• Proceedings of the Korean Vacuum Society Conference
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• 2013.08a
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• pp.184.2-184.2
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• 2013

대기압 플라즈마와 생체용액과의 상호작용은 Bio-medical 분야에서 주목 받고 있다. 대기압 플라즈마는 전자온도가 고온 플라즈마 보다 상대적으로 낮기 때문에 생체에 적용하기가 적합하다. 따라서 플라즈마가 세포에 미치는 영향을 관측하기 위해서 대기압 플라즈마를 이용하여 생체용액과의 반응을 살펴보고자 한다. Ar gas를 이용하여 플라즈마를 발생시켜 생체용액 표면을 처리하고 OES (Optical Emission Spectroscopy)을 이용해 방출 선을 조사했다. Ar 기체를 이용한 대기압 플라즈마를 사용하여 다른종류의 용액내의 OH Radical Density를 측정하였다. 용액으로는 DI (deionized) water 와 PBS (1x phosphate buffered saline)를 사용하였다. Ar gas를 200 sccm ($cm^3/min$) 으로 흐르게 하였을 때, DI water의 OH Radical Density 는 $4.33{\times}10^{16}cm^{-3}$ 으로 측정되었으며, 자외선 흡수분광법으로 측정한 완충용액인 PBS의 OH Radical Density 측정값은 $1.87{\times}10^{16}cm^{-3}$ 이다. 이런 특성을 기반으로, PBS 용액내의 H460 (Lung Cancer Cell) 와 L132 (Lung Normal Cell)을 깊이와 시간에 따라 대기압 플라즈마로 처리하여 cell의 변화를 보았다. 실험 각각의 조건은 깊이를 2 mm, 4 mm, 6 mm이며 시간은 10 sec, 30 sec, 60 sec 로 설정하였다. 표면으로부터의 깊이가 2 mm, 4 mm, 6 mm 일때 의 OH Radical Density는 각각 $1.87{\times}10^{16}cm^{-3}$, $0.5{\times}10^{16}cm^{-3}$, 0으로써 용액이 깊어질수록 OH Radical Density가 감소함을 볼 수 있다. OH radical density가 높은 2 mm 에서, 처리한 시간이 길어질수록 Cell 은 영향을 많이 받음을 관찰 할 수 있었다. H460 이 L132 보다 플라즈마에 영향을 많이 받음을 확인하였다. 특성변화를 알아보기 위하여 raman spectroscopy, flow cytometry, electron spin resonance로 측정한다.

• Progress in Medical Physics
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• v.4 no.2
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• pp.19-25
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• 1993

Treatment planning of lung cancer with density corrected Computed tomography. Eighty-seven patients with lung cnacer who had radiation therapy in Yeungnam University Medical Center between, April 1 1990 and Aug. 30 1993 were retrospectively evaluated total tumor dose, dose distribution, field correction, and loading change, compared with contour or CT image planning and density corrected CT planning. In dose distribution, higher dose was calculated in compare with density corrected CT planning less than 5% difference were found in 45 patient(52%), 5-10% in 25 patients (29%), 10-15% in 15 patients (17%) and over 15% in 2 patients (2%). Correction of treatment field was performed in 18 patients (21%) and changing of dose loading was given in 15 patients (17%). In conclusion, we emphasize that density corrected CT planning is the very important factor which contribute to increase therapeutic gain by exact selection of target volume, target dose, normal tissue dose and dose of critical organ.

• Progress in Medical Physics
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• v.15 no.1
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• pp.23-29
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• 2004

The relationship between the dose calculated with a radiotherapy treatment planning system (RTPS) and CT number verses the relative electron density curve was investigated for various CT voltages and beam qualifies. We obtained the relationship between the CT numbers and electron densities of the tissue equivalent materials for various CT voltages and beam qualifies. At lower CT voltages, the higher density materials, like cortical bone, showed larger CT numbers and the soft tissues showed no variations. We peformed a phantom study in a RTPS, where a phantom consisted of lung and bone legions in water. We calculated the dose received behind the lung and bone regions for 6 MV photon beams, in which the regions below the lung, water and bone received higher doses in this listed order. The result was the same for 10 MV photon beams. For the clinical application, the doses were calculated for the lung and pelvis. No difference was observed when using different electron density conversion tables with various CT voltages from a same CT. A relative dose difference of 1.5% was obtained when the CT machine for the density conversion table was different from that for the CT image for planning.

• Journal of the Korean Chemical Society
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• v.19 no.5
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• pp.375-380
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• 1975

An enzyme capable of hydrolyzing histidylleucine was purified 50 fold from hog lung. The final preparation hydrolyzed $1.6{\mu}moles$ of histidylleucime per minute per mg of protein. The $K_m$ of the enzyme for the enzyme was found to be $2{\times}10^{-4}M$. The enzyme was required a number of free dipeptides for the substrate specificity, and was inhibited by EDTA and 1,10-phenan-throline. The molecular weight of the enzyme was estimated to be 80,000 daltons from sucrose density gradient sedimentation analysis. The corrected $s_{20,w}$ value was 5.3 S.

• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2009.10a
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• pp.214-214
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• 2009

• Journal of Chest Surgery
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• v.25 no.2
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• pp.205-209
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• 1992

The intrapulmonary teratoma is an extremely tumor. This paper reports a case of int-rapulmonary teratoma located in the right upper and middle lobes of the lung in a 16-years-old male patient. The initial symptoms were right chest pain and coughing. Chest X-ray revealed huge soft tissue mass density in the right lower lung field. Right upper and middle lobectomy with resection of invaded pericardium was done. The gross and microscopic findings of res-ected specimen revealed characteristic findings of the intrapulmonary teratoma. The patient was recovered uneventually. We would like to describe this case of rare tumor with the review of literatures.

• Korean Journal of Digital Imaging in Medicine
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• v.2 no.1
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• pp.74-82
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• 1996

This paper were studied the evaluation in compare with the conventional and AMBER of analog images, PACS and CR of digital images which were collected every ten sampling chest images with the J.J.Vucicuh chest evaluated chart, and were measured the chest phantom surface dose and the density of several part in chest images. The evaluated numbers were total 22 persons who were 6 persons of the M.D., 6 of the radiotechnological professors and 10 of the radiotechnologists. The obtained results summarized as following : 1. Approaching the optimum standard density of the several part in chest images drew near at the lung round region density in PACS images, the sternum region density in CR and AMBER images, the heart region density in CR AMBER images, the diaphram region density in AMBER and conventional images. 2. The evaluation measured surface dose were appeared orderly lesser dose at the AMBER images (spine 21 mR, lung 2mR, heart 12mR, apex 6mR) than the conventional images(32 mR), CR images(38mR) and PACS images(81mR). 3. The anatomical physical evaluation marks were taken the highest points at CR images(88.3), and orderly PACS images(82), AMBER images(79.2) and conventional images(65.2). 4. It is exposured with lesser surface dose at the analog images, but analog images leaves much room for image quality improvement, and digital images demand for lesser exposure surface dose, although excellent image quality.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.14
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• pp.5819-5823
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• 2014

Purpose: To investigate the expression of hypoxia-inducible factor prolyl hydroxylase 3 (HIFPH3) in non-small cell lung cancer (NSCLC) and explore the correlation of HIFPH3 expression with lymph node metastasis and microvessel density (MVD). Materials and Methods: A total of 73 cases of NSCLC specimens, 24 cases of para-cancerous tissues, and 20 normal pulmonary tissues were collected for HIFPH3 and CD31 immunohistochmical (IHC) study. Microvessel density (MVD) of the NSCLC tissues was also determined based on the expression of CD31. Results: The expression of HIFPH3 in carcinoma tissue was statistically higher than para-cancerous and normal pulmonary tissues (${\chi}^2=48.806$, p<0.05). Compared withthe negative lymph node metastasis group, the lymph node metastasis group showed significantly higher HIFPH3 expression (${\chi}^2=6.300$, p<0.05). The strong HIFPH3+group displayed a significantly higher MVD than weak HIFPH3+ and HIFPH3- groups (p<0.05). No differences in positive HIFPH3 expression were noted regarding the tumor diameter, age, smoking status, gender of NSCLC patients, tumor size, histopathology, or differentiation. Conclusions: HIFPH3 expression in human NSCLC lesions is significantly higher than that in para-cancerous and normal lung tissues and is positively associated with lymph node metastasis and MVD.

• Tuberculosis and Respiratory Diseases
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• v.45 no.5
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• pp.992-999
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• 1998

Background: To correlate the emphysema score for quantification of the overall extent of emphysema in both lungs by CT with physiologic fingings and to get more objective and simple method to assess the extent of emphysema. Method: Thin-section CT and pulmonary function test(PFT) were performed in 17 patients with emphysema (all males, mean age, 62 years). Emphysema score was obtained as percentage of emphysematous lung area, dividing the total area of the emphysema(voxels with attenuation value less than -880, -900, -920HU, respectively) by the overall area of both lungs(voxels with attenuation value less than -400HU) with highlighting voxels using "Density mask" program. Emphysema score was calculated from whole lung(ESV) and 5 representative scans(ESR) using "Density mask", Visual emphysema score(ESV) was obtained by visual assessment from 5 representative scans. Correlation of these emphysema scores(ESW, ESR, ESV) and physiologic findings were performed, comparing the ESW with ESR and ESV. Results: ESW had correlation with DLCO(r=0.53-0.64) and $FEV_1/FVC$(r=0.42-0.57) among PFT parameters. ESR had good correlation with ESW and with PFT parameters as well. ESV did not correlate with PFT parameters except DLCO. Conclusion: CT quantification of emphysema using "density mask" correlated well with physiologic findings. To assess the severity of emphysema, both ESW and ESR are more reliable than ESV, and ESR is recommended in routine practice as it is objective, simple and reliable.

• Journal of Yeungnam Medical Science
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• v.34 no.2
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• pp.270-274
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• 2017

A nodular density was detected on a chest radiograph taken from a 57-year-old Korean woman who was visiting a hospital for a routine check. Chest computed tomography revealed a 4.8 cm lobulated mass in the right lung and another focal nodular lesion in the left lung; biopsies of both lungs revealed adenocarcinoma. We conducted DNA sequencing and peptide nucleic acid clamping to investigate the potential double primary lung cancer. The results verified that the mass in the right lung had a mutation in the epidermal growth factor receptor, whereas the nodule in the left lung had a wild-type sequence, showing that these two were genetically different cancers from one another. Thus, we demonstrate that genetic testing is useful in determining double primary lung cancer, and we herein report on this case.