• Archives of Pharmacal Research
• /
• v.21 no.6
• /
• pp.718-722
• /
• 1998

Scopoletin (7-hydroxy-6-methoxycoumarin), a coumarin, was isolated from the aerial part of Solanum lyratum Thunb. by the activity-guided fractionation employing carbon te trachloride-intoxicated primary cultured rat hepatocytes as a screening system. Its hepatoprotective activity was first evaluated by measuring the release of glutamic pyruvic transaminase and sorbitol dehydrogenase from carbon tetrachloride-intoxicated rat hepatocytes into the culture medium. Scopoletin significantly reduced the releases of glutamic pyruvic transaminase and sorbitol dehydrogenase from the carbon tetrachloride-intoxicated primary cultured rat hepatocytes by 53% and 58%, respectively, from the toxicity in a dose-dependent manner over concentration ranges of 1mcM to 50mcM. Further studies revealed that at the concentration of 10mcM, scopoletin significantly preserved glutathione content by 50% and the activity of superoxide dismutase by 36% and also inhibited the production of malondialdehyde to the degree as seen in the control.

• Korean Management Science Review
• /
• v.21 no.2
• /
• pp.43-60
• /
• 2004

Every iteration of interior-point methods of large scale optimization requires computing at least one orthogonal projection. In the practice, symmetric variants of the Gaussian elimination such as Cholesky factorization are accepted as the most efficient and sufficiently stable method. In this paper several specific implementation issues of the symmetric factorization that can be applied for solving such equations are discussed. The code called McSML being the result of this work is shown to produce comparably sparse factors as another implementations in the $MATLAB^{***}$ environment. It has been used for computing projections in an efficient implementation of self-regular based interior-point methods, McIPM. Although primary aim of developing McSML was to embed it into an interior-point methods optimizer, the code may equally well be used to solve general large sparse systems arising in different applications.

• Knowledge Management Research
• /
• v.11 no.4
• /
• pp.21-39
• /
• 2010

Recommender system is a core component of e-commerce. Correspondingly, metrics to evaluate the system performance have been developed and applied. However, even though we have lots of applications that have tried to adopt recommender systems, the dearth of successfully installed recommender systems for more than a decade leads us to a skeptical thinking that current metrics do not sufficiently indicate the recommender system success in business viability point of view. Hence, the purpose of this paper is to reconfigure measures for recommender system success. Adopting DeLone and McLean's amended model of information system success as the underlying framework, content analysis with intellectual properties on recommender systems was conducted to modify the currently used metrics. Then a model of recommender system success is proposed based on the newly identified metrics are compared with traditional metrics.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.39 no.4
• /
• pp.301-307
• /
• 2015

The diameter of a proton beam emanating from the MC-50 cyclotron is about 2-3 mm with Gaussian distribution. This widely irradiated proton beam is not suitable for semiconductor etching, precise positioning, and micromachining, which require a small spot. In this study, a beam cutting method using a microhole is proposed as an economical alternative. We produced a microhole with aspect ratio, average diameter, and thickness of 428, $21{\mu}m$, and 9 mm, respectively, for cutting the proton beam. By using this high-aspect-ratio microhole, we conducted machinability tests on microstructures with sizes of tens of ${\mu}m$. Additionally, the results of simulation using GEANT4 and those of the actual experiment were compared and analyzed. The outcome confirmed the possibility of implementing a micro process technology for the fabrication of three-dimensional microstructures of 20 micron units using the MC-50 cyclotron with the microhole.

• Imaging Science in Dentistry
• /
• v.33 no.3
• /
• pp.179-185
• /
• 2003

Purpose: To investigate the effects of irradiation on the phenotypic expression of the MC3T3-El osteoblastic cell line, particularly on the expression of osteocalcin and osteopontin. Materials and Methods: Cells were irradiated with a single dose of 0.5, 1,4, and 8 Gy at a dose rate of 5.38 Gy/min using a cesium 137 irradiator. After the specimens were harvested, RNA was extracted on the 3rd, 7th, 14th, and 21st day after irradiation. The RNA strands were reverse-transcribed and the resulting cDNAs were subjected to amplification by PCR. Results: The irradiated cells demonstrated a dose-dependent increase in osteocalcin and a dose-dependent decrease in osteopontin mRNA expression compared with the non-irradiated control group, The amount of osteocalcin mRNA expression decreased significantly at the 3rd day after irradiation of 0,5, 1,4, and 8 Gy, and also decreased significantly at the 3rd, 14th, and 21 st day after irradiation in the 8 Gy exposed group compared with the control group, The degree of osteopontin mRNA expression increased significantly at the 7th day after irradiation of 0,5, 1,4, and 8Gy, Conclusion: These results showed that each single dose of 0,5, 1, 4, and 8 Gy influenced the mRNA expression of osteocalcin and osteopontin associated with the calcification stage of osteoblastic cells, suggesting that each single dose affected bone formation at the cell level.

• Journal of Broadcast Engineering
• /
• v.21 no.4
• /
• pp.472-483
• /
• 2016

This paper proposes a blocking artifacts detection algorithm in frequency domain for MC-FRUC (Motion Compensated Frame Rate Up-Conversion). Conventional MC-FRUC algorithms occur blocking artifacts near interpolated block boundaries since motion compensation is performed from block-based motion vector. For efficiently decreasing blocking artifacts, this paper analyses frequency characteristics of the interpolated frame and reduces blocking artifacts on block boundaries. In experimental results the proposed method shows better subjective quality than some conventional FRUC method and also increases the PSNR(Peak Signal to Noise Ratio) value on average 0.45 dB compared with BDMC(Bi-Directional Motion Compensation).

