• 한국식품영양과학회지
• /
• 제16권1호
• /
• pp.18-21
• /
• 1987

마그네슘, 칼슘 및 인삼을 첨가하여 사육한 토끼의 혈청콜레스테롤 농도에 미치는 영향을 조사하여 다음과 같은 결론을 얻었다. 1. 인삼분말의 급여로 체중증가는 별차가 없었으며 간장의 무게는 상당한 증가를 나타냈다. 2. Total cholesterol은 인삼 4mg을 첨가한 실험군에서 가장 낮았고, 마그네슘과 칼슘이 1:2로 급여한 군에서 낮게 나타났다. 3. Free cholesterol과 cholesterol ester도total cholesterol의 경우와 같이 인삼 4mg을 첨가한 것과 마그네슘과 칼슘을 1:2로 급여한 실험군에서 가장 낮았다. 4. Total cholesterol이 가장 낮은 실험군에서 LDL이 가장 낮았으며, HDL/T-CHOL의 비는 가장 높게 나타났다. 5. Triglyceride와 phospholipid에 있어서는 인삼 첨가로 TG의 양은 점점 감소되었으나 PL의 경우는 상당히 증가되었다. 6. 전해질의 경우는 마그네슘과 칼슘을 1:2로 첨가하고 인상 4mg을 급여한 실험군의 $Na^+$이 120mEq/l, $K^+$이 6.8mEq/l를 보여 인삼이 전해질의 이동에 크게 작용하고 있는 것으로 생각된다. 이상과 같은 결과로 인삼은 토끼의 혈청 전해질의 분포상태와 콜레스테롤의 농도에 영향은 주며, 콜레스테롤 농도를 저하시키는 작용을 함과 동시에 지방질을 감소시키고 인지질은 증가시키는 작용을 하는 것으로 추정된다.

• 한국식품영양과학회지
• /
• 제15권1호
• /
• pp.75-81
• /
• 1986

w-3계 linolenic acid가 풍부한 들깨기름 및 EPA와 DHA가 함유된 말쥐치기름의 혈청 및 간장의 지질성분에 미치는 영향을 구명하기 위해 지방산조성이 다른 몇가지 유지를 고콜레스테롤 식이 흰쥐에 식이하므로서 혈청 및 간장중의 지질농도에 미치는 영향을 비교 실험하여 다음과 같은 결과를 얻었다. 1. 사료섭취량과 증체량은 전 시험군간에 있어 별다른 차이가 없었다. 2. 혈청의총 cholesterol농도는 soybean oil perilla oil및 file fish oil 식이군이 대조군에 비해 유의적으로 낮았다. HDL-cholesterol 농도는 file fish oil 식이군이 가장 높았으며, perilla oil 식이군도 약간의 상승효과가 있었다. 총 cholesterol에 대한 HDL-cholesterol의 비율은 file fish oil식이군이 가장 높았다. 3. 간장의 총 cholesterol농도는 전 시험군간에 유의적인 차이는 없으나 file fish oil 및 perilla oil 식이군에서 약간 낮은 경향이었다. 4. 혈청의 triglyceride농도는 soybean oil 및 perilla oil식이군이 대조군에 비해 유의적으로 낮았다. phospholipid의 농도는 file fish oil식이군이 가장 낮았으며, soybean oil 및 perilla oil식이군에서도 대조군에 비해 유의적으로 낮았다. 5. 간장중의 triglyceride및 phospholipid의 농도는 전시험군간에 유의적인 차이는 없으나, perilla oil식이군이 약간 낮은 경향이었다. 이상의 결과로 미루어 보아 perilla oil 및 file fish oil은 혈청의 총 cholesterol, 및 phospholipid의 농도저하 효과가 다소 있는 것으로 사려된다.

