• Animal cells and systems
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• v.1 no.3
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• pp.483-489
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• 1997

This study was performed to investigate the differentiation and distribution of choline acetyltransferase (ChAT}-immunoreactive cells in the magnacellular preoptic nucleus (MCPO) of the postnatal and adult rat forebrains, utilizing techniques of immunocytochemistry. According to the cell shape and the ratio of long axis versus short axis of cell soma, the ChATimmunoreactive nerve cells in the MCPO were classified into six types: 1) round, 2) oval, 3) elongated, 4) fusiform, 5) triangular, and 6) polygonal types. Frequency distributions of the oval and round nerve cells on the postnatal day (PND) 0 were observed to be high. But in the adult, frequency distributions of the same cells were shown to decrease. Compared to those of the postnatal rats, frequency distributions of elongated, fusiform, triangular, and polygonal nerve cells in the adult were increased. The total mean volumes of ChAT-immunoreactive cell somata in the MCPO of PND 0 rat were the lowest, while those in the PND 17 rat were shown to be the highest and decreased in the adult. The soma volumes of the immunoreactive cells at the PND 17 were evenly distributed, but those in the other developmental stages (e.g. PND 7 and adult) appeared to exhibit unimodal distributions. On the electron micrography, the free ribosomes, polysomes, and rough endoplasmic reticula (RER) of the nerve cells in the MCPO of PND 21 rat forebrains were immunoreactive to ChAT in the tissues untreated with triton X-100. According to the observations in the present study, it is considered that the ChAT-immunoreactive nerve cells in the MCPO of the rat forebrains are differentiated throughout the following processes during the postnatal development: 1) increase in cell soma volumes, 2) development of neurites, 3) increase in the frequency of differentiated cell types, and 4) decrease in cell soma volumes. The ribosomes, polysomes, and RER are considered to be closely related to the intracellular localization and biosynthesis of the ChAT but not Golgi complex.

• Korean Journal of Computational Design and Engineering
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• v.15 no.3
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• pp.212-221
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• 2010

Proposed in the paper is a methodology to generate kinematic template for 3D JIG models. Recently, according to increase of the rate of automatic facility in manufacturing system, the 3D manufacturing and verification research and development have been issued. So, unlike in the past, moving 3D facilities are very various like JIGs, turn table, AS/RS worked in the automated manufacturing industry. Because 3D mesh models are used in these kinds of 3D simulation, users have to define the kinematic information manually. This 3D mesh data doesn't have parametric information and design history of the 3D model unlike the design level data. So, it is lighter than 3D design level data and more efficient to render on the 3D virtual manufacturing environment. But, when user wants to find a common axis located between the links, the parameter information of the model has to reconstruct for defining kinematic construction. It takes a long time and very repetitive to define an axis and makes a joint using 3D mesh data and it is non-intuitive task for user. This paper proposed template model that provides kinematic information of the JIG. This model is kinds of a state diagram to describe a relation between links. So, this model can be used for a kinematic template to the JIG which has a same mechanism. The template model has to be registered in the template library to use in the future, after user made the model of the specific type of the 3D JIG model.

• Journal of Ocean Engineering and Technology
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• v.31 no.3
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• pp.196-201
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• 2017

A cylindrical structure has a very long period of heave and pitch motion response in ocean waves. To obtain the dynamic stability of a cylindrical structure, it is necessary to obtain the suitable metacentric height (GM). However, in a structure with sufficient metacentric height, Mathieu instability can occur if the natural frequency of the heave motion is double the natural frequency of the roll and pitch motion. This study carried out numerical calculations and experiments for vertical-axis wind turbines with cylindrical floaters, which had three different centers of gravity. In the regular wave experiment, the divergence of the structure motion without yaw was observed when the natural frequency of the heave motion was double the natural frequency of the roll and pitch motion. In the irregular wave experiment, the motion spectra of the structures with the different centers of gravity were compared, and one was very high when the natural frequency of the heave motion was double the natural frequency of the roll and pitch motion.

