• 제목/요약/키워드: MCF10A-ras

검색결과 45건 처리시간 0.036초

Capsaicin-induced apoptosis in H-ras MCF10A cells involves activation of MAPkinases

  • Kang, Hye-Jung;Yunjo Soh;Lee, Eun-Jung;Kim, Mi-Sung;Surh, Young-Joon;Aree Moon
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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    • pp.157-157
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    • 2001

  • Capsaicin (8-methyl-N-vanillyl-6-nonenamide), the principal pugent ingredient found in hot red pepper, has been recently known to have anticarcinogenic or chemopreventive properties. In the previous study, we showed that capsaicin selectively induces apoptosis in H-ras MCF10A cells.(omitted)

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RAS SIGNALING IN INVASION AND MOTILITY OF MCF10A HUMAN BREAST EPITHELIAL CELLS

  • Kim, Mi-Sung;Lee, Eun-Jung;Shin, Il-Chung;Ahn, Seong-Min;Hyun Song;Kim, Hyeong-Reh-Choi;Aree Moon
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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    • pp.76-77
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    • 2002

  • Ras expression has been suggested as a marker for tumor aggressiveness of breast cancer including the degrees of invasion and tumor recurrence. Expression of H-, K-, and N-ras is regulated in a tissue-specific manner and during development, indicating that ras proteins may have different cellular functions.(omitted)

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Roles of MAPKs in H-ras-induced Invasion and Motility

  • Kim, Mi-Sung;Lee, Eun-Jung;Kim, Hyeong-Reh;Moon, A-Ree
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.119-120
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    • 2003

  • One of the most frequent defects in human cancer is the uncontrolled activation of the ras-signaling pathways. Elevated p21 ras expression is associated with tumor aggressiveness in breast cancer including the extent of invasion into fat tissues. infiltration into lymphatic vessels and tumor recurrence, We demonstrate that H-ras, but not N-ras, upregulates matrix metalloproteinase(MMP)-2 expression and induces invasive phenotype in MCF10A human breast epithelial cells. (omitted)

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Roles of PI3K and Rac Pathways in H-ras Induced Invasion and Motility

  • Ilchung Shin;Kim, Seonhoe;Aree Moon
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2003년도 추계학술대회
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    • pp.144-144
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    • 2003

  • Phosphatidylinositol 3-kinase (PI3K) and Rac play important roles that regulate cellular functions including cell survival and .migration. In the present study, we investigated the functional roles of PI3K and Rac1 pathways in H-ras-induced invasive phenotype and motility of MCF10A cells.(omitted)

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