• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권11호
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• pp.4483-4501
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• 2020

Recent findings identified the scatter and shape of MFD (macroscopic fundamental diagram) is heavily influenced by the spatial distribution of link density in a road network. This implies that the concept of MFD can be utilized to divide a heterogeneous road network with different degrees of congestion into multiple homogeneous subnetworks. Considering the actual traffic data is usually incomplete and inaccurate while most traffic partition algorithms rely on the completeness of the data, we proposed a three-step partitioned algorithm called Iso-MB (Isoperimetric algorithm - Merging - Boundary adjustment) permitting of incompletely input data in this paper. The proposed algorithm was implemented and verified in a simulated urban transportation network. The existence of well-defined MFD in each subnetwork was revealed and discussed and the selection of stop parameter in the isoperimetric algorithm was explained and dissected. The effectiveness of the approach to the missing input data was also demonstrated and elaborated.

• 한국컴퓨터정보학회논문지
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• 제25권9호
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• pp.31-36
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• 2020

본 연구에서는 딥러닝 처리기술을 이용한 이미지 분석을 통하여 위치정보가 없는 사진의 위치를 사용자에게 제공하는 장소이미지 수집기술을 설계하였다. 본 서비스는 사용자가 생활 중에 관심 있는 장소의 이미지 사진을 서비스에 업로드하면 해당 장소의 이름과 위치뿐만 아니라 관련 주변 정보를 확인 할 수 있는 서비스 개발을 목적으로 설계되었다. 본 연구는 이미지에 해당하는 정보를 제공하고 그 위치 정보를 기반으로 사용자가 관심 있는 주변정보를 제공할 수 있는 서비스의 기반기술이다. 이를 통하여 다양한 서비스에 활용이 가능하다.

• The Journal of Advanced Prosthodontics
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• 제8권3호
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• pp.219-223
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• 2016

PURPOSE. This study aimed to create a digitized database of fabricated obturators to be kept for patients' potential emergency needs. MATERIALS AND METHODS. A chairside intraoral scanner was used to scan the surfaces of an acrylic resin obturator. The scanned data was recorded and saved as a single standard tessellation language file using a three-dimensional modeling software. A simulated obturator model was manufactured using fused deposition modeling technique in a three-dimensional printer. RESULTS. The entire obturator was successfully scanned regardless of its structural complexity, modeled as three-dimensional data, and stored in the digital system of our clinic at a relatively small size (19.6 MB). A simulated obturator model was then accurately manufactured from these data. CONCLUSION. This study provides a proof-of-concept for the use of digital technology to create a digitized database of obturators for edentulous maxillectomy patients.

• 동의생리병리학회지
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• 제20권6호
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• pp.1502-1506
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• 2006

To investigate the inhibitory effects of Citaowan (CTW) on the growth and angiogenesis of breast cancer in vivo. Orthotopic breast cancer model was established by injection of MDA-MB-231 cells into mammary fat pad of nude mice. Seven weeks after injection, CTW was orally administered at dose of 50, 100 mg/mouse every day for 40 days. Body weight, tumor volume, tumor apoptosis, microvessel density and tumor proliferation were evaluated, after the mice were sacrificed. The body weight and tumor volume were not significantly changed in CTW group compared with the control group. Tumor apoptosis, proliferation and microvessel density were significantly reduced in CTW group (100 mg/mouse) compared with the control group. These data indicate that CTW has anti-angiogenic and proapoptotic effects on breast cancer.

• 디지털산업정보학회논문지
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• 제10권4호
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• pp.79-87
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• 2014

In this paper, we implemented the HearCAM platform with Raspberry PI B+ model which is an open source platform. Raspberry PI B+ model consists of dual step-down (buck) power supply with polarity protection circuit and hot-swap protection, Broadcom SoC BCM2835 running at 700MHz, 512MB RAM solered on top of the Broadcom chip, and PI camera serial connector. In this paper, we used the Google speech recognition engine for recognizing the voice characteristics, and implemented the pattern matching with OpenCV software, and extended the functionality of speech ability with SVOX TTS(Text-to-speech) as the matching result talking to the microphone of users. And therefore we implemented the functions of the HearCAM for identifying the voice and pattern characteristics of target image scanning with PI camera with gathering the temperature sensor data under IoT environment. we implemented the speech recognition, pattern matching, and temperature sensor data logging with Wi-Fi wireless communication. And then we directly designed and made the shape of HearCAM with 3D printing technology.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2015년도 춘계학술대회 및 임시총회
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• pp.41-41
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• 2015

