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Antimicrobial Properties of Turmeric (Curcuma longa L.) Rhizome-Derived ar-Turmerone and Curcumin

  • Lee, Hoi-Seon
    • Food Science and Biotechnology
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    • v.15 no.4
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    • pp.559-563
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    • 2006
  • The growth responses of six bacterial strains exposed to materials extracted from turmeric (Curcuma longa) rhizomes were examined using impregnated paper disk agar diffusion. Methanol extracts of turmeric rhizomes exhibited strong inhibitory activity against Clostridium perfringens and weak inhibitory activity toward Escherichia coli at 5 mg/disk. However, in tests conducted with Bifidobacterium adolescentis, B. bifidum, B. longum, and Lactobacillus casei, the methanol extract showed no inhibitory response. The biologically active constituent isolated from the turmeric rhizomes extracts was characterized as ar-turmerone using various spectroscopic analyses including EI-MS and NMR. The responses varied according to the dosage, chemicals, and bacterial strain tested. At 2 and 1 mg/disk, ar-turmerone strongly inhibited the growth of C. perfringens and moderately inhibited the growth of E. coli without any adverse effects on the growth of four lactic acid-bacteria. Of the commercially available compounds originating from turmeric rhizomes, curcumin exhibited strong and moderate growth inhibition against C. perfringens at 2 and 1 mg/disk, respectively, and weak growth inhibition against E. coli at 1 mg/disk. However, little or no activity was observed for borneol, 1,8-cineole, and sabinene against all six bacteria strains tested. The observed inhibitory activity of the turmeric rhizome-derived curcumin and ar-turmerone against C. perfringens and E. coli demonstrate one of the important pharmacological activities of turmeric rhizomes.

Chemical Composition and Active Antioxidants of Eucommia ulmoides Oliv. Bark

  • Qu, Guan-Zheng;Si, Chuan-Ling;Yin, Yu;Wang, Myeong-Hyeon
    • Nutritional Sciences
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    • v.9 no.4
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    • pp.330-334
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    • 2006
  • Chemical composition of the Eucommia ulmoides bark, including extractives, proximate, mineral, fatty acid and monosaccharide compositions, was studied The most abundant mineral was calcium (533.17 mg/l00 g). $\alpha-linolenic$ acid (24.7%) and linoleic acid (24.3%), showed higher contents among the fatty acids. Major monosaccharides of E. ulmoides balk were arabinose (13.94 mg/g), xylose (18.91 mg/g) and glucose (119.7 mg/g). From the bark of E ulmoides, four compounds were isolated and their structures were elucidated as caffeic acid (I), kaempferol (II), quercetin (III) and isoquercitrin (IV) by spectroscopic analysis such as NMR and MS, including cellulose TLC and other chemical evidence such as hydrolyzation and acetylation. The antioxidant activities of four isolated compounds were evaluated by DPPH free radical scavenging, hydroxyl scavenging and reducing power assays. The results indicated that all the isolated compounds showed higher DPPH radical scavenging activity than $\alpha-tocopherol$ and BHT that were used as positive controls and these four compounds exhibited considerable reducing power and hydroxyl radical (OH) scavenging activity. Considering from the results above, it suggests that the E. ulmoides bark is a potential natural source of antioxidant material.

Effect of the Holding Temperature and Vacuum Pressure for the Open Cell Mg Alloy Foams

  • Yue, Xue-Zheng;Hur, Bo-Young
    • Korean Journal of Materials Research
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    • v.22 no.6
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    • pp.309-315
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    • 2012
  • Metal foam has many excellent properties, such as light weight, incombustibility, good thermal insulation, sound absorption, energy absorption, and environmental friendliness. It has two types of macrostructure, a closed-cell foam with sealed pores and an open-cell foam with open pores. The open-cell foam has a complex macrostructure consisting of an interconnected network. It can be exploited as a degradable biomaterial and a heat exchanger material. In this paper, open cell Mg alloy foams have been produced by infiltrating molten Mg alloy into porous pre-forms, where granules facilitate porous material. The granules have suitable strength and excellent thermal stability. They are also inexpensive and easily move out from open-cell foamed Mg-Al alloy materials. When the melt casting process used an inert gas, the molten magnesium igniting is resolved easily. The effects of the preheating temperature of the filler particle mould, negative pressure, and granule size on the fluidity of the open cell Mg alloy foam were investigated. With the increased infiltration pressure, preheat temperature and granule sizes during casting process, the molten AZ31 alloy was high fluidity. The optimum casting temperature, preheating temperature of the filler particle mould, and negative pressure were $750^{\circ}C$, $400-500^{\circ}C$, and 5000-6000 Pa, respectively, At these conditions the AZ31 alloy had good fluidity and castability with the longest infiltration length, fewer defects, and a uniform pore structure.

