• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5835-5838
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• 2014

Background: Gastric cancer is one of the most common causes of cancer death in Taiwan. The literature has previously shown that age, tumor site, T categories, and number of metastatic nodes significantly affect prognosis. The aim of this study was to determine the long-term survival of patients with gastric cancer, as well as the effect of particular prognostic factors on survival. Materials and Methods: This was a survival analysis study with retrospective design. We reviewed the records of 64 patients with adenocarcinoma of the stomach who had undergone gastrectomy with curative intent between 2009 and 2012 at a teaching hospital in southern Taiwan. Data extracted from patient documents included age, gender distribution, tumor location, and pathological grading. Results: The median follow-up time was 4 years, and there were 31 deaths attributed to gastric cancer. Kaplan-Meier analysis revealed that retrieval of less than 15 lymph nodes from a patient was a significant predictor of survival. A significant predictor of poorer survival was higher pathological grading. Conclusions: Our results indicate that the number of lymph nodes retrieved and pathological grading could be viewed as crucial prognostic factors affecting the survival of individuals with gastric cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7069-7077
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• 2014

Background: This retrospective study aimed to validate the safety and effectiveness of hepatectomy for huge hepatocellular carcinoma (HCC). Materials and Methods: Data of patients who underwent hepatectomy for HCC between January 2006 and December 2012 were reviewed. The patients were divided into three groups: huge HCC(${\geq}10cm$ in diameter), large HCC(${\geq}5$ but<10 cm in diameter) and small HCC(<5cm in diameter). Results: Characteristics of pre-operative patients in all three groups were homogeneously distributed except for alpha fetal protein (AFP)(p<0.001).The 30, 60, 90-day post-operative mortality rates were not different among the three groups (p=0.785, p=0.560, and p=0.549). Laboratory data at 1, 3, and 7 days after surgery also did not vary. The 5-year overall survival (OS) and 5-year disease-free survival (DFS) rates in the huge and large HCC groups were lower than that of the small HCC group (OS: 32.5% vs 36.3% vs 71.2%, p=0.000; DFS: 20.0% vs 24.8% vs 40.7%, p=0.039), but there was no difference between the huge and large HCC groups (OS: 32.5% vs 36.3%, p=0.667; DFS: 20.0% vs 24.8%, p=0.540). In multivariate analysis, five independent poor prognostic factors that affected OS were significantly associated with worse survival (p<0.05), namely, AFP level, macrovascular invasion, Edmondsone Steiner grade, surgical margin and Ishak score. AFP level, macrovascular invasion, microvascular invasion, and surgical margin influenced disease-free survival independently (p<0.05). Conclusions: The safety of hepatectomy for huge HCC is similar to that for large and small HCC; and this approach for huge HCC may achieve similar long-term survival and disease-free survival as for large HCC.

• Journal of Chest Surgery
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• 제26권12호
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• pp.934-939
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• 1993

Mediastinal lymph node involvement [N2 disease] is generally accepted as an important factor influencing the outcome of patients with lung cancer.The long-term survival rates of completely resected patients with N2 disease are frequently reported from 15% to 30%.To improve the management and the outcome of patients with resectable N2 disease, we analyzed the survival rates and the prognostic factors for resected N2 lung cancer. Between August 1989 and September 1993, we experienced 27 patients with N2 disease of 115 surgically treated lung cancer at the Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Ulsan University Medical School. Of these 27 N2 disease 4 had only an exploratory thoracotomy, and 23 underwent pulmonary resection by pneumonectomy[15], bilobectomy[3], lobectomy[4] and sleeve lobectomy[1].All of resected 23 patients received postoperative adjuvant chemotherapy[3], radiotherapy[2] or combined chemo-radiotherapy[18].Complete follow-up was obtained in 23 patients and median survival was 22 months and overall 1-year and 2-year survival rates by Kaplan-Meir method were 65 % and 45 %, respectively. Survival differences according to histology, tumor location, number of positive nodal station and operative method were not significant, statistically. Conclusively, we think that in resectable N2 lung cancer, complete tumor resection and mediastinal lymph node dissection, and postoperative adjuvant therapy should be done to improve the survival.

