• 대한약침학회지
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• 제25권3호
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• pp.233-241
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• 2022

Objectives: Asthma is a chronic disease, and the demand for herbal medicines in this field has increased in recent years. The new findings highlight the role of the gut-lung axis in the pathophysiology of asthma. Hence, this study will evaluate the safety and efficacy of Glasthma syrup, an herbal formula based on Persian medicine, in improving asthma and regulating intestinal permeability. The formula consists of five herbal ingredients that have anti-inflammatory effects on the respiratory tract, also known as gut tonics. Methods: The study will be conducted as a placebo-controlled, triple-blind, randomized trial. It will consist of a 4-week intervention followed by a 4-week follow-up period. The target sample size is 20 patients with moderate asthma aged 18 to 60 years. Eligible participants will be randomly assigned to either the experimental group or the control group in equal numbers. Patients in the experimental group will take Glasthma syrup (7.5 mL, twice a day), while patients in the control group will take a matching placebo. Both groups will receive a 4-week combination of a long-acting beta2 agonist and a leukotriene modulator as standard of care. Inhaled corticosteroids can be used as rescue medication as needed. Results: The primary outcomes are asthma symptom scale, lung function, and intestinal permeability. Secondary outcomes include quality of life, symptom recurrence rates, and blood tests. A safety assessment will also be conducted during the trial. Conclusion: In this trial, the effects of Glasthma syrup in patients with moderate asthma will be examined. The study will also assess the effects of the formulation on the gut-lung axis by simultaneously monitoring the gut permeability index, asthma symptoms, and lung function.

• 치위생과학회지
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• 제17권5호
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• pp.454-461
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• 2017

The purpose of this study was to confirm the relevance of dental health capacity and pulmonary function status. The subjects of this study were adults aged 40 years and older, who participated in pulmonary function and oral examinations. The data used for this study were raw data from the sixth Korea National Health and Nutrition Examination Survey (2013~2015). Statistical analysis was performed by analysis of complex sample survey data. The results were as follows: First, restrictive and obstructive patterns were more prevalent among males than females. They were even worse in older subjects. Approximately 67% of smokers had obstructive pattern. Second, there was a relevance between dental health capacity and pulmonary function status. The functioning teeth index, number of present teeth, and number of sound teeth (ST), which are indicators of dental health, declined with decreased pulmonary function. The number of missing teeth (MT) increased as the pulmonary function deteriorated (p<0.05). Third, the relevance between dental health capacity and pulmonary function status after stratifying the life-long smoking experience was statistically significant in the tissue health (T-health) index and ST among non-smokers. The relevance between dental health capacity and pulmonary function status after stratifying the life-long smoking experience was statistically significant (p<0.05) for the T-health index, ST, and MT among smokers. However, there was no relevance between dental health capacity and pulmonary function status after stratifying the life-long smoking experience and adjusting confounding variables. In conclusion, there was a relevance between dental health capacity and pulmonary function status after confounding variables were adjusted. However, there was no relevance between dental health capacity and pulmonary function status after stratifying the life-long smoking experience and adjusting confounding variables.

• Tuberculosis and Respiratory Diseases
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• 제40권3호
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• pp.259-266
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• 1993

연구배경 : 전산화 단층촬영 유도하 경피적 폐침생검시 가장 많은 합병증인 기흉의 위험인자를 조사하기 위하여 폐기능 검사상 폐쇄성 환기장애 유무에 따른 기흉 발생의 정도를 조사하였다. 방법 : 흉부 X-선 사진상 종괴양음영으로 CT 유도하 경피적 폐침생검을 시행한 예들 중 시술후 기흉이 발생한 16예와 대조군으로 이들과 연령, 신장 및 체중, 흡연력, 종괴의 크기 및 깊이가 비등한 기흉이 발생하지 않은 16예를 대상으로 시술전 측정한 폐활량과 노력성 호기곡선 및 기류-용량곡선에서 계측한 여러 지표들과 폐확산능 성적을 비교 검토하였다. 결과 : 1) 폐활량 및 노력성호기곡선에서 계측한 지표들 가운데 VC와 FVC는 두군사이에 유의한 차이가 없었으나 $FEV_1$, $FEV_1$/FVC% 및 FEF25-75%은 기흉이 발생한 군에서 유의하게 감소하였으며 기류-용량곡선의 모든 계측치도 기흉이 생긴 군에서 저명하게 감소하였다. 2) $D_{LCO}$ 및 $D_{LCO}/V_A$는 개인차는 심하였으나 기흉이 생긴군에서 감소하는 경향이 있었다. 3) 폐쇄성 환기장애가 있는 경우 폐기능 검사상 정상인 군에 비해 기흉의 발생빈도가 2배 이상이었으며 기흉의 치료로써 흉관삽입술이 필요한 빈도도 6배 이상이었다. 결론 : 이상의 결과에서 경피적 폐침생검시 시술전 폐기능 검사를 통한 폐쇄성 폐질환 유무에 대한 정확한 조사는 기흉의 발생을 예측할 수 있는 하나의 인자로 고려될 수 있음을 알 수 있었다.