In Vitro Mass Propagation and Soil Adjastment of Zanthoxylum piperitum var. inerme Makino through Apical Meristem Culture (生長點 培養에 依한 민초피나무(Zanthoxylum piperitum var. inerme Makino)의 器內 大量 增殖 및 土壤 活着)

  • Jeong, Woo-Gyu;Lee, Sang-Rae
    • Korean Journal of Plant Resources
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    • v.6 no.2
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    • pp.171-179
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    • 1993
  • This study was conducted to investigate the effect of growth regulators and medium composition on the growth of each stage in apical meristem culture for mass propagation of Zanthoxylum piperitum var. inerme Makino. The source material, shoot tip segments were taken from three-years old graft trees. Apical meristems were cultured in vitro on basal MS, GD, WS, half strength MS(1/2MS) and half strength GD(1/2GD) media supplemented with various concentrations for growth regulators(BA, IBA) and inorganic nutrients. The results summarized are as follows: 1. In culture establishment stage, ratio of culture establishment was 96.7% and the best resuit was obtained using MS medium supplemented with 1.0mg/l BA and 0.2mg/l IBA. 2. In shoot multitication stage, both shoot multiplication and growth were achieved in average 5.6cm. These results were obtained on in MS medium supplemented with 1.0mg/l BA and 0.2mg/l IBA. 3. In roothing stage, phloroglucinol(PG) acted as IBA synergist in root initiation. The most faverable combinations for root development was half-strength MS medium supplemented with 162mg/l PG and 0.2mg/l IBA, and ratio of rooting was 58.0%. 4. In Vitro formed plantlets were transplanted to paper pots in greenhouse with 85% of relative humidity. 96% of survival rate was obtained from artificial soil mix having same volume of sand, vermiculite, peat, and soil.

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Evaluation of Chlorine Demand and Chlorine Decay Kinetics for Drinking Water (정수처리에서 염수요구량 및 반응거동에 관한 연구)

  • 이윤진;조관형;최종헌;명복태;남상호
    • Journal of Environmental Health Sciences
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    • v.27 no.1
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    • pp.27-35
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    • 2001
  • This aim of the work presented in this paper is to investigate the factors that affcet chlorine decay and to develop functional relationships that can be used to enhance the durability of network models. predictive relationships were established that correlated the rate of chlorine decay to the various water conditions such as DOC, N $H_3$-N, initial chlorine, contact time, temperature and pH values. Free chlorine residual decreased with increasing temperature, DOC, N $H_3$-N, reaction time and chlorine dose. At 2$0^{\circ}C$, pH 7, The initial chlorine demand per mg as DOC/L and mg as N $H_3$-N/L was about 0.43, 2.69 mg/$\ell$ respectively at 180 minutes contact time. The Reaction between chlorine and humic acids was lasted intil 48hr, but the reaction between chlorine and N $H_3$-N was almost completed in 180 min. When the temperature is raised by 1$0^{\circ}C$, chlorine is more consumed about 0.25 mg/$\ell$ in the absence of organic substances and it is more consumed about 3.4 mg/$\ell$ in the presence of humic acid (5 mg/$\ell$) in water at pH 7 for 180 min. Regression Analysis created the resulting prediction equation for the chlorine decay in a SPSS package of the computer system. The model is as follows; $C_{t}$=1.239+0.707(Co)-0.000529(Time)-0.0112(Temp)+0.02227(pH)-0.42(DOC)-2.132(N $H_3$-N).).

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Study on the Chemical Characteristics of $PM_{10}$ at Background Area in Korean Peninsula (한반도 서해안 배경지역 미세입자의 화학적 특성 연구)

