• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.22 no.4
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• pp.303-329
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• 2019

Intestinal failure (IF) is the critical reduction of the gut mass or its function below the minimum needed to absorb nutrients and fluids required for adequate growth in children. Severe IF requires parenteral nutrition (PN). Pediatric IF is most commonly due to congenital or neonatal intestinal diseases or malformations divided into 3 groups: 1) reduced intestinal length and consequently reduced absorptive surface, such as in short bowel syndrome (SBS) or extensive aganglionosis; 2) abnormal development of the intestinal mucosa such as congenital diseases of enterocyte development; 3) extensive motility dysfunction such as chronic intestinal pseudo-obstruction syndromes. The leading cause of IF in childhood is the SBS. In clinical practice the degree of IF may be indirectly measured by the level of PN required for normal or catch up growth. Other indicators such as serum citrulline have not proven to be highly reliable prognostic factors in children. The last decades have allowed the development of highly sophisticated nutrient solutions consisting of optimal combinations of macronutrients and micronutrients as well as guidelines, promoting PN as a safe and efficient feeding technique. However, IF that requires long-term PN may be associated with various complications including infections, growth failure, metabolic disorders, and bone disease. IF Associated Liver Disease may be a limiting factor. However, changes in the global management of IF pediatric patients, especially since the setup of intestinal rehabilitation centres did change the prognosis thus limiting "nutritional failure" which is considered as a major indication for intestinal transplantation (ITx) or combined liver-ITx.

• Journal of the Society of Disaster Information
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• v.15 no.2
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• pp.239-248
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• 2019

Purpose: This study aims to enhance the resistance against sulfate attack compared to ordinary Portland cement (OPC) concrete by using liquid crystal display (LCD) as binder. Method: The fundamental properties including compressive strength and porosity of concrete replaced by LCD up to 15% at increments of 5% and in turn, the weight, volume, and strength loss of LCD-mixed concrete was analyzed. Results: For the concrete substituted by 5% of LCD, it showed the highest compressive strength at 28 days of curing, and particular at immersion of $Na_2SO_4$ solution, it was achieved the lowest loss of weight, volume and strength due to an decreased porosity at capillaries. In contrast, there is no distinct difference of the sulfate attack resistance between LCD-mixed concretes under exposure of $MgSO_4$ solution, excepted for OPC concrete. Conclusion: In this study, comparison of resistance to sulfate attack between LCD-mixed concretes, and it would be proposed the possibility of LCD usage as binder through long-term verification with extended replacement ratio and identification of changes of hydrates in the cement matrix.

• Journal of Environmental Science International
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• v.27 no.11
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• pp.1029-1048
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• 2018

In this study, seasonal Mann - Kendall test method was applied to 12 stations of the water quality measurement network of Nam-River based on data of BOD, COD, TN and TP for 11 years from January 2005 to December 2015 The changes of water quality at each station were examined through linear trends and the tendency of water quality change during the study period was analyzed by applying the locally weighted scatter plot smoother (LOWESS) method. In addition, spatial trends of the whole Nam-River were examined by items. The flow-adjusted seasonal Kendall test was performed to remove the flow at the water quality measurement station. As a result, BOD, COD concentration showed "no trand" and TN and TP concentration showed "down trand" in regional Kendall test throughout the study period. BOD and TP concentration in "no trand", COD, and TN concentration showed an "up trand" tendency in Nam-River dam. LOWESS analysis showed no significant water quality change in most of the analysis items and stations, but water quality fluctuation characteristics were shown at some stations such as NR1 (Kyungho-River 1), NR2 (Kyungho-River 2), NR3 (Nam-River), NR6 (Nam-River 2A). In addition, the flow-adjusted seasonal Kendall results showed that the BOD concentration was "up trand" due to the flow at the NR3 (Nam-River) station. The COD concentration was "up trand" due to the flow at NR1 (Kyungho-River 1) and NR2 (Kyungho-River 2) located upstream of the Nam-River. The effect of influent flow on water quality varies according to each site and analysis item. Therefore, for the effective water quality management in the Nam-River, it is necessary to take measures to improve the water quality at the point where the water quality is continuously "up trand" during the study period.

