• Title/Summary/Keyword: Loss of head

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The Analysis of Mitochondrial DNA in the Patients with Essential Tremor and Parkinson's Disease (본태성 수전증과 파킨슨병 환자에서 미토콘드리아 DNA 비교 분석)

  • Kim, Rae Sang;Yoo, Chan Jong;Lee, Sang-Gu;Kim, Woo-Kyung;Han, Ki-Soo;Kim, Young-Bo;Park, Cheol-Wan;Lee, Uhn
    • Journal of Korean Neurosurgical Society
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    • v.29 no.11
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    • pp.1415-1420
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    • 2000
  • Essential tremor(ET) is the most common movement disorder however there has been little agreement in the neurologic literature regarding diagnostic criteria for ET. Familial ET is an autosomal dominant disorder presenting as an isolated postural tremor. The main feature of ET is postural tremor of the arms with later involvement of the head, voice, or legs. In previous studies, it was reported that ET susceptibility was inherited in an autosomal dominant inheritance. As with previous results, it would suggest that ET might be associated with defect of mitochondrial or nuclear DNA. Recent studies are focusing molecular genetic detection of movement disorders, such as essential tremor and restless legs syndrome. Parkinson's disease(PD) is a neurodegenerative disease involving mainly the loss of dopaminergic neurons in substantia nigra by several factors. The cause of dopaminergic cell death is unknown. Recently, it has been suggested that Parkinson's disease many result from mitochondrial dysfunction. The authors have analysed mitochondrial DNA(mtDNA) from the blood cell of PD and ET patients via long and accurate polymerase chain reaction(LA PCR). Blood samples were collected from 9 PD and 9 ET patients. Total DNA was extracted twice with phenol followed by chloroform : isoamylalcohol. For the analysis of mtDNA, LA PCR was performed by mitochondrial specific primers. With LA PCR, 1/3 16s rRNA~1/3 ATPase 6/8 and COI~3/4 ND5 regions were observed in different patterns. But, in the COI~1/3 ATPase 6/8 region, the data of PCR were observed in same pattern. This study supports the data that ET and PD are genentic disorders with deficiency of mitochondrial DNA multicomplexes.

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A Study on the Effects of Various Disk Shape of Hydrant on the Pressure Drop (옥외소화전의 디스크 형상을 고려한 압력손실에 관한 연구)

  • You, Woo Jun;Shim, Myoung Gyu;Sung, Kun Hyuk;Yu, Jae Bum;Youm, Moon Cheon;Ryou, Hong-Sun
    • Fire Science and Engineering
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    • v.27 no.6
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    • pp.1-7
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    • 2013
  • In this study, the effects of various disk shapes of hydrant on the pressure drop are experimentally and numerically analyzed. The test methods for measuring pressure drop of hydrant are comply with standard of Underwriters Laboratory (UL). The hydrant as used in this study has one inlet, diameter 150 mm, and three outlet, 114.3 mm diameter for one outlet and 63.5 mm diameter for the others. The pressure of the hydrant are measured in the range 760 L/min~2,270 L/min for 63.5 mm outlet and 3,030 L/min~6,060 L/min for 114.3 mm outlet. Also, the numerical results of pressure drop are compared with the experiments to verify the accuracy and to analyze the of various valve shape of hydrant on the pressure drop. The engineering parameters, flow coefficients, are reduced from 181.57 to 136.35 ($L/min/kPa^{0.5}$) with inclined angle of disk from $0^{\circ}$ to $45^{\circ}$. These results are able to practical use for design hydrant to minimize pressure drop.

Simultaneous Carbon and Nitrogen Removal Using an Integrated System of High-Rate Anaerobic Reactor and Aerobic Biofilter (고효율 혐기성반응조 및 호기성여상 조합시스템에 의한 질소·유기물 동시 제거)

