• Journal of Korean Society for Quality Management
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• v.45 no.4
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• pp.677-696
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• 2017

Purpose: This study suggests that Six Sigma MBB should be used as a key talent to lead the fourth industrial revolution era by training them with big data processing capability. Methods: Through the analysis between articles on the fourth industrial revolution and Six Sigma related papers, common competencies of data scientists and Six Sigma MBBs were identified and the big data analysis capabilities needed for Six Sigma MBB were derived. Then, training was conducted to improve the big data analysis capabilities so that Six Sigma MBB is able to design algorithms required in the fourth industrial revolution era. Results: Six Sigma MBBs, equipped with the knowledge in field site improvement and basic statistics, were provided with 40 hours of big data analysis training and then were made to design a big data algorithm. Positive results were obtained after applying a AI algorithm which could forecast process defects in a field site. Conclusion: Six Sigma MBB equipped with big data capability will make the best talent for the fourth industrial revolution era. A Six Sigma MBB has an excellent capability for improving field sites. Utilizing the competencies of MBB can be a key to success in the fourth industrial revolution. We hope that the results of this study will be shared with many companies and many more improved case studies will arise in the future as a result of this study.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.7
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• pp.1017-1024
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• 2014

This study was carried out to develop mulberry wines fermented with traditional microorganisms (Saccharomyces cerevisiae B-8). S. cerevisiae B-8 is a traditional fermentation microorganism isolated from domestically grown Rubus occidentalis. Each S. cerevisiae B-8 and Fermivin was inoculated into mulberry up to $1{\times}10^9$ CFU/kg, followed by incubation at $25^{\circ}C$ for 10 days. Mulberry fermented with S. cerevisiae B-8 (MBB) had a high alcohol content (16.47%), and the fermentation rate of MBB was faster than that of mulberry fermented with Fermivin (MBF). The total polyphenol and flavonoid contents of MBB were higher than those of MBF. DPPH radical scavenging activity of MBB was as high as that of MBF. ABTS radical scavenging activity of MBF was higher than those of MBB and mulberry juice (MBJ). In addition, reducing power of MBB was much higher than other samples. Flavor constituents of the two fermented wines were analyzed by gas chromatography and mass spectrometry. Twenty-three compounds from the sample were separated and identified as fifteen esters, six alcohols, an aldehyde, and an acetate. Particularly, tetradecanoic acid, ethyl ester of orris and violet flavor were ten times more abundant in MBB than in MBF. Several ester components were two times more abundant in MBB than in MBF. In conclusion, current findings indicate that MBB might have better antioxidant activities with flavor, which contributes to improved wine production with high quality and function.

• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.2
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• pp.26-42
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• 2009

Purpose: This study was performed to evaluate the anti-inflammatory effect of Manbunbang extract (MBB). Methods: In order to understand the mechanism of anti-inflammatory effect of MBB, expression of cytokines and its levels in RAW 264.7 cell lines, as well as changes of cytokine gene expressions in serum, spleen, and liver tissues in acute inflammation induced mouse model were investigated. Results: 1. MBB significantly suppressed the expression levels of IL-1${\beta}$, TNF-${\alpha}$ and COX-2 mRNAs at 100 and 50 ${\mu}$g/m${\ell}$ concentrations, and IL-6 and NOS-II genes at 100, 50 and 10 ${\mu}$g/m${\ell}$ concentrations in RAW 264.7 cell lines, compared to those of the control. 2. MBB significantly reduced the production level of IL-$1{\beta}$, IL-6 and TNF-${\alpha}$ at 100 and 50 ${\mu}$g/m${\ell}$ concentrations in RAW 264.7 cell lines compared the those of the control. 3. MBB significantly reduced the production of IL-1${\beta}$, IL-6 and TNF-${\alpha}$ levels in sera of acute inflammation induced mice. 4. MBB significanlty suppressed the expression level of IL-1${\beta}$, TNF-${\alpha}$ mRNA in spleen tissues as well as IL-6 mRNA in liver tissues in acute inflammation induced mice. Conclusion: From the results above, anti-inflammatory effect of MBB through its immune regulation could be experimentally explained. Wide treatment of inflammatory diseases such as pelvic inflammation using MBB are recommended.