• Journal of Yeungnam Medical Science
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• 제27권1호
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• pp.57-62
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• 2010

Pulmonary alveolar proteinosis (PAP) is a rare disorder that's characterized by accumulation of surfactant components in the alveolar space. Idiopathic PAP is recognized as an autoimmune disease that's due to impaired alveolar macrophage function and this caused by autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF). We report here a case of pulmonary alveolar proteinosis that was deemed interstitial lung disease at the initial diagnosis. A 61-year-old man presented with intermittent blood tinged sputum and dyspnea on exertion. The man was a painter for 30 years and he had a 10 pack-years smoking history. Chest computerized tomography (CT) revealed multifocal ground-glass opacity with interstitial thickening at both lungs. His pulmonary function tests and methacholine test revealed non specific results. He was diagnosed with interstitial lung disease on the basis of the chest CT finding and occupational history. However, seven months later, his symptoms progressed. Follow-up chest CT was performed. Wedge resection via video-assisted thoracoscopic surgery (the anterior basal segment of the left lower lobe) was done. Microscopic examination showed large groups of alveoli with excessive amounts of surfactant and a complex mixture of protein and lipid (fat) molecules. Finally, he was diagnosed as having pulmonary alveolar proteinosis.

• Tuberculosis and Respiratory Diseases
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• 제43권4호
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• pp.651-656
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• 1996

저자 등은 입원 당시 전이성 암 또는 원발성 폐암의 방사선학적 소견을 보인 환자의 진단과정 중에 우리가 흔히 보는 형태가 아닌 유육종증 1예를 경험하여 문헌 고찰과 함께 보고하는 바이다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5473-5476
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• 2013

Background: In our study, the LDH, albumin, hemoglobin, neutrophile, thrombocyte, lymphocyte counts and prognostic significance of neutrophile-lymphocyte and thrombocyte-lymphocyte ratios in NSCLC derived from these counts obtained during regular examinations of patients were examined. Materials and Methods: Histopathologically diagnosed non-small-cell-lung cancer patients between 2008 and 2010 were included in the study. Before the treatment, full blood count including routine lymphocyte count, blood biochemistry examinations including liver (AST, ALT, total protein, Albumin), LDH and kidney (BUN, Cre) function tests were performed. Results: A total of 156 patients, 76 of whom (48.7%) were female and 80 of whom (51.3%) were male were included. Mean hemoglobin level was determined as 12. Overall survival was found to be significantly dependent on whether patients were anemic or not (p: 0.005). Mean LDH level was determined as 233.4. There was nosurvival difference between patients with and without high LDH (p: 0.532). In patients where NLR showed systemic inflammatory response, overall survival was 10.8 months whereas this duration was 19.6 months in patients where the systemic inflammatory response was negative (p: 0.012). In patients where TLR showed systemic inflammatory response, overall survival was 13.6 months whereas this duration was 21.9 months in patients where the systemic inflammatory response was negative (p: 0.04). Conclusions: Molecular methods have been changing rapidly in today's world and they manage the treatment besides defining the prognosis of patients. However, easily accessible and cheap laboratory parameters should be considered in the prognosis of patients besides these new methods.

• 한국보건간호학회지
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• 제28권1호
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• pp.22-31
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• 2014

Purpose: The purpose of this study was to examine the impact of body mass index (BMI) and waist circumference (WC) for pulmonary function in normal-weight and obese women. Methods: Data from women aged ${\geq}40$ years were obtained from the 2011 Korean National Health and Nutrition Examination Survey. Obesity was measured by BMI and WC and pulmonary function was measured by forced vital capacity (FVC), forced expiratory volume in 1 second ($FEV_1$), and a ratio between forced expiratory volume in 1 second ($FEV_1$/FVC). Multiple linear regression analysis was performed for assessment of the association between FVC, $FEV_1$, $FEV_1$/FVC and obesity variables. Results: BMI showed positive association with FVC, $FEV_1$, $FEV_1$/FVC, and WC showed positive association with $FEV_1$ and $FEV_1$/FVC in normal-weight women. BMI and WC showed negative association with FVC, $FEV_1$ in obese women. A 1 unit increase in BMI showed an association with a 25-mL reduction in FVC and a 19-mL reduction in $FEV_1$. A 1-cm increase in WC showed an association with a 6-mL reduction in FVC and a 4-mL reduction in $FEV_1$. Conclusions: BMI and WC showed negative association with pulmonary function in obese adult women. Therefore, obese women with reduced pulmonary function should be encouraged to lose weight for improvement of their pulmonary function.

