• 대한약침학회지
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• 제23권2호
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• pp.62-70
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• 2020

Coronavirus disease-19 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). Currently, the management of patients with COVID-19 depends mainly on repurposed drugs which include chloroquine, hydroxychloroquine, lopinavir/ritonavir, ribavirin, remdesivir, favipiravir, umifenovir, interferon-α, interferon-β and others. In this review, the potential of Nigella sativa (black cumin seeds) to treat the patients with COVID-19 analyzed, as it has shown to possess antiviral, antioxidant, anti-inflammatory, anticoagulant, immunomodulatory, bronchodilatory, antihistaminic, antitussive, antipyretic and analgesic activities. Medline/PubMed Central/PubMed, Google Scholar, Science Direct, Directory of open access journals (DOAJ) and reference lists were searched to identify articles associated with antiviral and other properties of N.sativa related to the signs and symptoms of COVID-19. Various randomized controlled trials, pilot studies, case reports and in vitro and in vivo studies confirmed that N.sativa has antiviral, antioxidant, anti-inflammatory, immunomodulatory, bronchodilatory, antihistaminic, antitussive activities related to causative oraganism and signs and symptoms of COVID-19. N. sativa could be used as an adjuvant therapy along with repurposed conventional drugs to manage the patients with COVID-19.

• 대한수의사회지
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• 제19권1호
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• pp.33-38
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• 1983

Aeromonas punctata subgroup caviae and Plesiomonas shigelloides were isolated and identified from the lesion of ulcer disease of crusion carp in Ban Wol storing reservoir, the kyungki-do province.

• 대한핵의학회지
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• 제15권1호
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• pp.1-11
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• 1981

To evaluate the diagnostic accuracy of the measurement of free thyroxine (FT4) by radioimmunoassay, we measured free $T_4\;and\;T_4,\;T_3,\;T_3RU$, TSH and TBG serum levels by radioimmunoassay in 18 healthy persons and 52 patients with various thyroid diseases and 11 normal pregnant women. The results are as follows. 1. In 19 cases of overt hyperthyroidism, $T_3,\;free\;T_4$ and FTI, $T_4/TBG$ ratio reflect hyperfunction in all cases. $T_4$ is increased in 94% (18/19) and TBG and TSH are decreased in 79% (15/19). 2. In 8 patients with overt hypothyroidism, TSH is increased in all cases and free $T_4$ and FTI is decreased in all cases. $T_4$ is decreased in 87.5% (7/8), $T_3$ is decreased in 75% (6/8) and $T_4/TBG$ ratio is decreased in 62.5% (5/8). 3. In 5 patients who are clinically in euthyroid state after treatment of hyperthyroidism, $T_4,\;free\;T_4$, FTI and TSH are in the normal range in all cases and $T_3$ is normal in 60% (3/5) and slightly increased in 40% (2/5). 4. In 10 patients who showed clinically borderline hypothyroidism after treatment of hyperthyroidism, TSH is increased in all cases and free $T_4$ and FTI are decreased in all cases, but $T_4\;and\;T_3,\;T_4/TBG$ ratio are in the normal limit in all cases. So after treatment of hyperthyroidism, TSH, free $T_4$ or FTI are recommended as optimal thyroid function test. 5. In normal pregnancy, free $T_4$, FTI and $T_4/TBG$ ratio reflect normal function, but the other parameters revealed unreliable due to the influence of increased TBG. Also TBG and TSH level in pregnancy is increased significantly compared with normal healthy control group. 6. The coefficients of correlation between free $T_4$ and FTI were 0.862 (p<0.001) and 0.685 (p<0.001) between free $T_4\;and\;T_4/TBG$ ratio. In most patients, diagnostic value of free $T_4$ was comparable and even superior to FTI, so free $T_4$ measurement can be used routinely with thyrotropin assay in the diagnosis of hypothyrodism or with $T_3$ for the diagnosis of hyperthyroidism.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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• pp.195-195
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• 2001

The inhibitory potentials of TCAs (imipramine, desipramine, amitriptyline, and nortriptyline) on phenytoin p-hydroxylation and probe metabolic pathways of each CYP isoforms were evaluated from incubation studies of human liver microsomes and cDNA-expressed cytochrome P450s in vitro in order to understand the mechanism of drug interaction between TCAs and phenytoin, a substrate of CYP2C9 and CYP2C19. (omitted)

• 대한한의학회지
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• 제39권2호
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• pp.64-79
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• 2018