• 한국축산식품학회지
• /
• 제38권2호
• /
• pp.259-272
• /
• 2018

This study aims to investigate the protective effects of kefir against myocardial infarction induced by isoproterenol (ISO). The rats were randomly divided into 4 groups, each group consisting of 8 rats. The control group, the kefir group (5 mL/kg/d kefir administered to rats as intra-gastric gavage for 60 d), the ISO group (100 mg/kg ISO was administered to rats, s.c. on 61. and 62. d), and kefir+ISO group (5 mL/kg/d kefir was administered to rats intra gastric gavage for 60 days prior to ISO, 100 mg/kg in two doses on day 61 and 62). 12 h after the last ISO dose, all rats were decapitated and their blood samples were collected. Cardiac tissue was reserved for histopathological examination. creatine kinase (CK), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), triglycerides, total cholesterol,very low density lipoprotein (VLDL), low density lipoprotein (LDL), high density lipoprotein (HDL) and glucose were measured by autoanalyzer, whole blood malondialdehyde (MDA), glutathione (GSH) and plasma advanced oxidation protein products (AOPP) levels were measured spectrophotometrically. It was determined that in the group of kefir+ISO, the levels of AST (p<0.001), CK (p<0.001), LDH (p<0.001), MDA (p<0.001) and AOPP (p<0.001) were decreased, while the GSH (p<0.05) increased, compared to ISO group. There were no significant changes in lipid profile and glucose levels between these two groups. In conclusion, by examining cardiac enzymes and histopathological changes in cardiac tissue, it can be concluded that the administration of kefir in myocardial infarction induced by ISO can protect the heart with its antioxidant characteristic and minimize the toxic damage created by ISO.

• Nutrition Research and Practice
• /
• 제9권1호
• /
• pp.37-42
• /
• 2015

BACKGROUND/OBJECTIVES: Red grape seeds as functional food are a good source of important bioactive components such as phenolics and antioxidants, which decrease oxidative stress that contributes to the pathogenesis of hepatotoxicity. The current study was conducted in order to evaluate the protective effect of red grape dried seeds (RGDS) on antioxidant properties, lipid metabolism, and liver and kidney functions of rats with paracetamol (750 mg/kg) induced hepatotoxicity. MATERIALS/METHODS: RGDS was added to the basal diet at 5, 10, and 20%. Thirty five adult male rats were assigned to five groups (n = 7) for a six-week feeding period; group (1) normal control, group (2) induced control, groups (3, 4, and 5) fed a diet with RGPS at different levels, 5, 10, and 20%, respectively. At the end of the feeding period, animals' blood and tissues were collected for estimation of serum lipid profile, serum liver, and kidney biomarkers. The protection was measured by detecting lipid peroxidation (LPO), glutathione (GSH), superoxide dismutase (SOD), Catalase (CAT) (in liver tissues), and liver histological examination. RESULTS: The results showed a significant (P < 0.05) decrease in levels of serum cholesterol, triglycerides, low density lipoprotein (LDL-C), and very low density lipoprotein (VLDL-C), with a significant increase in level of high density lipoprotein (HDL-C) for RGDS groups compared to induced control. Rats administered a diet containing RGDS levels produced significant (P < 0.05) hepatoprotection by decreasing the activities of liver enzymes, kidney parameters, and lipid peroxidation, while levels of GSH, SOD, and CAT were increased significantly to near the normal levels. CONCLUSION: The RGDS 20% group was more effective than others against hepatotoxicity of paracetamol, which may be attributed to RGDS total phenols and antioxidant contents, which were 1.438 mg and 1.231 mg, respectively.

• The Korean Journal of Physiology and Pharmacology
• /
• 제18권6호
• /
• pp.469-474
• /
• 2014

