• Journal of Chest Surgery
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• 제5권1호
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• pp.1-8
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• 1972

On the study of surface activity in excized lung extracts of various pulmonary diseases, following facts were concluded. 1]The minimum surface tension measured in lung extracts of tuberculous tissue surrounding cavitary lesion was 26.3dyne/cm and its stability index was 0.53. 2]Macroscopically almost normal lung tissue at a distance of tuberculous lesion in same lobe revealed 21.3 dyne/cm of minimum surface tension in extracts and its stability index showed 0.66. This low surface activity may be due to the chronic pneumonitis microscopically. 3] In the atelectatic lung which had been collapsed by chronic empyema the extracts revealed much higher minimum surface tension in 27.3 dyne/cm and its stabillry index revealed the least value of 0.47 without correlation of duration of disease. This suggests that the longstanding collapsed lung may be soon collapsed even after mechanical full expansion because of lack of surfactant.

• Tuberculosis and Respiratory Diseases
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• 제43권5호
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• pp.720-727
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• 1996

연구배경: 최근에 $^{201}TI$, $^{99m}Tc$ - MIBI, $^{99m}Tc$(V) - DMSA 등의 새로운 핵종들을 이용한 단일광자 전산화단층촬영 (SPECT)이 폐종괴성 질환에서 폐암과 양성질환의 감별에 유용하다는 보고가 되고 있다. 저자들은 폐종괴 소견을 보이는 같은 환자에서 세가지 방사성핵종을 이용한 SPECT를 모두 시행하여, 폐암에 대한 이들 핵종들의 예민도 및 특이도 비교와 함께 임상적 유용성을 알아보았다. 방법: 흉부사진상 종괴소견으로 내원하여 폐암으로 확진된 27예와 활동성 폐결핵 6예를 포함한 양성질환 10예로 총 37예를 대상으로 하였으며, 이들 환자에서 치료전에 세가지 핵종에 대한 SPECT를 임의순으로 1주일내에 모두 시행하였다. 주위정상폐조직에 비해 병소부위의 섭취가 뚜렷할때 양성으로 판정하고 이 경우에 병소부의 평균 방사능 섭취비(병소의 방사능/반대측 정상폐의 방사능)를 측정하였다. $^{201}TI$을 이용한 SPECT에서는 방사성핵종 주입후 10분의 초기섭취비와 3시간때의 자연섭취비를 각각 계산하였고, 또한 이들로부터 $^{201}TI$의 정체지수를 구하였다. 결과: 세가지 핵종 $^{201}TI$, $^{99m}Tc$ - MIBI 및 $^{99m}Tc$(V) - DMSA의 폐암에 대한 예민도는 각각 100%, 96%, 73%였고, 특이도는 40%, 70%, 70%로서 $^{201}TI$를 이용한 SPECT에서 예민도가 가장 높았으나 특이도는 가장 낮았다. 양성질환의 활동성 폐결핵 등에서 세가지 핵종에 섭취증가를 보이는 예도 있었으며, 섭취증가된 폐암과 활동성 폐결핵간의 섭취비 및 정체지수 비교에서 유의한 차이가 없었다. 그리고 폐암의 세포조직형에 따른 모든 섭취비와 정체지수 비교에서도 뚜렷한 차이가 없었다. 결론: $^{201}TI$, $^{99m}Tc$ - MIBI, $^{99m}Tc$ - DMSA SPECT중 $^{201}TI$과 $^{99m}Tc$ - MIBI 을 이용한 경우가 폐암진단에 높은 예민도를 나타냈으나, 이들을 활동성 폐결핵의 유병율이 높은 지역에서 양성질환과의 감별진단에 사용하기에는 제한적인 것으로 생각된다.

