• 동의생리병리학회지
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• 제20권2호
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• pp.471-476
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• 2006

Chongmyung-tang(CMT, 聰明湯), oriental herbal medicine which consists of Polygaglae Radix(遠志), Acori Graminei Rhizoma(石菖蒲) and Hoelen(白茯神) has effect on amnesia, dementia. In order to evaluate effect of CMT on memory and learning in mice, CMT extract was used for studies. This paper describes the effects of CMT extract on memory and learning processes by using the passive and active avoidance performance tests, novel object recognition task and water maze task. The CMT extract ameliorated the memory retrieval deficit induced by ethanol in the passive avoidance responses but did not affect ambulatory activity of normal mice. These results suggest that CMT has an ameliorating effect on memory retrieval impairment. CMT extract decreased spontaneous motor activity(SMA) in the latter sessions of memory registration in active avoidance responses. These results suggest that CMT has partly transquilizing or antianxiety effects. In novel object recognition task to measure visual recognition memory, CMT-administered mice enhanced in long term memory for 1-3 days. In water maze task to measure spatial learning, which requires the activation of NMDA receptors in the hippocampus, spatial learning in CMT-administered mice was faster than in wild-type mice. These results suggest that CMT enhances memory and activates NMDA receptors.

• 응용통계연구
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• 제26권6호
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• pp.1053-1061
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• 2013

본 논문은, 장기기억 특성과 이분산성을 고려한 인터넷 트래픽 예측 모형을 제안하고자 한다. 트래픽 과부하를 대비하기 위해서, 트래픽 용량은 트래픽의 예측치와 트래픽의 변동 크기에 따라 트래픽의 최대용량을 설정하여야 한다. 이를 위하여 교내 트래픽 자료 중 교내로 들어오는 트래픽과 교외로 나가는 트래픽에 이분산성과 장기기억 모형의 유용성을 확인하였다. 이에 대하여 AR-GARCH 모형, ARMA-GARCH 모형과 장기기억모형인 Fractional ARIMA와 장기기억과 이분산성을 고려한 Fractional ARMA-GARCH 모형을 적용하여 모형의 예측성능을 비교하였다.

• 한국인터넷방송통신학회논문지
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• 제19권5호
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• pp.79-85
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• 2019

본 연구에서는 Long Short Term Memory (LSTM) 신경망과 Gated Recurrent Unit(GRU) 신경망을 Internet of Things (IoT) 파워미터에 적용하여 단기 전력사용량 예측방법을 제안하고, 실제 가정의 전력사용량 데이터를 토대로 예측 성능을 분석한다. 성능평가 지표로써 Mean Absolute Error (MAE), Mean Absolute Percentage Error (MAPE), Mean Percentage Error (MPE), Mean Squared Error (MSE), Root Mean Squared Error (RMSE)를 이용한다. 실험 결과는 GRU 기반의 모델이 LSTM 기반의 모델에 비해 MAPE 기준으로 4.52%, MPE 기준으로 5.59%만큼의 성능개선을 보였다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권1호
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• pp.239-260
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• 2023

The underwater acoustic wireless communication networks are generally formed by the different autonomous underwater acoustic vehicles, and transceivers interconnected to the bottom of the ocean with battery deployed modems. Orthogonal frequency division multiplexing (OFDM) has become the most popular modulation technique in underwater acoustic communication due to its high data transmission and robustness over other symmetrical modulation techniques. To maintain the operability of underwater acoustic communication networks, the power consumption of battery-operated transceivers becomes a vital necessity to be minimized. The OFDM technology has a major lack of peak to average power ratio (PAPR) which results in the consumption of more power, creating non-linear distortion and increasing the bit error rate (BER). To overcome this situation, we have contributed our symmetry research into three dimensions. Firstly, we propose a machine learning-based underwater acoustic communication system through long short-term memory neural network (LSTM-NN). Secondly, the proposed LSTM-NN reduces the PAPR and makes the system reliable and efficient, which turns into a better performance of BER. Finally, the simulation and water tank experimental data results are executed which proves that the LSTM-NN is the best solution for mitigating the PAPR with non-linear distortion and complexity in the overall communication system.