DWP208 is a sodium succinate form of ZYM-201 which is a triterpenoid glycoside isolated from Sanguisorba officinalis, a medicinal plant prescribed for various diseases, such as duodenal ulcers and bleeding in East Asian counties. We demonstrated that this compound is able to normalize the altered lipid metabolism induced by hyperglycemia and a high fat diet. In this study, we determined whether hyperlipidemic conditions induced with chronically treated alcohol can also be restored by DWP208. Similar to our previous results, orally administered DWP208 (1 to 10 mg/kg) also ameliorated the hyperlipidemia that was induced by alcohol. This compound reversed the alcohol-induced hyperlipidemia including (i) up-regulated hyperlipidemic parameters such as low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), atherosclerotic index (AI), triglyceride, and total cholesterol, and (ii) down-regulated hyperlipidemic parameters such as absolute body weight, superoxide dismutase (SOD) activity, and high-density lipoprotein (HDL) in serum and liver. According to our data, the ameliorative activity of DWP208 is due to its indirect anti-oxidative activity as a result of which lipid peroxide and hydroxyl radical levels were reduced and the activity of SOD was enhanced. Therefore, our data strongly suggest that DWP208 can be used as a remedy against alcohol-induced hyperlipidemia.

• Child Health Nursing Research
• /
• 제7권2호
• /
• pp.213-224
• /
• 2001

This study was conducted to identify the effect on the weight control of the REBT group program as a nursing intervention. For this purpose, non-equivalent control group design with pretest and posttest and follow-up test as quasi-experiment was used. Subjects of the study were consisted of twenty-four obese girls (Experimental group: 10, control group: 14) who appeared to having above 20％ of the body mass index from ane high school in M city. The whole program was carried out from January to June, 2000. Used dependent variables for evaluating the effect of the REBT group program including were weight control belief(rational thinking, emotion about exercise, eating self-efficacy, eating behavior), body mass index and serum lipids(total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein). For evaluating the effect of the program, dependent variables was analyzed by experimental stages three times; the first week, the fourth week, and the eighth week since the experimental input began. Data were analyzed by the SAS PC＋ program with t-test, repeated measure ANOVA to determine the effect of program. The results of this study can be summarized as follows; 1. After the REBT group program, only eating self-efficacy among the weight control belief of experimental group was significantly increased than that of control group. 2. After the REBT group program, body mass index of experiment group was significantly decreased than that of control group. 3. After the REBT group program, triglyceride and low density lipoprotein among the serum lipids in the experiment group were significantly decreased than those of control group.

• Clinical Nutrition Research
• /
• 제13권1호
• /
• pp.22-32
• /
• 2024

Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disorder with widespread synovitis. Isoflavones, the main active component of soy, have been reported to have potent anti-inflammatory effects; the previous RA animal models showed the promising effect of soy supplementation. We aimed to evaluate the effect of soy bread on inflammatory markers and lipid profiles in RA patients. The present study was designed as a randomized controlled trial. RA patients were randomly allocated to obtain soy bread (n = 22) or placebo bread (n = 22) for 8 weeks. Fasting serum levels of lipid profile, total antioxidant capacity (TAC), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and DAS28 were checked. Findings showed that there were no significant differences between the two groups in physical activity and dietary intake at the beginning of the study and the end of the study. There were no significant differences between the two groups in measured lipid profile markers, including high-density lipoprotein, low-density lipoprotein, total cholesterol, triglyceride, and very low-density lipoprotein, at the end of the trial. In addition, TAC and CRP also were not significant at the end of the trial between the 2 groups (0.66 and 0.12, respectively). However, the serum levels of TNF-α reduced significantly in the soy bread group at the end of the intervention (p < 0.000) and compared with the control group (p < 0.019). Soy bread consumption only decreased circulating TNF-α serum concentration. Other outcome measures were not changed following supplementation. Future long-term, well-designed studies are needed to confirm these findings.

