• Asian-Australasian Journal of Animal Sciences
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• v.28 no.7
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• pp.936-942
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• 2015

The purpose of this study was to characterize genetic architecture of behavior patterns in Sapsaree dogs. The breed population (n=8,256) has been constructed since 1990 over 12 generations and managed at the Sapsaree Breeding Research Institute, Gyeongsan, Korea. Seven behavioral traits were investigated for 882 individuals. The traits were classified as a quantitative or a categorical group, and heritabilities ($h^2$) and variance components were estimated under the Animal model using ASREML 2.0 software program. In general, the $h^2$ estimates of the traits ranged between 0.00 and 0.16. Strong genetic ($r_G$) and phenotypic ($r_P$) correlations were observed between nerve stability, affability and adaptability, i.e. 0.9 to 0.94 and 0.46 to 0.68, respectively. To detect significant single nucleotide polymorphism (SNP) for the behavioral traits, a total of 134 and 60 samples were genotyped using the Illumina 22K CanineSNP20 and 170K CanineHD bead chips, respectively. Two datasets comprising 60 (Sap60) and 183 (Sap183) samples were analyzed, respectively, of which the latter was based on the SNPs that were embedded on both the 22K and 170K chips. To perform genome-wide association analysis, each SNP was considered with the residuals of each phenotype that were adjusted for sex and year of birth as fixed effects. A least squares based single marker regression analysis was followed by a stepwise regression procedure for the significant SNPs (p<0.01), to determine a best set of SNPs for each trait. A total of 41 SNPs were detected with the Sap183 samples for the behavior traits. The significant SNPs need to be verified using other samples, so as to be utilized to improve behavior traits via marker-assisted selection in the Sapsaree population.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7221-7227
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• 2013

Background: Fascin, an actin-bundling protein forming actin bundles including filopodia and stress fibers, is overexpressed in multiple human epithelial cancers including esophageal squamous cell carcinoma (ESCC). Previously we conducted a microarray experiment to analyze fascin knockdown by RNAi in ESCC. Method: In this study, the differentially expressed genes from mRNA expression profilomg of fascin knockdown were analyzed by multiple bioinformatics methods for a comprehensive understanding of the role of fascin. Results: Gene Ontology enrichment found terms associated with cytoskeleton organization, including cell adhesion, actin filament binding and actin cytoskeleton, which might be related to fascin function. Except GO categories, the differentially expressed genes were annotated by 45 functional categories from the Functional Annotation Chart of DAVID. Subpathway analysis showed thirty-nine pathways were disturbed by the differentially expressed genes, providing more detailed information than traditional pathway enrichment analysis. Two subpathways derivated from regulation of the actin cytoskeleton were shown. Promoter analysis results indicated distinguishing sequence patterns and transcription factors in response to the co-expression of downregulated or upregulated differentially expressed genes. MNB1A, c-ETS, GATA2 and Prrx2 potentially regulate the transcription of the downregulated gene set, while Arnt-Ahr, ZNF42, Ubx and TCF11-MafG might co-regulate the upregulated genes. Conclusions: This multiple bioinformatic analysis helps provide a comprehensive understanding of the roles of fascin after its knockdown in ESCC.

• Journal of Korean Society for Atmospheric Environment
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• v.33 no.6
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• pp.593-604
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• 2017

The suspended particulate matter(PM) was measured in subway tunnel of Seoul Line 1 to 9 in order to evaluate the pollution degree and characteristics of the PM in the subway tunnel. Also, to analyze the effect of outdoor aerosol concentration on the PM concentration of subway tunnels, the ambient PM concentration around the subway station was extracted by spatial analysis using $PM_{10}$ data of Seoul air pollution monitoring network. Finally, in order to understand pollution pattern in the Seoul subway tunnels, cluster analysis was performed based on input data set such as PM levels in tunnel, tunnel depth, length, curvature radius, outdoor ambient air pollution levels and so on. The average concentration of $PM_{10}$, $PM_{2.5}$, and $PM_1$ on subway tunnels were $98.0{\pm}37.4$, $78.4{\pm}28.7$, and $56.9{\pm}19.2{\mu}g/m^3$, respectively. As a result of the cluster analysis, tunnels from Seoul subway Line-1 to Line-9 were classified into five classes, and the concentrations and physical properties of the tunnels were compared. This study can provide a method to reduce PM concentration in tunnel for each pollution pattern and provide basic information about air quality control in Seoul subway tunnel.

