• The Korean journal of internal medicine
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• 제39권2호
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• pp.338-346
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• 2024

Background/Aims: Systemic lupus erythematosus (SLE) responder index (SRI)-4 response has been achieved with belimumab treatment in patients with moderate disease activity in cornerstone clinical trials and following studies. However, most studies involved patients treated with a mean prednisolone-equivalent dose of approximately 10 mg/d and focused on the steroid-sparing effect of belimumab. We aimed to identify the effect of belimumab in patients with mild-to-moderate SLE who were treated with low-dose or no corticosteroids. Methods: We retrospectively reviewed the electronic medical records of patients treated with belimumab for at least 6 months between May 2021 and June 2022. The primary endpoint was SRI-4 response at 6 months. Results: Thirty-one patients were included (13 low dose- and 18 steroid non-users). The mean age was 39.2 ± 11.4 years, and 90.3% of patients were female. The baseline Safety of Estrogens in Lupus Erythematosus National Assessment-Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI) score was 6.0 (4.0-9.0). The primary endpoint was achieved in 32.3% (10/31) of patients. Significant improvements in anemia, C4 levels, and SELENA-SLEDAI score were observed during treatment. Univariate analysis showed that the baseline SELENA-SLEDAI and arthritis were significantly associated with SRI-4 response at 6 months, and only the SELENA-SLEDAI remained significant (p = 0.014) in multivariate analysis. Conclusions: This cohort study is the first to report the efficacy of belimumab after minimizing the effect of corticosteroids. Belimumab showed efficacy in improving the SELENA-SLEDAI score, anemia, and low C4 in patients who did not receive corticosteroids or received only low doses.

• Toxicological Research
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• 제6권2호
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• pp.131-142
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• 1990

The selective toxicity of lead was tested in central catecholaminergic nervous system of postnatally lead exposed rats. Three groups of animals were prepared; 1) rats exposed to low dose of lead (0.05%PbAc); 2) rats exposed to high dose of lead(0.2%PbAc); 3) age-matched normal control rats. At2, 4, 6 and 8 weeks of age brain and body weight gain, and lead concentrations in brain tissues were measured. At the same ages tyrosine hydroxylase and Na-K ATPase activities were measured in the 4 brain areas of each animal. Body weight gain was decreased after 6 weeks of age in rats exposed to high dose of lead. Concentrations of lead in whole brain tissues were increased from 0.37 to 0.83 (ng/mg wet tissue) in these animals. in lead exposed rats, tyrosine hydroxylase activities were higher but Na-K ATPase activities were lower than those of age-matched control animals. Brain areas where tyrosine hydroxylase activities were detected without concomitant changes of Na-K ATPase activities were pons-medulla (2 weeks of age) and telencephalon (6 weeks of age) in rats exposed to low dose of lead, and those in rats exposed to high dose of lead were midbrain (4 and 6 weeks of age). These data indicate that catecholaminergic nervous system in the brain areas described above could selectively be affected by lead.

• 전기의세계
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• 제23권5호
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• pp.54-60
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• 1974

Proposals were mode on how to differentiate radiation effects in morphological phases of polyethylene and discussions were developed with the results obtained on a low density polyethylene, SOCAREX, specified by number average molecular weight; overbar Mn=5,400, density; 0.92, and degree of branch; 3.4/100 carbon atom, which was irradiated to Co$^{60}$ .gamma. ray at the dose rate of 0.5 Mrad/hr in ambient temperature under the pressure of 10$^{-5}$ Torr. or 1 atm. respectively. The effect to crystalline phase in possibly deduced from dose dependent variation of relative area between (110) and (200) peaks on X ray diffraction spectrum and that, the effects to amorphous phase can be understood through dose dependent relaxation behaviours of .betha. peak on internal friction characteristics of the specimen. The results obtained thus far indicate that, in crystalline phase, relative crystallinity shows a rather rapid decrease up to 20 Mrad with increasing dose, however, little change of crystallinity can be observed in the region between 20-200 Mrad, and degradation appears to be more predominant than crosslinking up to 60 Mrad. While in amorphous phase the indication also shows that degradation is only predominant up to 20 Mrad. Furthermore several correlations can be seen with amenable explanation between dose dependent behaviours observed in both phases.

