• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.12C
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• pp.1044-1051
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• 2010

In this paper, we propose an efficient soft-output signal detection method for spatially multiplexed multiple input multiple output (MIMO) systems. The proposed method is based on the ordered successive interference cancellation (OSIC) algorithm, but it significantly improves the performance of the original OSIC algorithm by solving the error propagation problem. The proposed method combines this enhanced OSIC (ESIC) algorithm with a multiple ordering technique in a very efficient way. As a result, the log likelihood ratio (LLR) values can be computed by using a very small set of candidate symbol vectors. The proposed method has been implemented with a $0.13{\mu}m$ CMOS technology for a $4{\times}4$ 16-QAM MIMO system. The simulation and implementation results show that the proposed detector provides a very good solution in terms of performance and hardware complexity.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.7C
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• pp.616-626
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• 2007

In spatially multiplexed MIMO systems that enable high data rate transmission over wireless communication channels, the spatial demultiplexing at the receiver is a challenging task, and various demultiplexing methods have been developed recently by many researchers. Among the previous methods, maximum likelihood detection with QR decomposition and M-algorithm (QRM-MM)), and sphere decoding (SD) schemes have been reported to achieve a (near) maximum likelihood (ML) performance. In this paper, we propose a novel signal detection method that achieves a near ML performance in a computationally efficient manner. The proposed method is demonstrated via a set of computer simulations that the proposed method achieves a near ML performance while requiring a complexity that is comparable to that of the conventional MMSE-OSIC. We also show that the log likelihood ratio (LLR) values for all bits are obtained without additional calculation but as byproduct in the proposed detection method, while in the previous QRM-MLD, SD, additional computation is necessary after the hard decision for LLR calculation.

• The Journal of the Acoustical Society of Korea
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• v.36 no.4
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• pp.279-284
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• 2017

The localization of sources has a numerous number of applications. To estimate the position of sources, the relative time delay between two or more received signals for the direct signal must be determined. Although the GCC (Generalized Cross-Correlation) method is the most popular technique, an approach based on CCA (Canonical Correlation Analysis) was also proposed for the TDE (Time Delay Estimation). In this paper, we propose a new adaptive algorithm based on CCA in order to utilized the sparsity in the eigenvector of CCA based time delay estimator. The proposed algorithm uses the eigenvector corresponding to the maximum eigenvalue with log-sum regularization in order to utilize the sparsity in the eigenvector. We have performed simulations for several SNR(signal to noise ratio)s, showing that the new CCA based algorithm can estimate the time delays more accurately than the conventional CCA and GCC based TDE algorithms.

• Journal of the korean Society of Automotive Engineers
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• v.14 no.5
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• pp.41-53
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• 1992

The main purpose of this study is to investigate the atomizing characteristics of a two phase spray by using a liquid column type coaxial nozzle. The experiments have been carried out to analyze the atomization behavior, the droplet size distributions, and the statistical properties of droplet size distributions. Immersion sampling method and the image processing technique were adapted for the measurements of particles, and the distributions of the droplet sizes were statistically analyzed. In the experiments, the mass ratio defined as Mr= $M_{\sigma}$/ $M_{1}$ has been changed from 1.0 to 3.4 and the measurements have been performed along the axis of the spray. As a result of this experimental study, the distributions of droplet size were satisfied with the Log-Normal distributions and arithmetic mean diameter and deviation of mass ratio. Droplet volume-surface mean diameter was denoted by a exponential function of mass-ratio and the exponent was denoted by linear relation according to the central axis from the nozzle. Dispersions, skewness factors and flatness factors had comparatively constant values regardless of mass ratio and location.

• Journal of Microbiology and Biotechnology
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• v.15 no.6
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• pp.1377-1383
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• 2005

In a cDNA microarray experiment using Cy3 and Cy5 as labeling agents, particularly for the direct design, cDNAs from some genes incorporate one dye more efficiently than the other, which is referred to as the gene-specific dye bias. Dye-swaps, in which two dyes are switched on replicate arrays, are commonly used to control the gene-specific dye bias. We developed a simple procedure to extract the gene-specific dye bias information from a partial dye swap experiment. We detected gene-specific dye bias by identifying outliers in an X-Y plane, where the X axis represents the average log-ratio from two sets of dye swap pairs and the Y axis exhibits the average log ratio of four forward labeled arrays. We used this information for detecting differentially expressed genes, of which the additionally detected genes were validated by real-time RT-PCR.