• 한국경영정보학회:학술대회논문집
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• 한국경영정보학회 2008년도 춘계학술대회
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• pp.493-517
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• 2008

The purpose of this research is to identify effect of communication strategy as effectively communication method which is decreasing Internet Web site users' perceived information privacy concerns as important factor affecting to positive behavior or behavioral intentions on long-term relational outcome perspectives. This study suggests alternatives concepts and causal relationship about information privacy issues. First, it addressed collaborative communication strategy (CCS) model of effective communication method for Web site's IPP to users. Second, it provided comparing and integrating streams of information privacy research on long-term relational outcomes perspective. Third, it assessed effectiveness of Web site's IPP on organization legitimacy ensured continuous survival of organization. A research model was proposed and subsequent hypotheses were empirically tested with partial least square (PLS) based on 684 responses from the users of 21 Internet Website among entirely finance, recruit, portal /e-store Web site. It was learned that CCS(as a communication method) and relationship quality(representing long-term relational outcomes)was positively associated with decreasing user's IPC more than privacy risk. Also, legitimacy to information privacy practice positively associated with willingness to information providing more than negative effect of IPC. Lastly, their association strength was partially moderated by the type of real information sensitivity.

• Journal of Chest Surgery
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• 제17권2호
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• pp.212-222
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• 1984

A total of and consecutive 291 patients underwent isolated mitral valve replacement using the Ionescu-Shiley bovine pericardial xenograft valve during the 5-year period between October 1978 and June 1983. Thirty-two patients were the children under 15 years of age. There were 15 deaths within 30 days after surgery [operative mortality, 5.2%]. All early survivors except 6 children were placed on the long-term oral anticoagulation longer than postoperative 3 months. A total follow-up period extended for 398.2 patient-years, and 12 patients died [late mortality, 4.1%, or 3.0%/patient- year]. Ten patients experienced the thromboembolic complication [2.51%/patient-year], occurring in 8 patients within the first 3 postoperative months, and 4 died. Three patients had the late prosthetic valve endocarditis [0.75%/patient-year] and 2 died. The incidence of overall valve failure according to the criteria was 3.01%/patient-year, or 12 patients, and 2 had replacement of the failed bioprostheses [primary tissue failure, 0.5%/patient-year]. The long-term survival rate was 87.8%\ulcorner2.6% at 5 years postoperatively, and 84% of the late survivors were in NYHA Class I at the end of the follow- up. The probability remaining free from thromboembolism and overall valve failure was 89.8%\ulcorner6.3% and 81.2%\ulcorner.8% at 5 years respectively. These clinical results confirm the safety of mitral valve replacement. The only remaining clinical problem is the structural and functional durability of the bovine pericardial xenograft valve, and its use in young patients may be stopped in preference to the mechanical prosthetic valves.

• Journal of Chest Surgery
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• 제42권1호
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• pp.22-27
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• 2009

배경: 관상동맥우회술은 관상동맥질환의 대표적인 치료법으로 서구에서는 장기 성적에 관하여 많은 보고들이 있으나, 우리나라에서는 매우 드물다. 따라서, 본원에서의 장기 임상성적에 관하여 알아보고자 하였다. 대상 및 방법: 1984년 2월 본원에서 처음으로 관상동맥 우회로술을 시행한 이후 2006년 12월 31일까지 시행하였던 342명의 환자를 대상으로 하였으며, 의무기록을 토대로 후향적으로 분석하였다. 총 286명(83.6%)에서 추적관찰이 가능하였으며, 평균추적관찰기간은 $75.7{\pm}46.1$개월이었다. 결과: 조기사망은 5.6%였으며, 만기사망은 23.1%였다. 1년 생존율은 91.5%였으며, 5년 생존율은 82.1%, 10년 생존율은 60.7%, 15년 생존율은 50.0%였다. 60세 이상의 고령의 환자(p=0.002), 당뇨(p=0.000), 고혈압(p=0.002), 다중혈관질환 환자(p=0.006), 그리고, 좌심실 기능부전 환자들(p=0.015) 환자들에서 생존율이 유의하게 낮았으며, 성별은 장기생존에 차이가 없는 것으로 나타났다. 다변량 분석에서는 당뇨(p=0.001), 나이(p=0.005), 좌내흉동맥을 사용하지 않는 경우(p=0.037)가 유의한 위험인자로 나타났다. 결론: 관상동맥우회술은 관상동맥질환 환자에게 있어서 효과적인 치료방법이라고 생각되며, 장기 생존을 위해서는 내흉동맥의 적극적인 사용과 당뇨환자에서 술후 혈당조절과 같은 적절한 약물치료와 외래추적관찰이 필요할 것으로 생각된다.