• 대한임상검사과학회지
• /
• 제50권3호
• /
• pp.236-244
• /
• 2018

타우린은 심혈관 질환을 예방하고 간 기능 개선 및 당뇨병 및 혈소판 기능을 향상시키는 여러 작용을 보고하고 있다. 하지만, 타우린이 인체에 미치는 영향에 대하여 우리나라에서 연구된 결과가 많지 않다. 이에 기본 용량을 복용 후 혈당질환과 간질환, 지질 질환에 대한 영향을 알아보고자 하였다. 대상자는 타우린 복용군 15명과 대조군 15명을 대상으로 시행하였다. 타우린은 기본 용량인 1,000 mg을 식후에 2주 동안 복용 후 변화를 확인하였다. 대상자 모두 기숙사에서 제공하는 식사 외에 약이나 기타 음식을 절제하도록 하였다. 그 결과 타우린 복용군에서 간 기능 검사인 GGT는 섭취 전 $23.53{\pm}25.73IU/L$, 섭취 후 $15.15{\pm}4.91IU/L$로 감소하였다(P=0.186). 지질 대사인 TG는 섭취 전 $100.4{\pm}28.33mg/dL$, 섭취 후 $80.22{\pm}17.08mg/dL$로 유의한 결과를 보였다(P<0.05). T-cho, LDL-C이 감소를 보였고, HDL-C이 약간 증가를 보였다. 결과적으로 간 기능과 지질대사 개선에 도움을 주는 것으로 나타났다. 혈액학적 검사에서는 segmented neutrophil 백분율이 감소하고, lymphocyte 백분율이 증가를 보였다. 결과적으로 면역학적 기능과 관계가 있으리라 사료된다.

• 대한한방내과학회지
• /
• 제31권3호
• /
• pp.569-577
• /
• 2010

Background & Objectives : Yellow fur on the tongue is known to be associated with prognosis of disease in oriental medicine. Higher ratios of low-density lipoprotein cholesterol(LDL) to high-density lipoprotein cholesterol(HDL) & total cholesterol (TC) to high-density lipoprotein cholesterol(HDL) are associated with a greater risk of cardiovascular disease. The aim of this study was to assess the relationship between cardiovascular disease index and yellow fur - oriental medical index - in stroke patients over 60 years old. Methods & Subjects : Among 802 of the recruited patients(434 male, 368 female), 340 were yellow fur group(209 male, 131 female). We assessed their general characteristics and risk factors. We compared the cardiovascular disease index between yellow fur and non-yellow fur groups by sex. Results : On the General Characteristics males have yellow fur more often than females. In cardiovascular disease index, the male yellow fur group showed higher ratios of TC/HDL(atherogenic index), (TC-HDL)/HDL, LDL/HDL and higher LDL and showed lower HDL than the non-yellow fur group. In female patients, there were no differences between the two groups about cardiovascular disease index. There were more patients diagnosed with Fire & Heat in the male yellow fur group, and Dampness & Phlegm in the male non-yellow fur group. The male yellow fur group eat fast food more than the non-yellow fur group. Conclusions : The results indicated that yellow fur may be associated with a high risk of cardiovascular disease. We can thus use yellow fur on the tongue as a cardiovascular disease index in male stroke patients over 60 years old.

• 한국방사선학회논문지
• /
• 제14권7호
• /
• pp.863-870
• /
• 2020

본 연구는 연령대별로 복부 초음파 검사로 진단된 지방간 등급과 고지혈증 및 비만 지표와의 상관관계를 분석하고자 하였다. 충북 소재 H검진센터에서 복부초음파 검사를 받은 다양한 성별 및 나이대의 총 1470명의 검진자들을 대상으로 하였다. 복부 초음파 검사로 진행된 검진자들을 연령대별(20대, 30대, 40대, 50대, 60대 이상)로 정상과 지방간 환자로 분류하였다. 지방간의 정도는 세부적으로 경도, 중등도, 고도로 분류하였다. 고지혈증 지표로 총콜레스테롤, 중성지방, 저밀도 및 고밀도지질단백 콜레스테롤을 대상으로 하였으며, 비만지표로 신장, 체중, 체질량지수, 허리둘레를 검사하였다. 통계 분석은 연령대별 인구학적 기술통계분석과 빈도분석을 수행하였다. 고지혈증과 비만 지표의 평균의 차이와 상관관계를 분석하였다. 그 결과, 고령일수록 성별과 관계없이 지방간이 있었으며, 모든 연령대에서 중성지방, 고밀도지단백질 콜레스테롤, 체중, 체질량지수, 허리둘레가 지방간 유무의 유의한 차이를 보였다. 지방간의 정도에 따른 연령대별 상관관계에서는 허리둘레와 체질량지수가 가장 높은 양(+)의 상관관계를 보였다.