• 해양환경안전학회지
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• 제29권5호
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• pp.505-511
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• 2023

본 논문에서는 소형어선의 운동 응답을 예측하기 위해 딥러닝 모델을 구축하였다. 크기가 다른 두 소형어선을 대상으로 유체동역학 성능을 평가하여 데이터세트를 확보하였다. 딥러닝 모델은 순환 신경망 기법의 하나인 장단기 메모리 기법(LSTM, Long Short-Term Memory)을 사용하였다. 딥러닝 모델의 입력 데이터는 6 자유도 운동 및 파고의 시계열 데이터를 사용하였으며, 출력 라벨로는 6 자유도 운동의 시계열 데이터로 선정하였다. 최적 LSTM 모델 구축을 위해 hyperparameter 및 입력창 길이의 영향을 평가하였다. 구축된 LSTM 모델을 통해 입사파 방향에 따른 시계열 운동 응답을 예측하였다. 예측된 시계열 운동 응답은 해석 결과와 전반적으로 잘 일치함을 확인할 수 있었다. 시계열의 길이가 길어짐에 따라서 예측값과 해석 결과의 차이가 발생하는데, 이는 장기 데이터에 따른 훈련 영향도가 감소 됨에 따라 나타난 것으로 확인할 수 있다. 전체 예측 데이터의 오차는 약 85% 이상의 데이터가 10% 이내의 오차를 보였으며, 소형어선의 시계열 운동 응답을 잘 예측함을 확인하였다. 구축된 LSTM 모델은 소형어선의 모니터링 및 경보 시스템에 활용될 수 있을 것으로 기대한다.

• 동의생리병리학회지
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• 제34권2호
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• pp.81-87
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• 2020

Cognitive impairment is symptoms of dementia, a degenerative brain disease that is drawing attention in a rapidly aging society. This study was conducted to investigate the improvement of cognitive function of Leonurus japonicus on scopolamine-induced memory impairment in mice and the effect and mechanism of memory recovery. In vivo studies were conducted on mice orally pretreated with L. japonicus in doses of 50, 100 and 200 mg/kg (p.o.) and scopolamine (1 mg/kg, i.p.) were injected 30 min before the behavioral task. Antioxidant activity was assessed by 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay, and acetylcholinesterase (AChE) inhibition activity evaluated by Ellman's method. In behavior studies showed that L. japonicus has an improved the memory of scopolamine-treated mice in Y-maze, passive avoidance and Morris water maze test. In addition, L. japonicus was also exerted free radical scavenging activity and inhibited acetyl cholinesterase activity. These results suggest that L. japonicus improves short-term and long-term memory in scopolamine-induced memory decline model and prevents scopolamine-induced memory impairments through in reduced oxidative stress and acetyl cholinesterase inhibition effect. Thus, L. japonicus is related to functional medicinal materials for prevention and treatment of human dementia patients.

• 대한의생명과학회지
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• 제28권4호
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• pp.211-222
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• 2022

After more than two years of efforts to end the corona pandemic, a gradual recovery is starting in countries with high vaccination rates. Easing public health policies for a full-fledged post-corona era, such as lifting the mandatory use of outdoor mask and quarantine measures in entry have been considered in Korea. However, the continuous emergence of new variants of SARS-CoV-2 and limitations in vaccine efficacy still remain challenging. Fortunately, T cells and memory T cells, which are key components of adaptive immunity appear to contribute substantially in COVID-19 control. SARS-CoV-2 specific CD4⁺/CD8⁺ T cells are induced by natural infection or vaccination, and rapid induction and activation of T cells is mainly associated with viral clearance and attenuated clinical severity. In addition, T cell responses induced by recognition of a wide range of epitopes were minimally affected and conserved against the highly infectious subsets of omicron variants. Polyfunctional SARS-CoV-2 specific T cell memory including stem cell-like memory T cells were also developed in COVID-19 convalescent patients, suggesting long lasting protective T cell immunity. Thus, a robust T-cell immune response appears to serve as a reliable and long-term component of host protection in the context of reduced efficacy of humoral immunity and persistent mutations and/or immune escape.

