• Journal of Pharmaceutical Investigation
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• v.34 no.4
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• pp.311-317
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• 2004

A bioequivalence study of $Gomcillin^{TM}$ capsules (DAEWOONG Pharmaceutical Co., Korea) to $Famoxin^{TM}$ capsules (Dong Wha Pharm. Ind. Co., Korea) was conducted according to the guideline of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the amoxicillin dose of 500 mg in a $2{\times}2$ crossover study. There was a one-week wash out period between the doses. Plasma concentrations of amoxicillin were monitored by a high-performance liquid chromatography for over a period of 8 hours after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 8 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Gomcillin^{TM}/Famoxin^{TM}$ were $log0.91\;{\sim}\;log1.03$ and $;log0.93\;{\sim}\;log1.10$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80\;{\sim}\;log1.25$. Thus, our study demonstrated the bioequivalence of $Gomcillin^{TM}$ and $Famoxin^{TM}$ with respect to the rate and extent of absorption.

• Transactions of the Korean Society of Mechanical Engineers
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• v.4 no.2
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• pp.47-53
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• 1980

Kikukawa-Compliance method using a conventional clip-on gauge was employed to investigate fatigue crack growth and crack closure in 2017-T3 aluminum alloy. The crack growth rate plot against stress intensity range .DELTA.K on a log-log diagram exhibits a bilinear form with a transition at the growth rate of 10$\^$-4/ mm/cycle. The bilinear form appears still in the plot of growth rate versus effective stress intensity range .DELTA.K$\_$eff/. Fatigue crack growth rate could be well represented by .DELTA.K$\_$eff. The experimental results indicate that the effective stress intensity range ratio U depends on the maximum stress intensity factor K$\_$max/, but the stress ratio R does not affect U. The crack opening stress intensity factor K$\_$op/ tends to increase with increasing K$\_$max/ and decrease with increasing .DELTA.K.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.12C
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• pp.1197-1207
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• 2009

Orthogonal Frequency Division Multiple Access (OFDMA) is widely used as a multiple access technique for next generation mobile communication systems, however, its main drawback is the high peak-to-average ratio (PAPR). Thus for the uplink case where the transmit power is strictly limited due to the battery life of mobile units, single carrier frequency division multiple access (SC-FDMA) with low PAPR is preferred to OFDMA method. In this paper, we propose a method to improve the performance of SC-FDMA using frequency domain MMSE equalization. The proposed improved log-likelihood ratio (LLR) generation method exploits both the diversity characteristic of channels and the reciprocity that is obtained from the received signals. The complexity of the proposed method is analyzed and its performance gain is demonstrated via a set of computer simulations.

• Speech Sciences
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• v.9 no.2
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• pp.135-146
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• 2002

Generally a speaker verification system improves its system recognition ratio by regularizing log likelihood ratio, using a speaker model and its background speaker model that are required to be verified. The speaker-based cohort method is one of the methods that are widely used for selecting background speaker model. Recently, Gaussian-based cohort model has been suggested as a virtually synthesized cohort model, and unlike a speaker-based model, this is the method that chooses only the probability distributions close to basic speaker's probability distribution among the several neighboring speakers' probability distributions and thereby synthesizes a new virtual speaker model. It shows more excellent results than the existing speaker-based method. This study compared the existing speaker-based background speaker models and virtual speaker models and then constructed new virtual background speaker model groups which combined them in a certain ratio. For this, this study constructed a speaker verification system that uses GMM (Gaussin Mixture Model), and found that the suggested method of selecting virtual background speaker model shows more improved performance.

• Journal of Pharmaceutical Investigation
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• v.38 no.2
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• pp.135-142
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• 2008

The present study describes the evaluation of the bioequivalence of two atorvastatin tablets, Lipitor $Tablet^{(R)}$ (Pfizer, reference drug) and Atorva $Tablet^{(R)}$ (Yuhan, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Forty-nine healthy male Korean volunteers received each medicine at the atorvastatin dose of 40 mg in a $2{\times}2$ crossover study with a two weeks washout interval. After drug administration, serial blood samples were collected at a specific time interval from 0-48 hours. The plasma atorvastatin concentrations were monitored by an high performance liquid chromatography -tandem mass spectrometer (LC-MS/MS) employing electrospray ionization technique and operating in multiple reaction monitoring (MRM) and positive ion mode. The total chromatographic run time was 4.5 min and calibration curves were linear over the concentration range of 0.1-100 ng/mL for atorvastatin. The method was validated for selectivity, sensitivity, linearity, accuracy and precision. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 48hr) was calculated by the linear log trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were complied trom the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Atorva $Tablet^{(R)}$ / Lipitor $Tablet^{(R)}$ were ${\log}\;0.9413{\sim}{\log}\;1.0179$ and ${\log}\;0.831{\sim}{\log}\;1.0569$, respectively. These values were within the acceptable bioequivalence intervals of ${\log}\;0.8{\sim}{\log}\;1.25$. Based on these statistical considerations, it was concluded that the test drug, Atorva $Tablet^{(R)}$ was bioequivalent to the reference drug, Lipitor $Tablet^{(R)}$.

