• Archives of Plastic Surgery
• /
• v.43 no.4
• /
• pp.344-351
• /
• 2016

Background Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by xerosis, ultraviolet light sensitivity, and cutaneous dyspigmentation. Due to defects in their DNA repair mechanism, genetic mutations and carcinogenesis inevitably occurs in almost all patients. In these patients, reconstruction of cutaneous malignancies in the head and neck area is associated with some challenges such as likelihood of recurrence and an aggressive clinical course. The aim of this study is to discuss the therapeutic options and challenges commonly seen during the course of treatment. Methods Between 2005 and 2015, 11 XP patients with head and neck cutaneous malignancies were included in this study. Demographic data and treatment options of the patients were evaluated. Results The mean age of the patients was 32 years (range, 10-43) (4 males, 7 females). The most common tumor type and location were squamous cell carcinoma (6 patients) and the orbital region (4 patients), respectively. Free tissue transfer was the most commonly performed surgical intervention (4 patients). The average number of surgical procedures was 5.5 (range, 1-25). Six patients were siblings with each other, 5 patients had local recurrences, and one patient was lost to follow-up. Conclusions Although genetic components of the disease have been elucidated, there is no definitive treatment algorithm. Early surgical intervention and close follow-up are the gold standard modalities due to the tendency toward rapid tumor growth and possible recurrence. Treatment must be individualized for each patient. In addition, the psychological aspect of the disease is an important issue for both patients and families.

• Korean Journal of Veterinary Research
• /
• v.16 no.2
• /
• pp.165-171
• /
• 1976

Experimental approaches on the effectiveness of thimerosal to control growth of Nosema apis (Zander, 1909) were carried out in the rearing honey bees. The rearing honey bees were artificially infected with various levels of spore isolated from local honey bees. The results obtained were summarized as follows: 1. In the experiments of therapeutic chemicals for Nosema disease, 0.01% and 0.02% thimerosal of sucrose-honey mixture was the most effective agent but the each concentration of amprolium, furazolidone, hygiene, sulfadimethoxine and terramycin did not show the any effects 2. It showed very high therapeutic effectiveness (over than 90%) that the treatment of three times every other day after the treatment of three times consecutive every day with 0.01% thimerosal, or the treatment of three times consecutive every day with 0.02% thimerosal. 3. When 0.02% thimerosal was administered three times consecutive every day to honey bees at the 4th day before artificial inoculation of N. apis, it showed very high degree (100%) of prevalence control effectiveness, and it also showed high degree (over than 90%) in administration at the 7th day before, and over than 80% at the 10th day before. Then authors found that thimerosal has the prevalence control effectiveness as well as the treatment effectiveness. 4. In the rearing honey bee colony, 0.02% thimerosal showed the high degree (over than 80%) of therapeutic effectiveness with the various levels which contained from the light decree of infection to the severe degree of it.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.2 no.2
• /
• pp.120-133
• /
• 2008

This paper presents a novel approach for facial motion tracking and facial expression cloning to create a realistic facial animation of a 3D avatar. The exact head pose estimation and facial expression tracking are critical issues that must be solved when developing vision-based computer animation. In this paper, we deal with these two problems. The proposed approach consists of two phases: dynamic head pose estimation and facial expression cloning. The dynamic head pose estimation can robustly estimate a 3D head pose from input video images. Given an initial reference template of a face image and the corresponding 3D head pose, the full head motion is recovered by projecting a cylindrical head model onto the face image. It is possible to recover the head pose regardless of light variations and self-occlusion by updating the template dynamically. In the phase of synthesizing the facial expression, the variations of the major facial feature points of the face images are tracked by using optical flow and the variations are retargeted to the 3D face model. At the same time, we exploit the RBF (Radial Basis Function) to deform the local area of the face model around the major feature points. Consequently, facial expression synthesis is done by directly tracking the variations of the major feature points and indirectly estimating the variations of the regional feature points. From the experiments, we can prove that the proposed vision-based facial expression cloning method automatically estimates the 3D head pose and produces realistic 3D facial expressions in real time.