• The Journal of Advanced Prosthodontics
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• 제13권3호
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• pp.172-179
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• 2021

Purpose. This intra-patient retrospective study of up to 10 years evaluated the clinical success and risk factors of 6- and 8-mm long implants and their respective prostheses. Materials and Methods. The sample consisted of patients treated at a Military Polyclinic dental service, who received both 6- and 8-mm long tissue level implants in the posterior region of the same arch. Data were collected from the dental charts, clinical and radiographic exams, self-report of sleep bruxism, measurement of maximum occlusal force, and clinical crown-to-implant (C/I) ratio. Data were analyzed by descriptive and inferential statistics with univariate and hierarchical multivariate models, at the 0.05 significance level. Results. The 30 patients (27 women) had 85 implants and 83 prostheses. Two implants were lost before prosthesis installation (implant survival: 97.6%). Ten events of prosthetic complication (screw tightening loss) occurred in five patients (success rate: 87.9%) in a single moment. Only the variable C/I ratio had a significant effect for repairable prosthesis complication (P<.05). Conclusion. The results suggest that 6- and 8-mm long implants have similar long-term clinical success for implants and prostheses.

• Clinical and Experimental Pediatrics
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• 제46권8호
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• pp.769-776
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• 2003

목 적 : 한 나라의 건강 지표로 중요한 의의를 갖는 영아 사망의 2/3는 신생아기에 일어나며 주로 저출생 체중아에 의한 것이다. 최근 신생아 집중치료의 발달로 1,500 gm 미만의 극소 저출생 체중아의 생존율이 향상되는 추이여서, 본 연구는 1996년 부터 2001년까지 6년간 전남대학교병원에서 극소 저출생 체중아의 발생 빈도와 생존율 및 이환율 변화를 알아보고자 하였다. 방 법 : 본 연구는 1996년 1월부터 2001년 12월까지 전남대학교병원 신생아 집중 치료실에 입원했던 1,500 gm 미만의 극소 저출생 체중아 565명을 대상으로 하였다. 1996년부터 1998년까지를 전반기, 1999년부터 2001년까지를 후반기로 나누어 기간별 VLBWI의 생존율, 이환율 및 입원 기간의 차이를 비교하였고, 이를 또한 출생 체중과 재태 연령별로도 비교하였다. 생존 환아에서의 이환율은 '단기 질환'과 '장기 질환'으로 질환을 구분하여 비교하였고, 원내 출생아에서의 VLBWI 발생 빈도 및 기간별 변화, 기간별 주산기 인자와 생존율과의 상관관계, 사망 원인에 대해서도 조사하였다. 결 과 : 원내 출생 VLBWI의 발생 빈도는 총 8.3%이었으며 전반기 6.0%, 후반기 11.0%로 후반기에 그 빈도가 증가하였다. VLBWI 총 생존율은 76.8%이었으며, 전반기(71.8%)에 비해 후반기(80.1%)에 향상되었고, 특히 출생 체중 1,000-1,249 gm과 재태 연령 28-30주에서 개선되었다. 주산기 인자 중 후반기에 제왕 절개 분만이 증가하였고, 다태아에 비해 단태아일 경우, 질식 분만에 비해 제왕 절개 분만일 경우에 생존율이 증가하였다. 사망의 빈도는 생후 7일 이전 사망이 전체 사망의 58.8%로 가장 빈번하였다. 사망 원인으로는 신생아 호흡 곤란 증후군이 주요한 원인이었고, 패혈증, 폐출혈 빈도순이었다. 이환율은 전반기(82.5%)에 비해 후반기(92.3%)에 유의하게 증가하였다. 생존한 환아에서 전반기에 비해 후반기에 총 이환율과 단기 이환율은 증가하였으나 장기 이환율은 통계학적으로 유의한 차이가 없었으며, 출생 체중 1,000-1,499 gm과 제태 연령 28-33주에서는 단기 이환율이 유의하게 후반기에 증가한 반면 오히려 장기 이환율은 감소하였다. 생존 환아에서 평균 입원 기간은 전반기에 비해 후반기에 유의하게 연장되지는 않았다. 결 론 : VLBWI의 빈도가 증가하고 생존율이 향상된 반면 이환율은 증가되었다. 그러나, 출생 체중 1,000-1,249 gm과 재태 연령 28-30주에서 현격한 생존율 증가와 함께 '단기 이환율'은 증가되었으나 오히려 '장기 이환율'은 감소하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.6899-6902
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• 2015