• Proceedings of the Korean Information Science Society Conference
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• 2003.10b
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• pp.145-147
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• 2003

시간이 흐름에 따라 위치가 연속적으로 변경되는 객체를 이동 객체(Moving Objects)라고 한다. 이러한 이동 객체의 대용량 궤적 정보를 효율적으로 검색하기 위해서 색인이 필요하며 대표적인 색인으로 TB-tree가 있다. 그러나 전통적인 공간 색인인 R-tree 기반의 TB-tree는 엄격한 궤적 보존 정책에 의해 레코드가 삽입될 때마다 해당 레코드의 선행자(predecessor)를 포함하는 단말 노드를 검색해야 하며, 레코드 삽입으로 인한 단말 노드 MBB의 변경을 해당 단말 노드에서부터 루트 노드까지 반영해야하는 갱신 부하를 가지고 있다. 본 논문에서는 대용량 궤적 정보의 효율적인 색인을 위한 TB-tree 갱신 기법을 제안한다. 본 기법은 앞으로 삽입될 이동 객체의 궤적을 포함하는 예상된 MBB(EMBB: Expected Minimum Bounding Box)를 트리에 먼저 반영한다. 그 후 새로운 레코드가 삽입될 때마다 중간 노드의 MBB를 갱신하지 않고, 삽입되는 레코드의 MBB가 EMBB을 벗어났을 때 EMBB를 재설정하여 실제로 삽입된 레코드의 MBB와 재설정된 EMBB를 포함하도록 중간 노드의 MBB를 조정하므로 TB-tree의 MBB 조정 횟수를 줄인다. 또한 TB-tree에 선행자를 포함하는 단말 노드를 직접적(direct)으로 접근하기 위하여 별도의 선행자 테이블(Predecessor Table) 구조를 두어 레코드 삽입을 위해 선행자를 포함하는 단말 노드의 검색비용을 줄여 전체적인 색인 갱신 비용이 감소된다.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.1
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• pp.55-82
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• 2008

Purpose: In this study, we evaluated anti-inflammatory activity and anti-thrombosis effect of Manbunbang(MBB) prescribed to chronic PID patients. Methods: We studied inhibitory effect of platelet aggregation, suppression effect of GPIIb/IIIa activity and inhibitory effect of $TXB_2$ and $PGE_2$ biosynthesis which were caused by ADP, epinephrine, collagen and arachidonic acid in vitro. And suppression of pulmonary embolism, changes of related factors in dextran coagulation condition model and anti-oxidative effect of oxidative damage were studied in vivo. Results: MBB extract showed LD50 of $200\;{\mu}g/ml$ or higher in mouse lung fibroblast cells, and significantly decreased the GPT and GPT level in dextran coagulation condition model compared to the control. MBB extract showed dose-dependent inhibition effect on platelet coagulation induced by ADP, epinephrine, collagen, arachidonic acid. MBB extract showed dose-dependent inhibition effect on GPIIb/IIIa activities compared to the control. MBB extract significantly suppressed TXB2 and PGE2 biosynthesis compared to the control. MBB extract suppressed pulmonary embolism triggered by collagen and epinephrine by 37.5% compared to the control. MBB extract significantly suppressed the decrease of speed of bloodstream caused by blood coagulation in dextran coagulation condition model compared to the control. Concluson : The results strongly suggest the anti-inflammatory activity of Manbunbang through anti-thrombus. Various applications using Manbunbang on inflammatory diseases are anticipated. Anti-oxidative efficacy comparison data between the Manbunbang prescription and the drug compositions may be used as important clinical information, and further investigation of anti-oxidative activities of Chrysanthemum indicum and Rhemaniae Radix should be followed.

• 한국공간정보시스템학회:학술대회논문집
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• 2003.11a
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• pp.141-146
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• 2003

시간이 흐름에 따라 연속적으로 위치를 변경하는 객체를 이동 객체(Moving Objects)라고 한다. 이러한 이동 객체의 대용량 위치 정보를 효율적으로 검색하기 위하여 색인이 필요하며, 대표적인 색인으로 TB-tree가 제안되었다. 그러나 전통적인 R-tree 기반의 TB-tree는 엄격한 궤적 보존 정책에 의해 레코드가 삽입될 때마다 해당 레코드의 선행자(predecessor)를 포함하는 단말 노드를 검색해야 하며, 레코드 삽입으로 인한 단말 노드 MBB의 변경을 중간 노드들의 MBB에도 반영해야 하는 갱신 부하를 가지고 있다. 본 논문에서는 대용량 이동 객체 궤적 정보의 효율적인 색인을 위한 최소 전파 TB-tree를 제안한다. 본 기법은 앞으로 삽입될 이동 객체의 궤적을 포함하는 예상된 MBB(EMBB: Expected Minimum Bounding Box)를 트리에 먼저 반영한 후 레코드가 삽입될 때마다 중간 노드의 MBB를 갱신하지 않고, 객체가 EMBB을 벗어났을 때 중간 노드의 MBB를 조정하여 TB-tree의 MBB조정 횟수를 줄이고, 또한 TB-tree에 별도의 테이블 구조를 둠으로써 레코드 삽입을 위한 단말 노드 검색 비용을 줄여 전체적인 TB-tree의 갱신 비용을 감소시킨다.

