• 한국동물위생학회지
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• 제44권1호
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• pp.45-49
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• 2021

A 23-month-old Holstein cattle showed excess salivation and reluctance of walking and suddenly died after forced sudden movements. Grossly, numerous fibrous adhesions were present within cranial abdominal cavity including the reticulum and diaphragm and thoracic cavity involving lungs, pericardial sac, and heart. A perforation made by a 10 cm-long sharp-ended wire was detected in the reticulum. Histopathologically, fibrous suppurative epicarditis and myocardial necrosis were observed. Fibrosis with neovascularization were found in lungs, spleen, and liver. And granulomatous reticulitis was observed. For differential diagnosis, no pathogenic bacteria were detected through microbiological tests and PCR results were also negative for bovine susceptible pathogenic antigens. Based on the gross and histopathological examination, we diagnosed this case as chronic traumatic pericarditis. Cattle are inquisitive and prone to swallow various kinds of metallic foreign bodies since they do not use their lips. Therefore, avoiding ingestion of metallic objects in animal feed and animal areas by careful environmental management of farms is required and farmers should give the adequate minerals and vitamins into the feeds not to lick or shallow foreign bodies in case of mineral deficiency. For veterinary practitioners, physical examination, blood tests, and diagnostic imaging (X-ray and Ultrasonography) are required for an exact diagnosis. Furthermore, placing the magnets in rumen would be effective for prophylactic administrations.

• Journal of Genetic Medicine
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• 제18권2호
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• pp.127-131
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• 2021

Autosomal recessive spinocerebellar ataxia 20 (SCAR20; OMIM #616354) is a recently described disorder that is characterized by ataxia, intellectual disability, cerebellar atrophy, macrocephaly, coarse face, and absent speech. It is caused by loss-of-function mutations in SNX14. To date, all cases with homozygous pathogenic variants have been identified in consanguineous families. This report describes the first Korean cases of SCAR20 family caused by homozygous variants in SNX14. Two siblings were referred to our clinic because of severe global developmental delay. They presented similar facial features, including a high forehead, long philtrum, thick lips, telecanthus, depressed nasal bridge, and broad base of the nose. Because the older sibling was unable to walk and newly developed ataxia, repeated brain magnetic resonance imaging (MRI) was performed at the age of 4 years, revealing progressive cerebellar atrophy compared with MRI performed at the age of 2 years. The younger sibling's MRI revealed a normal cerebellum at the age of 2 years. Whole-exome sequencing was performed, and homozygous variants, such as c.2746-2A>G, were identified in SNX14 from the older sibling. Sanger sequencing confirmed homozygous SNX14 variants in the two siblings as well as a heterozygous variant in both parents. This report extends our knowledge of the phenotypic and mutational spectrum of SCAR20. We also highlight the importance of deep phenotyping for the diagnosis of SCAR20 in individuals with developmental delay, ataxia, cerebellar atrophy, and distinct facial features.

• 융합정보논문지
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• 제12권5호
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• pp.225-236
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• 2022

본 연구의 목적은 프로폴리스 추출물이 함유된 립밤 제품과 LED 기기를 적용한 입술 임상 연구를 하여 임상정보과 양적자료로 도움이되고자 한다. 본 연구의 참여자는 서울·경기 소재 만 19~50세 여성을 대상으로 시험제품 선정 후 입술의 LED 기기와 립 크림의 입술 탄력, 입술 보습, 입술 각질 개선 및 12시간 입술 보습 지속 효과를 알아보기 위하여 제품 사용 전, 사용 직후, 사용 6시간 후, 사용 12시간 후 사용 2주 후에 사용 시험항목을 측정 후 제품의 안전성, 유효성, 기호도 설문조사를 분석하고자 한다. 일련의 연구절차를 통하여 도출된 결과는 다음과 같다. 1회 또는 2주 사용으로 입술 탄력, 입술 보습, 입술 각질 개선 및 12시간 입술 보습 지속력에 도움을 주는 것으로 나타났다.

• Journal of Oral Medicine and Pain
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• 제22권1호
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• pp.23-29
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• 1997

A 49 years old male patient was referred from the Department of Medicine, KNUH for the management of painful oral lesions. The patient had disability of food and drug intake due to multiple intraoral ulcers. Extraoral findings showed upper and lower lip swelling, crust formation on the lips. The lesions were diagnosed as Stevens-Johnson syndrome based on clinical and hematologic findings. The patient was treated with saline irrigation and pulsed Nd:YAG laser irradiation. After 5 daily treatment, the lesions decreased in size and severity, and the patient became more comfortable for food intake and speeching. It was suggested from the results of this clinical trial that a pulsed Nd:YAG laser therapy would be helpful for the symptoms associated with Stevens-Johnson syndrome.