  • Sung, Moon Sung;Chang, Duk;Seo, Seong Cheol;Chung, Bo Rim
    • Journal of Korean Society of Water and Wastewater
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    • v.13 no.2
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    • pp.55-65
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    • 1999
  • AF(anaerobic filter)/BAF(biological aerated filter) system and UASB(upflow anaerobic sludge blanket)/BAF system, of which system effluents were recirculated to the anaerobic reactors in each system, were operated in order to investigate the performance in simultaneous removal of organics and nitrogen in high-strength dairy wastewater. Advanced anaerobic treatment processes of AF and UASB were evaluated on applicability as pre-denitrification reactors, and BAF was also evaluated on the performance in oxidizing the remaining organics and ammonia nitrogen. At system HRTs of 4.0 to 4.5 days and recirculation ratios of one to three, the AF/BAF system could achieve more than 99% of organics removals and 64 to 78% of total nitrogen removals depending upon the recirculation ratio. Although the UASB/BAF system also showed more than 99% of organics removals, total nitrogen removals in the UASB/BAF system were 53 to 66% which are lower than those in the AF/BAF system at the corresponding recirculation ratios. Optimum recirculation ratios considering simultaneous removal of organics and nitrogen and cost-effectiveness, were in the range of two to three. The upflow AF packed with crossflow module media, as a primary treatment of the anaerobic reactor/BAF system, showed better performances in denitrification, SS removals, and gas production than the UASB. Higher loading rate of suspended solids from the UASB increased the backwashing times in the following BAF. Especially, at a recirculation ratio of three in the UASB/BAF system, the increase in head loss due to clogging in the BAF caused frequent backwashing, at least once d day. The BAF showed the high nitrification efficiency of average 99.2% and organics removals more than 90% at organics loading rate less than $1.4KgCOD/m^3/d$ and $COD/NH_3-N$ ratio less than 6.4. It was proved that the simplified anaerobic reactor/BAF system could maximize the organics removal and achieve high nitrogen removal efficiencies through recirculation of system effluents to the anaerobic reactor. The AF/BAF system can, especially, be a cost effective and competitive alternative for the simultaneous removal of organics ana nitrogen from wastewaters.

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Clinical Study of Empyema Thoracis (농흉에 대한 임상적 고찰)

  • Kim, Tae-Nyeun;Lee, Young-Hyun;Chung, Jae-Chun;Kim, Chong-Suhl
    • Journal of Yeungnam Medical Science
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    • v.3 no.1
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    • pp.87-94
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    • 1986
  • Empyema thoracis following pneumonia, intra-abdominal pathology, trauma, and surgical procedure continues to be a source of major morbidity and mortality. Thirty seven adult and eleven pediatric patients with empyema thoracis were treated at the University of Yeungnam Medical Center from May 1983 to November 1986. Age distribution ranged from 6 months to 72 years and showed a double-peaked curve with the highest incidence between 36 and 65 years and below 15 years of age. There were male predominence in patients above 16 years of age. The most common predisposing factors was impaired consciousness due to either alcoholism or head injury. The causes of empyema were as follows: pneumonia 64.6%, lung abscess 6.4%, intraabdominal pathology 6.4%, and surgical procedure 6.4%. The cardinal symptoms were fever, cough, chest pain, dyspnea, sputum, weight loss, anorexia, and night sweat in orders. Culture of empyema fluid were positive in 50% of patients. The isolated organisms were Gram-negative bacilli 33.3%, staphylococcus aureus 25%, and streptococcus 25%. The patients received antibiotics in conjunction with various invasive procedures : chest tube drainage 77.1%, decortication 6.3%, and repeated thoracentesis 10.3%. There were 4 deaths, 1 child and 3 adults, with a overall mortality of 8.3%.

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Extraction of Sternocleidomastoid Muscle for Ultrasound Images of Cervical Vertebrae (경추 초음파 영상에서 흉쇄유돌근 추출)

  • Kim, Kwang-Baek
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.15 no.11
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    • pp.2321-2326
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    • 2011
  • Cervical vertebrae are a complex structure and an important part of human body connecting the head and the trunk. In this paper, we propose a method to extract sternocleidomastoid muscle from ultrasonography images of cervical vertabrae automatically. In our method, Region of Interests(ROI) is extracted first from an ultrasonography image after removing unnecessary auxiliary information such as metrics. Then we apply Ends-in search stretching algorithm in order to enhance the contrast of brightness. Average binarization is then applied to those pixels which its brightness is sufficiently large. The noise part is removed by image processing algorithms. After extracting fascia encloses sternocleidomastoid muscle, target muscle object is extracted using the location information of fascia according to the number of objects in the fascia. When only one object is to be extracted, we search downward first to extract the target muscle area and then search from right to left to extract the area and merge them. If there are two target objects, we extract first from the upper-bound of higher object to the lower-bound of lower object and then remove the fascia of the target object area. Smearing technique is used to restore possible loss of the fat area in the process. The thickness of sternocleidomastoid muscle is then calculated as the maximum thickness of those extracted objects. In this experiment with 30 real world ultrasonography images, the proposed method verified its efficacy and accuracy by health professionals.

