• 생명과학회지
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• 제34권2호
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• pp.128-137
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• 2024

이 리뷰 논문에서는 혈관 투과성, 내피세포 모집, 종양관련 혈관 및 림프관의 유지 등에서 핵심적인 과정인 angiogenesis와 lymphangiogenesis에 있어서 vascular endothelial growth factors (VEGF)가 이행하는 중요한 역할에 대해 재조명하고자 한다. VEGF는 tyrosine-kinase receptor인 VEGFR-1, VEGFR-2, VEGFR-3를 통해 그 역할을 이행하며, 이러한 VEGF-VEGFR 시스템은 암에서뿐만 아니라 비정상적인 혈관 및 림프관 형성으로 인해 야기되는 다른 질병들에 있어서도 핵심적인 요소로 각광받고 있다. 암의 측면에서 보았을 때, VEGF와 그 수용체는 종양관련 혈관 및 림프관을 형성하는 과정에서 필수적이라는 점에서 치료적인 타겟으로 이목을 끌고 있다. 때문에 암세포의 성장을 방해하기 위한 항VEGF 항체, 수용체 길항체, 수용체 기능 억제제 등과 같은 여러 가지 시도들이 있었지만, 아직까지 그 임상효과가 불확실하며 더 많은 연구들이 필요한 실정이다. 이 논문에서는 VEGF의 생리적 역할을 VEGF-A, VEGF-B, VEGF-C, VEGF-D, PLGF에 따라 나누어 설명하면서 VEGF/VEGFR 시스템의 중요성을 강조한다. VEGFR-1과 VEGFR-3은 각각 angiogenesis와 lymphangiogenesis에 핵심적인 인자이며, VEGFR-2의 경우 두 가지 모두를 일으킨다. 전반적으로 이 리뷰는 현재까지 밝혀진 암을 포함한 다양한 질병에서의 VEGF와 VEGFR의 역할에 대해 상세히 설명하고자 하였다. 이를 통해 치료 표적으로서 VEGF와 VEGFR의 활용이 더욱 촉진될 것으로 기대된다.

• Tuberculosis and Respiratory Diseases
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• 제75권3호
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• pp.116-119
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• 2013

Sarcoidosis, a systemic granulomatous disease of unknown etiology. The presentation of sarcoidal granuloma in neck nodes without typical manifestations of systemic sarcoidosis is difficult to diagnose. We describe the case of a 37-year-old woman with an increasing mass on the right side of neck. The excisional biopsy from the neck mass showed noncaseating epithelioid cell granuloma of the lymph nodes. No evidence of mycobacterial or fungal infection was noted. Thoracic evaluations did not show enlargement of mediastinal lymph nodes or parenchymal abnormalities. Immunohistochemistry showed abundant expression of tumor necrosis factor-${\alpha}$ in the granuloma. However, transforming growth factor-${\beta}$ was not expressed, although interleukin-$1{\beta}$ was focally expressed. These immunohistochemical findings supported characterization of the granuloma and the diagnosis of sarcoidosis. Sarcoidosis can present with cervical lymph node enlargement without mediastinal or lung abnormality. Immunohistochemistry may support the diagnosis of sarcoidosis and characterization of granuloma.

• Parasites, Hosts and Diseases
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• 제41권1호
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• pp.69-73
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• 2003

Lymphatic filariasis due to Brugia malayi infection was endemic in several areas of South Korea. The infection was controlled, or disappeared, in most areas, with the exception of the remote southwestern islands of Jeonranam-do, including the Heugsan Islands. To discover its current situation, a small-scale survey was performed on the Heugsan islands in September 2000. A total of 378 people, 151 male and 227 female, living in 8 villages (6 on Daeheugsan-do, 1 on Daejang-do, and 1 on Yeongsan-do) were subjected to a night blood survey for microfilaremia, and physical examination for elephantiasis on the extremities. There were 6 (1.6%) microfilaria positive cases, all in females aged 57-72 years, and from only two villages of the Daeheugsan-do area. There were 4 patients with lower leg elephantiasis, but they showed no microfilaremia. The results show that a low-grade endemicity of filariasis remains on the Daeheugsan-do.

• Tuberculosis and Respiratory Diseases
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• 제53권3호
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• pp.319-324
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• 2002

저자들은 장기간의 흡연력이 있는 60세 남성흡연자에서, 방사선소견상 다발성의 공동을 지니는 병변을 보여 흉부 전산화 단층촬영과 기관지 내시경을 통해 큰 공동을 형성한 원발성 폐암의 다발성 공동 형성 전이로 확진한 1예를 경험하였기에 문헌고찰과 함께 보고하였다.

• 한국식품영양과학회지
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• 제45권6호
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• pp.783-788
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• 2016