BSA-seq technologies, combined Bulked Segregant Analysis (BSA) and Next-Generation Sequencing (NGS), are making it faster and more efficient to establish the association of agronomic traits with molecular markers or candidate genes, which is the requirement for marker-assisted selection in molecular breeding. Clubroot disease, caused by Plasmodiophora brassicae, is a serious threat to Brassica crops. Even we have breed new clubroot resistant varieties of Chinese cabbage (B. rapa ssp. pekinesis), the underlying genetic mechanism is unclear. In this study, an $F_2$ population of 340 plants were inoculated with P. brassicae from Xinye (Pathotype 2 on the differentials of Williams). Resistance phenotype segregation ratio for the populations fit a 3:1 (R:S) segregation model, consistent with a single dominant gene model. Super-BSA, using re-sequencing the parents, extremely R and S DNA pools with each 50 plants, revealed 3 potential candidate regions on the chromosome A03, with the most significant region falling between 24.30 Mb and 24.75 Mb. A linkage map with 31 markers in this region was constructed with several closely linked markers identified. A Major QTL for clubroot resistance, CRq, which was identified with the peak LOD score at 169.3, explaining 89.9% of the phenotypic variation. And we developed a new co-segregated InDel marker BrQ-2. Joint BSA-seq and traditional QTL analysis delimited CRq to an 250 kb genomic region, where four TIR-NBS-LRR genes (Bra019409, Bra019410, Bra019412 and Bra019413) clustered. The CR gene CRq and closely linked markers will be highly useful for breeding new resistant Chinese cabbage cultivars.

• 한국지하수토양환경학회지:지하수토양환경
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• 제16권4호
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• pp.38-52
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• 2011

Sorption and sequential desorption experiments were conducted for Zn using a natural soil (NS) in background status by aging (1, 30 and 100 days). The sorption isotherm showed that Zn had high sorption capacity but low sorption affinity in NS. Sequential desorption was biphasic with appreciable amount of sorbed Zn residing in the desorption-resistant fraction after several desorption steps. The biphasic desorption behavior of Zn was characterized by a biphasic desorption model that includes a linear term to represent labile or easily-desorbing fraction and a Langmuirian-type term to represent desorption-resistant fraction. The biphasic desorption model indicated that the size of the maximum capacity of desorption-resistant fraction ($q^{irr}_{max}$) increased with aging in NS. Desorption kinetics and desorption-resistance of Zn in the soils collected from mine tailings (MA, MB and MC collected from surface, subsurface soils and mine waste, respectively) were investigated and compared to the bioavailability to earthworm (Eisenia fetida). Desorption kinetic data of Zn were fitted to several desorption kinetic models. The ratio ($q_{e,d}/q_0$) of remaining Zn at desorption equilibrium ($q_{e,d}$) to initial sorbed concentration ($q_0$) was in the range of 0.53~0.90 in the mine tailings which was higher than that in NS, except MA. The sequential desorption from the mine tailings with 0.01M Na$NO_3$ and 0.01M $CaCl_2$ showed that appreciable amounts of Zn are resistant to desorption due to aging or sequestration. The SM&T (Standard Measurements and Testing Programme of European Union) analysis showed that the sum of oxidizable (Step III) and residual (Step IV) fractions of Zn was linearly related with its desorption-resistance ($q^{irr}_{max}$) determined by the sequential desorption with 0.01M Na$NO_3$ ($R^2$= 0.9998) and 0.01M $CaCl_2$ ($R^2$= 0.8580). The earthworm uptake of Zn and the desorbed amount of Zn ($q_{desorbed}$ = $q_0-q_{e,d}$) in MB soil were also linearly related ($R^2$ = 0.899). Our results implicate that the ecological risk assessment of heavy metals would be possible considering the relation between desorption behaviors and bioavailability to earthworm.

• 한국해양학회지
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• 제29권4호
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• pp.325-337
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• 1994