Background: Retinoblastoma (RB) is rare, albeit the most common primary intraocular malignancy among children. To elucidate the true incidence, trend and survival, we studied incidences and trends of retinoblastoma in a large population with long-term follow-up using data from 3 population-based cancer registries. Objective: To describe the incidence, trends and survival of RB between 1990 and 2009 in Khon Kaen, Songkhla and Chiang Mai, Thailand. Materials and Methods: We sourced the data from the cancer registries in Khon Kaen, Songkhla and Chiang Mai on children with retinoblastoma, diagnosed between 1990 and 2009. Retinoblastoma was defined as per the International Classification of Disease for Oncology version 3 using the code 9510/3. Incidence was analyzed using the standard method with the criteria of the International Association of Cancer Registries. The Kaplan-Meier method was applied to calculate cumulative survival. Trends were calculated using the log rank test. Results: We identified 75 cases of children between 0 and 15 years of age diagnosed with RB (Khon Kaen 31, Chiang Mai 20, Songkhla 24). Males and females were equally affected. The most common age group was 0-4 years. The morphological verification of the disease was 90.7%. The respective ASR in Khon Kaen, Chiang Mai and Songkhla was 4.4, 4.0 and 4.6 per million; for which the overall ASR for all 3 areas was 4.3 per million. The respective trend in incidence was 4, 2.8, 5.8 and 5.4 during 1990-4, 1995-9, 2000-4 and 2005-9. Overall, incidence trended gradually upward by 2% annually. The respective survival rate in Khon Kaen, Chiang Mai and Songkhla was 50, 40 and 75% (differences not significantly different at p=0.14) and the overall survival for all centers was 60%. Conclusions: Over the last two decades, the incidence and overall survival of retinoblastoma has increased. The ASRs and survival in Thailand were less than those in resource-rich countries.

• 대한족부족관절학회지
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• 제22권1호
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• pp.8-15
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• 2018

Ankle osteoarthritis is a debilitating condition that causes severe pain associated with functional impairment and decreased activity. Ankle osteoarthritis, unlike that of the knee or hip joint, is rare in primary arthritis. Most cases are traumatic arthritis that occur after ankle sprain or fractures or chronic ankle instability. Although ankle fusion has been regarded as the standard treatment of ankle osteoarthritis in the past, total ankle arthroplasty (TAA) is increasing due to the development of the implant design and surgical techniques. TAA is biomechanically superior to ankle fusion by preserving the movement of the ankle joint. In particular, it is functionally superior to ankle fusion because it enables normal joint motion during gait. In addition, there is an advantage of preserving the movement of the hindfoot and reducing the abnormal stress applied to the adjacent joints after ankle fusion to prevent the occurrence of long-term adjacent joint arthritis. Although the short-term and mid-term results of TAA have been reported to be excellent, long-term follow-up has a relatively low survival rate and high complication rate compared to total knee or hip arthroplasty. Therefore, continuous and further research is needed.