• Journal of Life Science
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• v.19 no.4
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• pp.436-441
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• 2009

B23/nucleophosmin, a nucleolar protein, translocates into the nucleus from the nucleolus when cells are damaged by extracellular stresses. Recently, it was shown that such translocation of B23/nucleophosmin in normal fibroblasts under stress conditions increases both the stability and activation of the p53 protein by disrupting its interaction with MDM2. Senescent cells have a single large nucleolus and a diminished capacity to induce p53 stability upon exposure to various DNA damaging agents. To investigate the role of B23/nucleophosmin in p53 stability in senescent cells, we established a senescence model system by expressing the ras oncogene in IMR90 cells. The stability of p53 was reduced in these cells in response to nucleolar stress, although the level of B23/nucleophosmin protein was not changed. In addition, p53 did not accumulate in the nucleus and B23/nucleophosmin did not translocate into the nucleoplasm. The binding affinity of B23/nucleophosmin with p53 was reduced in senescent cells, whereas the interaction between MDM2 and p53 was stable. Taken together, the stability of p53 in ras-induced senescent cells may be influenced by the ability of B23/nucleophosmin to interact with p53 in response to nucleolar stress.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.27 no.4
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• pp.9-20
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• 2019

A military aircraft generally includes external stores such as fuel tanks or external arming, depending on the purpose of the operation. When a store is dropped from a military aircraft at high subsonic, transonic, or supersonic speeds, the aerodynamic forces and moments acting on the store can be sufficient to send the store back into contact with the aircraft. This can cause damage to the aircraft and endanger the life of the crew. In this study, time accurate computational fluid dynamics (CFD) with dynamic moving grid (moving and deformable mesh, MDM) technique has been used to accurately calculate store trajectories. For the verification of the present numerical approach, a wind tunnel test model for the wing-pylon-finned store configuration has been considered and analyzed. The comparison results for the ejected store trajectories between the present numerical analysis and the wind tunnel test data at the Mach number of 0.95 and 1.2 are presented. It is also importantly shown that the numerical parameter of MDM technique gives significant effect for the calculated store trajectory in the low-supersonic flow such as Mach 1.2.

• The Bulletin of The Korean Astronomical Society
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• v.41 no.1
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• pp.70.4-71
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• 2016

The links between super-massive black hole masses and their host galaxy properties are observed, indicating that black hole growth and host galaxy evolution are closely related. Reverberation mapping, which uses the time delay from the central black hole to broad line regions, is one of the best methods to estimate masses of black holes of active galactic nuclei (AGNs). However, only masses of about 50 black holes have been determined in reverberation mapping studies so far, and most of them are limited to optical luminosities below 10^45 erg/s due to the challenges of long-term time domain observations in both photometry and spectroscopy. In this project, we expand reverberation mapping samples to higher luminosities of > 10^44.5 erg/s at 0.1 < z < 0.35, that have expected time lags of 40 - 250 light days. Photometric (using LOAO 1-m and MDM 1.3-m) and spectroscopic (using MDM 2.4-m and Lick 3-m) monitoring campaigns are being conducted for a 3 year duration and 20 day cadence. Precedent photometric observations in 2015B show some targets with variability and follow-up spectroscopic observations are on-going. In this presentation, we introduce our project, present reverberation mapping simulation results, and preliminary results on photometry. These reverberation mapping masses of relatively high luminous AGNs will provide a strong constraint on black hole mass calibration, e.g., the single-epoch mass estimation.

• Journal of Advanced Research in Ocean Engineering
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• v.3 no.2
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• pp.59-65
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• 2017

When an anchor is dropped into the sea, there exists a danger of collision on the pipeline and subsea cables in the seabed. This collision could cause huge environmental disasters and serious economic losses. In order to secure the safety of subsea structures such as pipelines and subsea cables from the external impact, it is necessary to estimate the exact external force through the anchor's terminal velocity on the water. FLUENT, a computational fluid dynamic program, was used to acquire the terminal velocity and drag coefficient computation. A half-symmetry condition was used in order to reduce the computational time and a moving deforming mesh technique also adapted to present hydrostatic pressure. The results were examined with the equation based on Newton's Second Law to check the error rate. In this study, three example cases were calculated by stockless anchors of 5.25 ton, 10.5 ton, and 15.4 ton, and for the onshore experiment dropped height was back calculated with the anchor's terminal velocity in the water.

• The Bulletin of The Korean Astronomical Society
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• v.42 no.2
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• pp.76.4-77
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• 2017

We have been performing a long term AGN Monitoring project, to measure the time lag of H beta line with respect to AGN optical continuum based on the reverberation mapping method. From October 2015, 69 AGNs have been monitored with BVR band photometry, using the MDM 1.3m & 2.4m and LOAO 1m telescopes, and long-slit spectroscopy, using the Lick 3m and MDM 2.4m telescopes. In this poster, we report the preliminary results of the variability study of a subsample of 9 AGNs, particularly with a few of tentative time rag measurements between B band magnitude and H beta luminosity based on the 1st year data set from February 2016 - January 2017.

