• Journal of Chest Surgery
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• 제30권4호
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• pp.445-448
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• 1997

폐암의 진단에 유용한 방법인 경피적 폐생검술에 미세바늘이 도입된 1970년대 이후 경피적 폐생검술 에 의한 폐암의 흉벽 전이는 아주 희귀하게 보고되고 있으며, 치명적 인 합병증으로 인식되고 있다. 저자들은 65세 남자로 폐암(편평상피세포암, T2N0M0)진단으로 우상엽과 우중엽의 양폐엽 절제술을 시행한 환자에서, 수술전 시행한 경피적 폐생검술 60일(폐절제술 48일)만에 흉벽에 촉지된 직경 1mm 의 돌기를 발견하였라.이 돌기는 20일 만에 직경 1.5cm의 화농성 종괴로급속히 성장하여 폐암의 흉벽 전이로 진단하고 ni생검술 80일째 종괴를 포함한 광범위 절제술과 피부 이식술을 시행하였다. 병리 조직 검사상 피부와 피하 지방 조직의 흉벽에 전이된 암으로 훤발성 폐암과 같은 편평상피세포암으로 확 인하였다.

• Tuberculosis and Respiratory Diseases
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• 제67권3호
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• pp.244-248
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• 2009

Primary myelofibrosis is characterized by replacement of bone marrow with fibrotic tissue and the development of extramedullary hematopoiesis. Extramedullary hematopoiesis primarily involves the spleen and liver, but can also occur in the lungs. We report the case of an 80-year-old male who was admitted for evaluation of a lung mass and persistent thrombocytopenia. A percutaneous needle aspiration from the mass in the right lower lung showed myelopoietic cells with fatty tissue. A bone marrow biopsy revealed a hypercellular marrow with an increased number of atypical megakaryocytes. The final diagnosis was a prefibrotic stage of primary myelofibrosis leading to extramedullary hematopoiesis in the lung.

• Korean Journal of Radiology
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• 제22권3호
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• pp.464-475
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• 2021

Objective: This study aimed to evaluate the tumor doubling time of invasive lung adenocarcinoma according to the International Association of the Study for Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) histologic classification. Materials and Methods: Among the 2905 patients with surgically resected lung adenocarcinoma, we retrospectively included 172 patients (mean age, 65.6 ± 9.0 years) who had paired thin-section non-contrast chest computed tomography (CT) scans at least 84 days apart with the same CT parameters, along with 10 patients with squamous cell carcinoma (mean age, 70.9 ± 7.4 years) for comparison. Three-dimensional semiautomatic segmentation of nodules was performed to calculate the volume doubling time (VDT), mass doubling time (MDT), and specific growth rate (SGR) of volume and mass. Multivariate linear regression, one-way analysis of variance, and receiver operating characteristic curve analyses were performed. Results: The median VDT and MDT of lung cancers were as follows: acinar, 603.2 and 639.5 days; lepidic, 1140.6 and 970.1 days; solid/micropapillary, 232.7 and 221.8 days; papillary, 599.0 and 624.3 days; invasive mucinous, 440.7 and 438.2 days; and squamous cell carcinoma, 149.1 and 146.1 days, respectively. The adjusted SGR of volume and mass of the solid-/micropapillary-predominant subtypes were significantly shorter than those of the acinar-, lepidic-, and papillary-predominant subtypes. The histologic subtype was independently associated with tumor doubling time. A VDT of 465.2 days and an MDT of 437.5 days yielded areas under the curve of 0.791 and 0.795, respectively, for distinguishing solid-/micropapillary-predominant subtypes from other subtypes of lung adenocarcinoma. Conclusion: The tumor doubling time of invasive lung adenocarcinoma differed according to the IASCL/ATS/ERS histologic classification.

• Tuberculosis and Respiratory Diseases
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• 제45권3호
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• pp.604-608
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• 1998

Von Recklinghausen병에 동반되는 악성종양은 주로 신경섬유육종이지만 드물게는 폐암이 동반되는 경우가 보고되고 있고 ras 유전자가 양 질환의 발생에 영향이 있음이 알려져 있어 앞으로 이에 관한 연구가 필요하리라 생각된다.