• Journal of Korea Multimedia Society
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• v.15 no.11
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• pp.1330-1340
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• 2012

In this paper, a new algorithm is proposed for the heart valves stenosis region detection using heart sounds. Many researches for detecting primary components or removing heart murmurs have been studied, but their performances are degraded at abnormal heart sounds such as aortic stenosis and mitral stenosis because of large heart murmurs. In this paper, heart murmur detection method is proposed based on noise intensity function. The proposed noise intensity function detect the primary components S1, S2, then set session up using S1, S2. And then noise intensity function was computed using autocorrelation value of each session. The proposed noise intensity function estimated noise intensity of each sessions and detected heart murmurs. According to simulation results, the proposed algorithm has better performance than former study for detecting heart valve stenosis region.

• Herbal Formula Science
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• v.20 no.2
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• pp.37-46
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• 2012

Objectives : Oyaksungi-san(Wuyaoshunqisan) has been used for treatment of stroke and rheumatoid arthritis in Korea. In this study, a simple and accurate high-performance liquid chromatography(HPLC) method was established for simultaneous determination of six main components, liquiritin, ferulic acid, naringin, hesperidin, neohesperidin, and glycyrrhizin in Oyaksungi-san, a traditional Korean herbal prescription. Methods : The analytical column for separation of six constituents was used a Gemini $C_{18}$ column maintained at $40^{\circ}C$. The mobile phase consisted of two solvent systems, 1.0% (v/v) acetic acid in $H_2O$ (A) and 1.0% (v/v) acetic acid in acetonitrile (B) by gradient flow. The flow rate was 1.0 mL/min and the detector was a photodiode array (PDA) set at 254 nm for glycyrrhizin, 280 nm for liquiritin, naringin, hesperidin, and neohesperidin, and 320 nm for ferulic acid. Results : Calibration curves were acquired with $r^2$ values ${\geq}0.9998$. The results of recovery test were 91.58%-105.90% with a relative standard deviations (RSDs, %) value less than 2.0%. The values of RSD for intra- and inter-day precision were 0.03%-1.72% and 0.03%-1.63%, respectively. The contents of the six compounds in Oyaksungi-san were 0.33-9.30 mg/g. Conclusions : The newly established HPLC method will be helpful to improve quality control of Oyaksungi-san.

• Asian Journal of Atmospheric Environment
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• v.11 no.1
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• pp.33-36
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• 2017

China is suffering from severe air pollution especially fine $PM_{2.5}$ pollution. In 2015, the annual average $PM_{2.5}$ concentration of the 338 municipal cities was $50{\mu}g/m^3$, 78% cities at or above the prefectural level failed to comply with the $PM_{2.5}$ concentration standards. The $13^{th}$ Five-Year Plan for National Economic and Social Development set the goal that the annual average concentration of $PM_{2.5}$ in the municipal cities which failed to attain the ambient air quality standards shall be decreased by 18% by 2020 (CCCPC, 2016). In this study, an air pollution control scenario during the $13^{th}$ Five-Year Plan period was proposed and the $SO_2$, $NO_x$ and PM emission reductions in response to different measures in 31 provincial-level regions mainland China by 2020 were estimated. The air quality in the target year (2020) was simulated using the WRF-CMAQ model. The results showed that by 2020, the emissions of $SO_2$, $NO_x$ and primary PM in mainland China will be reduced by 4.19 million tons, 3.94 million tons and 4.41 million tons, a drop of 23%, 21% and 25% respectively compared with that in 2015, and the annual average concentration of $PM_{2.5}$ will decrease by 19%. Coal-fired power plant contributes the most pollutant emission reduction.