• 마이크로전자및패키징학회지
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• 제20권2호
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• pp.1-9
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• 2013

Recently flexible electronic devices have attracted a great deal of attention because of new application possibilities including flexible display, flexible memory, flexible solar cell and flexible sensor. In particular, development of flexible memory is essential to complete the flexible integrated systems such as flexible smart phone and wearable computer. Research of flexible memory has primarily focused on organic-based materials. However, organic flexible memory has still several disadvantages, including lower electrical performance and long-term reliability. Therefore, emerging research in flexible electronics seeks to develop flexible and stretchable technologies that offer the high performance of conventional wafer-based devices as well as superior flexibility. Development of flexible memory with inorganic silicon materials is based on the design principle that any material, in sufficiently thin form, is flexible and bendable since the bending strain is directly proportional to thickness. This article reviews progress in recent technologies for flexible memory and flexible electronics with inorganic silicon materials, including transfer printing technology, wavy or serpentine interconnection structure for reducing strain, and wafer thinning technology.

• Journal of Ginseng Research
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• 제40권1호
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• pp.55-61
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• 2016

Background: A number of neurological and neurodegenerative diseases share impaired cognition as a common symptom. Therefore, the development of clinically applicable therapies to enhance cognition has yielded significant interest. Previously, we have shown that activation of lysophosphatidic acid receptors (LPARs) via gintonin application potentiates synaptic transmission by the blockade of $K^+$ channels in the mature hippocampus. However, whether gintonin may exert any beneficial impact directly on cognition at the neural circuitry level and the behavioral level has not been investigated. Methods: In the current study, we took advantage of gintonin, a novel LPAR agonist, to investigate the effect of gintonin-mediated LPAR activation on cognitive performances. Hippocampus-dependent fear memory test, synaptic plasticity in the hippocampal brain slices, and quantitative analysis on synaptic plasticity-related proteins were used. Results: Daily oral administration of gintonin for 1 wk significantly improved fear memory retention in the contextual fear-conditioning test in mice.We also found that oral administration of gintonin for 1 wk increased the expression of learning and memory-related proteins such as phosphorylated cyclic adenosine monophosphate-response element binding (CREB) protein and brain-derived neurotrophic factor (BDNF). In addition, prolonged gintonin administration enhanced long-term potentiation in the hippocampus. Conclusion: Our observations suggest that the systemic gintonin administration could successfully improve contextual memory formation at the molecular and synaptic levels as well as the behavioral level. Therefore, oral administration of gintonin may serve as an effective noninvasive, nonsurgical method of enhancing cognitive functions.

• 동의생리병리학회지
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• 제36권1호
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• pp.18-22
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• 2022

To investigate effects of cognitive function improvement whether against Taegeuk ginseng on scopolamine-induced memory impairment in rats. All experiments were conducted in three groups: the control group (CTR), the scopolamine 0.4mg/kg (SCP), and the scopolamine (SCP+T) treated with Taegeuk ginseng 100 mg/kg. Taegeuk ginseng 100 mg/kg daily was orally administered for one month and treated with scopolamine was only for 7 consecutive days on the Morris water maze task. 3 weeks after oral administration of Taegeuk ginseng, subjects were performed the Morris water maze test for 8 days and then the open-field exploration test which to assessed for cognitive function improvement. After behavioral testing, subjects were sacrificed and microdissected brains for neurochemical analysis. In the cognitive-behavioral test, long-term administration of Taegeuk ginseng improved spatial navigation learning task compared with the impeded by scopolamine treatment. In neurochemistry, the expression of the synaptic marker PSD95 (postsynaptic density protein 95) was increased in the hippocampus compared to the scopolamine group. Also, brain-derived neurotrophic factor (BDNF) expression was significantly increased in the taegeuk ginseng administration group. These data suggested that long-term administration of taegeuk ginseng might improve cognitive-behavioral functions on hippocampal related spatial learning memory, and it was correlated with neurotropic and synaptic reinforcement. In conclusion, treatment with taegeuk ginseng may positive outcome on learning and memory deficit disorders.