• The Korean Journal of Physiology and Pharmacology
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• v.23 no.6
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• pp.475-482
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• 2019

Glioma is the most common brain tumor with a dismal prognosis. While temozolomide (TMZ) based chemotherapy significantly improves survival in glioma patients, resistance against this compound commonly leads to glioma treatment failure. Overexpression of long-noncoding RNA (LncRNA) FoxD2 adjacent opposite strand RNA 1 (FoxD2-AS1) was identified to promote glioma development, but the role in TMZ resistance remains unclear. In this paper, we found that FoxD2-AS1 was overexpressed in recurrent glioma, high FoxD2-AS1 expression was significantly correlated with poor patient outcome. Methylation of $O^6$-methylguanine-DNA methyltransferase (MGMT) is significantly less frequent in high FoxD2-AS1 expression patients. Knockdown of FoxD2-AS1 decreased the proliferation, metastatic ability of glioma cells and promote the sensitivity to TMZ in glioma cells. Furthermore, knockdown of FoxD2-AS1 induced hypermethylation of the promoter region of MGMT. Our data suggested that FoxD2-AS1 is a clinical relevance LncRNA and mediates TMZ resistance by regulating the methylation status of the MGMT promoter region.

• Investigative Magnetic Resonance Imaging
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• v.22 no.3
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• pp.158-167
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• 2018

Purpose: To investigate the surgical, perfusion, and molecular characteristics of glioblastomas which influence long-term survival after treatment, and to explore the association between MR perfusion parameters and the presence of MGMT methylation and 1p/19q deletions. Materials and Methods: This retrospective study was approved by our institutional review board. A total 43 patients were included, all with pathologic diagnosis of glioblastoma with known MGMT methylation and 1p/19q deletion statuses. We divided these patients into long-term (${\geq}60\;months$, n = 7) and short-term (< 60 months, n = 36) survivors, then compared surgical extent, molecular status, and rCBV parameters between the two groups using Fisher's exact test or Mann-Whitney test. The rCBV parameters were analyzed according to the presence of MGMT methylation and 1p/19q deletions. We investigated the relationship between the mean rCBV and overall survival using linear correlation. Multivariable linear regression was performed in order to find the variables related to overall survival. Results: Long-term survivors (100% [7 of 7]) demonstrated a greater percentage of gross total or near total resection than short-term survivors (54.5% [18 of 33]). A higher prevalence of 1p/19q deletions was also noted among the long-term survivors (42.9% [3 of 7]) than the short-term survivors (0.0% [0 of 36]). The rCBV parameters did not differ between the long-term and short-term survivors. The rCBV values were marginally lower in patients with MGMT methylation and 1p/19q deletions. Despite no correlation found between overall survival and rCBV in the whole group, the short-term survivor group showed negative correlation ($R^2=0.181$, P = 0.025). Multivariable linear regression revealed that surgical extent and 1p/19q deletions, but not rCBV values, were associated with prolonged overall survival. Conclusion: While preoperative rCBV and 1p/19q deletion status are related to each other, only surgical extent and the presence of 1p/19q deletion in GBM patients may predict long-term survival.

• Proceedings of the Korean Environmental Sciences Society Conference
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• 2002.05b
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• pp.402-406
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• 2002

• International conference on construction engineering and project management
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• 2005.10a
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• pp.360-365
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• 2005

The need of constructing high-tech facilities is one of the important issues concerning the competitiveness by the high-tech companies. It, simultaneously, offers a magnificent opportunity for construction participants. Nevertheless, the high-tech construction is experience-based, resulting in little related construction knowledge that has been statistically analyzed and documented. This study measures and confers with the profit patterns causing the disparity between the traditional and high-tech construction. The database was the result of collecting detailed information of 65 construction projects from eight construction companies, including detailed records of over 20 main construction operations in each project. All of these were performed during the recent 10 years and encompassed in the project types of the high-tech construction, residential building, and commercial building. Rendering suggestions regarding profit management and expecting to economize cost of learning from inexperience while extending to the high-tech construction were both presented.

• Journal of Gastric Cancer
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• v.6 no.4
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• pp.227-236
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• 2006

Purpose: Methylation of gene regulatory elements plays an important role in gene inactivation without genetic alteration. Gastric cancer is one of the tumors that exhibit a high frequency of CpG island hypermethylation. The purpose of this study was to investigate the occurrence of CpG island hypermethylation in gastric carcinoma in relation to H. pylori infection, CIMP and clincopathologic variables. Materials and Methods: We investigated the promoter methylation Status of six genes (hMLH1, p16, p14, COX-2, MGMT, E-cadherin) and CIMP in 36 gastric carcinoma tissues as well as in nontumor tissues. CIMP status was investigated by examining the methylation status of MINT 1, 2, 12, 25 and 31. The methylation status of the promoter was examined by methylation-specific PCR (MSP) and H. pylori infection was examined by histological diagnosis after staining with Warthin-Starry silver. Results: Among the 36 gastric carcinoma tissues, DNA hypermethylation was detected in the following frequencies: 14 (38.9%) for p14, 13 (36.1%) for p16, 8 (22.2%) for MGMT, 10 (27.8%) for COX-2, 21 (58.3%) for E-cadherin, and 6 (16.7%) for hMLH1. The frequencies for MINT1 and MINT25 hypermethylation were significantly higher in tumor tissues than in nontumor tissues. 16 (44.4%) of the 36 gastric carcinoma tissues were positive for the CIMP CIMP-H tumors were associated with older patients and larger tumor size than CIMP-L tumors. We found a significant association between the presence of the CIMP and hypermethylation of p16. Hypermethylation of p16 and MINT2 were significantly different when compared by age. MINT1 gene methylation was significantly associated with H. pylori infection (P=0.004). Conclusion: Our results suggest that aberrant hypermethylation of multiple tumor related genes (hMLH1, p16, p14, COX-2, MGMT, E-cadherin, MINT1, 2, 12, 25, 31) occurs frequently in gastric carcinoma tissues. The hypermethylation of MINT1 was significantly higher in the tumor tissues and was associated with H. pylori infection.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.5
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• pp.2727-2728
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• 2016