• Journal of KIISE:Information Networking
• /
• v.32 no.6
• /
• pp.745-752
• /
• 2005

BGP is a unique routing protocol in broadband internet. It chooses routing paths considering internet hierarchy and local policies. As BGP routers selectively bypass routing information to a subset of neighboring BGP routers, connectivity by way of a series of links between source and destination nodes does not mean reachability of routing information of the two. In emergency when BGP routers or links over wide range are not available, BGP routers have to use links that are not normally used to keep reachability. This paper listed out the requirements for BGP backup routing and proposed a routing solution that hides most demerits in currently published ones. The proposed backup operates in three tiers according to network damage. Under this rule, BGP routers use tier-0 routing paths at normal. If networks are impaired, they choose tier-1 paths. If networks are seriously damaged, tier-2 paths are allowed to use. Also this paper proves that the proposed backup guarantees stability and safeness. As results, the proposed backup is very adaptive to light network damages as well as serious ones and provides strong routing reachability at all times.

• The Journal of Engineering Geology
• /
• v.5 no.2
• /
• pp.181-192
• /
• 1995

The discrimination studies between earthquakes and underground nuclear explosions have been carried out by various seismologists(Nuttli and Kim, 1976; Dahiman and Israelson, 1977; Masse, 1981). The discrimination between local microearthquakes and artificial underground explosions(epicentral distance not greater than 400Km), however, has not been actively studied so far in the light of seismological aspects. Futhermore this kind of research has never been performed in Korea even if it is of great importance for IAEA (International Atomic Energy Agency) to clearly analyze the military nuclear power of North Korea at present. This research has been carried out by using some of the artificial underground explosions(about 100 events) have occurred in North Korea for the last six years. The azimuths, apparent incidence angles, epicentral distances and locations are determined using a single station of 3 - component data. The detection, location and identification are performed through the polarization and the bandpass filtering. This technique can be also applied to study the inhomogeneous crustal structure finding the converted waves.

• Journal of the Korean Academic Society of Industrial Cluster
• /
• v.2 no.1
• /
• pp.14-27
• /
• 2008

Ousters have become a key focus of interest and analysis over the last decade or so, informed by the work of the Harvard business economist Michael Porter. Recent research, however, suggests that the classic Porterian conception of clusters needs to be rethought. In particular, the idea that clusters are geogaphically bounded and integrated units whose primary link to the outside world is through the export of goods and services to global markets is highly Questionable, if not untenable. Relational approaches to clusters and regional development stress the importance of the wider networks and 'pipelines' through which knowledge is exchanged with key partners and collaborators located outside of the particular cluster in question. Rather than the main external links being those between leading firms and global markets, firms may engage in a range of global relations with collaborators and suppliers. This paper address the challenge of rethinking clusters in the light of the recent emphasis on global networks md connections, drawing on experience from m old industrial region in Western Europe Scotland. In assessing cluster experiences and initiatives in Scotland, I examine the development of the oil and gas and electronics clusters. In conclusion, I suggest that cluster initiatives me only likely to generate lasting benefits for the region in question if there is significant local ownership md control of key industries and clusters.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.33 no.4B
• /
• pp.174-183
• /
• 2008

In this paper we design and implement a sensor network management framework(SNMF) for ubiquitous sensor networks(USNs). The SNMF employs the policy-based management approach for the autonomous and energy-efficient management of USNs. Moreover, a new light-weight policy distribution protocol called TinyCOPS-PR is designed and USN PIB for low-level policy is also defined. This allows the high-level policies defined by an administrator to translate into the specific low-level policies. The low-level policies are executed on sensor nodes so it can fulfill the proper management actions. The sensor nodes that receive some policies from an administrator perform local management actions according to those policies. SNMF can therefore realize small energy consumption and bring long network lifetime. It can also manage USNs automatically with a minimum of human interference.

