• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.14 no.2
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• pp.183-193
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• 2001

Background: Ramsay Hunt syndrome is a disease that cause faical palsy, ear pain, ear vesicle, tinnitus, hardness of hearing by geniculate ganglion herpes. Ramsay Hunt syndrome could be taken two sides view of herpes zoster and facial palsy. In traditional oriental medicine Ramsay Hunt syndrome could be diagnosed as heat and dryness syndromes. Object: These studies are clinical observations about two Ramsay Hunt syndrome patient cases that is recovered under the treatment by herbal-acupuncture therapy and moxibustion. Methods: For treatment in acute state, acupuncture therapy was used and in convalescent stage, herbal acupuncture therapy and moxibustion therapy were used. For diagnosis system, House-Brackmann system, Yanagihara's system used as diagnosis scales. Result&Conclusion: The results as follows. 1. Generally, to treat Ramsay Hunt syndrome, it is knwon that from invasion of virus to period of first effect a short term bring about good result, but in these two cases, though a long term. considerable effect was braught out. 2. In treating two cases, herbal acupuncture therapys what are called CF, JSD were used. satisfactory results was produced.

• Advances in Traditional Medicine
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• v.8 no.3
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• pp.207-214
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• 2008

In recent years, the combined use of Herbal medicines and Western drugs has been increasing. Though certain problems may occur when both types of medicines are taken together, they havenot been adequately analyzed. It was reported that anticoagulation was enhanced in addition tobleeding when patients took long-term warfarin therapy in combination with Salvia miltiorrhiza(danshen), and laxative herbs accelerate intestinal transit and interfere with the absorption. Herbal constituents, curcumin, ginsenosides, piperine, catechins and silymarin were found to beinhibitors of P-glycoprotein. St John's wort induces the intestinal expression of P-glycoprotein. Anthraquinone, quercetin and coumarins were found to be a potent inhibitor of P-450. Glycyrrhizin or liquorice extracts, Garlic and St John's wort are a potent inducer of CYP3A4. This review provides a critical overview of interactions between herbal medicines and other drugs. Hence, it is necessary to study the pharmacodynamic and pharmacokinetic interactions of many herbal medicines between western drugs.

• The Journal of Pediatrics of Korean Medicine
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• v.33 no.4
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• pp.89-99
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• 2019

Objectives The purpose of this study is to report a case of a child with alopecia areata who was reintroduced with the same herbal treatment that was used before. Methods The patient was treated for 10 months with the herbal medicine. After a relapse, this patient took the same herbal medicine for another 2 months. Results After the treatment, the patient's hair loss and hair conditions were improved. After a relapse, alopecia areata was resolved by reintroducing the same herbal medicine treatment, and the condition was maintained well for several months even after the end of the treatment. Conclusion This study shows the effects of the herbal medicine for alopecia areata in a child. However, further studies are needed, including long-term follow-up studies after the end of the treatment.

• The Journal of the Society of Stroke on Korean Medicine
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• v.16 no.1
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• pp.89-102
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• 2015

■ Objectives This study aimed to investigate the domestic research trend about Amyotrophic Lateral Sclerosis(ALS) treated with Traditional Korean Medicine(TKM). ■ Methods Searches of two major TKM databases were conducted for articles published up to July 2015. Searching keyword was "Lou Gehrig's disease" OR "amyotrophic lateral sclerosis". Studies dealt TKM for ALS were included. ■ Results 18 studies were met our inclusion criteria(two prospective studies, one retrospective study, one follow-up study, 14 case reports). Complex TKM intervention of herbal medication, acupuncture and pharmacopuncture was the most frequently used treatment. Individually, herbal medication was the most frequent followed by acupuncture. Short-term assessment showed improvement in ALS symptoms but long-term assessment showed progression of disease. Accessory symptoms including depression, anxiety and insomnia were improved in four studies. ■ Conclusion For more definite evidence, larger studies with long-term follow-up period are needed. Moreover, benefits that TKM can provide for ALS patients as a part of multi-disciplinary approach should be studied in depth.

• The Journal of Pediatrics of Korean Medicine
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• v.31 no.1
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• pp.74-81
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• 2017

Objectives The purpose of this study is to report the case of precocious puberty in two children treated by taking herbal medicine. Methods Two patients diagnosed with precocious puberty were prescribed Jogyeongseongjang-tang and were observed the effect of treatment on height, body weight, body composition, sex hormone test. Results During the treatment period, rapid progression of puberty was inhibited, and slow changes in sex hormones and steady growth were achieved. Conclusions This study showed the long-term effects of herbal medicine in treating precocious puberty, but further studies should be conducted for scientific validation.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.3
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• pp.65-80
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• 2007

Purpose: This study is to examine anti-obesity effect and cytotoxicity of the long-term oral administration of Ephedra Sinica(Ma-hwang, ES) Methods: Using diet-induced obesity C57BL/6 mouse model, anti-obesity effect and DNA chip expression and cytotoxicity of the long-term oral administration of this herbal extract were investigated. Results: The herbal extract treated groups were arrested in weight increment only when they were lodged together. Such effects were abolished when they kept individually. ES fed mice behaved very rudely and violently. On the basis of histological studies of liver tissues and also in vitro cytotoxicity tests of the liver and kidney cell lines, no significant toxicity was found by 14 weeks of ES treatments. However, we found significant changes in gene expression profile in ES treated group by micro-array analysis. In case of ES group, up-regulated genes were 113 and down-regulated were 120. Some of lipid metabolism related genes also significantly changed in treatment groups. Conclusion: ES had effects of increasing the basal metabolic rate by stimulating the sympathetic nervous systems.

