• Applied Microscopy
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• v.33 no.2
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• pp.145-154
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• 2003

The present study was designed to demonstrate ionic zinc in the rat nasal mucosa by means of zinc selenium autometallography ($ZnSe^{AMG}$). Rats were given sodium selenide either intraperitoneally (i.p) or intranasally (i.n). Prior to the i.n. administration the rats were anesthetized with pentobarbital sodium (30 mg/kg, i.p.). A thin plastic tube coupled to a Hamilton syringe was then inserted into the right nostril and $10{\mu}l$ of the solution was instilled. For the i.p. administration non-anesthetized rats were given $100{\mu}l$ of the sodium selenide solution (10 mg/kg). Control rats were instilled with saline. After 2 hrs survival, the rats were anaesthetized and transcardially perfused with 3% glutaraldehyde. The olfactory area was removed and put into same fixative. The nose was then sectioned ($30{\mu}m$) horizontally, autometallography (AMG) was performed according to Danscher et al. (1997). After silver enhancement, fine AMG grains were scattered in the whole length of the olfactory epithelium containing olfactory receptor neurons, sustentacular and basal cells. However, much higher concentration of the AMG grains occupied near the surface and in the basal region of the olfactory epithelium. Both groups of i.p. and i.n. administration showed almost same level in the concentration of the AMG grains. In i.n. group, few AMG grains were also found in olfactory nerves of the lamina propria, suggesting zinc transport into the olfactory bulb via olfactory axons. At the electron microscopic level, the AMG grains were most entirely found in the supporting cells of the olfactory epithelium, and they were mostly localized in lysosome-like organelles. The i.n. group showed various signs of tissue damage of the olfactory mucosa, where dense concentration of AMG grains were localized at crystalloid structures. The present study demonstrated dense population of ionic zinc in the rat olfactory epithelium. zinc may play a role in the olfactory functioin and in the pathogenesis of the neurodegerative disorders affecting nose.

• The Journal of the Acoustical Society of Korea
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• v.39 no.1
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• pp.16-23
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• 2020

In High-Intensity Focused Ultrasound (HIFU) treatment, effective localization of HIFU focus is important for developing a safe treatment plan. While Magnetic Resonance Imaging guided HIFU (MRIgHIFU) can visualize the ultrasound path during the treatment for localizing HIFU focus, it is challenging in ultrasound imaging guided HIFU (USIgHIFU). In the present study, a real-time ultrasound beam visualization technique capable of localizing HIFU focus is presented for USIgHIFU. In the proposed method, a short pulse, with the same center frequency of an imaging ultrasound transducer below the regulated acoustic intensity (i.e., Ispta < 720 mW/㎠), was transmitted through a HIFU transducer whereupon backscattered signals were received by the imaging transducer. To visualize the HIFU beam path, the backscattered signals underwent dynamic receive focusing and subsequent echo processing. From in vitro experiments with bovine serum albumin gel phantoms, the HIFU beam path was clearly depicted with low acoustic intensity (i.e., Ispta of 94.8 mW/㎠) and the HIFU focus was successfully localized before any damages were produced. This result indicates that the proposed ultrasound beam path visualization method can be used for localizing the HIFU focus in real time while minimizing unwanted tissue damage in USIgHIFU treatment.

• Journal of Korea Water Resources Association
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• v.50 no.4
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• pp.223-232
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• 2017

The ability to defend against floods in urban areas was weakened, because the increase in the impervious rate of urban areas due to urbanization and industrialization and the increase in the localized torrential rainfall due to abnormal climate. In order to reduce flood damage in urban areas, various runoff reduction facilities such as detention ponds and infiltration facilities were installed. However, in the case of domestic metropolitan cities, it is difficult to secure land for the installation of storm water reduction facilities and secure the budget for improving the aged pipelines. Therefore, it is necessary to design a storage system (called the detention pond in trunk sewer) that linked the existing drainage system to improve the flood control capacity of the urban area and reduce the budget. In this study, to analyze the effect of reducing runoff amounts according to the volume of the detention pond in trunk sewer, three kinds of virtual watershed (longitudinal, middle, concentration shape) were assumed and the detention pond in trunk sewer was installed at an arbitrary location in the watershed. The volume of the detention pond in trunk sewer was set to 6 cases ($1,000m^3$, $3,000m^3$, $5,000m^3$, $10,000m^3$, $20,000m^3$, $30,000m^3$), and the installation location of the detention pond in trunk sewer was varied to 20%, 40%, 60%, and 80% of the detention pond upstream area to the total watershed area (DUAR). Also, using the results of this study, a graph of the relationship and relational equation between the volume of the detention pond in trunk sewer and the installation location is presented.

