000 single nucleotide polymorphisms (SNPs) for which $r^2$ value was calculated. Average distance between SNP pairs was 1.14 Mb across all breeds. Average $r^2$ between adjacent SNP pairs ranged between was 0.1 for Yanbian to 0.3 for Qinchuan. Effective population size of the breeds based on $r^2$ varied from 16 in Hainan to 226 in Yanbian. Amongst the Korean native breeds effective population size of Brindle Hanwoo was the least with Ne = 59 and Brown Hanwoo was the highest with Ne = 83. The effective population size of the Korean cattle breeds has been decreasing alarmingly over the past generations. We suggest appropriate measures to be taken to prevent these local breeds in their native tracts.

• Korean Journal of Digital Imaging in Medicine
• /
• v.9 no.1
• /
• pp.31-35
• /
• 2007

외부 데이터가 진료병원 Server에 저장됨에 있어서 판독을 의뢰하지 않을 경우, 대부분의 병원이 무상으로 이루어 지고 있는 상황이며 이에 외부 데이터 단순 import의 효율적인 관리를 위한 수가 적용 여부를 검토하였다. 2007년 3월부터 4월까지 서울 경기 지역의 PACS가 도입 된지 1년 이상, 병상 수 500Bed 이상의 종합 대학병원 25곳에 근무하는 각 병원의 PACS 운영실 및 PACS 관리자를 대상으로 하였다. 외부 데이터에 관한 10가지 항목의 설문지를 작성하여 각 병원의 PASC 담당자 및 관리자를 대상으로 E-mail을 이용한 자기 기입 방식, 전화를 통한 질의응답 방식으로 조사하였다. 조사된 25개의 종합 대학병원의 96%이상이 외부 데이터 단순 import를 지원하고 있었으며, 그 중 92%의 병원은 무상으로 이루어지고 있었다. 이와 같이 진행 되는 부분에 대하여 각 병원의 PACS 담당자 70% 이상이 단순 import에 대한 수가 적용의 필요성을 느끼고 있으며, 현재 많은 병원에서 단순 import의 무상 지원으로 인한 문제점을 인식하고 있었다. K병원을 기준으로 단순 import에 년간 H/W 소요 비용은 336만원이고, 년간 인건비 소요비용은 421만원이다. 또한 단순 import 한 건당 평균 데이터 size는 48MB 정도로 조사되었다. 환자 입장에서 진료에 참고자료로 사용 될 외부 데이터의 정확한 저장과 정당한 PACS 사용을 위해서는 그에 상응하는 수가가 적용 되어야 할 것이다. 보험심사평가원 급여기준에 따라 수가적용이 인정되어 의료영상 디지털화로 인한 초기의 고액 투자비용 보장과 회수를 위해 단순 Import의 수가 적용이 반드시 필요하다고 사료 된다.

• Journal of Animal Science and Technology
• /
• v.57 no.12
• /
• pp.47.1-47.10
• /
• 2015

Background: Knowledge of linkage disequilibrium (LD) levels among different populations can be used to detect genetic diversity and to investigate the historical changes in population sizes. Availability of large numbers of SNP through new sequencing technologies has provided opportunities for extensive researches in quantifying LD patterns in cattle breeds. The aim of this study was to compare the extent of linkage disequilibrium among Iranian cattle breeds using high density SNP genotyping data. Results: A total of 70 samples, representing seven Iranian indigenous cattle breeds, were genotyped for 777962 SNPs. The average values of LD based on the $r^2$ criterion were computed by grouping all syntenic SNP pairwises for intermarker distances from 0 Kb up to 1 Mb using three distance sets. Average $r^2$ above 0.3 was observed at distances less than 30 Kb for Sistani and Kermani, 20 Kb for Najdi, Taleshi, Kurdi and Sarabi, and 10 Kb for Mazandarani. The LD levels were considerably different among the Iranian cattle breeds and the difference in LD extent was more detectable between the studied breeds at longer distances. Lower level of LD was observed for Mazandarani breed as compared to other breeds indicating larger ancestral population size in this breed. Kermani breed continued to have more slowly LD decay than all of the other breeds after 3 Kb distances. More slowly LD decay was observed in Kurdi and Sarabi breeds at larger distances (>100 Kb) showing that population decline has been more intense in more recent generations for these populations. Conclusions: A wide genetic diversity and different historical background were well reflected in the LD levels among Iranian cattle breeds. More LD fluctuation was observed in the shorter distances (less than 10 Kb) in different cattle populations. Despite of the sample size effects, High LD levels found in this study were in accordance with the presence of inbreeding and population decline in Iranian cattle breeds.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.28 no.6
• /
• pp.29-51
• /
• 2001

The purpose of this research is to analyze of biotope structure focused on the evaluation for the species and biotope preservation in the case of Soosung District in Daegu metropolitan city. We analyzed the structure of urban biotope, and investigated the disposition of space and several characteristics through the material collection relating to the existing urban ecological material and the field investigation. The results of this study were as follows; 1) The result of biotope type classification was divided into 17 biotope type groups and 90 biotope types belonging to them. 2) The biotope type of mixed forest(QD) has the highest rate in occupation area, 1.764ha and the biotope type of cultivation areas by vinyle-hothouse(KC) has the lowest rate, 0.3ha. 3) In the result of the first evaluation for the species and biotope preservation, biotope types such as QB, QI, PA, PB, NB and NC etc. possess great value. Particulary, these biotope types come from forest areas and transition zone. They have not appeared in the inner of cities. 4) The biotope types such as CA, NA, NB, ND and PB are proved to possess high value in the result of rarity and riskiness evaluation. There appear EE, MA, NB, QC and QD in IV grade which is impossible to have them regenerative. They usually have appeared in forest areas. 5) There emerge 3a biotope type that has the highest value in the result of the second evaluation such as CC, EE, KF, LD, MB, NC, PB, QB and QI etc. Most of them were presented into the large area of site size and were distributed in the forest areas intensively. So, it is certain that the space for the species and biotope preservation connected with residential district is scarce. 6) The detailed biotope plan must be made out specially continuously. It is about biotope spaces that are especially important for the species and biotope preservation from the result of this research. Also, the study on the detailed index settlement of the urban landscape plan based on the biotope map must be continued.

• Convergence Security Journal
• /
• v.12 no.4
• /
• pp.9-15
• /
• 2012

In recently years, repackaged malwares are becoming increased rapidly in Android smartphones. The repackaging is a technique to disassemble an app in a market, modify its source code, and then re-assemble the code, so that it is commonly used to make malwares by inserting malicious code in an app. However, it is impossible to collect all the apps in many android markets including too many apps. To solve the problem, we propose RePAD (RePackaged App Detector) scheme that is composed of a client and a remote server. In the smartphone-side, the client extracts the information of an app with low CPU overhead when a user installs the app. The remote server analyzes the information to decide whether the app is repackaged or not. Thus, the scheme reduces the time and cost to decide whether apps are repackaged. For the experiments, the client and server are implemented as an app on Galaxy TAB and PC respectively. We indicated that seven pairs of apps among ones collected in official and unofficial market are repackaged. Furthermore, RePAD only increases the average of CPU overhead of 1.9% and the maximum memory usage of 3.5 MB in Galaxy TAB.