Objectives: This study was aimed to research clinical characteristics of female patients with cold hypersensitivity on the hands and feet compared with non-cold hypersensitivity group. Methods: 134 women patients were collected from 6 Korean medicine hospitals, and divided into 2 groups(cold hypersensitivity group and non-cold hypersensitivity group). This survey was composed of 19 questions related to clinical symptoms of cold hypersensitivity. Results: We found out the differences between 2 groups in 10 questions among 19 questions in the survey results. (Body Type, Energy, Digestibility, Skin Type, Facial Complexion, Chill, Dry Mouth and Thirst, Preference between Coolness and Warmth, Thickness of Tongue Fur, Floating and Sinking of Pulse) Conclusions: From these results, Patients with cold hypersensitivity on hands and feet have relative clinical characteristics as follows. They are relatively weak and lethargic. They have dry skin and look more pale. They feel chill easily and have dry mouth and thirst. They prefer warmth and have indigestion more. They had more various infirm and ill clinical characteristics compared with the other group from the view of Korean medicine.

• 대한핵의학회지
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• 제16권2호
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• pp.91-96
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• 1982

Influence of aging on plasma renin activity was evaluated in healthy normotensive subjects (age range $21\sim63$ years, 413 males) devoid of cardiorenal or endocrinological problems. The age-related decrease of plasma renin activity in the subjects between $21\sim28$ years group and $36\sim42$ years group was slight, but over the 43 years groups was significantly different. The age-related suppression of plasma renin activity was much more smooth and continuous all over the age ranges evaluated. The sexual difference in plasma renin activity was noticed between the subjects of 22 years old group(34 males) and 19 years grop(34 females) (p<0.003). The data suggest that the age-related suppression of plasma renin activity appeared in healthy normotensive subjects should be considered in the case of evaluation of low renin essential hypertension.

• Journal of Acupuncture Research
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• 제19권6호
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• pp.171-183
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• 2002

Objective : To research the trends of study related to myofascial pain syndrome(MPS) and acupuncture in PubMed, and to establish the hereafter direction of myofascial pain syndrome(MPS) with acupuncture. Methods : We searched in PubMed, with myofascial pain syndrome and acupuncture, trigger point and acupuncture limitted by abstract. Results : 1. The pattern of the study was as follows : Review article(11), Clinical(11) rondomized controlled trials(21). We further estimated 24 articles. 2. Many of these studies provide equivocal results because of designs, sample size and the other, affirmative view is 10 articles, contradictive view is 6 articles, and somewhat reservative regards are 8 articles for therapeutic effect of myofascial pain syndrome with acupuncture. 3. Suggestions on further endolphin related research, neurophysiology, biophysics and phamacology are made. 4. More clinical data would be needed to prove effects of myofascial pain syndrome with acupuncture.

• Fisheries and Aquatic Sciences
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• 제19권1호
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• pp.2.1-2.2
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• 2016

• 한국콘텐츠학회논문지
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• 제19권3호
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• pp.396-404
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• 2019

본 연구의 목적은 체계적 문헌고찰을 통해 월경곤란증에 관한 요가의 효과를 확인하는 것이다. 자료수집은 체계적 문헌고찰 보고지침(preferred reporting items for systematic reviews and meta-analysis[PRISMA])에 따라 진행하였다. 분석대상 논문은 1966년부터 2018년 11월까지 CINAHL, Cochrane Library, Embase, CycINFO, PubMed 및 KoreaMed 등 전자데이터베이스와 "footnote chasing"를 통해 최종 7편이 추출되었다. 주요 결과는 요가를 적용한 실험군에서 대조군에 비해 생리통 강도 및 기간, 스트레스, 삶의 질, 우울, 불안 및 분노 등에서 유의하게 감소되었고, 생리통 유발인자인 호모시스테인, 성선자극 호르몬, 여포자극호르몬, 황체형성호르몬, 프로락틴 등이 유의하게 감소하는 것으로 보고되었다. 이러한 결과는 요가가 월경곤란증의 완화를 위한 적절한 중재방법임을 암시한다.

• 한국정보통신학회논문지
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• 제19권10호
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• pp.2409-2416
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• 2015

본 논문에서는 효과적인 무손실 영상압축을 위한 방향성 기반 적응적 예측방법을 제안한다. 제안하는 예측방법은 작은 변화에 민감한 픽셀단위가 아닌 지원영역(support region) 단위로 방향성 및 부호화 픽셀이 속한 영역의 특성을 판단하여 강인한 예측이 이루어지도록 한다. 예측픽셀은 부호화 픽셀과 주변 픽셀에 대한 지원영역 사이의 유사도에 따라 적응적으로 선택함으로써 예측성능을 효과적으로 높인다. 기존의 MED, GAP 및 EDP와 같은 예측방법과 비교하여 제안한 방향성 기반 적응적 예측방법은 예측에러에 대한 엔트로피 측면에서 우수한 예측성능을 나타내고, 복잡도 측면에서도 가장 간단한 MED와 비교해 큰 차이가 없음을 다양한 실험을 통해 보인다.