• 제목/요약/키워드: MED

검색결과 2,778건 처리시간 0.029초

Suppression of MED19 expression by shRNA induces inhibition of cell proliferation and tumorigenesis in human prostate cancer cells

  • Cui, Xingang;Xu, Danfeng;Lv, Chao;Qu, Fajun;He, Jin;Chen, Ming;Liu, Yushan;Gao, Yi;Che, Jianping;Yao, Yacheng;Yu, Hongyu
    • BMB Reports
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    • 제44권8호
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    • pp.547-552
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    • 2011
  • MED19 is a member of the Mediator that plays a key role in the activation and repression of signal transduction or the regulation of transcription in carcinomas. To tested the functional role of MED19 in human prostate cancer, we downregulated MED19 expression in prostate cancer cells (PC-3 and DU145) by lentivirus-mediated short hairpin (shRNA), and analyzed the effect of inhibition of MED19 on prostate cancer cell proliferation and tumorigenesis. The in vitro prostate cancer cell proliferation, colony formation, and in vivo tumor growth in nude mice xenografts was significantly reduced after the downregulation of MED19. Knockdown of MED19 caused S-phase arrest and induced apoptosis via modulation of Bid and Caspase 7. It was suggested that MED19 serves as a novel proliferation regulator that promotes growth of prostate cancer cells.

부산지역 4개 백화점의 공기오염도에 관한 조사연구 (The Study on the Level of Air Pollution at Four Department Stores in Pusan Area)

  • 문덕환;이현우;이채언
    • 한국산업보건학회지
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    • 제1권2호
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    • pp.164-180
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    • 1991
  • For the purpose of contributing to the promotion of health of the employees working at the same kind of department store or similar type of business and the people utilizing them and preparing the basic data for the establishment of mangagement measure by assessing the level of air pollusion at indoor and outodoor of four department store among the distribution service business in Pusan area, authors measured the concentration of sulfur dioxide, nitrogen dioxide, formaldehyde and total suspanded particle according to the measuring height of variable at indoor and outodoor from Aug. 1990. to sep. an. d Jan, 1991 to Feb.: for each two months in summer and winter, and studied by dividing the variable factor into atmospheric factor (temperature, humidity and air velociy) The results are as follows ; 1. The mean concentration of air pollutants at indoor to total subjects was nitrogen dioxide 31.1ppb, sulfur dioxide 51.7ppb, formaldehyde 162.lppb and total suspanded particle $67.7{\mu}g/m^3$, and it was higher in winter than in summer (P>0.05) 2. The mean concentration of formaldehyde to total subjects was higher indoors than outdoors (P<0.001), in case of nitrogen dioxide there was no significant difference and sulfur dioxide and total suspanded particle were higher outdoors than indoors (P<0.05) 3. The concentration of nitrogen dioxide and sulfur dioxide proved to be a adverse correlation, reducing with height. 4. According to the result questioned about the exposure concentration of pollutant and the general symptom caused by the pollutant, nitorgen dioxide and symptom proved to be a positive correlation (P<0.09).

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의약품 부작용에 관한 국제 분류체계인 WHO-ART와 MedDRA의 비교분석 (Comparison of WHO-ART Versus MedDRA, Internationally Standardized Terminology of Adverse Drug Reaction Classification)

  • 임경화;신현택;손현순;전효정;이주현;이유정;이영숙;송인숙
    • 한국임상약학회지
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    • 제17권1호
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    • pp.46-51
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    • 2007
  • This study was aimed to provide the controlled terminology for adverse drug reactions by selecting an appropriate internationally standardized classifications (WHO-ART or MedDRA). We collected the relevant information on ADR terminology systems including WHO-ART and MedDRA by online searching and visiting pharmaceutical companies and WHO UMC (Uppsala Monitoring Centre, Uppsala, Sweden). For MedDRA, project leader directly communicated with the officer of MSSO (Maintenance and Support Services Organization). Collecting all the pertinent information, two possible terminology classifications or systems (WHO-ART and MedDRA) were compared in the views of acceptability, cost-effectiveness and international feasibility and reviewed by the consultation committee and finally WHO-ART was selected.

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