• 약학회지
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• 제47권1호
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• pp.52-55
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• 2003

Antidiabetic activities of white ginseng 50％ ethanol extract (WGE) and IH901, an intestinal metabolite of ginsenoside R $b_1$, were compared in multiple low dose streptozotocin (STZ)-induced diabetic rats. WGE or IH901 were coadministered with STZ on Day 1 at dose of 100 and 300 mg or 10 and 30 mg, respectively, and continually administered for 16 days. STZ dissolved in citrate boner was injected intraperitoneally at dose of 20 mg/kg for 5 consecutive days. During the experiment, plasma glucose level and body weight were measured every 4$^{th}$ day. Amount of food and water intake were evaluated once a week and compared between groups. WGE and IH901 both significantly reduced the plasma glucose levels on Day 16 as compared with those of the diabetic control group. In the meantime, amount of food and water intake in WGE-and IH901-treated groups were significantly improved in a dose dependent fashion as compared with those of the diabetic control group. Taken together WGE and IH901 showed the comparable antidiabetic activities at the corresponding doses used in this experiment.

• Progress in Superconductivity
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• 제3권1호
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• pp.36-40
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• 2001

We have studied vortex dynamics in$ Bi_2$$Sr_2$$CaCu_2$O$_{8}$single crystals of unirradiated and irradiated samples by using 100 $\times$ $100\mu\textrm{m}^2$Hall sensor. Doses equivalent magnetic fields are 20 G, 100 G and 1 kG. In the magnetization measurement, a second magnetization peak (SMP) was observed in unirradiated, 20 G dose and 100 G dose samples in contrast to 1 kG dose sample. In the unirradiated sample, the SMP was observed in the range of 18 K ~ 35 K and the amplitude of the SMP decreased with increasing temperature. With increase of the irradiation dose, temperature region and sharpness of the SMP were reduced. In the magnetic relaxation measurement, we observed that the normalized relaxation rate S decreased with increasing the irradiation dose. Our results suggest that the vortex dynamics is not greatly affected by low-density columnar defects.s.

• 대한방사선기술학회지:방사선기술과학
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• 제41권2호
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• pp.115-122
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• 2018

We aims to perform comparative analysis on the dose area and image qualities varying on the slice thickness when using Automatic Exposure Controller (AEC) and manual exposure; thus, it wants to suggest a measure to reduce exposure dose by setting the optimal examination condition for each slice thickness. The method was to set the thickness as Thin, Normal, and Heavy adult and evaluate the dose area, spatial resolution, low contrast resolution, Signal to Noise Ratio (SNR) and Contrast to Noise Ratio (CNR) according to each slice thickness by using the AEC and the manual exposure controller. The dose area according to each slice thickness all increased both when using the AEC and the manual exposure. However, the manual exposure showed lower dose area product than the AEC. Spatial resolutions and low contrast resolutions were all observed to be higher than the evaluation standard. Also, the SNR and CNR of each thickness all increased when using the AEC. When using the manual exposure, SNR and CNR increased in all cases other than the Heavy Adult. Consequently, the Thin and Normal Adult showed dose reduction about 2 times when using the manual exposure controller, while ensuring the image quality. Heavy adult was able to maintain good image quality by using AEC.

• Radiation Oncology Journal
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• 제16권4호
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• pp.357-366
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• 1998

Brachytherapy is an essential part of radiotherapy for uterine cervical cancer. The low dose rate (LDR) regimen has been the major technique of intracavitary therapy for cervical cancer. However, there has been an expansion in the last 20 years of high dose rate (HDR) machines using Ir-192 sources. Since 1979, HDR brachytherapy has been used for the treatment of uterine cervical cancer in Korea. The number of institutions employing HDR has been increasing, while the number of low dose rate system has been constant. In 1995, there was a total 27 HDR brachytherapy units installed and 1258 cases of patients with cervical cancer were treated with HDR Most common regimens of HDR brachytherapy are total dose of 30-39 Gy at point A with 10-13 fractions in three fractions per week. 24-32 Gy with 6-8 fractions in two fractions per week, and 30-35 Gy with 6-7 fractions in two fractions per week. The average fractionation regimen of HDR brachytherapy is about 8 fractions of 4.1 Gy each to Point A. In Korea, treatment results for HDR brachytherapy are comparable with the LDR series and appears to be a safe and effective alternative to LDR therapy for the treatment of cervical carcinoma. Studies from the major centers report the five-year survival rate of cervical cancer as. 78-86$\%$ for Stage 1, 68-85$\%$ for stage 11, and 38-56$\%$ for Stage III. World-wide questionnaire study and Japanese questionnaire survey of multiple institutions showed no survival difference in any stages and dose-rate effect ratio (HDR/LDR) was calculated to be 0.54 to 0.58. However the optimum treatment doses and fractionation schemes appropriate to generate clinical results comparable to conventional LDR schemes have yet to be standardized. In conclusion, HDR intracavitary radiotherapy is increasingly practiced in Korea and an effective treatment modality for cervical cancer. To determine the optimum radiotherapy dose and fractionation schedule, a nation-wide prospective study is necessary in Korea. In addition, standardization of HDR application (clinical, computer algorithms, and dosimetric aspects) is necessary.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.214-215
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• 2002

