• 자원환경지질
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• 제48권3호
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• pp.241-246
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• 2015

Helicobacter pylori는 사람의 위점막에서 발견되는 전염성이 있는 중요한 병원균이다. 장기간 기생하면서 만성위염, 소화성궤양, 위 변연부 B세포 림프종, 그리고 위암을 일으키는 세균으로 알려져 있다. 국내에서는 프로톤펌프 억제제(proton pump inhibitor, PPI)와 두 가지 항생제(amoxicillin, clarithromycin)를 포함하는 표준 삼제 요법을 1차 치료로 사용하여 왔으나, 점점 증가하고 있는 항생제 내성으로 인해 제균율은 점차 감소하고 있다. 여기서는 H. pylori의 현재의 치료법들과 이들 치료법들의 문제점들을 검토하고, 표적치료의 필요성과 표적치료에 활용할 수 있는 약물전달체로서의 점토광물의 가능성에 대해 알아보고, 이들을 이용한 새로운 치료 방향에 대한 향후 연구계획 등에 대해서 논하고자 한다.

• 대한두경부종양학회지
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• 제34권1호
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• pp.49-53
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• 2018

Primary non-Hodgkin's lymphoma (NHL) rarely involves the parotid gland and its incidence is only 1.7% to 3.1% of all salivary gland neoplasms. The mucosa associated lymphoid tissue (MALT) is the most common subtype of NHL, followed by follicular lymphoma (FL) and diffuse large B cell lymphoma (DLBCL). However, two distinct types of lymphomas occurring synchronously in the parotid gland and cervical lymph node have not been reported earlier. A 72-year-old man with rubbery-hard and fixed mass on the left parotid area came to our clinic. We performed the left total parotidectomy with ipsilateral excision of lymph node (level II), and he was finally diagnosed as DLBCL in parotid gland and FL in upper neck. It is presumed that the DLBCL appeared to be a transformation from FL. We report the unique and rare disease entity with brief literature review.

• Tuberculosis and Respiratory Diseases
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• 제52권2호
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• pp.179-185
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• 2002

원발성 쇼그렌 증후군 (Primary Sj$\ddot{o}$gren's syndrome) 환자에서 폐에 발생하는 Bronchus-associated lymphoid tissue(BALT) 림프종은 드문 질환이다. 본 환자는 49세 여자 환자로 5년 전부터 안구 건조증 및 구강 건조증이 점차 진행하였으나 그냥 지내던 중 2년 전부터 운동시 호흡곤란 및 전신 무력감이 계속 진행하여 본원에 입원하였다. 흉부청진상 호흡음이 거칠게 들렸으며 양측 폐야 전체에 걸쳐 흡기시 악 설음이 관찰되었다. 형광항핵항체시험 (FANA)이 양성으로 "speckled pattern"을 보였으며 anti-SSA(Ro) Ab 및 anti-SSB(La) Ab는 강양성 소견을 보였다. 단순 흉부 방사선 사진 상 양측 폐에서 미만성의 망상 결절성 음영 증가가 관찰되었으며 고해상도 흉부 컴퓨터 단층촬영상에서 양측 폐에 걸쳐 미만성 분포를 보이는 모자이크 양상의 비균질성 감쇠 (mosaic pattern of inhomogeneous attenuation) 소견이 관찰되었다. 경기관지 폐 조직 생검상 림프구의 침윤이 관찰되었고 개흉 폐 생검술을 이용하여 얻은 폐조직의 병리 소견에서 'low grade marginal zone B cell lymphoma of BALT(bronchus associated lymphoid tissue) type'에 합당한 소견을 얻어 원발성 쇼그렌 증후군 (Primary Sj$\ddot{o}$gren's syndrome) 환자에서 폐에 발생한 Bronchus-associated lymphaid tissue(BALT) 림프종으로 확진되었다.

• 대한세포병리학회지
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• 제10권2호
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• pp.157-162
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• 1999

Primary non-Hodgkin's lymphoma of the lung is rare among extranodal lymphomas. The most common form is low grade B-cell type originated from the mucosa-associated lymphoid tissue (MALT) of the lung and primary peripheral T cell lymphoma of the lung is extremely rare. We recently experienced a case of fine needle aspiration cytology of primary peripheral T cell lymphoma of the lung in a 39-year-old male patient. The cytologic smears revealed some sheets of reactive epithelial cells, epithelioid histiocytes, and numerous polymorphous population of lymphoid cells composed of small and intermediate sized lymphoid cells and mature lymphocytes. Lymphoid cells were slightly larger than normal mature lymphocytes and showed significant irregularity of nuclear membrane. The internal nuclear structure was marked by chromatin clumping, clear parachromatin areas, and inconspicuous nucleoli. Histopathologically, atypical small lymphocytes infiltrated in the interstitium and alveolar sac. By the immunohistochemical study and molecular biologic study of gene rearrangement, the T cell clonality of atypical lymphoid cells was confirmed.

• 대한두경부종양학회지
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• 제17권1호
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• pp.26-31
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• 2001

Background: Primary malignant lymphoma of the parotid gland is a rare disease and defined as any malignant lymphoma that first manifests in the parotid gland, regardless of the subsequent stage of the diseases, whether it arises in the parenchyma or intraglandular lymph nodes. This study was performed to review the clinicopathological characteristics of primary parotid lymphoma and identify its optimal treatment modality. Materials and Methods: Six cases with parotid mass as first presentation of malignant lymphoma between 1988 and 2000, were studied on the basis of clinical features, diagnostic tools, treatment modality, treatment outcomes, and clinical stage by Ann Arbor Criteria. All were microscopically reevaluated and classified by NCI working formulation. Results: All patients were males and mean age was 36.7 years (2-66 years). Rapid growing non-tender mass was presented in all the cases and cervical lymphnodes were palpated in 4 cases. However, there was not any evidence of concurrent autoimmune disease such as Sjogren's syndrom or Rheumatoid arthritis. One case was confirmed by surgical specimen after superficial parotidectomy, 2 by excisional biopsy, and 3 by incisional biopsy. The stage of disease by NCI working formulation was IE in 1 patient, IIE in 4 and IV in 1. All were classified into non-Hodgkin' lymphoma, of which there were 5 cases of B-cell type and 1 case of T-cell type. There were 3 diffuse large cell lymphomas, 1 Burkitt lymphoma, 1 MALT lymphoma and 1 T-lymphoblastic lymphoma. Three cases were treated by chemotherapy only, 2 by radiotherapy only and 1 by chemo-radiotherapy. One case with Burkitt lymphoma was died from the disease and one case was lost to follow-up. The others are alive with no evidence of recurrence. Conclusions: Although primary parotid lymphoma is rare and difficult to diagnose preoperatively, most were detected in early stage and showed a relatively good response to the chemotherapy or radiotherapy like other types of extranodal malignant lymphoma.