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Bragg-curve simulation of carbon-ion beams for particle-therapy applications: A study with the GEANT4 toolkit

  • Hamad, Morad Kh.
    • Nuclear Engineering and Technology
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    • v.53 no.8
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    • pp.2767-2773
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    • 2021
  • We used the GEANT4 Monte Carlo MC Toolkit to simulate carbon ion beams incident on water, tissue, and bone, taking into account nuclear fragmentation reactions. Upon increasing the energy of the primary beam, the position of the Bragg-Peak transfers to a location deeper inside the phantom. For different materials, the peak is located at a shallower depth along the beam direction and becomes sharper with increasing electron density NZ. Subsequently, the generated depth dose of the Bragg curve is then benchmarked with experimental data from GSI in Germany. The results exhibit a reasonable correlation with GSI experimental data with an accuracy of between 0.02 and 0.08 cm, thus establishing the basis to adopt MC in heavy-ion treatment planning. The Kolmogorov-Smirnov K-S test further ascertained from a statistical point of view that the simulation data matched the experimentally measured data very well. The two-dimensional isodose contours at the entrance were compared to those around the peak position and in the tail region beyond the peak, showing that bone produces more dose, in comparison to both water and tissue, due to secondary doses. In the water, the results show that the maximum energy deposited per fragment is mainly attributed to secondary carbon ions, followed by secondary boron and beryllium. Furthermore, the number of protons produced is the highest, thus making the maximum contribution to the total dose deposition in the tail region. Finally, the associated spectra of neutrons and photons were analyzed. The mean neutron energy value was found to be 16.29 MeV, and 1.03 MeV for the secondary gamma. However, the neutron dose was found to be negligible as compared to the total dose due to their longer range.

How satisfied are they with husbands' sharing of domestic labor? Comparing couples from single-earner and dual-earner households (남편의 가사노동과 자녀돌봄 분담 유형별 관련요인 및 부부의 가사분담만족도: 맞벌이 부부와 비맞벌이 부부 비교)

  • Kim, Soyoung
    • Journal of Family Relations
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    • v.22 no.3
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    • pp.47-72
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    • 2017
  • Objectives: Do husbands with working wives share domestic labor more equally than husbands with unemployed housewives? Is the husband's contribution sufficient enough to satisfy his wife? These questions have long inspired many researchers to find ways to more accurately estimate husband's domestic contributions and narrow the emotional gap following the different threshold of satisfaction within couples, but not without some limits. This study attempted to figure out an answer to the above-mentioned subject by using time diaries of Korean married couples with a preschooler as their first-born child and relying on the typology of husbands' sharing of housework and childcare, which allowed me to overcome some limitations of prior research. Method: I analyzed a total of 1,716 diaries of 858 married couples from 2014 Korea Time Use Survey with descriptive statistics, t-test, cluster analysis, and multinomial logit. Results: Analytic results showed that husbands in dual-earner households did share domestic labor more equally than husbands in single-earner households, but there were different types of husband's contribution depending on time they spent in housework and childcare. While more than half of husbands with employed wives shared more or less than ten percent of domestic labor, the rest were divided into one group of husbands who shared both housework and childcare more heavily and evenly, and another group who were mainly involved in childcare duties. It is interesting that husbands who made the least contributions to domestic labor were not the ones with the lowest level of satisfaction with their sharing of household labor, whereas their wives were deeply dissatisfied, leading to a huge emotional gap within couples. Conclusion: Identifying factors associated with the three different types allowed me to find a point of intervention to narrow the emotional gap that is likely to harm the marital relationship if left unattended to.