본 연구는 수수의 섭취가 대표적인 트랜스지방산인 elaidic acid, linoelaidic acid와 cholesterol의 소장흡수에 어떤 영향을 미치는지를 조사하기 위하여 설계하였다. 소장의 지방흡수를 in vivo 상태에서 측정하기 위해 소장흡수율 측정모델을 이용하여 십이지장주입관과 림프채취관을 삽입하는 미세수술을 진행하였다. 실험동물의 십이지장으로 $146.4{\mu}mol$ trielaidin, $36.8{\mu}mol$ trilinoelaidin, $452.0{\mu}mol$ triolein, $1.0{\mu}Ci$ $^{14}C-cholesterol$, $20.7{\mu}mol$ cholesterol, $396.0{\mu}mol$ Na-taurocholate, PBS buffer(pH 6.4)가 포함된 지질유화액만 공급받는 동물군을 대조군, 수수추출물이 혼합된 지질유화액을 공급받는 동물군을 수수군으로 설계하였다. 지질유화액은 시간당 3 mL씩 8시간 동안 주입하면서 림프관으로 흡수되는 elaidic acid, linoelaidic acid와 각종 지방산 그리고 $^{14}C-cholesterol$의 양을 분석하여 수수에 의한 영향을 비교하였다. 먼저 8시간 동안 분비된 림프액의 양은 대조군과 수수군 간에 유의적인 차이를 나타내지 않았다. 하지만 8시간 동안의 elaidic acid 흡수는 수수추출물의 공급으로 유의적으로 억제되는 것으로 나타났다. Linoelaidic acid 또한 마찬가지로 수수추출물 공급으로 유의적으로 그 흡수가 억제된 것으로 나타났다. 트랜스지방산을 비롯해 palmitic acid, stearic acid, oleic acid, linoleic acid, arachidonic acid, docosahexaenoic acid, $^{14}C-cholesterol$ 또한 대조군보다 수수군에서 흡수가 유의적으로 억제된 것으로 나타났다. 이상의 결과들은 수수추출물이 트랜스지방산과 cholesterol의 소장 흡수를 억제할 수 있다는 사실을 증명한다. 이번 연구를 바탕으로 수수 섭취가 트랜스지방이나 cholesterol의 흡수를 농도 비례적으로 억제할 수 있을지, 소화흡수 과정 중 정확히 어떤 과정에 영향을 미쳤는지에 관한 연구가 앞으로 진행될 과제라고 판단된다.

• 척추신경추나의학회지
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• 제9권2호
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• pp.1-9
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• 2014

Objectives : Many studies are being done in the method of experimental chuna science in China. The aim of this review is to understand and study the methods of experimental chuna science, focusing on the effects of chuna on circulatory system. Methods : We reviewed "實驗推拿學" and Chinese journals were searched using China National Knowledge Infrastructure(CNKI). Korean journals were searched using 3 Korean web databases(OASIS, NDSL, RISS). Results : By experimental chuna science, effect of chuna on blood pressure, cardiovascular system, hemorheologic system, blood flow velocity, circulation and lymphatic system were proved. Conclusions : Experimental chuna science is necessary for improvement of chuna to a higher level. In Korea, not many experimental studies are being done, especially in chuna and it has very narrow target diseases. For this reason we need to learn and adapt the methods of experimental chuna science of China.

• Tuberculosis and Respiratory Diseases
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• 제69권1호
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• pp.52-55
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• 2010

Pulmonary tuberculosis has intermediate prevalence in Korea. It is known that tuberculosis infection predominantly involves the upper lobes, based on the fact that multiplication of Mycobacterium tuberculosis is favored in areas with decreased pulmonary blood flow, impaired lymphatic drainage, and high oxygen tension. We report this case of a 40-year-old man who was brought to our hospital with hemoptysis and dyspnea. Prior to admission, the patient had been in a bedridden state for 15 years due to an injury of the cervical spine 4~5. A 3-Dimensional computed tomography showed predominantly longitudinal distribution of centrilobular nodules along the anterior chest wall, in the left lung. MTB-PCR and AFB culture of bronchial washing fluid revealed pulmonary tuberculosis. This case shows that long-standing supine posture and decreased motion of the anterior chest wall may change the distribution of preferential infection site of Mycobacterium tuberculosis in the lung, resulting in a ventral predominance of tuberculosis infection in the quadriplegic patient.

• Tuberculosis and Respiratory Diseases
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• 제52권6호
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• pp.640-644
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• 2002

저자들은 성인에서는 드문 것으로 알려진 종격동 내에서 발생한 해면상 임파관종 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제47권5호
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• pp.697-703
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• 1999

Mycobacterium celatum is a recently described nontuberculous mycobacterium. Even though pulmonary or lymphatic infection cases were reported previously in human, the clinical significance of the infection with M. celatum is not yet understood completely. Mast infections with this species occurred in the patients with suppressed cell-mediated immunity such as AIDS, and there are only a few cases of pulmonary infection with M. celatum in immunocompetent adults or infants in the world. In Korea, mycobacterial pulmonary infection is a major problem of respiratory disease but, there has been no pulmonary infection with M. celatum reported. We report, to our knowledge, the first Korean case of pulmonary infection with M. celatum, which was identified by rpoB genomic sequencing.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.1925-1929
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• 2014

Background: Vascular endothelial growth factor-C (VEGF-C), which contributes to lymphatic metastasis (LM) in malignant disease, is one of the most important factors involved in physical and pathological lymphangiogenesis. Some VEGF-C related factors such as sine oculis homeobox homolog (SIX) 1, contactin (CNTN) 1 and dual specificity phosphatase (DUSP) 6 have been extensively studied in malignancies, but their expression levels and associations have still to be elucidated in stomach cancer. Methods: We detected their expression levels in 30 paired stomach cancer tissues using quantitative real-time reverse transcription-PCR (qRT-PCR). The expression and clinical significance of each factor was analyzed using Wilcoxon signed rank sum test. The correlation among all the factors was performed by Spearman rank correlation analysis. Results: The results suggest that VEGF-C and CNTN1 are significantly correlated with tumor size, SIX1 with the age and CNTN1 also with the cTNM stage. There are significant correlations of expression levels among VEGF-C, SIX1, CNTN1 and DUSP6. Conclusions: There exists an important regulatory crosstalk involving SIX1, VEGF-C, CNTN1 and DUSP6 in stomach cancer.