Studies on Intestinal Trematodes in Kores XIV. Infection Status of Loaches with Metacercariae of Echinostoma cinetoychis and Their Development in Albino Rats (한국의 간흡충에 관한 연구 XIV. 미꾸리의 이전고환극구흡충(Echinostoma cinertorchis) 피낭유충 감염상황 흰쥐내에서의 성장발육)

  • 서병설;박양의
    • Parasites, Hosts and Diseases
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    • v.22 no.2
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    • pp.181-189
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    • 1984
  • The metacercariae of Echinostoma cineterchis (Trematoda: Echinostomatidae) were found infected in the loaches (Misgurnus anguillicaudatus) purchased from two local markets in Korea. Identification of the metacercariae was done after obtaining adult worms from experimentally infected albino rats. Brief course of worm development in rats was also observed up to 28th post-infection day. The results are as follows: 1. The metacercariae of E. cinetorchis were detected from 5 (10.9%) out of 46 loaches examined and the average metacercarial burden per infected loach was 34.4. They were always found from the posterior abdominal wall. 2. The worm recovery rate from 8 rats was 24.6% in average. It was observed that the rate decreased according to age of infection; from 40.7% after 6 days to 15.0% after 28 days. 3. The adult worms were morphologically characterized by the presence of head crown with derfally uninterrupted collar spines, 37-38 in number, and the tendency of migration or disappearance of testes. So that they were identified as Echinostoma cinetorchis Ando et Ozaki, 1923. 4. The development of worm was very rapid during 6-10 days after infection and became much slower thereafter. During the rapid worm growth the development of genital organs was more prominent than that of non-genital organs. From the results it is concluded that the loach is involved in the life cycle of E. cinetorchis in this country and may take a role for infection source to animals and man. It is also confirmed that migration or loss of testes is the distinct specific character of this echinostomatid fluke.

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Fungal Distribution and Varieties Resistance to Kernel Discoloration in Korean Two-rowed Barley (국내 육성 2조 겉보리 변색 종실에서의 곰팡이 분포와 품종 저항성)

  • Shin, Sang-Hyun;Seo, Eun-Jo;Choi, Jae-Seong;Kang, Chun-Sik;Lee, JungKwan;Park, Jong-Chul
    • Research in Plant Disease
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    • v.19 no.3
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    • pp.183-187
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    • 2013
  • Barley kernel discoloration (KD) leads to substantial loss in value through downgrading and discounting of malting barley. The objective of this research is to investigate fungal distribution and varieties resistance to KD in Korean two-rowed barley. Several fungal organisms including Alternaria spp., Fusarium spp., Aspergillus spp., Epicoccum spp. and Rhizopus spp. were isolated from Korean two-rowed barley representing KD. The symptoms of KD were brown and black discolorations of the lemma and palea. The most frequently detected fungal species was Alternaria spp. which exhibited 69.1% and 72.2% in 2011 and 2012, respectively. Epicoccum spp., Fusarium spp., and Aspergillus spp. were also detected. Fusarium spp., primary pathogen of barley head blight, were rarely occurred in the 2011 and their occurrence increased to 4.7% in 2012. Twenty cultivars of Korean two-rowed barely were evaluated to KD. The average percentage of KD was 8.0-36.0% in 2011 and 5.2-36.6% in 2012. Two cultivars ('Sacheon 6' and 'Dajinbori') showed KD of 6.2% to 8.8% and determined resistant, however 'Samdobori' and 'Daeyeongbori' demonstrating KD of 22.2-36.6% were highly susceptible. 'Jinyangbori', 'Danwonbori', 'Sinhobori' and 'Kwangmaegbori' showing KD of less than 15% were moderately resistant cultivar.

Development of Birdcage Resonator for Various Absorption Regions at 3T (3T MRI에서 흡수영역의 변화에 따른 Birdcage Resonator의 개발)

  • 이정우;최보영;윤성익;이형구;서태석;허순녕
    • Progress in Medical Physics
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    • v.15 no.1
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    • pp.54-58
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    • 2004
  • The aim of this study was to develop special birdcage resonators for small objects including the human wrist, hand and small animals, using 3T MRI/MRS. Before substantial development, different types of parameters were arranged, based on theoretical analysis, through lumped element transmission line theory. The primary analysis was peformed with a network analyzer (HP 4195A) and the final experimental analysis was carried out with 3T MRI (Medinus, Korea). The manufactured birdcage resonator is typically composed of 12-element structures to which a low-pass filter is fundamentally applied. The diameter and length of each element of the birdcage resonator were as follows: (1) diameter 12 cm, length of element 22 cm, (2) diameter 15 cm, length of element 22 cm, and (2) diameter 17 cm, length of element 25 cm. Copper tape with a width of 1 cm was used for the coils. MRI acquisition parameters were TR=500 ms, TE=17 ms, and Ave=2 for T1-WT images, and TR=4,000 ms, TE=96 ms, and Ave=2 for T2-WT images. The ratio of the samples diameter to the birdcage resonators diameter was approximately 55%, 63% and 70%, respectively, for the three elements. This study determined that the best image quality and S/N ratio were obtained when the ratio of the object's diameter was approximately 50∼80%. A general theoretical analysis of the birdcage coil differs in many respects from the experimental results which were influenced by many factors that were not considering when the general theoretical analysis of the birdcage coil was peformed. The induced resistance may be considered as part of the resistive loss if the quantitative value can be determined using a radiation resistance approach.

