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검색결과 137건 처리시간 0.027초

Localization, activation and deactivation of $Ca^{2+}$ dependent $Cl^-$ channels in pancreatic acinar cells

  • Park, Myoung-Kyu;Richard Lomax;Alexei V. Tepikin;Ole H. Petersen
    • 한국생물물리학회:학술대회논문집
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    • 한국생물물리학회 2001년도 학술 발표회 진행표 및 논문초록
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    • pp.27-27
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    • 2001
  • In exocrine acinar cells, $Ca^{2+}$ -activated Cl$^{[-10]}$ channels in the apical membrane are essential for fluid secretion, but it is unclear whether such channels are important for Cl$^{[-10]}$ uptake at the base. Whole cell current recording, combined with local uncaging of caged $Ca^{2+}$, was used to reveal the Cl$^{[-10]}$ channel distribution in mouse pancreatic acinar cells, where ~90% of the current activated by $Ca^{2+}$ in response toacetylcholine was carried by Cl$^{[-10]}$ .(omitted)

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Recent Developments in the EU Investment Policy : Towards an Investment World Court?

  • Giupponi, Belen Olmos
    • 한국중재학회지:중재연구
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    • 제26권3호
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    • pp.175-230
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    • 2016
  • The controversies that have surrounded the negotiation of both the Comprehensive Economic and Trade Agreement (CETA) and the Transatlantic Trade and Investment Partnership (TTIP) have underlined the difficulties arising out from the adoption of a truly common EU investment policy. Non-governmental organizations have called into question transparency and legitimacy of international investment arbitration during the negotiations. The article presents a reflection about current developments of the EU investment policy addressing, in particular, the criticisms towards the whole investor-to-State system and the EU's efforts in developing a "tailor-made" investment agreement and Investor-to-State Dispute resolution system. Along these lines, the article critically assesses the recently announced proposal for the establishment of an 'Investment Court System' put forward by the EU during the TTIP negotiations.

Practical Implementation of an Interleaved Boost Converter for Electric Vehicle Applications

  • Wen, Huiqing;Su, Bin
    • Journal of Power Electronics
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    • 제15권4호
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    • pp.1035-1046
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    • 2015
  • This study presents a practical implementation of a multi-mode two-phase interleaved boost converter for fuel cell electric vehicle application. The main operating modes, which include two continuous conducting modes and four discontinuous conducting modes, are discussed. The boundaries and transitions among these modes are analyzed with consideration of the inductor parasitic resistance. The safe operational area is analyzed through a comparison of the different operating modes. The output voltage and power characteristics with open-loop or closed-loop operation are also discussed. Key performance parameters, including the DC voltage gain, input ripple current, output ripple voltage, and switch stresses, are presented and supported by simulation and experimental results.

Modal flexibility based damage detection for suspension bridge hangers: A numerical and experimental investigation

  • Meng, Fanhao;Yu, Jingjun;Alaluf, David;Mokrani, Bilal;Preumont, Andre
    • Smart Structures and Systems
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    • 제23권1호
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    • pp.15-29
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    • 2019
  • This paper addresses the problem of damage detection in suspension bridge hangers, with an emphasis on the modal flexibility method. It aims at evaluating the capability and the accuracy of the modal flexibility method to detect and locate single and multiple damages in suspension bridge hangers, with different level of severity and various locations. The study is conducted numerically and experimentally on a laboratory suspension bridge mock-up. First, the covariance-driven stochastic subspace identification is used to extract the modal parameters of the bridge from experimental data, using only output measurements data from ambient vibration. Then, the method is demonstrated for several damage scenarios and compared against other classical methods, such as: Coordinate Modal Assurance Criterion (COMAC), Enhanced Coordinate Modal Assurance Criterion (ECOMAC), Mode Shape Curvature (MSC) and Modal Strain Energy (MSE). The paper demonstrates the relative merits and shortcomings of these methods which play a significant role in the damage detection ofsuspension bridges.

Popularity-Based Adaptive Content Delivery Scheme with In-Network Caching

  • Kim, Jeong Yun;Lee, Gyu Myoung;Choi, Jun Kyun
    • ETRI Journal
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    • 제36권5호
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    • pp.819-828
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    • 2014
  • To solve the increasing popularity of video streaming services over the Internet, recent research activities have addressed the locality of content delivery from a network edge by introducing a storage module into a router. To employ in-network caching and persistent request routing, this paper introduces a hybrid content delivery network (CDN) system combining novel content routers in an underlay together with a traditional CDN server in an overlay. This system first selects the most suitable delivery scheme (that is, multicast or broadcast) for the content in question and then allocates an appropriate number of channels based on a consideration of the content's popularity. The proposed scheme aims to minimize traffic volume and achieve optimal delivery cost, since the most popular content is delivered through broadcast channels and the least popular through multicast channels. The performance of the adaptive scheme is clearly evaluated and compared against both the multicast and broadcast schemes in terms of the optimal in-network caching size and number of unicast channels in a content router to observe the significant impact of our proposed scheme.

