• YAKHAK HOEJI
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• v.51 no.2
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• pp.133-139
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• 2007

A simple and sensitive HPLC-MS method for quantitation of 10${\alpha}$-methoxy-9,10-dihydrolysergol (MDL), the main metabolite of nicergoline, in human plasma was developed and the bioavailability parameters of MDL was assessed in Korean healthy male volunteers. Clomipramine was used as an internal standard. MDL and internal standard in plasma sample were extracted using ethyl acetate. A centrifuged upper layer was then evaporated and reconstituted with mobile phase of 10 mM ammonium acetate-acetonitrile (10 : 90, v/v). The reconstituted samples were injected into a Zorbax SB-C8 column (2.1${\times}$150 mm,5 ${\mu}$m) at a flow-rate of 0.3 ml/min. Using MS with selected ion monitoring (SIM) mode, MDL and clomipramine were detected without severe interference from human plasma matrix. MDL produced a protonated molecular ion ([M+H]$^+$) at m/z 287. Internal standard produced a protonated molecular ion ([M+H]$^+$) at m/z 315. A linear relationship for MDL was found in the range of 2.5${\sim}$100 ng/ml. The lower limit of quantitation (LLOQ) was 2.5 ng/ml with acceptable precision and accuracy. The intra- and inter-day validation for all coefficients of variation (R.S.D.%) were found less than 15%. Main pharmacokinetic parameters of 30 mg of nicergoline were revealed as follows: AUC$_t$ 321.1${\pm}$64.5 ng${\cdot}$hr/ml, C$_{max}$, 51.2${\pm}$25.3 ng/ml, T$_{max}$ 3.6${\pm}$1.5 hr, K$_{el}$ 0.12${\pm}$0.07 hr$^{-1}$ and t$_{1/2}$ 7.6${\pm}$3.4 hr. Inter subject variations and race differences were shown in comparison with the published data in the literature.

• Journal of Korean Society for Atmospheric Environment
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• v.20 no.E1
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• pp.29-33
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• 2004

In environmental studies, decisions are often made on the analytical data indicating certain contaminants as being 'detected' or 'non-detectible.' Since detection limits are analytical method specific, one has to first review the concepts and definitions associated with analytical method systems and specifications. In this study, the experimental analytical values for a series of low level standards (for an ionic species) were used as an example to estimate two different method detection limits (MDL). The scores of EPA's MDL and Pallesen's MDL determined by real analytical scores are 0.0575 and 0.0561 mg/L, respectively for our nitrate data. These scores determined by two different MDL models are roughly similar, while there are apparent differences between two methods with respect to statistical and systematical procedure. However, determination of MDL for one's laboratory provides some practical applications which helps to assure one's regulating authorities that one's measured scores are accurate.

• Proceedings of the Korean Information Science Society Conference
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• 2010.06b
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• pp.414-418
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• 2010

많은 분야에서 사용되는 matlab을 이용한 test방식을 좀 더 유연하고 원하는 기능을 만들어 사용하기 위해 matlab의 데이터 저장 파일인 mdl 파일의 내부 구조를 분석하고 구문 분석기로 파싱하여 실행 가능한 그래프를 나타내는 자료구조를 만든다.

• Proceedings of the Korean Information Science Society Conference
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• 2007.10a
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• pp.50-51
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• 2007

UML을 이용한 소프트웨어의 설계가 널리 이용되고 있으므로 개발단계 초기의 소프트웨어 산출물인 UML을 대상으로 품질을 예측하는 메트릭의 개발 및 활용요구에 대응하기 위하여 메트릭 기술 언어를 개발 하였다. MDL4UML은 UML모델에 적용 가능한 메트릭을 기존 OCL을 이용하여 기술하였을 경우 메트릭의 표현이 복잡하고 측정 대상 UML모델의 깊은 이해가 선행되어야 하는 점을 보완하기 위하여 연구된 메트릭 기술 언어이다. 본 연구에서는 OCL을 이용한 메트릭 기술의 난해함을 보완하기 위한 수단인 MDL4UML을 정의하고 이를 지원하기 위한 도구로 METOOSE를 개발하였다.

• Analytical Science and Technology
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• v.36 no.5
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• pp.224-235
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• 2023

An analytical method was developed for the determination of phenol (P) and the seven substituted phenols in water samples and fish tissue samples collected from three streams located in eastern Gangwon State in spring and summer. The phenols were extracted and then derivatized to phenyl acetates using acetic anhydride. The derivatives were subsequently identified and quantified using gas chromatography coupled with mass spectrometry. P and 4-nitrophenol (4NP) were found at relatively high levels in water, ranging from below the method detection limit (MDL) to 3.32 ㎍/L and from < MDL to 4.91 ㎍/L, respectively. P and 4NP were also the dominant compounds in the fish tissue, ranging from < MDL to 407 ㎍/kg and from < MDL to 870 ㎍/kg, respectively. Phenol concentrations were significantly higher in spring than in summer. The ecological risk quotient calculated for P was higher than 4NP but not high enough to pose any risk of adverse effects to fish health.

