• Journal of Life Science
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• v.25 no.3
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• pp.336-344
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• 2015

The capacity for liver regeneration involves a variety of nutritional factors. Vitamin C has multiple metabolic and antioxidant functions. In this study, we investigated the role of vitamin C in liver regeneration following hepatectomy in senescence marker protein (SMP)-30 knockout (KO) mice. Partial hepatectomy was performed by resecting the median and left lateral lobes of mice. Vitamin C accelerated liver recovery in SMP30 KO mice treated with vitamin C (KV). The livers of the KV mice exhibited lower levels of aspartate aminotransferase and lower injury than those of the KO mice. Increased type II transforming growth factor-β receptor (TGF-βRII)-mediated regeneration signaling was accompanied by HGF and cMet in the KV but not the KO mice. Consistent with this, the expression of cell cycle regulatory proteins, including cyclin D1 and proliferating cell nuclear antigen (PCNA), increased rapidly in the KV mice. Enhanced activation of ERK and GSK-3β proteins and a significantly increased number of binuclear hepatocytes were also detected in the livers of the KV mice. Moreover, the KV mice synthesized the highest levels of albumin. These data suggest that treating SMP30 knockout mice with vitamin C resulted in earlier recovery and liver regeneration by activation of the regeneration system.

• Journal of The Korean Association For Science Education
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• v.18 no.4
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• pp.589-600
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• 1998

The present study tested the hypothesis that adolescent's prefrontal lobe growth plateau and spurt exists and that this plateau and spurt influence students' ability to reason scientifically and to learn theoretical science concepts. In theory, maturation of the prefrontal lobes during early adolescence allows for improvements in students' abilities to inhibit task-irrelevant information and coordinate task-relevant information, which along with both physical and social experience, influences scientific reasoning ability and the ability to reject scientific misconceptions and accept scientific conceptions. Two hundred six students ages 13 to 16 years enrolled in four Korean secondary schools were administered tests of prefrontal lobe functions, scientific reasoning, and theoretical concepts derived from kinetic-molecular theory. A series of 14 lessons designed to teach the concepts were then taught. The concepts test was then re-administered following instruction. As predicted among the 14-year-olds, performance on the measures of prefrontal lobe functions, scientific reasoning, and conceptual change remained similar or regressed. Performance then improved considerably among the 15 and 16-year-olds. Because so few of the present students were able to undergo this apparently necessary conceptual change, the value of introducing theoretical concepts to early adolescent is questioned.

• Investigative Magnetic Resonance Imaging
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• v.19 no.2
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• pp.88-98
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• 2015

Purpose: To compare the interobserver and intraobserver reliability of mean apparent diffusion coefficient (ADC) values using contrast-enhanced (CE) T1 weighted image (WI) and T2WI as structural images between manual and semiautomatic segmentation methods. Materials and Methods: Between January 2011 and May 2013, 28 patients who underwent brain MR with diffusion weighted image (DWI) and were pathologically confirmed as having glioblastoma participated in our study. The ADC values were measured twice in manual and semiautomatic segmentation methods using CE-T1WI and T2WI as structural images to obtain interobserver and intraobserver reliability. Moreover, intraobserver reliabilities of the different segmentation methods were assessed after subgrouping of the patients based on the MR findings. Results: Interobserver and intraobserver reliabilities were high in both manual and semiautomatic segmentation methods on CE-T1WI-based evaluation, while interobserver reliability on T2WI-based evaluation was not high enough to be used in a clinical context. The intraobserver reliability was particularly lower with the T2WI-based semiautomatic segmentation method in the subgroups with involved $lobes{\leq}2$, with partially demarcated tumor borders, poorly demarcated inner margins of the necrotic portion, and with perilesional edema. Conclusion: Both the manual and semiautomatic segmentation methods on CE-T1WI-based evaluation were clinically acceptable in the measurement of mean ADC values with high interobserver and intraobserver reliabilities.