• Journal of Wetlands Research
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• v.17 no.1
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• pp.80-90
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• 2015

Variability of precipitation pattern and intensity are increasing due to the urbanization and industrialization which induce increasing impervious area and the climate change. Therefore, more severe urban inundation and flood damage will be occurred by localized heavy precipitation event in the future. In this study, we analyze the future frequency based precipitation under climate change based on the regional frequency analysis. The observed precipitation data from 58 stations provided by Korea Meteorological Administration(KMA) are collected and the data period is more than 30 years. Then the frequency based precipitation for the observed data by regional frequency analysis are estimated. In order to remove the bias from the simulated precipitation by RCP scenarios, the quantile mapping method and outlier test are used. The regional frequency analysis using L-moment method(Hosking and Wallis, 1997) is performed and the future frequency based precipitation for 80, 100, and 200 years of return period are estimated. As a result, future frequency based precipitation in South Korea will be increased by 25 to 27 percent. Especially the result for Jeju Island shows that the increasing rate will be higher than other areas. Severe heavy precipitation could be more and more frequently occurred in the future due to the climate change and the runoff characteristics will be also changed by urbanization, industrialization, and climate change. Therefore, we need prepare flood prevention measures for our flood safety in the future.

• Journal of the korean academy of Pediatric Dentistry
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• v.26 no.2
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• pp.331-338
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• 1999

Chemoradiation therapy used on pediatric oncology patients often causes dental developmental anomalies that affect future dental care. Defects noted include tooth and root agenesis, root thining and shortening, and localized enamel defects. The effect of radiotherapy usually are confined to the radiation site, but the effects of chemotherapy may be more wide spread because of its systemic distribution and structures and organs unrelated to the primary tumor may be affected. Many pediatric cancers are treated with a combination of radiation and multiagent chemotherapy to create synergic and additive effects. Dental treatment affected by chemoradiation damage to developing teeth includes orthodontic tooth movement, prosthetic abutment considerations, periodontal health, space maintenance, requirements for home fluoride regimens to protect hypomineralized areas, restoration options for hypoplastic/hypomineralized teeth, and endodontic procedures. The following case demonstrate chemoradiation therapy effects on the dental development.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.30 no.6
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• pp.497-503
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• 2004

One of the most difficult problems to damage in dentistry is an odontogenic infection. These infections may range from low-grade, well-localized infections that require only minimal treatment to a severe, life-threatenig fascial space infection. Although the overwhelming majority of odontogenic infections are easily managed by minor surgical procedures and supportive medical therapy that includes antibiotic administration, the practitioner must constantly bear in mind that these infections may become severe in a very short time. We made an investigation was targeting on 78 male and 47 female patients (125 patients in total) who had been hospitalized because of the fascial space abscess on the oral and maxillofacial area and gained a complete recovery in Daegu Catholic University Hospital, Oral & Maxillofacial Surgery from January 1999 to December 2003. By tracing their charts, we could grasp the characteristics such as age, gender, the time of breakout and specific areas of the attacks, making a conclusive study of the statistical analysis and finally, we could reach conclusions. Now, we report the conclusion from the investigation with the literature. The proportion of males and females was approximately 3 to 2, and in age group, patients under 10 years old marked the highest, 22.4%. The patients between the age of 10 and 40 were only 14.4%, yet those who were between 40 and 80 marked 53.6% in contrast. In the monthly distribution, the order was Dec.(13.6%)-Sep.(12%)-Jan.(10.4%) and in seasonal distribution, it was winter(30.4%)-fall(28%)- summer(24.4%)- spring(19.2%). Considering the medical history, D.M. was the highest which was 30.3%, hypertension marked 24.4%, and the patients with both D.M. and hypertension were 9.0%. The major cause of infection of oral and maxillofacial areas was odontogenic infection, which marked about 96%, and especially the cases related to dental caries occurred most frequently, which was 51.2%. In the number of relaxed fascial space, single fascial space was 81.6%, and in the degree of relaxation of fascial space, the buccal space abscess marked 40.8%, following submandibular space abscess, which was 30.4%.

• Journal of the Korea Concrete Institute
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• v.25 no.1
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• pp.99-106
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• 2013

Concrete materials subjected to impact by high velocity projectiles exhibit responses that differ from those when they are under static loading. Projectiles generate localized effects characterized by penetration of front, spalling of rear and perforation as well as more widespread crack propagation. The magnitude of damage depends on a variety of factors such as material properties of the projectile, impact velocity, the mass and geometry as well as the material properties of concrete specimen size and thickness, reinforcement materials type and method of the concrete target. In this study, penetration depth of front, spalling thickness of rear and effect of spalling suppression of concrete by fiber reinforcement was evaluated according to compressive strength of concrete. As a result, it was similar to results of the modified NDRC formula and US ACE formula that the more compressive strength is increased, the penetration depth of front is suppressed. On the other hand, the increase in compressive strength of concrete does not affect spalling of rear suppression. Spalling of rear is controlled by the increase of flexural, tensile strength and deformation capacity.