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.11
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• pp.94-101
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• 2020

This study examined the effect of the sale price by excluding the PHC-pile cost from the construction costs for basic type (CCsBT) as an additional cost. The Ministry of Land, Infrastructure, and Transport excluded the PHC-pile cost in the CCsBT and new method so that only the designed pile quantity was recognized as an additional cost. The effect on the sale price was analyzed by comparing the pile cost of the existing and new methods. For this purpose, seven cases were selected, and the PHC-pile cost was estimated. The existing method was estimated as the ratio of the pile cost to CCsBT. The new method was estimated based on the bill of quantity. As a result, the CCsBT decreased by approximately 2-3% when the PHC-pile cost was calculated in the new method. Furthermore, as a result of comparing the sale price, excluding the PHC-pile cost with the sale price, the CCsBT decreased by approximately 1%. These results are expected to help improve the understanding of the CCsBT. Also, this paper contributes to promoting national housing stability through institutional improvement.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.10
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• pp.248-258
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• 2020

This study proposed a breakdown structure for maintenance and management technologies under the concept of comprehensive asset management at the life cycle level of infrastructure based on benchmarking with other developed countries. For this purpose, a comparative case study was performed to review and analyze the existing definitions and hierarchies for infrastructure maintenance, repair, and rehabilitation (MR&R) systems under major industrialized countries and South Korea. In accordance with the ratio of maintenance costs to GDP, the U.S., U.K, and Japan were selected to review their systems. The classifications and definitions of MR&R technologies under the laws were analyzed. The result showed that most developed countries differentiate maintenance and repair from improvement and constitute a system centered on preventive maintenance activities. On the other hand, Korea's system for facility management is not definitely classified and still focused on reactive structures, which need to be improved. In this study, as proposed, a breakdown structure established the concept of Maintenance and Management, Maintenance & Repair, and Performance Improvement. Consequently, this study could be used as the basis for the implementation of preventive MR&R activities and reasonable resource allocations from an asset management point of view.

• Journal of Korean Neurosurgical Society
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• v.59 no.1
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• pp.44-51
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• 2016

Objective : Malignant gliomas with neuronal marker expression (MGwNM) are rare and poorly characterized. Increasingly diverse types of MGwNM have been described and these reported cases underscore the dilemmas in the classification and diagnosis of those tumors. The aim of this study is to provide additional insights into MGwNM and present the clinicopathological features of 18 patients. Methods : We reviewed the medical records of 18 patients diagnosed as MGwNM at our institute between January 2006 and December 2012. Macroscopic total resection was performed in 11 patients (61%). We evaluated the methylation status of $O^6$-methylguanine-DNA methyltransferase (MGMT) and expression of isocitrate dehydrogenase 1 (IDH-1) in all cases, and deletions of 1p and 19q in available cases. Results : The estimated median overall survival was 21.2 months. The median progression-free survival was 6.3 months. Six patients (33%) had MGMT methylation but IDH1 mutation was found in only one patient (6%). Gene analysis for 1p19q performed in nine patients revealed no deletion in six, 19q deletion only in two, and 1p deletion only in one. The extent of resection was significantly correlated with progression free survival on both univariate analysis and multivariate analysis (p=0.002 and p=0.013, respectively). Conclusion : In this study, the overall survival of MGwNM was not superior to glioblastoma. The extent of resection has a significant prognostic impact on progression-free survival. Further studies of the prognostic factors related to chemo-radio therapy, similar to studies with glioblastoma, are mandatory to improve survival.

• Journal of the Korea Society of Computer and Information
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• v.26 no.1
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• pp.231-238
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• 2021

In this paper, we suggest a method of analysis for daily food delivery & consumption trends through big data of the post-Covid-19 era. Through analysis of big data and the database system, four analyzed factors, excluding weather, was proved to have significant correlation with delivery sales for 'Baedarui Minjok' of a catering delivery application. The research found that KBS, MBC and SBS Media showed remarkable results in food delivery & consumption sales soaring up to about 60 percent increase on the day after the Covid-19 related new article was issued. In addition, it proved that mobile media and web surfing were the main factors in increasing sales of food delivery & consumption applications, suggesting that viral marketing and emotional analysis by crawling data from SNS used by Millennials might be an important factor in sales growth. It can contribute the companies in the economic recession era to survive by providing the method for analyzing the big data and increasing their sales.