• Korean Journal of Plant Taxonomy
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• v.38 no.2
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• pp.121-149
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• 2008

Taxonomic treatment and the identification key for 6 species and 4 varieties from the genus Asarum (Aristolochiaceae) in Korea were presented on the basis of the morphological analyses. Recently the taxonomy of the genus Asarum in Korea is controversial in the definition of species and the establishment of variation range. Our morphological studies supported that the species A. patens, A. misandrum and A. versicolor should be recognized as independent species by the unique morphological characters such as calyx lobes, stylar protuberance and leaf variegation. Second, A. sieboldii var. cornutum, A. koreanum, A. maculatum and A. sonunsanense, regarded as species or variety by different scholars, showed a close relationship with A. sieboldii by the similar calyx characters. Thus, new combinations, such as A. sieboldii for. cornutum, A. sieboldii for. koreanum, A. sieboldii for. maculatum and A. sieboldii for. sonunsanense, are proposed. And A. heterotropoides var. seoulense and A. heterotropoides var. mandshuricum also had a close relationship, thus, new combinations, A. mandshuricum for. seoulense, A. mandshuricum for. mandshuricum, are proposed. Furthermore, it is appropriate that A. heterotropoides var. heterotropoides, only distributed in Japan, is revised into A. heterotropoides as independent species by the unique character from the 2 varieties above. Consequently, the genus Asarum in Korea is classified into 3 species and 7 forma.

• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.3
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• pp.17-31
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• 2005

Purpose : These studies were undertaken to evaluate the effects of the administration of different concentrated Morindae officinalis Radix extract solution on the spermatogenic abilities such as concentration, motility and morphological normality of sperm from the testis and the activities of sperm hyaluronidase, testicular peroxidase and testicular catalase. Methods : We used the 2-month-old mice and administered the extract solution of Morindae officinalis Radix in the different concentration once a day for 60 days. The control group was administered the normal saline in the same way and duration. We examined the number of total, motile and normal sperm from the cauda epididymis, the activities of sperm hyaluronidase, testicular peroxidase and testicular catalase. Also we observed changes of isolated testis before and after administration of Morindae officinalis Radix extract solutions the mice. And we compared to the testicular tissue especially seminiferous tubules between control and treated group by histochemical methods. Results : The significant dose-dependent differences were observed in the concentration of total sperm, the motility and normality of spermatozoa of Morindae officinalis Radix extract solution administered groups compared to the control group, respectively. In the histological analysis of the testicular tissues, the enlargement of testicular lobe diameter and apparent vasculogenesis between testicular lobes were observed in the Morindae officinalis Radix extract solution administered groups compared to the control group, respectively. Also, the activity of hyaluronidase was significantly increased in the Morindae officinalis Radix extract solution administered groups compared to the control group. In the antioxidant activity analysis, the activity of testicular peroxidase was significantly increased in the Morindae officinalis Radix extract solution administered groups compared to the control group, respectively. Conclusion : This study shows that Morindae officinalis Radix has the beneficial effect on the concentration, morphology and motility of sperm, the activities of sperm hyaluronidase and testicular peroxidase. We can suggest that Morindae officinalis Radix extract solution be useful for the treatment of male sexual dysfunctions and infertility.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.22 no.3
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• pp.336-344
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• 2011

The purpose of this study is to analyze the radiation-pattern characteristics above 1 GHz for the electromagnetic wave radiated from multi-slot such as ventilations, etc. on the enclosure of an EUT and so to make recommendations for suitable test methods. An experimental EUT was formed by putting a comb-generator at the center of a rectangular enclosure with 4 slots, and its radiation pattern was analyzed in the frequency range of 1~6 GHz. As analysis results, multi-lobe appears above 2 GHz and the number of multi-lobes is growing as the frequency increases. And real radiated-emission measurements were performed for the experimental EUT by scanning a receiving antenna in the height of 1~4 m and tilting toward maximum radiation, as well as setting the height of a receiving antenna to the central position of the EUT which is prescribed at the present standards. The measured results are +12.8 dB in the scanning and +16.4 in the scanning and tilting compared with the present standard test method. Therefore, the latter must be revised in order to consider the radiation pattern above 1 GHz.

• Journal of Veterinary Clinics
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• v.32 no.6
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• pp.530-535
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• 2015

An 11-year-old intact female miniature poodle presented with a four-month history of hemorrhagic effusion. The patient was alert on physical examination, although muffled heart sounds were noted upon auscultation of the right hemithorax. The radiographic finding was pleural effusion. Ultrasonography revealed cystic changes in both ovaries and several nodules in the liver. A refractory opacity in the right lung field, as visualized with computer tomography (CT), was diagnosed as right middle lung lobe torsion with a collapsed bronchus. Five days after diagnosis, a right fifth intercostal thoracotomy was performed to remove the right middle lung lobe; the right middle lung lobe was grossly shrunken as a result of chronic lung lobe torsion. Ovariohysterectomy was also performed. Histopathologic examination revealed papillary adenocarcinoma in both ovaries and suspected metastasized ovarian adenocarcinoma cells in the lung lobe. The patient recovered favorably and had been doing well up to two months post-surgery. However, after four months, the dog presented with respiratory difficulty. The radiographic findings were pleural effusion and collapse of the right cranial and left caudal lung lobes. Malignant cells of epithelial origin were observed in the pleural effusion. The tumor cells were suspected to be metastasized cells from the previously resected lung lobe. Although cancer treatment was recommended, the suggestion was suspended and the dog was discharged from hospital. This was a case of lung lobe torsion that had occurred because of hemorrhagic effusion due to tumor. Although ovariohysterectomy and lobectomy were performed, there was a relapse of hemorrhagic effusion because of metastasized tumor from the previously resected lung lobe.