• Journal of Information Processing Systems
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• v.14 no.2
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• pp.552-562
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• 2018

With the advent of the information society, image restoration technology has aroused considerable interest. Guided image filtering is more effective in suppressing noise in homogeneous regions, but its edge-preserving property is poor. As such, the critical part of guided filtering lies in the selection of the guided image. The result of the Expected Patch Log Likelihood (EPLL) method maintains a good structure, but it is easy to produce the ladder effect in homogeneous areas. According to the complementarity of EPLL with guided filtering, we propose a method of coupling EPLL and guided filtering for image de-noising. The EPLL model is adopted to construct the guided image for the guided filtering, which can provide better structural information for the guided filtering. Meanwhile, with the secondary smoothing of guided image filtering in image homogenization areas, we can improve the noise suppression effect in those areas while reducing the ladder effect brought about by the EPLL. The experimental results show that it not only retains the excellent performance of EPLL, but also produces better visual effects and a higher peak signal-to-noise ratio by adopting the proposed method.

• Journal of Pharmaceutical Investigation
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• v.37 no.3
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• pp.197-203
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• 2007

A bioequivalence study of $Dilast^{TM}$ Capsule (Chong Kun Dang Pharma. Co., Ltd.) to $Ketas^{(R)}$ Capsule (Han Dok Pharma. Co., Ltd.) was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty eight healthy male Korean volunteers received each medicine at the ibudilast dose of 20 mg in a $2{\times}2$ crossover study. There was one week wash-out period between the doses. Plasma concentrations of ibudilast were monitored by a liquid chromatography-tandem mass spectrometry (LC-MS/MS) for over a period of 36 hours after drug administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 36 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t\;and\;C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Dilast^{TM}$ $Capsule/Ketas^{(R)}$ Capsule were $log0.93{\sim}log1.06$ and $log0.93{\sim}log1.11$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80{\sim}log1.25$. Thus, our study demonstrated the bioequivalence of $Dilast^{TM}$ Capsule and $Ketas^{(R)}$ Capsule with respect to the rate and extent of absorption.

• Journal of Pharmaceutical Investigation
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• v.35 no.4
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• pp.303-308
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• 2005

The purpose of the present study was to evaluate the bioequivalence of two talniflumate tablets, SOMALGEN tablet (Kun Wha Pharm. Co., Ltd., Seoul, Korea, reference drug) and FLUTAL tablet (Kukje Pharm. Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four healthy male Korean volunteers received two tablets at the talniflumate dose of 740 mg in a $2{\pm}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of niflumic acid were monitored by an HPLC-UV for over a period of 14 hr after the administration. $AUC_t$(the area under the plasma concentration-time curve from time zero to 14 hr) was calculated by the linear trapezoidal rule method. $C_{max}$(maximum plasma drug concentration) and $T_{max}$(time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$, ratio and the $C_{max}$ ratio for SOMALGEN/FLUTAL were $log0.8510{\sim}log1.0318$ and $log0.9264{\sim}log1.0607$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80{\sim}log1.25$. Taken together, our study demonstrated the bioequivalence of SOMALGEN and FLUTAL with respect to the rate and extent of absorption.

• Journal of Pharmaceutical Investigation
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• v.36 no.2
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• pp.131-136
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• 2006

The purpose of the present study was to evaluate the bioequivalence of two losartan tablets, $Cozaar^{TM}$ tablet (MSD Korea. Co., Ltd., Seoul, Korea, reference drug) and $Losartan^{TM}$ tablet (DaeWon Pharm. Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four healthy male Korean volunteers received two tablets at the losartan kalium dose of 100 mg in a $2\;{\time}\;2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of losartan were monitored by an LC-MS/MS for over a period of 12 hr after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 12 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Cozaar^{TM}/Losartan^{TM}$ were $log\;0.97{\sim}log\;1.12\;and\;log\;0.93{\sim}log\;1.23$, respectively. These values were within the acceptable bioequivalence intervals of $log\;0.80{\sim}log\;1.25$. Taken together, our study demonstrated the bioequivalence of $Cozaar^{TM}$ and $Losartan^TM$ with respect to the rate and extent of absorption.

• Journal of Pharmaceutical Investigation
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• v.37 no.4
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• pp.255-261
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• 2007

A bioequivalence study of $Nimegen^{TM}$ soft capsule (Medica Korea Pharma. Co., Ltd.) to $RoAccutane^{(R)}$ soft capsule (Roche Korea Ind. Co., Ltd.) was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Thirty healthy male Korean volunteers received each medicine at the isotretinoin dose of 60 mg in a $2{\times}2$ crossover study. There was one week wash-out period between the doses. Plasma concentrations of isotretinoin were monitored by a high performance liquid chromatography (HPLC) for over a period of 48 hours after drug administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 48 hr) was calculated by the linear trapezoidal rule method. $C_{MAX}$ (maximum plasma drug concentration) and $T_{MAX}$ (time to reach $C_{MAX}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t\;and\;C_{MAX}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{MAX}$ ratio for $Nimegen^{TM}/RoAccutane^{(R)}$ were $log0.860{\sim}log0.98\;and\;log0.85{\sim}log1.00$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80{\sim}log1.25$. Thus, our study demonstrated the bioequivalence of $Nimegen^{TM}\;and\;RoAccutane^{(R)}$ with respect to the rate and extent of absorption.