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Treatment of Complete Scalp Avulsion with the Conditions of Unstable Vital Signs: A Case Report (불안정한 생체징후 하의 두피 결출상 환자의 치험례)

  • Lee, Kang Woo;Kang, Sang Yoon;Yang, Won Yong;Burm, Jin Sik
    • Archives of Craniofacial Surgery
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    • v.12 no.2
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    • pp.116-120
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    • 2011
  • Purpose: Scalp avulsion is a life-threatening injury that may cause trauma to the forehead, eyebrows, and periauricular tissue. It is difficult to treat scalp avulsion as it may lead to severe bleeding. Therefore, emergency scalp replantation surgery is necessary, and we must consider the function, aesthetics, and psychology of the patients. A case of scalp avulsion leading to massive bleeding was encountered by these authors, which led to a failure to achieve the proper operation conditions in an adequate time period. Methods: A 49-year-old female was hospitalized due to having had her head caught in a rotatory machine, causing complete scalp avulsion which included the dorsum of the nose, both eyebrows, and ears. Emergent microsurgical replantation was performed, where a superficial temporal artery and a vein were anastomosed, but the patient's vital signs were too unstable for further operation due to excessive blood loss. Three days after the microanastomosis, venous congestion developed at the replanted scalp, and a medicinal leech was used. Leech therapy resolved the venous congestion. A demarcation then developed between the vitalized scalp tissue and the necrotized area. Debridement was performed 2 times on the necrotized scalp area. Finally, split-thickness skin graft with a dermal acellular matrix ($Matriderm^{(R)}$) was performed on the defective areas, which included the left temporal area, the occipital area, and both eyebrows. Results: The forehead, vertex, right temporal area, and half of the occipital area were successfully replanted, and the hair at the replanted scalp was preserved. As stated above, two-thirds of the scalp survived; the patient could cover the skin graft area with her hair, and could wear a wig. Conclusion: Complete scalp avulsion needs emergent replantation with microsurgical revascularization, but it often leads to serious vital conditions. We report a case with acceptable results, although the microanastomosed vessel was minimal due to the patient's unstable vital signs.

The Physiological Responses and Subjective Sensation in the Subjects Wearing Dust-free Garment for Semiconductor Industrial Environments (방진복 착용에 따른 인체의 온열생리적 특성 및 주관적 감각)

  • 권오경;이창미
    • Proceedings of the Korean Society for Emotion and Sensibility Conference
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    • 1998.04a
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    • pp.255-263
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    • 1998
  • Dust-free garment prevents contamination which otherwise is caused by skin and clothes to protect from dust or dirt. Therefore, it requires high performance and should function as a working clothes. Clothes are a medium between human and thermal environmental system, and it is required to study human enviroment to ensure comfortableness of clothes and to satisfactorily go along with enviroment .This study investigates the physical and physiological features of dust-free garment used in the clean room at a semiconductor factory in oredr to scientifically clarify what the dust-free garmint is as well as to contribute to the design and development of high performance material and clothes. Three kinds of dust-free fabrics (DFG-I, DFG-II, DFG-III) which are being developed by a local company are used to manufacture dust-free garment. These dust-free garments are dressed and tested in such an enviroment as similar to semiconmemts with temperature at 23${\pm}$1$^{\circ}C$ and humidity at 50${\pm}$5%RH in order to investigate the thermo physiological and psychological features of human body. The results of this study are as follows. The results of this study are as follows. 1.The mean skin temperature was significantly different among the clothes, subjects and experimental time. Temperature tends to rise from the time of exercising load. Continuous motion coupled sealed clothes prevents heat transmittance, and temperature rises in the order of DFG-l, DFG-ll and DFG-lll as time course. 2.As for the skin temperature by local timperature is minimun on the head and torso and increares remarkably at the terminal part of human body. 3. As for the body mass loss was significantly higher in DFG-lll than DFG-l and DFG-ll. 4. Though there is no significant difference in the temperature within clothes among the kind of clothes temperature is 1$^{\circ}C$ higher in the back. Temperature within all the dust-free garments 29.7$^{\circ}C$ in the back and 31.3$^{\circ}C$ in the chest which belong to the comfort zone(31-33$^{\circ}C$). The relative humidity is 39.7%RH in the chest and 33.8%RH in the back which is slightly below the comfort zone(40-60%RH) 5. The thermal sensation belong to the comfort zone regardless of the kinds of clothes. The subjects feels a slight fatigue as times goes. As for the subjective sense of subjects the mean skin temperature as well as temperature and humidity within clothes show similar tendency. This means that they relate with each other.

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