• Journal of Biomedical Engineering Research
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• v.31 no.4
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• pp.321-327
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• 2010

Most of the ear shells of hearing aids are manufactured manually, and it is one of the reasons that the cost of the custom-made hearing aids can be increased. Thus it is required to manufacture the ready-made ear shell for the purpose of easy manufacturing and decrease in cost. In this study, we extract parameters in order to manufacture the ready-made ear shell for CIC type hearing aids and simulate to reconstruct the ear shell using the extracted parameters. To parameter extraction, we set up the eleven parameters for the ready-made ear shell based on anatomical characteristics of the ear canal, and we found values of the parameters from twenty-one impressions in their 20s and twelve impressions in their 60s using aperture detection and feature detection algorithms. Classifying the parameters by size, we also determine the parameters of ready-made ear shell into three types for people in their 20s and two types for people in their 60s. Each ready-made ear shell was simulated to reconstruct using figured parameters, and evaluated the rate of agreement with unused impressions for setting parameters. To evaluate the ready-made ear shell, we calculate the volume ratio and intersection between of the each impression and ready-made ear shell, and the intersection ratio using the intersection volume and ready-made ear shell volume. As a result, the volume ratio was about 70%, and volume match ratio was also up to 70%. It means that the ready-made ear shell we simulated is the significantly matched to impression.

• Transactions of Materials Processing
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• v.29 no.4
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• pp.203-210
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• 2020

In this study, formability and springback behavior of 1.5 GPa grade ultra-high strength steel (UHSS) sheet were predicted through the finite element simulation, and structural stability of the forming dies was verified by the coupled forming-structural analysis. Uniaxial tension and uniaxial tension-compression tests were performed to obtain experimental data for modeling the springback properties of the sheet material. The springback values predicted by simulation were compared with those from actual measurements. The results calculated from the kinematic hardening model were found to be much more accurate than those from the isotropic hardening model. Deformation of the forming die and springback of the product were calculated by the coupled forming-structural analysis. The higher the strength of the die material, the smaller the surface displacement of the die and the springback of the product. The internal stresses of the dies made of three materials, FC300, FCD550 and STD11 were compared with the yield stress of each material. The results provided a basis for determining the most suitable material for each part of the die set. As a result, simulation techniques have been established for predicting formability and springback in the UHSS sheet forming process.

• Journal of Radiation Protection and Research
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• v.14 no.1
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• pp.56-65
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• 1989

The nuclear criticality of the KSC-4 shipping cask which can load four assemblies of PWR spent fuel was analyzed using KENO-IV computer code and 19-group nuclear cross section set generated from 218-group neutron cross section library(DLC-43/CSRL) using AMPX system. In accordance with 10CFR71, the analysis was performed for fresh fuel assemblies, instead of the spent fuels, under both norml transportation and hypothetical accident conditions. The calculated maximum multiplication factors(Keff) of the KSC-4 cask were 0.85289 and 0.94185 for the normal transportation and hypothetical accident conditions, respectively. The highest Keff of the KSC-4 cask is within the subcritical limit prescribed in l0CFR71 and accordingly the KSC-4 cask is safely designed in terms of nulear criticality.

• Nuclear Engineering and Technology
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• v.46 no.6
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• pp.803-816
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• 2014

Defense-in-depth is a fundamental safety principle for the design and operation of nuclear power plants. Despite its general appeal, defense-in-depth is not without its drawbacks, which include its potential for concealing the occurrence of hazardous states in a system, and more generally rendering the latter more opaque for its operators and managers, thus resulting in safety blind spots. This in turn translates into a shrinking of the time window available for operators to identify an unfolding hazardous condition or situation and intervene to abate it. To prevent this drawback from materializing, we propose in this work a novel safety principle termed "observability-in-depth". We characterize it as the set of provisions technical, operational, and organizational designed to enable the monitoring and identification of emerging hazardous conditions and accident pathogens in real-time and over different time-scales. Observability-in-depth also requires the monitoring of conditions of all safety barriers that implement defense-in-depth; and in so doing it supports sensemaking of identified hazardous conditions, and the understanding of potential accident sequences that might follow (how they can propagate). Observability-in-depth is thus an information-centric principle, and its importance in accident prevention is in the value of the information it provides and actions or safety interventions it spurs. We examine several "event reports" from the U.S. Nuclear Regulatory Commission database, which illustrate specific instances of violation of the observability-in-depth safety principle and the consequences that followed (e.g., unmonitored releases and loss of containments). We also revisit the Three Mile Island accident in light of the proposed principle, and identify causes and consequences of the lack of observability-in-depth related to this accident sequence. We illustrate both the benefits of adopting the observability-in-depth safety principle and the adverse consequences when this principle is violated or not implemented. This work constitutes a first step in the development of the observability-in-depth safety principle, and we hope this effort invites other researchers and safety professionals to further explore and develop this principle and its implementation.