• Communications for Statistical Applications and Methods
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• v.5 no.3
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• pp.847-853
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• 1998

Suppose we want to compare following non-hierarchical log-linear models, $H_0:f(x, heta inTheta_a)$ vs H_1:g(x, heta inTheta_eta); for; Theta_a,;Theta_etasubsetTheta;such;that;Theta_$\alpha$/ Theta_eta$. The goodness of fit test using the likelihood ratio test statistic for comparing these models could not be acceptable. By using the polyhedrons plots of Choi and Hong (1995), we propose a method to decide a better model between two non-hierarchical log-linear models $f(x: heta inTheta_a) and g(x: heta inTheta_eta)$.

• The KIPS Transactions:PartA
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• v.8A no.4
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• pp.499-502
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• 2001

Fractal image coding suffers from the long search time of domain pool although it provides many properties including the high compression ratio. We find that the normalized variance of a block is independent of contrast, brightness. Using this observation, we introduce a self similar block searching method employing the d-dimensional nearest neighbor searching. This method takes Ο(log/N) time for searching the self similar domain blocks for each range block where N is the number of domain blocks. PSNR (Peak Signal Noise Ratio) of this method is similar to that of the full search method that requires Ο(N) time for each range block. Moreover, the image quality of this method is independent of the number of edges in the image.

• Journal of the Korean Association of Geographic Information Studies
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• v.13 no.1
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• pp.101-113
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• 2010

Recently actual rainfall pattern is decreasing rainy days and increasing in rainfall intensity and the frequency of flood occurrence is also increased. To consider recent situation, Engineers use deterministic methods like a PMP(Probable Maximum Precipitation). If design storm wouldn't occur, increasing of design criteria is extravagant. In addition, the biggest structure cause trouble with residents and environmental problem. And then it is necessary to study considering probability of rainfall parameter in each sub-basin for design of water structure. In this study, stochastic rainfall patterns are generated by using log-ratio method, Johnson system and multivariate Monte Carlo simulation. Using the stochastic rainfall patterns, hydrological analysis, hydraulic analysis and 2nd flooding analysis were performed based on GIS for their applicability. The results of simulations are similar to the actual damage area so the methodology of this study should be used about making a flood risk map or regidental shunting rout map against the region.

• Journal of Broadcast Engineering
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• v.1 no.2
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• pp.165-175
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• 1996

In this paper, the image segmentation method based on the hierarchical pyramid image structure of reduced resolution versions of the image for solving the problems in the conventional methods is presented. This method is described the object detection and delineation by statistical approach. In the object detection method, IFSVR( Inverse-father-son variance ratio) method and FSVR(father-son variance ratio ) method are proposed for solving clustering validity problem occurred In the hierarchical pyramid image structure. An optimal object pixel Is detected at some level by this method. In the object delineation method, the iterative algorithm by top-down traversing method is proposed for moving the optimal object pixel to levels of higher resolution. Using the computer simulation, the results by the proposed statistical methods and object traversing method are investigated for the binary Image and the real image. At the results of computer simulation, the proposed methods of image segmentation based on the hierarchical pyramid Image structure seem to have useful properties and deserve consideration as a possible alternative to existing methods of image segmentation. The computation for the proposed method is required 0(log n) for n${\times}$n input image.

• Journal of Pharmaceutical Investigation
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• v.37 no.5
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• pp.315-321
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• 2007

The purpose of the present study was to evaluate the bioequivalence of two lercanidipine hydrochloride tablets, Zanidip tablet (LG Life Sciences Ltd., Korea, reference drug) and Samchundang Lercanidipine tablet 10 mg (Sam Chun Dang Pharm. Co. Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (amlodipine maleate) to human serum, serum samples were extracted using hexan-isoamyl alcohol (100:1, v/v). Compounds were analyzed by liquid chromatography/tandem mass spectrometry. This method showed linear response over the concentration range of 0.05-20 ng/mL with correlation coefficient of 0.9999. The lower limit of quantitation using 0.5 mL of serum was 0.05 ng/mL which was sensitive enough for pharmacokinetic studies. Thirty healthy male Korean volunteers received each medicine at the lercanidipine hydrochloride dose of 20 mg in a $2\;{\times}\;2$ crossover study. There was a one-week washout period between the doses. Serum concentrations of lercanidipine were monitored by an LC/MS/MS fer over a period of 24 hr after the administration. $AUC_t$ (the area under the serum concentration-time curve from time 0 to 24 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (the maximum serum drug concentration) and $T_{max}$ (the time to reach $C_{max}$) were compiled from the serum concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters, indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Samchundang Lercanidipine/Zanidip were log 0.9505-log 1.2258 and log 0.9987-log 1.2013, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Samchundang Lercanidipine tablet 10 mg and Zanidip tablet are bioequivalent.