• Geomechanics and Engineering
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• v.11 no.2
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• pp.235-252
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• 2016

This paper presents a new numerical solution of the ultimate lateral capacity of rectangular piles in clay. The two-dimensional plane strain finite element was employed to determine the limit load of this problem. A rectangular pile is subjected to purely lateral loading along either its major or minor axes. Complete parametric studies were performed for two dimensionless variables including: (1) the aspect ratios of rectangular piles were studied in the full range from plates to square piles loaded along either their major or minor axes; and (2) the adhesion factors between the soil-pile interface were studied in the complete range from smooth surfaces to rough surfaces. It was found that the dimensionless load factor of rectangular piles showed a highly non-linear function with the aspect ratio of piles and a slightly non-linear function with the adhesion factor at the soil-pile interface. In addition, the dimensionless load factor of rectangular piles loaded along the major axis was significantly higher than that loaded along the minor axis until it converged to the same value at square piles. The solutions of finite element analyses were verified with the finite element limit analysis for selected cases. The empirical equation of the dimensionless load factor of rectangular piles was also proposed based on the data of finite element analysis. Because of the plane strain condition of the top view section, results can be only applied to the full-flow failure mechanism around the pile for the prediction of limiting pressure at the deeper length of a very long pile with full tension interface that does not allow any separation at soil-pile interfaces.

• Journal of Periodontal and Implant Science
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• v.44 no.4
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• pp.184-193
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• 2014

Purpose: The aim of the present study was to evaluate the in vivo accuracy of flapless, computer-aided implant placement by comparing the three-dimensional (3D) position of planned and placed implants through an analysis of linear and angular deviations. Methods: Implant position was virtually planned using 3D planning software based on the functional and aesthetic requirements of the final restorations. Computer-aided design/computer-assisted manufacture technology was used to transfer the virtual plan to the surgical environment. The 3D position of the planned and placed implants, in terms of the linear deviations of the implant head and apex and the angular deviations of the implant axis, was compared by overlapping the pre- and postoperative computed tomography scans using dedicated software. Results: The comparison of 14 implants showed a mean linear deviation of the implant head of 0.56 mm (standard deviation [SD], 0.23), a mean linear deviation of the implant apex of 0.64 mm (SD, 0.29), and a mean angular deviation of the long axis of $2.42^{\circ}$ (SD, 1.02). Conclusions: In the present study, computer-aided flapless implant surgery seemed to provide several advantages to the clinicians as compared to the standard procedure; however, linear and angular deviations are to be expected. Therefore, accurate presurgical planning taking into account anatomical limitations and prosthetic demands is mandatory to ensure a predictable treatment, without incurring possible intra- and postoperative complications.

• The Korean Journal of Ecology
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• v.28 no.5
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• pp.281-286
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• 2005

The ripe unfertilized eggs of Acheilognathus signifer were elliptical shape and baggily swollen toward animal pole. The size of fertilized eggs were $2.19{\pm}0.01$ mm in long axis and $1.85{\pm}0.08$ mm in short axis and oil globe were not observed. The zona radiata of A. signifer had the structure of regular fibrilar net and the diameter of outer opening micropyle was about $2.5{\mu}m$ and that of inner opening micropyle was about $1.5\sim2.0{\mu}m$. Development of fertilized eggs in A. signifer was proceeded in inclining position of animal pole and hatched in 49 hours under $20{\pm}1^{\circ}C$. The yolk sac was absolutely absorbed in 21 days after hatching.