• Clean Technology
• /
• v.13 no.2
• /
• pp.143-150
• /
• 2007

The objective of this study is to develop hydrocarbon-based cleaning agents by blending paraffins, glycol ethers and siloxanes in oder to effectively clean contaminants such as flux, solder and grease. And the effect of cleaning ability by wetting index, aniline points and solubility parameter of the formulated hydrocarbon-based cleaning agents were studied in this work. The formulated hydrocarbon-based cleaning agents were prepared on the base of physical properties of their individual components. Wetting indexes and aniline points of their were measured through experiments and solubility parameters of their were calculated based on the Hansen's equation. In this study, evaluation of cleaning ability by cleaning agents were carried out using contaminants such as flux, solder, and grease. The experimental results showed that the cleaning ability of the formulated cleaning agents was excellent in cleaning contaminants such as flux, solder and grease and that the influencing parameters on their cleaning efficiency were found to be different according to contaminant types. MC($20.3MPa^{1/2}$), DF-1 ($24.2MPa^{1/2}$) and DF-2($21.5MPa^{1/2}$) with similar solubility parameter as flux ($21.3MPa^{1/2}$) showed 100% cleaning efficiency within 3 minutes in flux cleaning. And CFC-113, MC and 1,1,1-TCE with low aniline point less than $-20^{\circ}C$ showed excellent cleaning efficiency in solder cleaning. DG-1($16.2\;MPa^{1/2}$) and DG-2($15.5\;MPa^{1/2}$) with similar solubility parameter as grease($15.0{\sim}17.0\;MPa^{1/2}$) showed relatively low cleaning efficiency of grease, but CFC-113 and MC with high wetting index and low aniline point showed good cleaning efficiency in grease cleaning. As a result of this study, the hydrocarbon-based cleaning agents alternative to regulated cleaning agents such as CFC-113, 1,1,1-TCE and MC were able to be developed through properly blending paraffins, glycol ethers and siloxanes for cleaning flux, solder and grease. And it can be shown that various influencing parameters of cleaning efficiency such as wetting index, aniline point, solubility parameter and etc. of the non-aqueous cleaning agent should be reviewed for prediction of their cleaning ability and can be applied to formulation of cleaning agents.

• Toxicological Research
• /
• v.16 no.1
• /
• pp.27-31
• /
• 2000

Recently, there is a worldwide concern that a great number of man-made chemicals have a hormone-like action both in humans and in animals. EPA and OECD are developing screening programs using validated test systems to determine whether certain substances may have an effect on humans. In the present study, the establishment of in vivo short-term test system for pubertal female assay with thyroid to detect endocrine disrupting chemicals was tried using a model substance, methoxychlor (MC), a chlorinated hydrocarbon insencticide. Forty female rats were assigned to four groups. MC was administered at dose levels of 0, 8, 40 and 200mg/kg by gavage to female rats from day 21 post partum to the completion of vaginal opening. We evaluated body weight change, age at vaginal opening, onset of estrous cyclicity, age at first esturs, ovary weight, and serum concentrations of thyroxine and thyroid stimulating hormone in female rats. The age at vaginal opening of females receiving 40 200mg/kg was significantly younger than control. The onset of estrus cyclicity and age at first estrus of females receiving 200mg/kg was also younger than controls. There was no effect of treatment on body weight, ovary weight, and hormone concentration. Based on these results, it can be concluded that application of MC at dose level of 40mg/kg affects the vaginal opening and application of MC at dose level of 200mg/kg accelerates the vaginal opening and the onset of estrus cylicity.

• Journal of Korean Society of Coastal and Ocean Engineers
• /
• v.21 no.4
• /
• pp.334-344
• /
• 2009

In the present paper, analytic solutions are derived for scattering of obliquely incident waves by a semi-infinite breakwater or a breakwater gap of partial reflection. In order to examine the appropriateness of the derived solutions, they are compared with the solutions derived by McIver in 1999 and Bowen and McIver in 2002 for a semi-infinite breakwater and a breakwater gap, respectively, in the case of perfect reflection. The derived analytic solutions are used to investigate the effect of reflection coefficient of the breakwater and wave incident angle upon the tranquility at harbor entrance. The tranquility is deteriorated by the reflected waves as the reflection coefficient increases and as the waves are incident more obliquely.

• Journal of Acupuncture Research
• /
• v.29 no.6
• /
• pp.11-21
• /
• 2012

Objectives : BHH10 is traditional medicine herb used for enhancing body resistance against various diseases. The aim of this study was to identify BHH10 extract induces osteogenic activity in human osteoblast-like MC3T3-E1 cells. Methods : MC3T3-E1, pre-osteoblast cell line, were treated with BHH10 of various concentrations($0.1{\mu}g/mL$, $1{\mu}g/mL$, $10{\mu}g/mL$). And then, the effect of BHH10 on osteoblast differentiation was examined by alkaline phosphatase(ALP) activity, von Kossa staining and RT-PCR for osteoblast differentiation markers such as osteocalcin(OCN), osteopontin(OPN). Results : BHH10 had dose-dependent effect on the viability of osteoblastic cells, and dose-dependently increased alkaline phosphatase(ALP) activity. BHH10 markedly increased mRNA expression for OCN, OPN in MC3T3-E1 cells. Also, BHH10 significantly induced mineralization in the culture of MC3T3-E1 cells. Conclusions : In conclusion, these results propose that BHH10 can play an important role in osteoblastic bone formation, osteogenesis, and may possibly lead to the development of bone-forming drugs.