• Korean Journal of Plant Taxonomy
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• v.35 no.1
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• pp.57-80
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• 2005

Morphological variation of Quercus L. subgen. Quercus in Korea was examined by numerical methods including principal components analysis of major morphological characters. Principal components analysis revealed the presence of five major species groups of the subgen. Quercus in Korea; these include 1) a group consisiting of Q. acutissima and Q. variabilis individuals, 2) Q. dentata, 3) Q. aliena, 4) Q. mongolica, and 5) Q. serrata. The putative interspecific hybrid individuals occupied intermediate position between the putative parent species in the PCA plot. The analysis also strongly suggested that size and shape of leaf blade and teeth or lobes, twig diameter, size and shape of nuts, and length and width of scales are very useful in distinguishing the species and the putative hybrids of the subgen. Quercus.

• Korean Journal of Veterinary Service
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• v.42 no.1
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• pp.39-42
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• 2019

Tetanus is an acute, often fatal, and infectious disease of all species of domestic animals caused by the neurotoxin of Clostridium tetani (C. tetani). This disease is usually known to develop after microbial contamination in the deep or penetrating wound sites. In February 2017, a farmer who was raising 76 cows injected foot and mouth disease vaccine to three or more cows with one syringe. Their clinical symptoms were observed 2 to 16 days after the vaccination. The initial symptoms were stiffness, rigidity of the neck and limbs, pricked ears, and prolapse of the third eyelid. Subsequently, there was recumbency with extension of the limbs, convulsions and opistotonus and the affected 20 cows were all died. Two dead cows were submitted to Animal and Plant Quarantine Agency for disease diagnosis. At necropsy, a focal edematous abscess of 15 to 20 cm in diameter was grossly observed in the subcutaneous and intramuscular tissue of scapular region and filled with a large amount of greenish pus. The feed was full in oral cavity and slightly observed in the trachea and lobes of lung. Histopathologically, focal granulomatous nodules with eosinophilic materials in the tissue were observed. In the lung, aspiration pneumonia and gram (+) bacteria were seen. The C. tetani was isolated in samples anaerobically cultured using reinforced clostridial medium and identified by PCR. To our knowledge, no previous outbreak of tetanus in cattle has affected such a high number of animals; neither has it been associated with misuse of the same syringe and needle to administer multiple individuals.

• Parasites, Hosts and Diseases
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• v.59 no.1
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• pp.35-45
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• 2021

Adult echinostomes having 37 collar spines collected from the intestine of Pitalah ducks in Aceh Province, Indonesia in 2018 were morphologically and molecularly determined to be Echinostoma miyagawai Ishii, 1932 (Digenea: Echinostomatidae). Among 20 ducks examined, 7 (35.0%) were found to be infected with this echinostome, and the number of flukes collected was 48 in total with average 6.9 (1-17) worms per duck. The adult flukes were 7.2 (6.1-8.5) mm in length and 1.2 (1.0-1.4) mm in width (pre-ovarian or testicular level) and characterized by having a head collar armed with 37 collar spines (dorsal spines arranged in 2 alternating rows), including 5 end group spines, and variable morphology of the testes, irregularly or deeply lobed (3-5 lobes) at times with horizontal extension. The eggs within the worm uterus were 93 (79-105) ㎛ long and 62 (56-70) ㎛ wide. These morphological features were consistent with both E. miyagawai and Echinostoma robustum, for which synonymy to each other has been raised. Sequencing of 2 mitochondrial genes, cox1 and nad1, revealed high homology with E. miyagawai (98.6-100% for cox1 and 99.0-99.8% for nad1) and also with E. robustum (99.3-99.8% for nad1) deposited in GenBank. We accepted the synonymy between the 2 species and diagnosed our flukes as E. miyagawai (syn. E. robustum) with redescription of its morphology. Further studies are required to determine the biological characteristics of E. miyagawai in Aceh Province, Indonesia, including the intermediate host and larval stage information.