Generally uniform dose distribution is assumed to be formed in a target region when a conventional dose formation method using a broad proton beam, a fixed modulation technique, a bolus and an aperture is employed. However, actual situations differ. We usually find non-uniformity in the target region. This is due to the insertion of a range-compensating bolus before the patient. Since the range-compensating bolus has an irregular shape, the scattering in the bolus depends on the lateral position. Dose distribution is overlapping results of dose distribution of pencil-proton beams traversing different lateral positions of the bolus. The lateral extent of dose distribution of each pencil beam traversing the different position differs each other at the same depth in the target object. This is a cause of the non-uniformity of the dose distribution. Therefore the same lateral extent of dose distribution should be attained for different pencil beams at the same depth to obtain a uniform dose distribution. For that purpose, we propose here a bi-material bolus. The bi-material bolus consists of a low-Z material determining mainly the range loss and a high-Z material defining mainly the scattering in the bolus. After passing through the bi-material bolus, protons traversing different lateral positions will have different residual range yet with the same lateral spread at a certain depth. Using the optimized bi-material bolus, we can obtain a more uniform dose distribution in the target region as expected.

• Radiation Oncology Journal
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• 제2권1호
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• pp.129-137
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• 1984

In brachytherapy, it is important to determine the positions of the radiation sources which are inserted into a patient and to estimate the dose resulting from the treatment. Calculation of the dose distribution throughout an implant is so laborious that it is rarely done by manual methods except for model cases. It is possible to calculate isodose distributions and tumor doses for individual patients by the use of a microcomputer. In this program, the dose rate and dose distributions are calculated by numerical integration of point source and the localization of radiation sources are obtained from two radiographs at right angles taken by a simulator developed for the treatment planning. By using microcomputer for brachytherapy, we obtained the result as following 1. Dose calculation and irradiation time for tumor could be calculated under one or five seconds after input data. 2. It was same value under$\pm2\%$ error between dose calculation by computer program and measurement dose. 3. It took about five minutes to reconstruct completely dose distribution for intracavitary irradiation. 4. Calculating by computer made remarkly reduction of dose errors compared with Quimby's calculation in interstitial radiation implantation. 5. It could calculate the biological isoffect dose for high and low dose rate activities.

• 대한영상의학회지
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• 제83권3호
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• pp.669-679
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• 2022

목적 필터보정역투영(filtered back projection; 이하 FBP)법과 적절한 커널로 재구성된 소아 저선량 안면 컴퓨터단층촬영(이하 CT)의 시행 가능성을 평가하고자 한다. 대상과 방법 응급실에서 안면 CT를 촬영한 10세 이하 환자의 임상 및 영상 데이터를 후향적으로 검토하였다. 환자들을 두 그룹으로 나누었다: 고정된 80 kVp와 자동관전류변조기법을 사용하는 저선량 CT (low-dose CT, 그룹 A, n = 73), 고정된 120 kVp와 자동관전류변조기법을 사용하는 표준 선량 CT (standard-dose CT, 그룹 B, n = 40). 모든 영상은 FBP로 재구성되었다: 그룹 A는 뼈와 연조직 커널을, 그룹 B는 뼈 커널을 이용하였다. 두 그룹의 영상 잡음, 신호대잡음비(signal-to-noise ratio; 이하 SNR), 그리고 대조대잡음비(contrast-to-noise ratio; 이하 CNR)를 비교하였다. 두 명의 영상의학과 의사가 뼈와 연조직의 영상 품질에 대해 주관적으로 점수화하였다. 용적 CT 선량지수(CT dose index volume)와 선량길이곱(dose length product)을 기록하였다. 결과 영상 잡음은 그룹 A가 그룹 B보다 높았다(p < 0.001). 연조직 커널을 사용한 그룹 A 영상에서 가장 높은 SNR과 CNR을 보였다(p < 0.001). 뼈의 정성적 평가에서 뼈 커널 영상들을 비교하면 그룹 A가 그룹 B보다 비슷하거나 높은 점수를 보였다. 연조직의 정성적 평가에서 연조직 커널을 이용한 그룹 A와 뼈 커널에 연조직 창 설정을 이용한 그룹 B 사이에는 통계적으로 유의한 차이가 없었다(p > 0.05). 그룹 A는 그룹 B에 비해 방사선 선량이 76.9% 감소했다(3.2 ± 0.2 mGy vs. 13.9 ± 1.5 mGy, p < 0.001). 결론 연조직 커널 영상을 FBP로 재구성된 전통적인 CT에 추가함으로써 영상 품질을 유지하면서 소아 저선량 안면 CT 프로토콜을 사용할 수 있다.