• 대한치과교정학회지
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• 제53권4호
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• pp.276-285
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• 2023

Objective: The aim of this retrospective study was to compare changes in hard tissue and soft tissue after the four first premolars were extracted with anterior teeth retraction according to the presence or absence of lip incompetence. Methods: Patients who underwent the four first premolars were extracted with anterior teeth retraction were divided into competent (n = 20) and incompetent lip (n = 20) groups. Cephalometric measurements for hard tissue and soft tissue changes were performed pre-treatment and post-treatment. Results: In the competent group, the upper and lower lips retreated by 2.88 mm and 4.28 mm, respectively, and in the incompetent group by 4.13 mm and 5.57 mm, respectively; the differences between the two groups were significant (p < 0.05). A strong positive correlation between retraction of the upper lip and upper incisors was observed in both groups (p < 0.05), whereas a correlation between retraction of the lower lip and lower incisors was only found in the incompetent group. A simple linear regression analysis showed that the pattern of lip retraction following the retraction of the anterior teeth was more predictable in the incompetent group than in the competent group. Conclusions: These findings suggest that the initial evaluation of lip incompetence in patients with skeletal Class II is essential for the accurate prediction of the soft tissue changes following retraction of the anterior teeth in premolar extraction treatment. Therefore, sufficient explanation should be provided during patient consultations.

• 대한두개안면성형외과학회지
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• 제24권6호
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• pp.266-272
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• 2023

Background: In recent years, there has been an increase in reports of perioral vascular complications resulting from filler injections, such as necrosis of the lip or alar rim, occlusion, and in severe cases, blindness. Conversely, the use of perioral arterial flaps is becoming more prevalent in the treatment of cleft lips, cancer, and trauma. A thorough understanding of perioral arteries is essential to minimize complications and maximize the success of these flaps. However, the course of the facial artery (FA) in the perioral region remains incompletely understood. The aim of this study was to describe the variations of the FA in the perioral region. Methods: We dissected 52 embalmed and formaldehyde-fixed Vietnamese cadavers. We then studied the size and distribution of perioral arteries in 102 specimens. Results: The superior labial artery (SLA) was the most common branch, occurring in 87.25% of cadavers, followed by the inferior labial artery (ILA) at 78.43%. The SLA primarily originated above the mouth corner (cheilion), accounting for 91.01% of cases, and predominantly exhibited a tortuous course within the submucosa (78.65%). The ILA's branching pattern varied, but it was primarily located below the cheilion (91.25%). The ILA also followed a twisted path, generally within the submucosa. The ILA exhibited two patterns: the typical pattern, distributed at the vermilion border of the lower lip (8.82%), and the horizontal labiomental artery pattern, which ran horizontally in the middle of the lower lip area (69.61%). At their origin, the SLA and ILA had average external diameters of 1.29 mm and 1.28 mm, respectively. Conclusion: Numerous anatomical variations in the FA in the perioral region were found. A detailed anatomic description, suggested landmarks, and angiography before the procedure will be useful to help doctors avoid complications.

• 정보처리학회 논문지
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• 제13권4호
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• pp.166-173
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• 2024

본 연구에서는 얼굴 동영상에서 입술의 움직임과 음성 간의 동기화 탐지 방법을 제안한다. 기존의 연구에서는 얼굴 탐지 기술로 얼굴 영역의 바운딩 박스를 도출하고, 박스의 하단 절반 영역을 시각 인코더의 입력으로 사용하여 입술-음성 동기화 탐지에 필요한 시각적인 특징을 추출하였다. 본 연구에서는 입술-음성 동기화 탐지 모델이 음성 정보의 발화 영역인 입술에 더 집중할 수 있도록 사전 학습된 시각적 Attention 기반의 인코더 도입을 제안한다. 이를 위해 음성 정보 없이 시각적 정보만으로 발화하는 말을 예측하는 독순술(Lip-Reading)에서 사용된 Visual Transformer Pooling(VTP) 모듈을 인코더로 채택했다. 그리고, 제안 방법이 학습 파라미터 수가 적음에도 불구하고 LRS2 데이터 세트에서 다섯 프레임 기준으로 94.5% 정확도를 보임으로써 최근 모델인 VocaList를 능가하는 것을 실험적으로 증명하였다. 또, 제안 방법은 학습에 사용되지 않은 Acappella 데이터셋에서도 VocaList 모델보다 8% 가량의 성능 향상이 있음을 확인하였다.