• Korean Journal of Soil Science and Fertilizer
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• v.24 no.2
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• pp.102-108
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• 1991

A field experiment with microplots(D.20cm, L. 85cm) was conducted to obtain quantitative information on the downward movement of nutrients applied to the soils by different amount of irrigation water. The microplots were installed by embedding PVC column(D. 20cm, L. 90cm) filled with sieved soils in the field. Urea, fused and superphosphate, and KCl were broadcasted over the soil in the microplots and surface layer was covered with lime-amended soils. Microplots were removed 1 week after water application and analysed for Cl, $NH_4$ and $NO_3-N$, Bray 1-P and exchangeable cations of Ca, Mg, and K in each segment. Effect of irrigation rate on the movement of these ions were evaluated with the mean downward movement(MDM) determined with nutrient concentration of each segment and the distance to the segment from the site fertilized. For the nutrient studied, MDM was linearly related to the amount of water applied. When one pore volume of water needed for 0.1 bar soil moisture tension was applied, MDM(cm), computed as the piston front of applied water advanced 10cm, was found to be in the order; Cl, 7.52>Inorganic N, 6.03> K, 3.50> Mg, 2.69>Ca, 1.19>P, 0.29. After the downward movement of applied nutrients soil pH seemed to decrease with irrigation in the surface layer(0-15cm) and increase in the subsurface layer. It was also found that ammonium-nitrogen evolved from urea hydrolysis was more effective in raising the subsoil pH rather than the exchangeable Ca and Mg.

• KSBB Journal
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• v.24 no.3
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• pp.217-226
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• 2009

p53 undergoes various post-translational modifications, including phosphorylation, ubiquitination, sumoylation, acetylation, methylation, and poly(ADP-ribosyl)ation. Modification of p53 widely affects to various functions of p53. Acetylation and phosphorylation of p53 have been studied for regulating its transcriptional activity which is observed in various stress condition. Otherwise, ubiquitination of p53 by Mdm2 has been well-studied as a canonical ubiquitin-mediated proteasomal degradation pathway. Moreover several investigators have recently reported that ubiquitination of p53 modulates not only its proteasome-dependent degradation by poly-ubiquitination but also its localization and transcriptional activity by mono-ubiquitination which usually does not serve the proteasome dependent degradation. Here we review recent studies on the cellular functions of p53 regulated by post-translational modifications, particularly focusing on mechanisms of ubiquitination.

• The Journal of Fisheries Business Administration
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• v.54 no.1
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• pp.37-49
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• 2023

Climate change is a major global problem. Oysters, one of the most representative farmed fish in Korea, are attracting attention as candidates for blue carbon, an alternative to carbon neutrality. This study is analyzed by the SSP scenarios to determine the impact of oyster aquaculture production according to climate change. Based on the analysis, future productions of oysters are predicted by the SSP scenario. Significant differences by the SSP scenario are confirmed through predictive power tests among scenarios. Regression analysis was conducted from January 2001 to December 2014. As a result of the analysis, water temperature, water temperature quadratic term, salinity, salinity quadratic term, and month × water temperature cross term were estimated as significant variables. Oyster production which is predicted by the SSP scenario based on the significant variables from 2015 to 2022 was compared with actual production. The model with the highest predictive power was selected by RMSE and MAPE criteria. The predictive power was compared with the MDM test to determine which model was superior. As a result, based on RMSE and MAPE, the SSP1-2.6 scenario was selected as the best model and the SSP1-2.6, SSP2-4.5, and SSP3-7.0 scenarios all showed the same predictive power based on the MDM test. In conculusion, this study predicted oyster aquaculture production by 2030, not the distant future, due to the short duration of the analytical model. This study was found that oyster aquaculture production increased in all scenarios and there was no significant difference in predictive power by the SSP scenario.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.31 no.1
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• pp.111-122
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• 2021

With the spread of technology in the 4th Industrial Revolution, the defense industry in South Korea is getting developed into an industrial structure in which high-tech technologies are concentrated. As the importance of defense technology has gradually increased, the government has enacted the Defense Technology Security Act and required to build a protection system for institutions that possess or manage defense technology. In order for the target institution to introduce a protection system, it is necessary to identify the defense technologies that are protected and to ensure systematic data management. In order to cope with this, we derived master data items for data management and analyzed the implementation types of defense technology master data system suitable for the defense industry environments. The derived method identified the defense technology master data, such as primary and secondary master data, and through AHP analysis, Co-existence type was suitable as the target model for the master data management system. We expect that stronger defense technology security policy will be implemented through the defense technology MDM system.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.1
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• pp.54.4-55
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• 2021

The Seoul National University AGN Monitoring Project (SAMP) is a welldesigned long-term AGN reverberation mapping project. SAMP focuses on the luminous AGNs out to z~0.5 with relative long time lags between AGN continuum and broad emission lines and aims to probe the high-end of the AGN broad line region (BLR) size-luminosity (R-L) relation. The pilot observations started in October 2015 for 100 AGNs to confirm the variability and the H and [O III] emission line strengths. Based on the initial variability test, 48 quasars has been continued spectroscopic monitoring since Feb. 2016 with Lick 3m and MDM 2.4m telescopes with a cadence of ~20 days. Supporting photometric monitoring in B and V band was conducted at multiple facilities including the MDM 1.3m, LOAO, and DOAO telescopes with a cadence of ~10 days. By the time of Feb. 2021, we have obtained five years spectroscopic and photometric data. More than 30 AGNs shows significant variability in five-year baseline and 16 of them show well detected lags between B-band and H. Here, we report some examples of SAMP light curves and lag detections using the first five-year data as well as the location of our 16 targets in the AGN BLR R-L relation. These measurements are consistent with the existing R-L relation and located at the high-end. With the coming data, SAMP are hopefully to report more AGNs with well detected lags. Our results demonstrate the general feasibility and potential of long-term reverberation project with medium cadence for luminous AGNs.