• Journal of the Korean Institute of Landscape Architecture
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• v.47 no.2
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• pp.133-145
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• 2019

This study was raised by the need to explain why the problems related to private parks have been sustained. In order to identify the fundamental cause, it is necessary to analyze the historical and institutional context of private parks. Therefore, the purpose of this study is to identify the direction of change in the private park system and to derive the characteristics of the system as it currently appears. The framework based on the historical institutionalism was divided into the Park Act (1967-1980), the former of Urban Park Act (1980-1993) and the late of Urban Park Act (1993-2005), and each was assessed using the analysis elements of the institutional environment and the outcomes of implementation. The analysis elements interpreted the path dependency, in which the inertia toward the choice of institution is maintained, despite the change in the environment. The institution took a special form of 'negative systeme' and secured profitability by expanding the types of park facilities while mitigating the criteria. Additionally, the designation of private park promoters as a landowner acted as a means of compensating those with property rights to unexecuted urban parks. The expectation effectiveness on urban park creation was insufficient and the environmental regulatory functions were weakened. Thus, historically, the private park system in Korea has experienced an 'institutional decoupling' as the purpose of the system and the results of actual outcomes are not consistent.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.3
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• pp.379-385
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• 2019

Osteoporosis is a disease that increases the risk of fractures by inducing a decrease in bone strength by the changes in hormones and a decrease in minerals. Recent reports have indicated that the long-term administration of Adefovir dipivoxil (ADV), which is used as a treatment for the hepatitis virus and AIDS, may have osteoporotic side effects. On the other hand, there are few studies on the cytopathic correlation of these causes. In this study, the biological relevance of ADV was evaluated using osteoblast hFOB1.19 and vascular endothelial cell HUVEC. First, the cells were treated with ADV at different concentrations, and DAPI and crystal violet staining were performed for morphological analysis of each cell and nucleus. A CCK-8 assay, real-time PCR, alkaline phosphatase (ALP) staining, and activity was performed to evaluate the drug effects on cell proliferation, gene expression, and osteoblast differentiation. As a result, ADV induced cell hypertrophy in hFOB1.19 cells and HUVEC cells. Furthermore, ADV not only inhibited cell proliferation and TGF-${\beta}$ expression but was also involved in osteoblast differentiation. Overall, these results provide basic data to help better understand the mechanism of ADV-induced osteoporosis and its clinical implications.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.5
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• pp.27-35
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• 2019

The purpose of this study is to analyze the displacement characteristics in slow-moving landslide area using digital elevation model and airborne LiDAR when unpredictable disaster such as slow-moving landslide occurred. We also aimed to provide basic data for establishing a rapid, reasonable and effective restoration plan. In this study, slow-moving landslide occurrence cracks were selected through the airborne LiDAR data, and the topographic changes and the scale of occurrence were quantitatively analyzed. As a result of the analysis, the study area showed horseshoe shape similar to the general form of slow-moving landslide occurrence in Korea, and the direction of movement was in the north direction. The total area of slow-moving landslide damage was estimated to about 2.5ha, length of landsldie scrap 327.3m, average width 19.3m, and average depth 8.6m. The slow-moving landslides did not occur on a large scale but occurred on the adjacent slope where roads were located, caused damage to retaining walls and roads. The field survey of slow-moving landslides was limited by accessibility and safety issues, but there was an advantage that accurate analysis was possible through the airborne LiDAR. However, because airborne LiDAR has costly disadvantages, it has proposed a technique to mount LiDAR on UAV for rapidity, long-term monitoring. In a slow-moving landslide damage area, information such as direction of movement of cracks and change of scale should be acquired continuously to be used in restoration planning and prevention of damage.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.36 no.4
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• pp.105-112
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• 2018

This study aims to apply 3D scanning technology to the field of landscape planning design. Through this, 3D scans were conducted on Soswaewon Garden and Seongrakwon Gardens to find directions for traditional landscape planning and designs. The results as follows. First, the actual measurement of the traditional garden through a 3D scan confirmed that a precise three-dimensional modeling of ${\pm}3-5mm$ error was constructed through the merging of coordinate values based on point data acquired at each observation point and postprocessing. Second, as a result of the 3D survey, the Soswaewon Garden obtained survey data on Jewoldang House, Gwangpunggak Pavilion, the surrounding wall, stone axis, and Aeyangdan wall, while the Seongnakwon Garden obtained survey data on the topography, rocks and waterways around the Yeongbyeokji pond area. The above data have the advantage of being able to monitor the changing appearance of the garden. Third, spatial information developed through 3D scans could be developed with a three-dimensional drawing preparation and inspection tool that included precise real-world data, and this process ensured the economic feasibility of time and manpower in the actual survey and investigation of landscaping space. In addition, modelling with a three-dimensional 1:1 scale is expected to be highly efficient in that reliable spatial data can be maintained and reprocessed to a specific size depending on the size of the design. In addition, from a long-term perspective, the deployment of 3D scan data is easy to predict and simulate changes in traditional landscaping space over time.

