• Bulletin of the Korean Chemical Society
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• v.35 no.7
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• pp.2097-2108
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• 2014

Chemical feature based quantitative pharmacophore models were generated using the HypoGen module implemented in DS2.5. The best hypothesis, Hypo1, which was characterized by the highest correlation coefficient (0.96), the highest cost difference (61.60) and the lowest RMSD (0.74), consisted of one hydrogen bond acceptor, one hydrogen bond donor, one hydrophobic and one ring aromatic. The reliability of Hypo1 was validated on the basis of cost analysis, test set, Fischer's randomization method and GH test method. The validated Hypo1 was used as a 3D search query to identify novel inhibitors. The screened molecules were further refined by employing ADMET, docking studies and visual inspection. Three compounds with novel scaffolds were selected as the most promising candidates for the designing of Mcl-1 antagonists. Finally, a 10 ns molecular dynamics simulation was carried out on the complex of receptor and the retrieved ligand to demonstrate that the binding mode was stable during the MD simulation.

• Journal of Forest and Environmental Science
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• v.29 no.4
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• pp.292-299
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• 2013

The study was undertaken to assess the tourist's carrying capacity and to explore ecotourism potential of Bangabandhu Sheikh Mujib Safari Park, the only safari park of Bangladesh. Carrying capacity was assessed both from physical and social aspect. On the other hand, 250 visitors were interviewed with semi structured questionnaire for ecotourism prospect evaluation along with some secondary data. The total daily-allowed visit was 17,300 with rotation coefficient of 3.46. Maximum daily average numbers of tourists were relatively below the physical carrying capacity of the Park (5,000). The social carrying capacity was 4.38 persons per day. As there are different categories of visitors, their choice of encounters and number of expected encounters also varied. Each year, the total tourist's number varied significantly ($p{\leq}0.05$). That proved the safari park had immense tourist prospect. 85 percent visitors were from lower and middle class family as entrance fees and other fees inside were very cheap in relation to other private amusement place. The ecological perspective of the park will remain unaltered if the carrying capacities of the area are followed with sustainability. Therefore, it is the proper time for taking appropriate decision.

• Journal of Korean Society of Forest Science
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• v.94 no.5 s.162
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• pp.342-348
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• 2005

An exploratory survey was performed to assess the present status of distribution and production of coconut palm (Cocos nucifera Linn.) in the rural landscape of Meghna floodplain of Bangladesh. A multistage simple random sampling technique was adopted to identify the study area and respondents. A total of 50 households were selected randomly for the study. Traditional knowledge on cultivation, management, and production of coconut palm was emphasized. Marketing of coconut palm products and income derived from coconut palm cultivation was taken into consideration. Perceptions of farmers, traders and professionals were described in due context of opportunities and constraints of coconut palm cultivation. Coconut palm cultivation was found to play an important role in household economy in rural Bangladesh sharing considerable contribution to the total income. About 10% of their total annual income was reported to come from coconut husbandry. Highest number of the coconut palms, 24%, was found to grow in the homestead compounds and in the pond banks. About one-third lands of the households were found to be covered by the coconut palms. Maximum, 19%, coconut palms were found in the 16-20 years age-class. Production of coconut was found highest at the age-class 11-15 years. The study found some important opportunities and constraints of coconut farming in rural Meghna floodplain area of Bangladesh. The results of this study would be useful for the rural development practitioners in Bangladesh.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.10
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• pp.823-829
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• 2020

In this competitive era, it has become a prerequisite for the financial firms providing banking services to understand and meet the customers' needs and demands to remain competitive in today's market environment. Without satisfying the customers, banking business cannot stand alone. To satisfy customers, it is often recommended to provide better quality banking services to the bank customers. Providing quality banking services has become a prime strategic tool for the banking sector nowadays. Therefore, the study investigates the effect of various dimensions of service quality of banking service on customer satisfaction in a developing country, Bangladesh. A total of 212 walking Bangladeshi banking customers participated in this research. A structured questionnaire was developed based on past research. SPSS is utilized for analysis and Likert scale was used in this study. Internal consistency of all items was found correct and a total of seven hypotheses were proposed. For testing, a 5% significance level is considered for acceptance of hypothesis. The findings show that, except employee competency, all other variables such as reliability, assurance, tangibles, responsiveness, empathy, and access to service have positive influence on customer satisfaction. The study provides policy implications for the management boards of the banking sectors.