• Analytical Science and Technology
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• v.12 no.1
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• pp.28-33
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• 1999

Glutathione(GSH) in biological samples was determined by high performance liquid chromatographic(HPLC) method with fluorescence detector(FLD) after monobromobimane(MBB) or 4-fluoro-7-sulfobenzofurazan(SBD-F) derivatization. The detection limit of $0.03{\mu}g/mL$ was obtained after MBB derivatization, derivative of MBB was about 200 times more sensitive than that of SBD-F. N-acetylcysteine was used as internal standard and tetrabutylammonium ion as counter ion for better separation. The determination by ion-pairing chromatography after MBB derivatization was characterized by linearity in the range between $0.08{\sim}8.33{\mu}g/mL$ with a good correlation coefficient of 0.998. By precision test appeared relative standard deviation at less than 5% at three different concentrations. This method can be used for the analysis of GSH in plasma and tissue.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.39
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• pp.21.1-21.6
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• 2017

Background: The purposes of the present study were to compare implant stabilities of mandibular block bone graft and bovine bone graft and to evaluate influencing factors for implant stability in mandibular block bone (MBB) graft. Methods: This retrospective study investigated 1224 cases and 389 patients treated by one surgeon in the Department of Oral and Maxillofacial Surgery of Pusan National University Dental Hospital (Yangsan, Korea) between January 2010 and December 2014. Proportions that MBB graft cases constitute in all implant restoration cases and in all bone graft cases were measured. Implant stability quotient (ISQ) values were achieved by the same surgeon before loading. The average ISQ values of the experimental groups were compared. In addition, ISQ values of influencing factors, such as age, sex, implant size, and implant placement site, were compared within the MBB group using $Osstell^{TM}$ Mentor ($Osstell^{(R)}$, $G{\ddot{o}}teborg$, Sweden). Paired t test and ANOVA were conducted for statistical analysis with a significance level of 0.05. Results: Fifty-five percent of all implant restoration cases performed bone graft while MBB cases constituted 34% of all implant restoration cases and 61% of all bone graft cases. Comparing ISQ values according to bone graft materials, the MBB group manifested sufficient implant stability by presenting comparable ISQ value to that of the experimental group without bone graft. Among the reviewed factors, females, mandibular molar regions, and implants in larger diameter displayed greater implant stabilities. Conclusions: Satisfactory implant stability was accomplished upon administration of MBB graft. Within the limitation of this study, gender, implant site, and implant diameter were speculated to influence on implant stability in MBB graft.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.17 no.9
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• pp.2573-2589
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• 2023

As 5G mobile systems carry multiple services and applications, numerous user, and application types with varying quality of service requirements inside a single physical network infrastructure are the primary problem in constructing 5G networks. Radio Access Network (RAN) slicing is introduced as a way to solve these challenges. This research focuses on optimizing RAN slices within a singular physical cell for vehicle-to-everything (V2X) and enhanced mobile broadband (eMBB) UEs, highlighting the importance of adept resource management and allocation for the evolving landscape of 5G services. We put forth two unique strategies: one being offline network slicing, also referred to as standard network slicing, and the other being Online reinforcement learning (RL) network slicing. Both strategies aim to maximize network efficiency by gathering network model characteristics and augmenting radio resources for eMBB and V2X UEs. When compared to traditional network slicing, RL network slicing shows greater performance in the allocation and utilization of UE resources. These steps are taken to adapt to fluctuating traffic loads using RL strategies, with the ultimate objective of bolstering the efficiency of generic 5G services.

• Journal of Korean Neurosurgical Society
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• v.40 no.4
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• pp.256-261
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• 2006

Objective : The goal of this study was to establish the benefit and prognostic factors of lumbar medial branch block[MBB] for low back pain. Methods : A retrospective analysis was based on the data obtained from 281 patients with low back pain, who visited our hospital between January 2001 and November 2004. Pain relief was evaluated at 2 weeks, 1 month and 3 months. The authors analyzed the results of MBB according to the patient's age, sex, symptom duration, pathologic condition, and presence of radiating pain. Results : Two hundred eighty one patients had sprain [151]. lumbar fracture [27], spinal stenosis [50], herniated lumbar disc [24] acute post-operative pain [8], and chronic post-operative pain [21] with success rate of 63.6%, 59.3%, 26.0%, 25.0%, 87.5% and 42.9%, respectively. The effects of MBB in sprain, lumbar fracture, and acute post-operative pain were significantly better than those in stenosis, herniated lumbar disc and chronic post-operative pain patients. The patients in young age group [<60 years], with short symptom duration [<6 months] and without radiating pain showed good response to lumbar MBB. Conclusion : The lumbar MBB appears to be safe and effective for low back pain in certain selected patients. Good prognostic factors were low back pain without surgical conditions and radiating pain, with short symptom duration [<6 months], and in relatively young age [<60 years] group.