• Journal of Chest Surgery
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• 제54권6호
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• pp.480-486
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• 2021

Background: Although various methods are already used to calculate predicted postoperative forced expiratory volume in 1 second (FEV₁) based on preoperative FEV₁ in lung surgery, the predicted postoperative FEV₁ is not always the same as the actual postoperative FEV₁. Observed postoperative FEV₁ values are usually the same or higher than the predicted postoperative FEV₁. To overcome this issue, we investigated the relationship between the number of resected lung segments and the discordance of preoperative and postoperative FEV₁ values. Methods: From September 2014 to May 2020, the data of all patients who underwent anatomical lung resection by video-assisted thoracoscopic surgery (VATS) were gathered and analyzed retrospectively. We investigated the association between the number of resected segments and the differential FEV₁ (a measure of the discrepancy between the predicted and observed postoperative FEV₁) using the t-test and linear regression. Results: Information on 238 patients who underwent VATS anatomical lung resection at Kyung Hee University Hospital at Gangdong and by DH. Kim for benign and malignant disease was collected. After applying the exclusion criteria, 114 patients were included in the final analysis. In the multiple linear regression model, the number of resected segments showed a positive correlation with the differential FEV₁ (Pearson r=0.384, p<0.001). After adjusting for multiple covariates, the differential FEV₁ increased by 0.048 (95% confidence interval, 0.023-0.073) with an increasing number of resected lung segments (R²=0.271, p<0.001). Conclusion: In this study, after pulmonary resection, the number of resected segments showed a positive correlation with the differential FEV₁.

• Tuberculosis and Respiratory Diseases
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• 제72권5호
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• pp.433-440
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• 2012

Background: The pulmonary function test is the most basic test method to diagnosis lung disease. The purpose of this study was to research the correlation of the body mass index (BMI), the fat percentage of the body mass (fat%), the muscle mass, the fat-free mass (FFM) and the fat-free mass index (FFMI), waist-hip ratio (WHR), on the forced expiratory volume curve. Methods: Between March and April 2009, a total of 291 subjects were enrolled. There were 152 men and 139 female (mean age, $46.3{\pm}9.92$ years), and they were measured for the following: forced vital capacity (FVC), forced expiratory volume at 1 second ($FEV_1$), and forced expiratory flow during the middle half of the FVC ($FEF_{25-75}$) from the forced expiratory volume curve by the spirometry, and the body composition by the bioelectrical impedance method. Correlation and a multiple linear regression, between the body composition and pulmonary function, were used. Results: BMI and fat% had no correlation with FVC, $FEV_1$ in male, but FFMI showed a positive correlation. In contrast, BMI and fat% had correlation with FVC, $FEV_1$ in female, but FFMI showed no correlation. Both male and female, FVC and $FEV_1$ had a negative correlation with WHR (male, FVC r=-0.327, $FEV_1$ r=-0.36; p<0.05; female, FVC r=-0.175, $FEV_1$ r=-0.213; p<0.05). In a multiple linear regression of considering the body composition of the total group, FVC explained FFM, BMI, and FFMI in order ($r^2$=0.579, 0.657, 0.663). $FEV_1$ was explained only fat% ($r^2$=0.011), and $FEF_{25-75}$ was explained muscle mass, FFMI, FFM ($r^2$=0.126, 0.138, 0.148). Conclusion: The BMI, fat%, muscle mass, FFM, FFMI, WHR have significant association with pulmonary function but $r^2$ (adjusted coefficient of determination) were not high enough for explaining lung function.

• 대한통합의학회지
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• 제12권2호
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• pp.133-140
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• 2024

Purpose : People who have suffered from COVID-19 suffer from decreased pulmonary function and various side effects. This study aims to present three respiratory exercise intervention methods to improve pulmonary function in COVID-19 survivors. Therefore, the purpose of this study will investigate the effects of breathing exercise interventions (aerobic exercise, diaphragm breathe exercise, and inspiratory muscle training on resistance) on pulmonary function in COVID-19 survivors. Methods : The subjects who participated in this study were 35 male and female college students confirmed with COVID-19. All subjects were randomly assigned to A, D, and I groups according to breathing exercise intervention method. Groups A, D, and I each performed aerobic exercise, diaphragm breathing exercise, and inspiratory muscle training on resistance, 3 times a week for 6 weeks. Pulmonary function was measured using a spirometer, and FVC (forced vital capacity), FEV₁ (forced expiratory volume in one second), FEV₁/FVC % (forced expiratory volume in one second / forced vital capacity ratio), and PEF (peak expiratory flow) were measured at 0, 3, and 6 weeks. Data analysis was compared by repeated measures analysis of variance, and post hoc tests for time were compared and analyzed using paired t-tests. Results : In the results of this study, FVC values showed statistically significant improvement in all groups. FEV₁ values also showed statistically significant improvement in all groups. And the FEV₁/FVC % value also showed statistically significant improvement in all groups. And the PEF values also showed statistically significant improvement in all groups. Conclusion : The results of this study reported that aerobic exercise, diaphragm breathing exercise, and resistance inspiratory muscle training were all effective in improving pulmonary function in COVID-19 survivors. Therefore, application of the three breathing exercise intervention methods presented in this study will help improve pulmonary function in COVID-19 survivors.