• Journal of Chest Surgery
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• 제47권5호
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• pp.458-464
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• 2014

Background: The effort to detect lung cancer in ever-earlier stages leads to the identification of an increasing number of patients without preoperative histological diagnosis. The aim of this study is to determine the prevalence and characteristics of benign lesions excised in the context of lung cancer surgery. Methods: We retrospectively analyzed data from 125 surgical procedures. We compared the preoperative clinical or cyto-histological diagnosis with the surgical-pathologic diagnosis in order to identify the percentage of benign lesions excised. Furthermore, other parameters were analyzed, such as age, sex, tumor size, the presence of calcification, and the type of surgery according to subgroup. Results: Of the 125 patients included in the study, 63 (50.4%) had a preoperative histological diagnosis of malignancy, corresponding to 56 cases (44.8%) of primary lung cancer and 7 cases (5.6%) of metastases. The 62 (49.6%) remaining cases without preoperative histological diagnosis were divided among 50 (40%) solitary pulmonary nodules and 12 (9.6%) pulmonary masses. According to the postoperative pathologic examination, we identified 12 (9.6%) benign lesions excised during lung cancer surgery. There were no statistically significant differences by subgroups with respect to age or sex. We found statistically significant evidence regarding the size and wedge resection as the surgical technique of choice for this type of benign lesion. Conclusion: Our study obtained results similar to those published by other groups regarding the resection of benign lesions in lung cancer surgery. This percentage could be a quality management index of indeterminate lung lesions.

• 한국동물위생학회지
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• 제26권2호
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• pp.121-128
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• 2003

This study was carried out to identify and investigate antimicrobial susceptibility for Mannheimuia haemolytical which is responsible for shipping fever. Samples were collected from nasal and lung of 100 adult healthy cattle which are slaughtered in Samsung meat corporation located in Incheon metropolitan city. lung lesion index have been investigated within 0-5 range according to Shewen and Willkie(Can J Vet Res 52:30-36, 1988). Eighty-seven of 100 cattle were under normal condition with 0-1 ranges. A total of 129 strains were collected from blood and tryptic soy agar. Among these strains, 100 strains were identified with Staphylococcus, Streptococcus and enterobacteria containing E coli. Biochemical and fermentation assay of arabinose, trehalose, xylose, mannose, mannitol, lactose and salicin were tested to identify with Mannheimia sp. for 7 strains shown haemolytic activity on blood agar. Five strains were identified with Mannheimia haemolytica and 2 strains were untyped. In seasonal survey, Mannheimia sp recovered from fall to winter(5 of 7) have been highly isolated rather than those from spring to summer(2 of 7). Mannheimiz haemolytica were susceptible to antibacterials tested in this study but more resistant to oxytetracycline and streptomycin.

• 한국방사선학회논문지
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• 제9권5호
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• pp.287-293
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• 2015

식도암은 병변의 길이가 길고 깊이의 불균질성으로 인하여 방사선의 균일한 선량분포를 얻기 어렵다. 이러한 문제점을 개선해 보고자 Half beam 법을 이용하여 선량분포의 균질성을 극복해 보고자 환자의 영상을 바탕으로 하여 Normal beam과 Half beam을 이용하여 각각 치료계획을 세워 표적체적포함율과 선량체적곡선, 일치성지수와 균질성지수를 상호 비교하고, 인접정상장기인 심장, 척수, 폐를 비교해 보고자 한다. 실험결과 Half beam을 이용한 치료계획이 표적체적포함율과 선량체적곡선 그리고 일치성지수와 균질성지수가 우수하였으며 정상조직 보호측면에서도 미미하지만 우수한 것으로 나타났다. 하지만 정확한 환자자세가 확보되지 않으면 부작용이 발생할 수 있다. 따라서, 기하학적으로 정확한 환자의 위치잡이를 수반한 Half beam의 적용은 선량적으로 유용할 수 있을 것으로 사료된다.