  • Bang So-Young;Baek Kwang-Wook;Chung Jin-Do;Nam Jae-Cheol
    • Journal of Environmental Health Sciences
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    • v.30 no.5 s.81
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    • pp.455-468
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    • 2004
  • The purpose of this paper is to understand the time series and origin of a chemical component and to compare the difference during yellow sand episodes for analysis $PM_{10}$ chemical components in the region of west in Korean Peninsula, 1999-2001. An annual mean concentration of $PM_{10}$ is $29.1\;{\mu}g/m^3$. A monthly mean and standard deviation of $PM_{10}$ concentration are very high in spring but there is no remarkably seasonal variation. Also, water soluble ionic component of $PM_{10}$ be influenced by double more total anion than total cation, be included $NO_{3}^-\;and\;SO_{4}^{2-}$ for the source of acidity and $NH_{4}^+$ to neutralize. Tracer metals of $PM_{10}$ slowly increases caused by emitted for soil and ocean (Fe, Al, Ca, Mg, Na) and Zn, Pb, Cu, Mn for anthropogenic source. According to method of enrichment factor (E.F) and statistics, assuming that the origin of metal component in $PM_{10}$ most of element in the Earth's crust e.g. Mg, Ca, Fe originates soil and Cu, Zn, Cd, Pb derives from anthropogenic sources. The ionic component for $Na^{+}\;Cl^-,\;Mg^{2+}\;and\;Ca^{2+}$ and Mg, Al, Ca, Fe originated by soil component largely increase during yellow sand period and then tracer metal component as Pb, Cd, Zn decrease. According to factor analysis, the first group is ionic component ($Na^+,\;Mg^{2+},\;Ca^{2+}$) and metal component (Na, Fe, Mn and Ni) be influenced by soil. The second group, Mg, Cr also be influenced by soil particle.

Cost-effectiveness Analysis of Pharmacologic Treatment in Hypercholesterolemia (고콜레스테롤혈증 치료 약물들에 대한 비용-효과 분석)

  • 정경래;문옥륜
    • Health Policy and Management
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    • v.9 no.3
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    • pp.70-94
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    • 1999
  • This paper was performed for a cost-effectiveness analysis of pharmacologic treatment of hypercholesterolemia. Agents modeled were cholestyramine, gemfibrozil. bezafibrate, lovastatin, pravastatin, simvastatin. Pharmacologic effectiveness was estimated by regression from reported clinical trials. Pharmacologic effects were expressed as the percent change of blood cholesterol level. Cost estimates included patients' travel expenses and time loss as well as resource consumption in the health care sector. Bezafibrate was the most efficient agent for reducing total cholesterol levels, having an cost over 1 year of ₩31.400 per percent reduction in total cholesterol. Simvastatin (10mg/d) was also efficient(₩33,100 per percent reduction). Chole styramine(8g/d) was least efficient at ₩90,200. For low-density lipoprotein cholesterol. simvastatin(10mg/d) was most efficient, at ₩23,200 per percent reduction, followed by lovastatin(20mg/d) at ₩28,000. Gemfibrozil was least efficient at ₩77,800 per percent reduction. For high-density lipoprotein cholesterol. bezafibrate(400mg/d) was most efficient at ₩39,300 per percent increase of high-density lipoprotein cholesterol. Cholestyramine was least efficient at ₩514,700. Analyses combining low-density lipoprotein cholesterol and high-density cholesterol effects suggest that bezafibrate(600mg/d) and simvastatin (10mg/d) were most efficient for reducing cardiovascular risk. The cost-effectiveness analysis results show that both simvastatin and bezafibrate could be efficient treatment. Simvastatin provide more effective treatment at higher cost, whereas bezafibrate is more cost-effective, as it may be less effective, at lower cost. Therefore, clinicians should choose reasonable treatment according to the patient's needs This pharmacoeconimc analysis will provide a guideline for efficient pharmacologic treatment and also be reference data for pricing new drugs.

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CO2 Respiration Characteristics with Physicochemical Properties of Soils at the Coastal Ecosystem in Suncheon Bay (순천만 연안 생태계에서 토양의 이화학적 성질에 의한 이산화탄소 호흡 특성)

  • Kang, Dong-Hwan;Kwon, Byung-Hyuk;Kim, Pil-Geun
    • Journal of Environmental Science International
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    • v.19 no.2
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    • pp.217-227
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    • 2010
  • This paper was studied $CO_2$ respiration rate with physicochemical properties of soils at wetland, paddy field and forest in Nongju-ri, Haeryong-myeon, Suncheon city, Jeollanam-do. Soil temperature and $CO_2$ respiration rate were measured at the field, and soil pH, moisture and soil organic carbon were analyzed in laboratory. Field monitoring was conducted at 6 points (W3, W7, W13, W17, W23, W27) for wetland, 3 points (P1, P2, P3) for paddy field and 3 points (F1, F2, F3) for forest in 10 January 2009. $CO_2$ concentrations in chamber were measured 352~382 ppm for wetland, 364~382 ppm for paddy field and 379~390 ppm for forest, and the average values were 370 ppm, 370 ppm and 385 ppm, respectively. $CO_2$ respiration rates of soils were measured $-73{\sim}44\;mg/m^2/hr$ for wetland, $-74{\sim}24\;mg/m^2/hr$ for paddy field and $-55{\sim}106\;mg/m^2/hr$ for forest, and the average values were $-8\;mg/m^2/hr$, $-25\;mg/m^2/hr$ and $38\;mg/m^2/hr$. $CO_2$ was uptake from air to soil in wetland and paddy field, but it was emission from soil to air in forest. $CO_2$ respiration rate function in uptake condition increased exponential and linear as soil temperature and soil organic carbon. But, it in emission condition decreased linear as soil temperature and soil organic carbon. $CO_2$ respiration rate function in wetland decreased linear as soil moisture, but its in paddy and forest increased linear as soil moisture. $CO_2$ respiration rate function in all sites increased linear as soil pH, and increasing rate at forest was highest.