• Tuberculosis and Respiratory Diseases
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• 제71권2호
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• pp.139-143
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• 2011

Small bowel metastasis of pleomorphic carcinoma of the lung is very rare. A 58-year-old man was admitted to our hospital with abdominal palpable mass in the right upper quadrant area. He underwent right middle and lower lobectomy for early stage pleomorphic carcinoma of the lung approximately 3 months ago. USG-guided biopsy was performed for abdominal mass. Pathologic examination revealed a metastatic pleomorphic carcinoma from the lung. He received chemotherapy followed by radiation therapy but died due to septic shock caused by intestinal stenosis and adhesion. We report the first case of small bowel metastasis by pleomorphic carcinoma of the lung after curative surgery.

• Genomics & Informatics
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• 제17권1호
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• pp.8.1-8.10
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• 2019

Alveolar type II cells constitute a small fraction of the total lung cell mass. However, they play an important role in many cellular processes including trans-differentiation into type I cells as well as repair of lung injury in response to toxic chemicals and respiratory pathogens. Transcription factors are the regulatory proteins dynamically modulating DNA structure and gene expression. Transcription factor profiling in microarray datasets revealed that several members of AP1, ATF, $NF-{\kappa}B$, and C/EBP families involved in diverse responses were expressed in mouse lung type II cells. A transcriptional factor signature consisting of Cebpa, Srebf1, Stat3, Klf5, and Elf3 was identified in lung type II cells, Sox9+ pluripotent lung stem cells as well as in mouse lung development. Identification of the transcription factor profile in mouse lung type II cells will serve as a useful resource and facilitate the integrated analysis of signal transduction pathways and specific gene targets in a variety of physiological conditions.

• Journal of Chest Surgery
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• 제40권11호
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• pp.786-788
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• 2007

원발성 폐 악성 섬유성 조직구종은 매우 드문 종양이다. 12세 남아가 우연히 발견된 폐 종괴를 주소로 입원하였다. 흉부 X-선, 흉부 전산화 단층촬영, 양전자 방출 단층촬영에서 우하엽에 위치하는 $2.5{\times}2.5 cm$크기의 종괴가 관찰되었다. 우측 측방 개흉술을 통해 종괴를 절제하여 냉동 절편 조직검사를 시행한 결과 악성 방추형세포 종양으로 진단되었다. 따라서 우하엽 절제술 및 종격동 림프절 청소술을 시행하였고, 최종 조직학적 진단은 악성 섬유성 조직구종이었다. 환자는 수술 후 7일째에 퇴원하였으며, 보조적 항암 약물치료는 시행하지 않았다.

• Tuberculosis and Respiratory Diseases
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• 제63권1호
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• pp.88-93
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• 2007

저자 등은 단일 폐종괴로 발견되어 결핵이나 종양과의 감별이 쉽지 않아 개흉 조직검사를 통해 Wegener 육아종증을 진단 후 면역 억제 치료를 하였으나 폐렴 및 호흡부전이 발생한 증례를 경험하였기에 보고하는 바이다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2443-2446
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• 2013

Published data have shown that the levels of vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (sVEGFR-1) in plasma and pleural effusion might be usefulness for lung cancer diagnosis. Here, we performed a prospective study to investigate the utility of VEGF and sVEGFR-1 in bronchoalveolar lavage fluid (BALF) for differential diagnosis of primary lung cancer. A total of 56 patients with solitary pulmonary massed by chest radiograph or CT screening were enrolled in this study. BALF and plasma samples were obtained from all patients and analyzed for VEGF and sVEGFR-1 using a commercially available sandwich ELISA kit. The results showed that the levels of VEGF in BALF were significantly higher in patients with a malignant pulmonary mass compared with patients with a benign mass (P < 0.001). However, no significant difference of sVEGFR-1 in BALF was found between malignant and non-malignant groups (P = 0.43). With a cut-off value of 214 pg/ml, VEGF showed a sensitivity and specificity of 81.8% and 84.2%, respectively, in predicting the malignant nature of a solitary pulmonary mass. Our study suggests that VEGF is significantly increased in BALF among patients with lung cancer than in benign diseases. Measurement of VEGF in BALF might be helpful for differential diagnosis of primary lung cancer.

• Tuberculosis and Respiratory Diseases
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• 제57권2호
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• pp.197-200
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• 2004

흉부방선균증은 임상양상 및 방사선학적 소견이 폐의 기타 염증성 질환이나 악성암과 유사한 경우가 많아 감별진단에서 놓치기 쉬우나, 대부분 항생제 치료에 좋은 반응을 보이므로 조기진단을 위한 적극적 접근으로 심각한 합병증의 발생 및 불필요한 수술을 막아야 한다. 저자들은 폐암을 의심하여 시행한 검사도중 폐를 침범하는 방선균증을 경험하였기에 문헌고찰과 함께 보고하는 바이다.