• Korean Journal of Radiology
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• 제23권1호
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• pp.112-123
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• 2022

Objective: To investigate the relationship between ¹⁸F-FDG PET/CT semi-quantitative parameters and the International Association for the Study of Lung Cancer, American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) histopathologic classification, including histological subtypes, proliferation activity, and somatic mutations. Materials and Methods: This retrospective study included 419 patients (150 males, 269 females; median age, 59.0 years; age range, 23.0-84.0 years) who had undergone surgical removal of stage IA-IIIA lung adenocarcinoma and had preoperative PET/CT data of lung tumors. The maximum standardized uptake values (SUVmax), background-subtracted volume (BSV), and background-subtracted lesion activity (BSL) derived from PET/CT were measured. The IASLC/ATS/ERS subtypes, Ki67 score, and epidermal growth factor/anaplastic lymphoma kinase (EGFR/ALK) mutation status were evaluated. The PET/CT semi-quantitative parameters were compared between the tumor subtypes using the Mann-Whitney U test or the Kruskal-Wallis test. The optimum cutoff values of the PET/CT semi-quantitative parameters for distinguishing the IASLC/ATS/ERS subtypes were calculated using receiver operating characteristic curve analysis. The correlation between the PET/CT semi-quantitative parameters and pathological parameters was analyzed using Spearman's correlation. Statistical significance was set at p < 0.05. Results: SUVmax, BSV, and BSL values were significantly higher in invasive adenocarcinoma (IA) than in minimally IA (MIA), and the values were higher in MIA than in adenocarcinoma in situ (AIS) (all p < 0.05). Remarkably, an SUVmax of 0.90 and a BSL of 3.62 were shown to be the optimal cutoff values for differentiating MIA from AIS, manifesting as pure ground-glass nodules with 100% sensitivity and specificity. Metabolic-volumetric parameters (BSV and BSL) were better potential independent factors than metabolic parameters (SUVmax) in differentiating growth patterns. SUVmax and BSL, rather than BSV, were strongly or moderately correlated with Ki67 in most subtypes, except for the micropapillary and solid predominant groups. PET/CT parameters were not correlated with EGFR/ALK mutation status. Conclusion: As noninvasive surrogates, preoperative PET/CT semi-quantitative parameters could imply IASLC/ATS/ERS subtypes and Ki67 index and thus may contribute to improved management of precise surgery and postoperative adjuvant therapy.

• 핵의학기술
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• 제14권1호
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• pp.147-148
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• 2010

Introduction: A metastatic calcification is known for taking in bone scintigram medicine at metastatic calcification lesion due to abnormal distribution of the calcium and phosphorus. The one paper reports that a metastatic calcification occurs mainly at lung, stomach, kidney and myocardium. Index: The patient is seventy four years old man who is afflicted with clonic kidney disease, hypercalcemia, hypertension. Because of an ability of the multiple myeloma, we take a bone scan after intravenous injection $^{99m}Tc$-DPD 25 mCi in three hours. We found out homogeneous $^{99m}Tc$-DPD uptake at both lung and myocardium. Conclusions: Nothing unusual was found in other bone scan. We obtains a purity beyond 95 percent at $^{99m}Tc$-DPD vial. In spite of no evidence about a myocardial infarction, the patient has a $^{99m}Tc$-DPD uptake at both lung and myocardium.

• 대한핵의학회지
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• 제32권2호
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• pp.143-150
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• 1998