• Journal of Korean Society of Forest Science
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• v.95 no.5
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• pp.532-538
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• 2006

Triphala is an important combination of three important forest fruits, i.e., Emblica officinalis, Terminalia chebula and Terminalia bellirica. Chittagong region in Bangladesh was once rich in triphala trees presently subject to the depletion. Thus, these forest resources are being threatened day by day. The study was conducted to learn the present using pattern of the triphala, causes of its depletion and the conservation strategies agreed by the villagers. Eight major uses of triphala trees were recognized. It was revealed that 100% respondents used the triphala as fruit tree followed by 71-78% as fuelwod. The present status of growing stock of triphala was found in depleted condition particularly in the Muslim dominated area. It was found that unawareness was the major cause for depleting the triphala trees agreed by the 87% respondents followed by depleting the village groves by 84%. Awareness creation (100%) and induction of social forestry program (92%) were found major recomendations by the vilagers to retard depleting the triphala tree species in the Chittagong region of Bangladesh.

• The Plant Pathology Journal
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• v.35 no.5
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• pp.486-497
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• 2019

Citrus canker is a devastating disease of citrus caused by Xanthomonas citri subsp. citri (Xcc). A total of 134 endophytic bacteria were isolated from various gymnospermic and angiospermic plants. They were screened for their antagonistic activities against three wild-type and six streptomycin-resistant Xcc strains. TbL-22 and TbL-26, both later identified as Bacillus thuringiensis, inhibited all the wild and resistant Xcc strains. TbL-22 exerted the highest antagonistic activity against XccW3 and XccM6 with inhibition zones of $20.64{\pm}0.69$ and $19.91{\pm}0.87mm$, respectively. Similarly ethyl acetate extract of TbL-22 showed highest inhibition zones $15.31{\pm}2.08$ and $19.37{\pm}3.17mm$ against XccW3 and XccM6, respectively. TbL-22 reduced canker incidence on infected leaves by 64.05% relative to positive controls. Scanning electron microscopy revealed that the cell membranes of Xcc treated with ethyl acetate extract of TbL-22 were ruptured, lysed, and swollen. B. thuringiensis TbL-22 can effectively and sustainably controls streptomycin-resistant citrus canker.

• Journal of the Korean Society of School Health
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• v.34 no.2
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• pp.87-97
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• 2021

Purpose: The authors used a meta-analysis approach to investigate the effects of exercise on gender-specific triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) in obese adolescents. Methods: This study is a systematic review and meta-analysis study to confirm the effect of exercise intervention according to gender for obese adolescents. PICO were obese a adolescents, exercise intervention, comparative intervention (control and general group),TG and HDL-C. Results: The group of obese male adolescents showed a statistically significant decrease of 51.72 in TG (n=175, MD=-51.72; 95% CI -52.44 to -51.00).There was a statistically significant increase of 4.44 in HDL-C (n=175, MD=4.44; 95% CI 3.79 to 5.10) in the group of obese male adolescents. Conclusion: Triglyceride and high-density lipoprotein cholesterol were analyzed to determine the effect of exercise interventions in obese adolescents according to gender differences. The results of this study can be used as basic data for the design of future exercise intervention studies, subjects, exercise methods, and intervention periods.