Polarity affects the antioxidant and antimicrobial activities of jellyfish (Acromitus hardenbergi) extracts

  • Khong, Nicholas M.H.;Foo, Su Chern;Yau, Sook Kun;Chan, Kim Wei;Yusoff, Fatimah Md.
    • Fisheries and Aquatic Sciences
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    • v.25 no.4
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    • pp.189-201
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    • 2022
  • Jellyfish is an emerging aquaculture species, farmed for Oriental cuisines and nutraceutical ingredients. This study aimed to examine antioxidative and antimicrobial potentials of various fractions of the jellyfish, Acromitus hardenbergi. The bell and oral arms of the jellyfish were sequentially extracted with petroleum ether (PE), dichloromethane (DCM), chloroform (CHCl3), methanol (MeOH), and water (H2O) to extract its bioactive in an increasing polarity gradient. Test fractions were assayed for antiradical activities using electron spin resonance spectrometry, β-carotene-linoleate model and Folin-Ciocalteu assay; and antimicrobial activity against 2 Gram-negative bacteria, 4 Gram-positive bacteria and 2 fungal species using the disc diffusion assay. All fractions were also subjected to Fourier Transform Infrared (FTIR) analysis to identify types of functional groups present. It was found that the hydrophilic extracts (H2O fractions) possessed the most effective radical scavenging activity (p < 0.05) while the lipophilic extracts (PE fractions) the most active antimicrobial activity, especially against Gram-positive bacteria (p < 0.05). Total oxidation substrates content was found to be highest in the PE fractions of jellyfish bell and oral arms (p < 0.05). FTIR data showed that the H2O and MeOH fractions contains similar functional groups including -OH, -C=O, -N-H and -S=O groups, while the PE, DCM, and CHCl3 fractions, the -CH3, -COOH groups. This study showed that A. hardenbergi contains antioxidants and antimicrobials, thereby supporting the traditional claim of the jellyfish as an anti-aging and health-promoting functional food. Bioassay-guided fractionation approach serves as a critical milestone for the strategic screening, purification, and elucidation of therapeutically significant actives from jellyfish.

Preliminary Test of 3D Printed Plastic Scintillators for Proton Beam (3D 프린팅 플라스틱 섬광체의 양성자 빔에 대한 적용)

  • Sung-Hwan, Kim
    • Journal of the Korean Society of Radiology
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    • v.16 no.6
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    • pp.681-686
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    • 2022
  • In this study, a scintillation resin for 3D printing was fabricated with 1.0 wt% of PPO organic scintillator, 5.0 wt% of MMA, and commercial acrylic resin. Using the scintillation resin, 3D-shaped plastic scintillator radiation sensors were successfully fabricated quickly and inexpensively with a commercial 3D DLP printer. The 3D printed plastic scintillator has a good dose-output linearity of R-square 0.998 was obtained in the range of 1 to 10 nA of beam current of the 45 MeV proton beam. The developed 3D plastic scintillator has low light output, so there is a limit to its use in low-dose-rate gamma-ray or X-ray dosimetry. However, it was confirmed that the tissue equivalent material could be usefully used for measuring high energy or high dose rates radiation, such as proton beams and ultra-high dose rate beams.

A Study on the Usefulness of Development of a Steam Sterilizer Equipped with an Electronic Bowie-Dick Test System

  • Bae, Young Ok;Hwang, Jun Soo;Kim, Sung Il;Lee, Joon Ha
    • Progress in Medical Physics
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    • v.28 no.4
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    • pp.156-163
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    • 2017
  • To verify the usefulness of a steam sterilizer equipped with an electronic Bowie-Dick test system, this study was carried out using two methods, utilizing both a steam sterilizer and an electronic Bowie-Dick tester. The first method is to confirm the error detection of the chemical Bowie-Dick test pack and the electronic Bowie-Dick tester in a malfunctioning sterilizer environment. For this purpose, the Bowie-Dick test program for the steam sterilizer was used to test three types of test packs commonly used in hospitals and the electronic Bowie-Dick tester by changing the set values of temperature, time, and vacuum frequency. The second is an experiment to check the sterilizer's normal operation with the electronic Bowie-Dick tester and the usefulness of grasping the cause of the malfunction. The results showed that the sterilization temperature was the same as that of the test pack at a temperature $1{\sim}6^{\circ}C$ lower than the reference temperature of $134^{\circ}C$. In the test with the sterilization exposure time as a variable, there was a normal discoloration at a time difference of 30~90 s. In the experiment using the number of vacuum cycles, the test was correct by performing the normal discoloration only at the normal condition of 3 times. The test results of 30 hospitals were 100 failure tests by a total of 291 Bowie-Dick tests. Of these, the failure factors related to an internal temperature that the chemical test packs could not detect were the greatest, and the four factors related to temperature, including the internal temperature, were found to be 71.18% of total malfunctions. In addition, the Bowie-Dick tester was provided within 30 min after the start of the Bowie-Dick test to confirm the performance of the sterilizer and the detailed cause. A steam sterilizer equipped with an electronic Bowie-Dick test system is used to manage individual sterilizers. In the current steam sterilizer with many temperature-related errors, it is possible to check the malfunction of the temperature difference that the test pack cannot detect, and the cause of error for the sterilizer is immediately detected after the test. The steam sterilizer equipped with the electronic Bowie-Dick test system assists with infection control with accurate sterilizer performance assurance.