한반도 주변해역에서 의 해면 열속과 응력의 분포를 김과 강(1994)의 지표층 flux 모델을 사용하여 구하였고 이들의 계절변화를 조사하였다. 모델의 입력자료는 유럽중 기기상예보소 (ECMWF)의 1000mb 온도, 비습, 지오포텐샬고도와 미국기상청(NMC)의 해 수면온도 자료를 사용하였다. 자료의 공간해상도는 위도, 경도 2도이며 기간은 1984년 부터 87년까지의 3년이다. 한편, 해면의 단파복사량은 미국항공우주국 (NASA)의 인공 위성 자료를 사용하였고 잔파복사량은 경험식을 사용하여 구하였다. 모든 열속을 합한 순열속을 한반도 주변해역에서 보면, 1월과 10월에 각각 200∼400 Wm/SUP -2/와 100 Wm/SUP -2/로 해양이 냉각되고 4월과 7월에는 약 100 Wm/SUP -2/로 가열되고 있음을 알 수 있다. 한편, 연평균 순열속은 황해 북부를 제외한 전해역에서 음의 값이 나타나 고 있다. 가장 큰 냉각이 일어나는 해역은 쿠로시오 해역으로 이 지역의 연평균 값은 약 120 Wm/SUP -2/이다. 동해에서는 북부와 남부해역에서 60∼80 Wm/SUP -2/의 냉각이 일어나며 중부해역에서는 비교적 적은 30 Wm/SUP -2/ 정도의 냉각이 일어나고 있다. 한편, 1월의 응력 크기는 다른 달에 대하여 3∼5배 정도 크게 나타나고 이에 따라 연 평균응력의 분포는 1월의 형태와 유사하다. 연평균 응력컬은 동지나해와 남해에서 음 의 값이 나타나지만 황해 북부에서는 양의 값을 보인다. 동해의 응력컬은 북부와 남동 해역에서 양의 값이 그리고 북서해역에서는 음의 값이 나타나고 있다.

• Journal of Ginseng Research
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• 제47권1호
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• pp.106-116
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• 2023

Background: Pirarubicin (THP) is an anthracycline antibiotic used to treat various malignancies in humans. The clinical usefulness of THP is unfortunately limited by its dose-related cardiotoxicity. Ginsenoside F1 (GF1) is a metabolite formed when the ginsenosides Re and Rg1 are hydrolyzed. However, the protective effects and underlying mechanisms of GF1 on THP-induced cardiotoxicity remain unclear. Methods: We investigated the anti-apoptotic and anti-oxidative stress effects of GF1 on an in vitro model, using H9c2 cells stimulated by THP, plus trigonelline or AKT inhibitor imidazoquinoxaline (IMQ), as well as an in vivo model using THP-induced cardiotoxicity in rats. Using an enzyme-linked immunosorbent test, the levels of malondialdehyde (MDA), brain natriuretic peptide (BNP), creatine kinase (CK-MB), cardiac troponin (c-TnT), lactate dehydrogenase (LDH), superoxide dismutase (SOD) and glutathione (GSH) were determined. Nuclear factor (erythroid-derived2)-like 2 (Nrf2) and the expression of Nrf2 target genes, including heme oxygenase-1 (HO-1), glutathione-S-transferase (Gst), glutamate-cysteine ligase modifier subunit (GCLM), and expression levels of AKT/Bcl-2 signaling pathway proteins were detected using Western blot analysis. Results: THP-induced myocardial histopathological damage, electrocardiogram (ECG) abnormalities, and cardiac dysfunction were reduced in vivo by GF1. GF1 also decreased MDA, BNP, CK-MB, c-TnT, and LDH levels in the serum, while raising SOD and GSH levels. GF1 boosted Nrf2 nuclear translocation and Nrf2 target gene expression, including HO-1, Gst, and GCLM. Furthermore, GF1 regulated apoptosis by activating AKT/Bcl-2 signaling pathways. Employing Nrf2 inhibitor trigonelline and AKT inhibitor IMQ revealed that GF1 lacked antioxidant and anti-apoptotic effects. Conclusion: In conclusion, GF1 was found to alleviate THP-induced cardiotoxicity via modulating Nrf2 and AKT/Bcl-2 signaling pathways, ultimately alleviating myocardial oxidative stress and apoptosis.

• 정보처리학회논문지C
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• 제12C권3호
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• pp.449-456
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• 2005

광 버스트 스위칭(OBS) 기술은 광 회선 스위칭에서 발생하는 자원의 비효율적인 사용을 개선시키며, 광 패킷 스위칭에서 해결하여야 할 과제인 광 버퍼링의 요구사항을 최소화한다. GSMP는 제어기와 레이블 스위치 사이에서 연결, 구성, 성능, 장애관리 및 동기화 기능을 제공하는 개방형 인터페이스이다. OBS 망을 위한 GSMP 개방형 인터페이스 도입은 OBS 망의 전달평면과 제어평면의 분리를 실현하여 OBS 스위치의 구현을 단순화한다. 본 논문에서는 GSMP 개방형 인터페이스가 적용된 OBS 망의 연결, 구성, 성능 및 장애관리를 위한 관리객체를 정의하였으며, 이들 관리정보가 관리 기능별로 OBS 스위치와 제어기에 분산되어 탑재되는 분산 망 관리 모델을 제안하였다. GSMP와 OBS 관리객체를 수용한 망 관리 기능의 구현을 통하여 GSMP 개방형 인터페이스가 적용된 OBS 망에서의 분산 망 관리 모델을 이용한 연결관리의 실현성을 확인하였다.