• Journal of the Economic Geographical Society of Korea
• /
• v.17 no.4
• /
• pp.801-816
• /
• 2014

This paper is a theoretically grounded empirical study aimed at shedding light on the Triple Helix of University-Industry-Government (U-I-G) relations in biotechnology cluster of Singapore. It questions the issue about the gap between theoretical consideration of the Triple Helix of U-I-G relations and the actual reality in biotechnology cluster, and the experience of Singapore was investigated. In terms of evolutionary perspective, biotechnology cluster in Singapore has gone through ongoing processes from a certain stage to other, and within the processes the Triple Helix nexus has been found. Analysis of the empirical study reveals significant findings: first, the government policies play a critical role in the operation of U-I-G relations rather than universities; second, therefore, the binding force of U-I-G relationships is based on the government policies being comprehensive including researchers immigration, student scholarship for local students, and tax and non-tax incentives for firms, rather than focusing on a targeted policy; third, the role of government starts from an initial stage, and it's role is ongoing processes by supporting infrastructure, human sources and continuous nourishment enabling the triple helix of U-I-G relations.

• YAKHAK HOEJI
• /
• v.55 no.1
• /
• pp.1-10
• /
• 2011

Mastic is a bleed resin formed in pistacia lentiscus tree extract form the anacatdiaceae family. Mastic is used as a food ingredient in the Mediteraanean resin, and has been used by local inhabitants as a traditional medicine for relief of upper abdominal discomfort, dyspepsiaand peptic ulcer. Clinically, mastic has been effective in the treatment of benign gastric and duodenal, ulcers, giving symptomatic relief and endoscopically proven healing. In this study, to enhance activiteies of poorly water soluble Mastic with oils, surfactants and cosurfactants and then the mixure was microemulsified in aqueous media under condition of gentle agitation and digestive motility that would be encountered in the gastrointestinal tract. Formulation development and screening were based on phase diagrams and characteristics of resultant microemulsion. For optimum mastic formulation, microemulsions with various ratio (w/w%) of mastics, oils, surfactants and cosurfactants were prepared and their solubility was evaluated by monitoring particles size in their buffer through visual asessment and electrophoretic light scattering spectrophotomerter (ELS). In vitro activity of self microemulsified mastic (SME mastic) was determined by minimum ingibition concentration (MIC) test against a panel of Helicobacter pylori (H. pylori) clinical strains. Additionally, in vivo activity of SME masitc was investigated us mouse infected by CH275 of H. pylori. The mean diameter of SME mastic was less then 100 nm in water and SME mastic was showed similar antiboisis effect compared to tometronidazole, clarithromycin and omeproazole. Consequently, SME mastic would be effective system to exterminate H. pylori. If mastic were dose with combined treatment, mastic might augur well for effect of H. pylori eradication as good remedy.

• Safety and Health at Work
• /
• v.3 no.2
• /
• pp.140-145
• /
• 2012

Objectives: To understand the personal experiences of mine workers that have experienced job relocation due to silicosis at the Andina Division of Corporaci$\acute{o}$n Nacional del Cobre (CODELCO), Chile. The purpose of the study was to provide useful information for the development of new local, business and public policies for the care of workers with silicosis. Methods: A qualitative study based on a practical case study of 5 workers. The information was collected by means of structured individual interviews. The method of analysis was phenomenology. Results: The corporal axis was the most commented upon. It included awareness of the illness, body pains, fatigue, and antagonistic mood disorders (sadness, or the difficulty in finding meaning in life). As far as personal relationships, there was evidence of strong relationships with family, coworkers and friends, as well as extended family. Over all, the experience of relocation was positive with periods of impatience and uncertainty. The job reassignment provided a new and pleasant context for the relocated workers and in the process improved their perception of their quality of life. Conclusions: A multidisciplinary team should attend mine workers relocated because of silicosis by addressing the mental and physical aspects of their disease, along with the integral participation of close family members. It is suggested that this investigation be maintain over time to record the personal experiences in the medium-term, adding new cases with the intention of shedding more light on the phenomenon being studied. As a preventive measure, continual workshops are needed on the proper use of respiratory protection in addition, a group of monitors is required.