Correlations among Different Tumble Measuring Methods and Significance of Tumble Ratios from Steady Flow Rig on SI Engine Combustion (엔진대상시험을 통한 텀블측정방식의 상관성 및 유의성에 관한 연구)

  • Lee, Si-Hun;Kim, Myoung-Jin
    • Transactions of the Korean Society of Automotive Engineers
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    • v.14 no.6
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    • pp.43-49
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    • 2006
  • Optimizing in-cylinder flow such as tumble or swirl is one of the key factors to develop better internal combustion engines. Especially, the tumble, which is more dominant flow in current high performance gasoline engines, has significant effects on the fuel consumptions and exhaust emissions under part load conditions. The first step for the tumble optimization is to find an accurate but cost-effective way to measure the tumble ratio. From this point of view, tumble ratios from three different measuring methods were compared and correlated in this research. Steady flow rig, water rig, and PIV were utilized for that purpose. Engine dynamometer test was also performed to find out the effect of the tumble. The results show that the tumble ratios from those methods are well correlated and that the steady flow rig is the effective method to measure the tumble despite its limitations.

The Influence of Depression, Temperament, Characteristic on Alcohol Drinking in Vocational High School Students in Gangwon-do (강원도지역 실업계 고등학생의 우울, 기질 및 성격특성이 음주상태에 미치는 영향)

  • So, Ae-Young;Sohn, Shin-Young;June, Kyung-Ja;Yi, Ggod-Me
    • Journal of the Korean Society of School Health
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    • v.23 no.2
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    • pp.181-191
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    • 2010
  • Purpose: The purpose of this study is to analyze the drinking status and to identify the impacts of depression, temperament, characteristic on drinking status in the vocational high school students. Methods: By using stratified sampling, 416 vocational high school students in Gangwon Do were selected and surveyed through self -administered questionnaires. Data were analyzed by SPSS 12.0 using $x^2$-test, t-test, ANOVA, Pearson correlation coefficient and multiple regression. Results: 88% of students had experienced of drinking. Depression was observed 59.1% of students from light to severe depression score. There was a positive correlation among drinking, the school records, novelty seeking, reward dependence and persistence. Also, there was a negative correlation among drinking, economic status, harm avoidance. The significant predictors of drinking were school records, depression, novelty seeking and persistence. Conclusion: These results suggest that vocational high school students who have the factors identified in this study are regarded as having the potential to drink. The results of this study can provide the information for the development of the health promotion program.

Development of Stream Width and Bed-slope Estimation Equations for Preparing Data for Distributed Storm Runoff Model (분포형 강우-유출모형의 하도자료 구축을 위한 하폭 및 하상경사 산정공식 개발)