• Journal of Periodontal and Implant Science
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• v.25 no.3
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• pp.497-517
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• 1995

The cells associated with normal defense mechanism in inflammation release free oxygen radicals, hydroxy radicals, and various protease, all of which can damage the surrounding cells(fibroblasts) and matrix molecules(collagen). The objective of this study was to evaluate the effects of "scavenger" enzyme, superoxide dismutase(SOD). to periodontal ligament (PDL) cells. Human PDL cells were cultured from the teeth extracted for non-periodontal reason. Cultured PDL cells in vitro were treated with SOD and LPS according to dosage and culture times. Cellular activity was exaimed by Microtitration(MTT) assay. The quantitative expression of cellular proliferation by proliferating cell nuclear antigen(PCNA), collagen type I and fibronectin by indirect immunocytochemically stain in PDL cells were done. The results were as follows: 1. As only SOD treated group at 2 and 3 days, PDL cell activity was significantly increased at more than 150U(P<0.05). 2. When LPS(0.5, $5{\mu}g/m{\ell}$) and SOD(more than 150U) were added together, it was significantly increased than LPS only treated and control groups at 2 days(P<0.05). 3. When LPS($5{\mu}g/m{\ell}$) and SOD(150, 300U) were added together, PCNA index was significantly increased than LPS only treated and control groups at 2 and 3 days(P<0.05). 4. When LPS($5{\mu}g/m{\ell}$) and SOD(150U) were added together, collagen type I was significantly increased than LPS only treated and control groups at 3 days(P<0.05). 5.When LPS($5{\mu}g/m{\ell}$) and SOD(300U) were added together, fibronectin was significantly increased than LPS only treated and control groups at 3 days(P<0.05). On the above the results, the SOD in association with collagen type I, fibonectin, and PCNA may afford biological protection to oxy-radicals that were typically liberated during normal inflammatory response. Thus, the exogenous application of SOD may be effective in sthe treatment of the localized breakdown associated with chronic periodontal disease.

• Journal of Arbitration Studies
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• v.19 no.3
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• pp.93-119
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• 2009

Nowadays the number of crimes is increasing rapidly and society is getting more and more dangerous. Recently the criminal aspect of our society, the intelligence, diversity, localized area, as well as for the crime victims also difficult to predict the damage recovery is not easy to change their level of pain and are also serious. This phenomenon is increasingly expected to intensify, the proper response is a factory. The more so if the victim of murder. The criminal mediation working on the operational adjustments Borrower payment, Construction charges, investments and financial transactions due to interpersonal conflicts that occurred as a fraud, embezzlement, breach of trust property crimes such accused, individuals between the defamatory, offensive, encroachment, violating intellectual property rights and private Disputes about the complaint case and other criminal disputes submitted to mediation to resolve it deems relevant to the case who are accused. But the core of a detective control adjustment, adjust the members' representative to the region, including front-line player or a lawyer appointed by the attorney general at this time by becoming parties to this negative view may be ahead. Some scholars are criticizing the current criminal justice system for the absence of proper care for the criminal victims, as an alternative to the traditional criminal justice system. The introduction of the summary trial and related legal cases, the command structure, compensation system, crime victims' structural system can be seen as more classify, crime subject to victim's complaint, By case with a criminal misdemeanor in addition to disagree not punish criminal, minor offense destination, traffic offenders, regular property crime, credit card theft, intellectual property rights violators can be seen due to more categories can try. They sued in law enforcement, Prosecution case has been received and if any one party to the criminal detective Arbitration request arbitration by the parties can agree to immediately contact must be referred to arbitration within 15 days of when the arbitration case will be dismissed. These kinds of early results of the case related to, lawyers are involved directly in the arbitration shall be excluded. Arbitration system is the introduction of criminal justice agencies working to help resolve conflicts caused by adjustment problems will be able to. This article does not argue that we should stick to the traditional justice system as a whole. Instead it argues that the restrictive role of the traditional justice is to be preserved.

• Journal of the Korea Concrete Institute
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• v.20 no.6
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• pp.713-719
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• 2008

Various types of coatings have been developed for use as reinforcement in concrete and to resist chloride environment. The most commonly used coatings are inhibited and sealed cement slurry coating, cement polymer compositing coating and epoxy coating. Cement slurry offers passive protection, epoxy coating offers barrier protection whereas polymer coating offers both passive protection and barrier protection. Moreover, damage during handling of the steel may result in disbondment of the epoxy coating, which would increase the risk of localized corrosion. In the present study, inhibiting technique was used to increase the calcium hydroxide content at the interface up to 20%. Calcium hydroxide provides a high buffering capacity that resists a local fall in pH and thus maintains the alkaline environment necessary to prevent chloride corrosion. This study examines the use of a calcium hydroxide coating on the steel surface to enhance the pH buffering capacity of steel-concrete interface. Finally, the chloride threshold level (CTL) of polymer inhibitive coating calcium hydroxide is evaluated.