목적: T1-201 SPECT는 악성과 양성폐질환을 감별하는데 비교적 높은 예민도를 가지는 정확한 검사법으로 보고되고 있으나, 이 검사법의 특이도 및 예측도는 대상환자군의 양성질환의 종류와 빈도에 의해 많은 영향을 받는 것으로 알려져 있다. 한국에서는 결핵에 의한 양성 폐결절이 많아 T1-201 SPECT의 악양성 감별능이 외국에서 보고되는 결과와는 많은 차이가 있을 것으로 생각되고 있다. 본 연구는 폐결절 환자를 대상으로 하여 T1-201 SPECT의 악양성감별능을 알아보고자 하였다. 대상 및 방법: 경북대학교 병원 호흡기 내과, 종양내과에서 컴퓨터 단층촬영상 단일폐결절을 가진 환자 133명을 대상으로 하였다. 이들 중 89명은 악성폐종양으로 조직학적으로 진단되었고, 44명은 양성폐결절로 확인되었다. 영상촬영은T1-201 111 MBq를 투여한 후 15분과 3시간에 영상을 촬영하였고, 판독은 2명의 핵의학과 전문의가 육안적으로 이상집적이 보인 경우를 양성으로 판독하였다, 양성으로 판독된 병변의 단위 voxel당 계수를 반대측 정상폐의 계수와 비교하여 T1-201 섭취비를 구하고, 초기영상과 지연영상의 섭취비를 이용하여 T1-201 정체율를 구하였다. 결과, 1) T1-201을 투여후 15분에 실시한 초기 T1-201 SPECT의 악성 폐질환의 진단의 예민도는 92%이고 3시간에 실시한 지연 T1-201 SPECT의 악성 폐질환의 진단율은 93%로 높았으나, 각각의 특이도는 39%와 41%로 낮았다. 2) 악성과 양성질환의 T1-201의 섭취비는 초기 및 지연영상 모두에서 악성폐질환의 섭취비가 유의하게 높았다(p=0.028, p=0.014). 그러나 중복되는 부분이 많았다. 3) T1-201 정체율은 악성질환에서 높은 경향을 보였으나, 유의한 차이는 없었다. 결론: 한국과 같이 활동성 염증성병변의 발생빈도가 높은 집단에서는 단일 폐결절환자를 대상으로한 T1-201 SPECT의 악성병변의 진단에 대한 예민도는 높으나 특이도가 낮고, T1-201 섭취비도 겹치는 부분이 많아 임상적으로 제한적인 가치를 가진다.

• Tuberculosis and Respiratory Diseases
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• 제68권6호
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• pp.358-362
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• 2010

Intralobar pulmonary sequestration is a rare congenital lung anomaly. It is defined as a portion of nonfunctioning lung parenchyma that receives its blood supply from an anomalous systemic artery. Patients often present with chronic or recurrent pneumonia. A chest radiograph may show a cystic lesion with air-fluid levels in the lung base. A high index of suspicion is needed for a diagnosis. Surgical removal of a symptomatic intralobar pulmonary sequestration is generally the treatment of choice. Identifying the aberrant artery is a difficult problem when resecting a pulmonary sequestration. The thoracic and abdominal aortas are the most common origins for the abnormal blood supply. However, arterial supply from the celiac artery is quite rare. We present a case of intralobar pulmonary sequestration with the blood supply originating from the celiac artery.

• Tuberculosis and Respiratory Diseases
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• 제72권1호
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• pp.15-23
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• 2012

Background: The survival of non-small cell lung cancer (NSCLC) patients with brain metastases is reported to be 3~6 months even with aggressive treatment. Some patients have very short survival after aggressive treatment and reliable prognostic scoring systems for patients with cancer have a strong correlation with outcome, often supporting decision making and treatment recommendations. Methods: A total of one hundred twenty two NSCLC patients with brain metastases who received gamma knife radiosurgery (GKRS) were analyzed. Survival analysis was calculated in all patients for thirteen available prognostic factors and four prognostic scoring systems: score index for radiosurgery (SIR), recursive partitioning analysis (RPA), graded prognostic assessment (GPA), and basic score for brain metastases (BSBM). Results: Age, Karnofsky performance status, largest brain lesion volume, systemic chemotherapy, primary tumor control, and medication of epidermal growth factor receptor tyrosine kinase inhibitor were statistically independent prognostic factors for survival. A multivariate model of SIR and RPA identified significant differences between each group of scores. We found that three-tiered indices such as SIR and RPA are more useful than four-tiered scoring systems (GPA and BSBM). Conclusion: There is little value of RPA class III (most unfavorable group) for the same results of 6-month and 1-year survival rate. Thus, SIR is the most useful index to sort out patients with poorer prognosis. Further prospective trials should be performed to develop a new molecular- and gene-based prognostic index model.