  • Jung, In-Kyun;Park, Jong-Yoon;Joh, Hyung-Kyung;Lee, Ji-Wan;Kim, Seong-Joon
    • Journal of The Korean Society of Agricultural Engineers
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    • v.52 no.4
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    • pp.1-10
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    • 2010
  • In this study, two estimation equations for preparing stream data for distributed storm runoff model were developed by analyzing the nonlinear relation between upstream flow-length and stream width, and between upstream flow-length and stream bed-slope. The equations for stream cell were tested in Chungjudam watershed (6,661 $km^2$) using KIMSTORM. Six storm events occurring between 2003 and 2008 were selected for the model calibration and verification before the test of equations. The average values of the Nash-Sutcliffe model efficiency (ME), the volume conservation index (VCI), the relative error of peak runoff rate (EQp), and the difference of time to peak runoff (DTp) were 0.929, 1.035, 0.037, and -0.406 hr for the calibrated four storm events and 0.956, 0.939, 0.055, and 0.729 hr for the two verified storm events respectively. The estimation equations were tested to the storm events, and compared the flood hydrograph. The test result showed that the estimation equation of stream width reduced the peak runoff and delaying the time to peak runoff, and the estimation equation of stream bed-slope showed the opposite results.

Potent Antimutagenic and Their Anti-Lipid Peroxidative Effect of Kaikasaponin III and Tectorigenin from the Flower of Puer-aria thunbergiana

  • Park, Kun-Young;Jung, Geun-Ok;Choi, Jong-Won;Lee, Kyung-Tae;Park, Hee-Juhn
    • Archives of Pharmacal Research
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    • v.25 no.3
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    • pp.320-324
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    • 2002
  • The MeOH extract of Pueraria thunbergiana (Leguminosae) flowers and its fractions were subjected to Ames test to test the antimutagenicity. EtOAc fraction (1 mg/plate) decreased the number of revertants of Salmonella typhymurium TA100 by 95% against aflatoxin $B_1{\;}(AFB_1)$. Phytochemical isolation of the EtOAc fraction afforded four isoflavonoids (tectorigenin, glycitein, tectoridin and glycitin) and one saponin (kaikasaponin III). Though the three isoflavonoids other than tectoridin showed significant antimutagenicity, the activity of kaikasaponin III was the most potent. Kaikasaponin III (1 mg/plate) decreased the number of revertants of S. typhymurium TA 100 by 99% against $AFB_1$ but by 75% against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Tectorigenin (1 mg/plate) inhibited the $AFB_1$-induced mutagenicity by 90% and MNNG-induced one by 76%. Glycitein and glycitin were less active than tectorigenin and kaikasaponin III. This result suggested that kaikasponin III prevents the metabolic activation of $AFB_1$ and scavenge electrophilic intermediate capable of mutation. The two components with potent activities, tectorigenin and kaikasaonin III, significantly prevented the malondialdehyde formation caused by bromobenzene in the rat.

A Study on Nutrition and Health Evaluation of Osteoarthritis Elderly in Community (지역사회 골관절염 노인의 영양위험도 및 건강상태 평가)

  • Yang, Sook-Ja
    • Research in Community and Public Health Nursing
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    • v.17 no.2
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    • pp.186-194
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    • 2006
  • Purpose: This study was to evaluate the nutritional risk and health status of osteoarthritis elderly comparing with that of non-osteoarthritis elderly in urban areas. Methods: A cross-sectional analysis was conducted. The subjects were 132 osteoarthritis elderly, 154 non-osteoarthritis elderly. Data were collected by using a questionnaire including Nutritional Screening Initiatives, blood test and measurement of weight & height. Collected data were analyzed through descriptive statistics and $x^2-test$ by using SPSS 12.0. Results: The percentage of high nutritional risk among osteoarthritis elderly were higher than those among non-osteoarthritis elderly(p<0.01). When comparing the main nutritional risk factors such as 'I eat alone most of the time', 'I don't always have enough money to buy', 'I have tooth or mouth Problems that make it hard for me to eat' between osteoarthritis elderly and non-osteoarthritis elderly, significantly differences were found(p<0.05). There were no statistically significant difference in ADL, BMI, Lymphocyte, Hemoglobin, Hematocrit, Albumin and total-Cholesterol between osteoarthritis elderly and non-osteoarthritis elderly. Conclusion: On the basis of this study, it is necessary to figure out the main factors of nutritional risk in arthritis elderly through the cohort study for effective prevention & control in nutritional risk.

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