• Journal of Ginseng Research
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• v.43 no.2
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• pp.272-281
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• 2019

Background: Diabetic sensorineural damage is a complication of the sensory neural system, resulting from long-term hyperglycemia. Red ginseng (RG) has shown efficacy for treatment of various diseases, including diabetes mellitus; however, there is little research about its benefit for treating sensorineural damage. Therefore, we aim to evaluate RG efficacy in alloxan-induced diabetic neuromast (AIDN) zebrafish. Methods: In this study, we developed and validated an AIDN zebrafish model. To assess RG effectiveness, we observed morphological changes in live neuromast zebrafish. Also, zebrafish has been observed to have an ultrastructure of hair-cell cilia under scanning electron microscopy. Thus, we recorded these physiological traits to assess hair cell function. Finally, we confirmed that RG promoted neuromast recovery via nerve growth factor signaling pathway markers. Results: First, we established an AIDN zebrafish model. Using this model, we showed via live neuromast imaging that RG fostered recovery of sensorineural damage. Damaged hair cell cilia were recovered in AIDN zebrafish. Furthermore, RG rescued damaged hair cell function through cell membrane ion balance. Conclusion: Our data suggest that RG potentially facilitates recovery in AIDN zebrafish, and its mechanism seems to be promotion of the nerve growth factor pathway through increased expression of topomyosin receptor kinase A, transient receptor potential channel vanilloid subfamily type 1, and mitogen-activated protein kinase phosphorylation.

• Convergence Security Journal
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• v.21 no.1
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• pp.177-189
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• 2021

Defense R&D is a key process for securing weapons systems determined by mid- and long-term needs to cope with changing future battlefield environments. In particular, the test and evaluation provides information necessary to determine whether or not to switch to mass production as the last gateway to research and development of weapons systems and plays an important role in ensuring performance linked to the life cycle of weapons systems. Meanwhile, if you look at the recent changes in the operational environment of the Korean Peninsula and the defense acquisition environment, you can see three main characteristics. First of all, continuous safety accidents occurred during the operation of the weapon system, which increased social interest in the safety of combatants, and the efficient execution of the limited defense budget is required as acquisition costs increase. In addition, strategic approaches are needed to respond to future battlefield environments such as robots, autonomous weapons systems (RAS), and cyber security test and evaluation. Therefore, in this study, we would like to present strategies for improving the testing and evaluation of weapons systems by considering the characteristics of the security environment that has changed recently. To this end, the improvement strategy was derived by analyzing the complementary elements of the current weapon system operational test and evaluation system in a multi-dimensional model and prioritized through the hierarchical analysis method (AHP).

• Journal of the Korean Society of Marine Environment & Safety
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• v.27 no.2
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• pp.324-339
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• 2021

In this study, we determined the correlation between the wave characteristics and the change in the area of Haeundae Beach, conducted regression analysis between the wave characteristics and the change in beach area, and derived a formula for calculating the change in beach area. The change in beach area was calculated by applying the derived formula to wave observation data corresponding to a period of approximately 10 months, and the formula was subsequently validated by comparing the obtained results with the observed area. It is found that the error associated with the formula for calculating the change in beach area ranges from 1.5 m to 2.7 m based on the average beach width, and the correlation coefficient corresponding to the observed area ranges from 0.91 to 0.94. Furthermore, it is observed that the change in beach area is af ected by the wave direction in the western zone, wave height in the central zone, and wave height and wave period in the eastern zone. These results can contribute to understanding the impact of a coastal improvement project on the beach area fluctuation characteristics of Haeundae Beach and the ef ectiveness of such a coastal improvement project. By applying the aforementioned derived formula to highly accurate wave prediction data, the change in beach area can be calculated and incorporated for predicting significant long-term changes in beach areas. Furthermore, such a prediction can be considered as the basis for making decisions while establishing preemptive countermeasure policies to prevent coastal erosion.