Dynamics of an elastic beam and a jumping oscillator moving in the longitudinal direction of the beam

  • Baeza, Luis;Ouyang, Huajiang
    • Structural Engineering and Mechanics
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    • 제30권3호
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    • pp.369-382
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    • 2008
  • An oscillator of two lumped masses linked through a vertical spring moves forward in the horizontal direction, initially at a certain height, over a horizontal Euler beam and descends on it due to its own weight. Vibration of the beam and the oscillator is excited at the onset of the ensuing impact. The impact produced by the descending oscillator is assumed to be either perfectly elastic or perfectly plastic. If the impact is perfectly elastic, the oscillator bounces off and hits the beam a number of times as it moves forward in the longitudinal direction of the beam, exchanging its dynamics with that of the beam. If the impact is perfectly plastic, the oscillator (initially) sticks to the beam after its first impact and then may separate and reattach to the beam as it moves along the beam. Further events of separation and reattachment may follow. This interesting and seemingly simple dynamic problem actually displays rather complicated dynamic behaviour and has never been studied in the past. It is found through simulated numerical examples that multiple events of separation and impact can take place for both perfectly elastic impact and perfectly plastic impact (though more of these in the case of perfectly elastic impact) and the dynamic response of the oscillator and the beam looks noisy when there is an event of impact because impact excites higher-frequency components. For the perfectly plastic impact, the oscillator can experience multiple events of consecutive separation from the beam and subsequent reattachment to it.

Minimize Reactive Power Losses of Dual Active Bridge Converters using Unified Dual Phase Shift Control

  • Wen, Huiqing;Su, Bin
    • Journal of Electrical Engineering and Technology
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    • 제12권2호
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    • pp.654-664
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    • 2017
  • This paper proposed an unified dual-phase-shift (UDPS) control for dual active bridge (DAB) converters in order to improve efficiency for a wide output power range. Different operating modes of UDPS are characterized with respect to the reactive current distribution. The proposed UDPS has the same output power capability with conventional phase-shift (CPS) method. Furthermore, its implementation is simple since only the change of the leading phase-shift direction is required for different operating power range. The proposed UDPS control can minimize both the inductor rms current and the circulating reactive current for various voltage conversion ratios and load conditions. The optimal phase-shift pairs for two bridges of DAB converter are derived with respect to the comprehensive reactive power loss model, including the reactive components delivered from the load and back to the source. Simulation and experimental results are illustrated and explained with details. The effectiveness of the proposed method is verified in terms of reactive power losses minimization and efficiency improvement.

A Web-Based IPTV Content Syndication System for Personalized Content Guide

  • Yang, Jinhong;Park, Hyojin;Lee, Gyu Myoung;Choi, Jun Kyun
    • Journal of Communications and Networks
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    • 제17권1호
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    • pp.67-74
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    • 2015
  • In this paper, we propose a web-based content syndication system in which users can easily choose Internet protocol television (IPTV) contents. This system generates personalized content guide to provide a list of IPTV contents with respect to users' interests and statistics information of their online social community. For this, IPTV contents and relevant metadata are collected from various sources and transformed. Then, the service and content metadata are processed by user metadata including audience measurement and community metadata. The metadata flows are separated from content flows of transport network. The implementation of IPTV content syndication system demonstrates how to arrange IPTV contents efficiently from content providers to the end user's screen. We also show that the user metadata including online community information are important for the system's performance and the user's satisfaction.

Power Factor Improvement of Distribution System with EV Chargers based on SMC Method for SVC

  • Farkoush, Saeid Gholami;Kim, Chang-Hwan;Jung, Ho-Chul;Lee, Sanghyuk;Theera-Umpon, Nipon;Rhee, Sang-Bong
    • Journal of Electrical Engineering and Technology
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    • 제12권4호
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    • pp.1340-1347
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    • 2017
  • Utilization of Electric Vehicles (EVs) have been growing popularity in recent years due to increment in fuel price and lack of natural resources. Random unexpected charging by home EV charger in distribution is predicted in the future. The power quality problems such as fluctuation of power factor in a residential distribution network was explored with random EV chargers. This paper proposes a high-performance nonlinear sliding mode controller (SMC) for an EV charging system to compensate voltage distortions and to enhance the power factor against the unbalanced EV chargers. For the verification of the proposed scheme, MATLAB-Simulink simulations are performed on 22.9-kV grid. The results show that the proposed scheme can improve the power factor of a smart grid due to the EV chargers on the grid.

Design and homogenization of metal sandwich tubes with prismatic cores

  • Zhang, Kai;Deng, Zichen;Ouyang, Huajiang;Zhou, Jiaxi
    • Structural Engineering and Mechanics
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    • 제45권4호
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    • pp.439-454
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    • 2013
  • Hollow cylindrical tubes with a prismatic sandwich lining designed to replace the solid cross-sections are studied in this paper. The sections are divided by a number of revolving periodic unit cells and three topologies of unit cells (Square, Triangle and Kagome) are proposed. Some types of multiple-topology designed materials are also studied. The feasibility and accuracy of a homogenization method for obtaining the equivalent parameters are investigated. As the curved elements of a unit cell are represented by straight elements in the method and the ratios of the lengths of the curved elements to the lengths of the straight elements vary with the changing number of unit cells, some errors may be introduced. The frequencies of the first five modes and responses of the complete and equivalent models under an internal static pressure and an internal step pressure are compared for investigating the scope of applications of the method. The lower bounds and upper bounds of the number of Square, Triangular and Kagome cells in the sections are obtained. It is shown that treating the multiple-topology designed materials as a separate-layer structure is more accurate than treating the structure as a whole.