Characteristics of Pollutants Discharge from Hoengseong Watershed during the Dry and Rainy Seasons (횡성호 유역의 비강우시 및 강우시 오염물질 유출특성)

  • Roh, Sung-Duk;Kim, Jang-Hyun;Lee, Dae-Keun;Kim, Seon-Joo;Sohn, Byeong-Yong;Chun, Yang-Kun
    • Journal of Korean Society on Water Environment
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    • v.22 no.4
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    • pp.695-705
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    • 2006
  • This study was carried out to make a basic information for establishment of countermeasures against water pollution of Hoengseong watershed, accordingly we investigated the characteristics of pollutants discharge and estimated the unit loads from Hoengseong watershed. Seven sites (S1~S7) were selected for sampling and samples were taken 4 times during the dry and rainy seasons, respectively. During rainfall events, measured site mean concentration (SMC) ranges of $BOD_5$, $COD_{Mn}$, TOC, SS, Turbidity, T-N and T-P were 0.8~1.3 mg/L, 2.3~6.3 mg/L, 1.284~2.110 mg/L, 3.4~69.3 mg/L, 2.36~52.68 NTU, 1.243~1.669 mg/L and 0.025~0.070 mg/L, respectively. And the calculated annual unit loads of $BOD_{5}$, $COD_{Mn}$, SS, T-N and T-P in Hoengseong watershed were 1.327 kg/ha/yr, 7.349 kg/ha/yr, 87.075 kg/ha/yr, 1.848 kg/ha/yr and 0.103 kg/ha/yr, respectively. It was difficult to directly compare the unit loads proposed in this study with the estimated existing those. Because the unit loads in this paper were estimated not by land use types, but by complex land use of non-urban area. From the survey results, they showed that the unit loads in Hoengseong watershed were similar to those exisiting in the forest area, and showed lower than those existing in the paddy/dry field.

Distribution Characteristic and Assessment of Soil Organic Matter, Nitrogen and Phosphorus in Soils of New born River Mouth Wetlands

  • Chen, Weifeng;Ann, Seoung-Won;Shi, Yanxi ;Mi, Qinhua
    • Journal of Environmental Science International
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    • v.12 no.2
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    • pp.111-117
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    • 2003
  • This paper investigates preliminarily spatial distribution soil organic matter (SOM), nitrogen (N) and phosphorus (P) and its environmental influence in wetland soil of different vegetation landscape in the Yellow River Mouth. The result shows the SOM and total nitrogen (TN), efficient N, efficient P in top layer soils of different vegetation district have significantly different content, The SOM is shown as Calamagrostis epigeios wetlands > Phragmites cmmunis wetlands > Tamarix chinensi wetlands above tidal > Suaeda salsa wetlands in high tidal > Tamarix chinensi wetlands in high tidal > tidal flats, the arrange of the TN and efficient N content is the same except that the content in Suaeda salsa wetlands in high tidal is heavier than Tamarix chinensi wetlands in high tidal. In different vegetation landscape wetland types the vertical change of soil nutrients are obvious except for p, gradually decrease from the upper to the lower. This case reflects the function of the vegetation on the wetland development of soil and proves the wetland soil has the characteristic of new born and bad degree of development. SOM, TN, efficient N and efficient P content in wetland soils have significantly positive correlation, but TP have no correlation with them but efficient p. The contents of TN in wetland soils range from 58~1480 mg/kg, total average content 408 mg/kg, average content of above 30 cm is 625 mg/kg. The range of TP content in the soil is 372~1042 mg/kg, total average is 569 mg/kg, average content of above 20 cm is 611 mg/kg. According the P it occurs mainly as calcium phosphates, and the validity is lower, therefore, N and P in the new born wetlands cannot produce serious impact on the environments at present.