• Journal of the Korean Association of Geographic Information Studies
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• v.22 no.1
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• pp.19-27
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• 2019

This study is to measure the length of the Demilitarized Zone and the Military Demarcation Line(MDL) on the Korean Peninsular. For this purpose, maps of the Armistice Agreement Volume II were used. These maps are nine sheets. In order to extract the MDL shown on the map, coordinates were assigned to the scanned image maps using the georeferencing module of ArcGIS based on the sheet line coordinates. The accuracy of the extracted vectors was checked by overlaying them on the maps of the Armistice Agreement Volume II. And I tried to validate these vectors through comparative analysis with vectors extracted from Kim(2007). Vectors extracted from Kim(2007) had errors in the curvilinear parts of the MDL, but the vectors extracted from this study exactly matched the MDL in the Armistice Agreement Volume II. The measured length is 239.42km(148.77miles). This means that the expression '155mile MDL' or '248km DMZ' in papers, reports or mass media has so far been inappropriate. I think this study will be able to provide information on the exact length of the DMZ in studies related with DMZ or in policy decisions by the national and local government. However, it is deemed necessary to verify this result by national organizations such as the NGII(National Geographic Information Institute). After these verification procedures, I hope that the national government will inform the people of the exact length of DMZ and MDL.

• Fibers and Polymers
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• v.2 no.3
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• pp.141-147
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• 2001

The effect of compositions of isophorone diisocyanate (IPDl)/4.4'-diphenylmethane diisocyalate (MDI) and polypropylene oxide diol (PPG, $M_w$: 3000)/1,4-butane diol (BD) on the properties of UV-cured polyurethane acrylate films based on 2-hydroxyethyl acrylate (HEA) was examined. UV-curable polyurethane acrylates were formulated from the prepolymer. trimethylol propane triacrylate (TMPTA) as a reactive diluent, and 1-hydroxycyclohexyl ketone (Irgacure 184) as a photoinitiator. Dynamic mechanical thermal properties and elastic properties of UV-cured polyurethane acrylates was fecund to depend on the chemical composition of IPDl/MDl and PPG/BD. As the BD content increased, the tensile storage modulus of all series samples increased significantly. The storage modulus increased in the order of samples A (IPDI based samples)> samples B (IPDI/MDl (7/3 molar ratio) based samples) > samples C (IPDI/MDl (5/5 molar ratio) based samples at the same composition. Two distinct louts modulus peaks for all samples are observed owing to the softs segment glass transition temperature ($T_gh$) and hard segment glass transition temperature ($T_gh$). The difference between $T_gh$, and $T_gh$, (Δ$T_g$) increases in the order of A > B > C at the same composition. In cycle test, the initial onset strain (%) was found to decrease with increasing BD content in PPG/BD and with increasing MDI content in IPDI/MDl.

• The Transactions of the Korea Information Processing Society
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• v.7 no.1
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• pp.286-295
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• 2000

We present a novel statistically adaptive method using the Minimum Description Length(MDL) principle for unsupervised segmentation of magnetic resonance(MR) images. In the method, Markov random filed(MRF) modeling of tissue region accounts for random noise. Intensity measurements on the local region defined by a window are modeled by a finite Gaussian mixture, which accounts for image inhomogeneities. The segmentation algorithm is based on an iterative conditional modes(ICM) algorithm, approximately finds maximum ${\alpha}$ posteriori(MAP) estimation, and estimates model parameters on the local region. The size of the window for parameter estimation and segmentation is estimated from the image using the MDL principle. In the experiments, the technique well reflected image characteristic of the local region and showed better results than conventional methods in segmentation of MR images with inhomogeneities, especially.

• Journal of Advanced Navigation Technology
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• v.27 no.4
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• pp.453-456
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• 2023

Fighter jets employ guided missiles equipped with seekers to counter enemy air threats. Short range guided missiles(SRM) usually carry infrared(IR) seekers and are used to engage targets within visual range. On the other hand, medium range guided missiles(MRM) often utilize radio frequency(RF) seekers to engage targets beyond visual range. Medium range guided missiles do not activate their seekers until they reach the detection range of the seeker, and the aircraft's radar guides them for a certain distance. This guidance method is called Missile Data Link(MDL), and it can be implemented in either one-way or two-way communication modes, depending on the missile's communication system. In this paper, we discuss MDL based on these two communication modes, along with the integration of RADAR, mission computers, and guided missiles.

• The Journal of the Acoustical Society of Korea
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• v.29 no.1
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• pp.56-61
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• 2010

This paper describes optimization methods of acoustic models in HMM-based continuous speech recognition. Most of the conventional speech recognition systems use the same number of Gaussian mixture components for each HMM state. However, since the number of data samples available for each state is different from each other, it is possible to reduce the overall number of model parameters and the computational cost at the decoding step by optimizing the number of Gaussian mixture components. In this study, we introduced the Gaussian mixture weight term at the merging stage of Gaussian components in the minimum description length (MDL) based acoustic modeling optimization. Experimental results showed that the proposed method can obtain better ASR accuracy than the previous optimization method which does not consider the Gaussian mixture weight term.