• The Journal of Korean Medicine
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• v.42 no.4
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• pp.75-101
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• 2021

Objectives: ncluding stroke. The aim of this study was to systematically review the clinical evidence of CT for stroke. Methods: To identify randomized controlled trials (RCTs) reporting the effectiveness and/or safety of CT, seven databases including PubMed, EMBASE, and Cochrane Library were searched for articles published from January 2000 to February 2021 without language restrictions. Meta-analysis was performed using Review Manager 5.4 software and the results were presented as mean difference (MD) or standard mean difference (SMD) for continuous variables and odds ratio (OR) for diverse variables with 95% confidence intervals (CIs). Assessment of the methodological quality of the eligible trials was conducted using the Cochrane Collaboration tool for risk of bias in RCTs. Results: Twenty-two RCTs with 1653 participants were included in the final analysis. CT provided additional benefit in improving upper limb motor function (Fugl-Meyer assessment for upper limb motor function, MD 6.91, 95% CI 4.64 to 1.67, P<0.00001) and spasticity (response rate, OR 3.28, 95% CI 1.31 to 8.22, P=0.08) in stroke survivors receiving conventional medical treatment. These findings were supported with a moderate level of evidence. CT did not significantly increase the occurrence of adverse events. Conclusions: This study demonstrated the potential of CT to be beneficial in managing a variety of complications in stroke survivors. However, to compensate for the shortcomings of the existing evidence, rigorously designed large-scale RCTs are warranted in the future.

• The Journal of Economics, Marketing and Management
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• v.11 no.4
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• pp.41-52
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• 2023

Purpose: The study examines the effect of TechTubers' unboxing videos on consumer buying behavior by highlighting the role of product touch, visual and verbal sensory cues. The study integrates the vicarious touch and the dual coding theory to analyze the Smartphone purchase behavior of Generation Z. Research design, data and methodology: The study collected data from 349 respondents who were viewers of YouTube unboxing videos. A structured questionnaire using a 5-point Likert scale was employed as a survey instrument. Convenience sampling technique was utilized to select the samples. The data were analyzed using structural equation modeling (SEM). Results: Results reveal that vicarious touch and verbal description have a statistically significant positive effect on Generation Z's purchase intention of Smartphone. Moreover, purchase intention positively affects Generation Z's actual purchase behavior of Smartphone. However, the visual images did not significantly affect purchase intention. Conclusions: The study offers significant theoretical and practical implications. The study adds new knowledge to the extant literary field by highlighting the impact of digital product presentation in the form of Unboxing videos on purchase intention for technology products. Moreover, the study suggests content sponsorship and advertising opportunities for marketers in collaboration with the TechTubers on YouTube unboxing video platform.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2020.12a
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• pp.14-14
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• 2020

In December 2019, the COVID-19 epidemic was discovered in Wuhan, China, and since has disseminated around the world impacting human health for millions. Herein, in-silico drug discovery approaches were utilized to identify potential candidates as Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) main protease (M^pro) inhibitors. We investigated several databases including natural and natural-like products (>100,000 molecules), DrugBank database (10,036 drugs), major metabolites isolated from daily used spices (32 molecules), and current clinical drug candidates for the treatment of COVID-19 (18 drugs). All tested compounds were prepared and screened using molecular docking techniques. Based on the calculated docking scores, the top ones from each project under investigation were selected and subjected to molecular dynamics (MD) simulations followed by molecular mechanics-generalized Born surface area (MM-GBSA) binding energy calculations. Combined long MD simulations and MM-GBSA calculations revealed the potent compounds with prospective binding affinities against M^pro. Structural and energetic analyses over the simulated time demonstrated the high stabilities of the selected compounds. Our results showed that 4-bis([1,3]dioxolo)pyran-5-carboxamide derivatives (natural and natural-like products database), DB02388 and Cobicistat (DB09065) (DrugBank database), salvianolic acid A (spices secondary metabolites) and TMC-310911 (clinical-trial drugs database) exhibited high binding affinities with SARS-CoV-2 M^pro. In conclusion, these compounds are up-and-coming anti-COVID-19 drug candidates that warrant further detailed in vitro and in vivo experimental estimations.