• 대한두경부종양학회지
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• 제39권2호
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• pp.75-78
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• 2023

Squamous cell carcinoma of the lip is a common malignant tumor originating from oral cancer. However, unlike other areas, the lips hold significant functional and aesthetic importance as a part of the face. As a result, a tailored approach based on the tumor's size, type, and location is essential. The Karapandzic flap is especially suitable for reconstructing lesions located on the lip, particularly when the size of the cancer is large and other surgical treatments like free flaps are not feasible. It allows for extensive resection beyond the size of the lower lip. In this case, considering the patient's overall condition, successful reconstruction of the lower lip was achieved using the Karapandzic flap.

• 대한두경부종양학회지
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• 제40권1호
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• pp.33-36
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• 2024

Pleomorphic adenoma (PA) is a commonly occurring benign tumor originating in the salivary glands. The incidence is mostly in the parotid glands (85%) followed by minor salivary glands (10%). Pleomorphic adenoma from minor salivary glands of the lips is a rare neoplasm. Here, we present a case of a patient with PA in the upper lip, reporting a common neoplasm in a rare site. A 82-year-old male with a slowly progressing swelling that occurred 20years ago on the upper white lip. This tumor is not associated with pain and tenderness. The mass was about 1.5x1.5cm sized, circumscribed, sessile and firm on the external upper lip without oral side bulging (Fig. 1). The tumor was removed completely with a elliptical incision under local anesthesia. The encapsulated mass was measured 0.9x0.9x0.6cm. On histology, a well-circumscribed growth was seen comprising epithelial and stromal components. The epithelial component formed glandular structures lined by round-to oval cells having small nuclei, pink cytoplasm and myoepithelial basal cell layer while the stroma had a fibromyxoid appearance(Fig. 2). Postoperatively wound was well healed without recurrence after 6months. Pleomorphic adenoma of the upper lip is a rare neoplasm, especially not intraoral growth. For aesthetic good result, the mass was removed without hesitation. It is required a high index of suspicion and a long-term follow-up because it could recur and rarely be transformed into malignancy.

• 한국방사선학회논문지
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• 제7권1호
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• pp.17-24
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• 2013

본 연구는 파노라마 표준 촬영에서 환자의 피폭 선량을 측정하여 방사선 생물학적 위험인자를 평가하고 환자의 피폭 선량 저감화 방안을 제시하고자 하였다. 피폭 선량의 측정 오차를 최소화하기 위하여 각 OSL 선량계의 교정상수를 구하였으며 파노라마 표준 촬영에서 간접적으로 포함되는 좌 우측 수정체와 갑상선, 직접적으로 포함되는 상 하 입술, 하악골 첨부, 촬영 중심점을 대상으로 ICRP에서 권고하는 인체 모형 표준 팬텀을 이용하여 측정하였다. 측정 결과, 촬영 중심점의 선량이 $413.67{\pm}6.53{\mu}Gy$로 최대였으며 상 하 입술의 경우 각각 $217.80{\pm}2.98{\mu}Gy$, $215.33{\pm}2.61{\mu}Gy$이었다. 또한 파노라마 표준 촬영에서 간접적으로 포함되는 좌 우측 수정체의 등가선량은 각각 $30.73{\pm}2.34{\mu}Gy$, $31.87{\pm}2.50{\mu}Gy$이었으며 하악골 첨부 및 갑상선의 등가선량은 $276.73{\pm}14.43{\mu}Gy$, $162.07{\pm}4.13{\mu}Gy$이었다. 결론적으로 측정된 피폭 선량은 방사선 생물학적 효과를 유발할 수 있었으며 치과 의료기관의 파노라마 표준 촬영에서 환자의 피폭 선량에 대한 저감화 방안으로 국제기구에서 권고하고 있는 방사선 방어 원칙에 대한 정당한 해석과 제도적 뒷받침(regulation)이 필요하다. 이에 파노라마 검사에 의한 피폭 선량은 기술적 경제적 측면뿐 만 아니라 사회적 인자를 고려하여 합리적으로 용인 가능한 수준까지 최소화하기 위한 체계화된 프로토콜의 제정과 주변 결정 장기를 방어하기 위한 방사선 보호 기구에 대한 추가적 연구가 필요할 것으로 판단되었다.