• The Journal of Korean Medicine
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• v.32 no.1
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• pp.12-35
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• 2011

Objectives: The two criteria to clarify the toxicity of a herbal diet are well known. Although mechanical analysis of effective ingredients, a western approach, is widely used, the toxicity presence classification through the herbal analysis from a viewpoint of a theory of the herbal medicine properties has been disregarded. This study is for the safe use of a herbal diet through classification and study of toxicity presence in the herbal diet from the view of a theory of herbal medicine properties, one of the methods of Oriental Medicine. Methods: We classified and studied the toxicity presence in four kinds of herbal diets, waters and grains, animals groups, fruits and vegetables, and herbs and trees, excluding mineral natural drugs, of 1,400 kinds of medicines in 16 chapters of Tang-aec-pyeon, Dong-ui-bo-gam, for which the herbal analysis from a viewpoint of the theory of the herbal medicine properties has been used. The criteria of the toxicity presence in the herbal diet have been largely classified into the toxicant and the non-toxicant, and the toxicant is in turn classified into the insignificant, the medium and the significant. The category to clarify herbal diet has been limited to simultaneous utilization of food and natural drugs. The main text is Dong-ui-bo-gam, although diverse other references have also been used. Results: There are toxicant diets: a kind of tortoise meat of animals groups; five kinds of grains part in fruits and vegetables: aengdo, peach, oyat, small apple and gingko nut; and 12 kinds of vegetables part in fruits and vegetables: ginger, oriental cabbage, lettuce, chongbaek, onion, garlic, leek, fern, houttuynia cordata (myeol), pyeongji, geundae, and spinach, which should be prohibited from long-term use both as food and medicine. Conclusion: If herbal diet is used as health food supplements or food, the toxicity presence should be considered on the grounds of an Oriental Medicine theory of the herbal medicine properties.

• Journal of Oriental Neuropsychiatry
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• v.32 no.3
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• pp.285-302
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• 2021

Objectives: To examine the effect of long-term Korean medicine treatment on mild cognitive impairment (MCI). Methods: This study was conducted on two patients who were diagnosed with mild cognitive impairment and received long-term Korean medicine treatment. In order to evaluate the degree of cognitive decline, SNSB and K-MMSE were performed 2~3 times at the first visit and during the treatment process. Results: Both cases 1 and 2 were diagnosed with MCI with a high possibility of developing dementia. In case 1, MCI progressed to early dementia at one year after the diagnosis of MCI. However, in case 2, that MCI status was maintained without progressing to dementia for 4 years after the diagnosis of MCI. The cause of such difference in the course of MCI might be attributed to the fact that Case 1 had lower K-IADL level but higher SGDS level than Case 2 at the time of initial diagnosis, with weak family support and irregular herbal medicine intake. Conclusions: Korean medicine treatment could improve and manage symptoms of cognitive decline due to MCI.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.4
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• pp.41-55
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• 2007

Purpose: This study is to examine anti-obesity effect and cytotoxicity of the long-term oral administration of Sinomenium acutum (Bang-gi, SA) Methods: Using diet-induced obesity C57BL/6 mouse model, anti-obesity effect and DNA chip expression and cytotoxicity of the long-term oral administration of this herbal extract were investigated. Results: The herbal extract treated groups were arrested in weight increment only when they were lodged together. Such effects were abolished when they kept individually. SA fed mice behaved very rudely and violently. On the basis of histological studies of liver tissues and also in vitro cytotoxicity tests of the liver and kidney cell lines, no significant toxicity was found by 14 weeks of SA treatments. However, we found significant changes in gene expression profile in SA treated group by micro-array analysis. In case of SA group, up-regulated genes were 1,213 and down-regulated ones were 2,558. Some of lipid metabolism related genes also significantly changed in both treatment groups. Conclusion: SA had effects of increasing the basal metabolic rate by stimulating the sympathetic nervous systems.

• The Journal of Pediatrics of Korean Medicine
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• v.27 no.1
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• pp.1-6
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• 2013

Objectives This clinical study was aimed to examine the effects of herbal medicine and acupuncture on early onset - essential tremor and report on the therapeutic progress. Methods Herbal medication (Kamiyangsintang) and acupuncture were used for treatment. Also, VAS scale were used to check the improvement. Results The hands tremor was relieved during 4 months of treatment. However, the symptom was aggravated after one and a half years. The patient has shown improvement after retreatment. Conclusions This study showed that child patient diagnosed with essential tremor who received Kamiyangsintang and acupuncture treatments was improved. However, it also can be aggravated depending on the patients and their body condition. More cases and long-term observation in relation to early onset of tremor are required.