• Journal of Korean Neurosurgical Society
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• v.42 no.2
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• pp.89-91
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• 2007

Objective : Cranioplasty is necessary to repair the cranial defect, produced either by decompressive craniectomy or removal of the contaminated depressed skull fracture. Complications are relatively common after cranioplasty, being reported up to 23.6%. We examined the incidence and risk factors of infectious complications after cranioplasty during last 6 year period. Methods : From January 2000 to December 2005, 107 cranioplasties were performed in our institution. The infectious complications occurred in 17 cases that required the removal of the bone flap. We examined the age of the patients, causes of the skull defect, timing of the cranioplasty the size of the defect, and kinds of the cranioplasty material. The size of the skull defect was calculated by a formula, $3.14{\times}long\;axis\;{\times}short$ axis. The cranioplasty material was autogenous bone kept in a freezer in 74 patients, and polymethylmetacrylate in 33 patients. Statistical significance was tested using the chi-square test. Results : The infection occurred in 17 patients in 107 cranioplasties (15.9%). It occurred in 2 of 29 cases of less than $75\;cm^2$ defect (6.9%), and 6 in 54 cases of $75{\sim}125\;cm^2$ defect (11.1%). Also, it occurred in 9 of 24 cases of more than $125\;cm^2$ defect (37.5%). This difference was statistically significant (p <0.01). Conclusion : During the cranioplasty, special attention is required when the skull defect is large since the infection tends to occurr more commonly.

• Journal of Institute of Control, Robotics and Systems
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• v.14 no.8
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• pp.800-808
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• 2008

This paper presents a localization algorithm of the outdoor wheeled mobile robot using the sensor fusion method based on indirect Kalman filter(IKF). The wheeled mobile robot considered with in this paper is approximated to the two wheeled mobile robot. The mobile robot has the IMU and encoder sensor for inertia positioning system and GPS. Because the IMU and encoder sensor have bias errors, divergence of the estimated position from the measured data can occur when the mobile robot moves for a long time. Because of many natural and artificial conditions (i.e. atmosphere or GPS body itself), GPS has the maximum error about $10{\sim}20m$ when the mobile robot moves for a short time. Thus, the fusion algorithm of IMU, encoder sensor and GPS is needed. For the sensor fusion algorithm, we use IKF that estimates the errors of the position of the mobile robot. IKF proposed in this paper can be used other autonomous agents (i.e. UAV, UGV) because IKF in this paper use the position errors of the mobile robot. We can show the stability of the proposed sensor fusion method, using the fact that the covariance of error state of the IKF is bounded. To evaluate the performance of proposed algorithm, simulation and experimental results of IKF for the position(x-axis position, y-axis position, and yaw angle) of the outdoor wheeled mobile robot are presented.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.7
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• pp.4033-4039
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• 2013

Links between cancer and metabolism have been suggested for a long time but compelling evidence for this hypothesis came from the recent molecular characterization of the LKB1/AMPK signaling pathway as a tumor suppressor axis. Besides the discovery of somatic mutations in the LKB1 gene in certain type of cancers, a critical emerging point was that the LKB1/AMPK axis remains generally functional and could be stimulated by pharmacological molecules such as metformin in cancer cells. In addition, AMPK plays a central role in the control of cell growth, proliferation and autophagy through the regulation of mTOR activity, which is consistently deregulated in cancer cells. Targeting of AMPK/mTOR is thus an attractive strategy in the development of therapeutic agents against non-small-cell lung cancer (NSCLC). In this review, the LKB1/AMPK/mTOR signaling pathway is described, highlighting its protective role, and opportunities for therapeutic intervention, and clinical trials in NSCLC.

• Korean Journal of Optics and Photonics
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• v.15 no.3
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• pp.241-247
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• 2004

The collimator is necessary for the assembly and evaluation of high resolution satellite telescope. Traditionally, the off-axis paraboloid has been used as a collimator. However, it has some disadvantages in that it can suffer from air turbulence when the focal length of a collimator is long, which may result in some error in the measurement. In contrast, since the Cassegrain type collimator folds the beam, it occupies smaller space compared to the off-axis paraboloid for the same focal length. This can reduce the air turbulence, which can improve the measurement accuracy. In this paper, we explain the process of design and manufacturing of a diameter 450 mm Cassegrain type collimator, to evaluate the diameter 300 mm satellite telescope. After assembly of primary and secondary mirrors, the final wavefront error of the collimator was 0.07λ(λ=633 nm), which is the diffraction limit.