• Asian-Australasian Journal of Animal Sciences
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• v.21 no.12
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• pp.1703-1709
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• 2008

As genetic markers, single nucleotide polymorphisms (SNP) are very appropriate for the development of genetic tests for economic traits in livestock. Several microsatellite markers have been identified as useful markers for the genetic improvement of Hanwoo. Among those markers, ILSTS035 was recently mapped at a similar position with four SNPs (AH1_11, AH1_9, 31465_446, and 12273_165) in a linkage map of EST-based SNP in BAT6. Among the four SNPs, two SNPs (31465_446 and 12273_165) were analyzed using BLAST at the NCBI web site. The sequences including the 12273_165 SNP were identified at the intron region within the LOC534614 gene on the gene sequence map (Bos taurus NCBI Map view, build 3.1). The LOC534614 gene represents a protein similar to myosin heavy chain, fat skeletal muscle, embryonic isoform 1 in the dog, and myosin_1 (Myosin heavy chain D) in Macaca mulatta. In cattle, the myosin heavy chain was associated with muscle development. The phenotypic data for growth and carcass traits in the 415 animals were analyzed by the mixed ANCOVA (analysis of covariance) linear model using PROC GLM module in SAS v9.1. By the genotyping of Hanwoo individuals (n = 415) to evaluate the association of SNP with growth and carcass traits, it was shown that the 12273_165 SNP region within LOC534614 may be a candidate marker for growth. The results of the statistical analyses suggested that the genotype of the 12273_165 SNP significantly affected birth weight, weight of the cattle at 24 months of age, average daily gain and carcass cold weight (p<0.05). Consequently, the 12273_165 SNP polymorphisms at the LOC534614 gene may be associated with growth in Hanwoo, and functional validation of polymorphisms in LOC534614 should be performed in the future.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.8
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• pp.1134-1140
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• 2018

Objective: Fatty acid composition is one of the most important meat quality traits because it can contribute to functional, sensorial, and nutritional factors. In this study, quantitative trait locus (QTL) analyses for fatty acid composition traits were investigated in thigh and breast meat of Korean native chicken (KNC). Methods: In total, 18 fatty acid composition traits were investigated from each meat sample using 83 parents, and 595 $F_1$ chicks of 20 week old. Genotype assessment was performed using 171 informative DNA markers on 26 autosomes. The KNC linkage map was constructed by CRI-MAP software, which calculated genetic distances, with map orders between markers. The half-sib and full-sib QTL analyses were performed using GridQTL and SOLAR programs, respectively. Results: In total, 30 QTLs (12 in the thigh and 18 in the breast meat) were detected by the half-sib analysis and 7 QTLs (3 in the thigh and 4 in the breast meat) were identified by the full-sib analysis. Conclusion: With further verification of the QTL regions using additional markers and positional candidate gene studies, these results can provide valuable information for determining causative mutations affecting the fatty acid composition of KNC meat. Moreover, these findings may aid in the selection of birds with favorable fatty acid composition traits.

• Journal of Practical Engineering Education
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• v.15 no.2
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• pp.509-517
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• 2023

The reactive web service provides a related word recommendation system using the TextRank algorithm and a word-based idea generation service selected by the user. In the related word recommendation system, the method of weighting each word using the TextRank algorithm and the probability output method using SoftMax are discussed. The idea generation service discusses the idea generation method and the artificial intelligence reinforce-learning method using mini-GPT. The reactive web discusses the linkage process between React, Spring Boot, and Flask, and describes the overall operation method. When the user enters the desired topic, it provides the associated word. The user constructs a mind map by selecting a related word or adding a desired word. When a user selects a word to combine from a constructed mind-map, it provides newly generated ideas and related patents. This web service can share generated ideas with other users, and improves artificial intelligence by receiving user feedback as a horoscope.

• Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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• 2006.04a
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• pp.333-337
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• 2006

As IT-based technologies develop, 3D GIS applications that digitally model real environment are being increased. Although the terms related with 3D CIS are used increasingly, research efforts and applications are mostly limited to only 2D GIS or 3D modeling respectively. The reasons are viewed that there have been less research findings or software tools about integration of 2D GIS and 3B models. Thus, this study presents a method to integrate 2D GIS and 3D models by using database as the means for linkage. To illustrate the process, we developed a prototype application using C# language. Within an interface we showed how to integrate different libraries - EON Studio and MapObjects. We expect that the integration techniques we suggest here can be applied to such areas as disaster prevention, transportation and natural resources management.

• International Journal of Industrial Entomology and Biomaterials
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• v.19 no.1
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• pp.143-154
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• 2009

Single nucleotide polymorphisms (SNPs) are the most frequent form of variation in the genome of any organism. Owing to their greater abundance, they are considered useful for identifying cultivars, construction of higher density linkage maps, and detection of genes (QTLs) associated with complex agronomic traits and diseases. Although, SNPs have been used recently for constructing a high density genetic map in silkworm and a set of 118 SNPs have been identified in tasar silkworms, not much progress has been made in sericulture to utilize the vast potential of SNPs. Thus, this review mainly focuses on some of the important methods of SNP discovery, validation and genotyping. Emphasis has also been given to the possible uses of SNP genotyping in the improvement of silkworms and their host plants.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2003.10a
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• pp.236-244
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• 2003

Summary: The analysis of human genetic variation is one of the key issues far the understanding of the different drug response among individuals and many programs are developed for this purpose. However, current publicly available programs have so many limitations such as time complexity problem for the analysis of large amount of alleles or SNPs, difficult manipulation for installation, data import, and usage, and low-quality visual output. Here we present workbench for SNP anlaysis, SNPAnalyzer. SNPAnalyzer consists of 3 main modules: 1)Hardy-Weinberg Equilibrium ,2) Haplotype Estimation, and 3) Linkage Disequilibrium. Each module has several different widely-used algorithms for the extensive analysis and can handle large amount of alleles and SNPs with simple format. Analysis results are displayed in user-friendly formats such as table, graph and map. SNPAnalyzer is developed using C and C$^{++}$ and users can easily access through web-interftce. Availability: SNPAnalyzer can be freely implemented at http://www.istech.info/istech/board/login_form.jsp

• Proceedings of the Korean Society of Potoscience Conference
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• 2006.06a
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• pp.57-57
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• 2006

• Genomics & Informatics
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• v.12 no.4
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• pp.208-215
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• 2014

Recently, new methods have been developed for estimating the current and recent changes in effective population sizes. Based on the methods, the effective population sizes of Korean populations were estimated using data from the Korean Association Resource (KARE) project. The overall changes in the population sizes of the total populations were similar to CHB (Han Chinese in Beijing, China) and JPT (Japanese in Tokyo, Japan) of the HapMap project. There were no differences in past changes in population sizes with a comparison between an urban area and a rural area. Age-dependent current and recent effective population sizes represent the modern history of Korean populations, including the effects of World War II, the Korean War, and urbanization. The oldest age group showed that the population growth of Koreans had already been substantial at least since the end of the 19th century.

• Microbiology and Biotechnology Letters
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• v.16 no.6
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• pp.536-539
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• 1988

A mutant of Bacillus subtilis with a defective cdd gene encoding deoxycytidine-cytidine deaminase (EC 3.5.4.5) has been characterized genetically. The genetic lesion, cdd, causing the altered deoxycytidine-cytidine deaminase was mapped at 225 min on the linkage map of B. subtilis by AR9 transduction, Transductional analysis of the cdd region established the gene order in clockwise as trp-lys-cdd-aroD. The cdd gene was linked 72% with the aroD and 20% with the lys.

• Journal of Plant Biotechnology
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• v.46 no.2
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• pp.71-78
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• 2019

The objective of this study was to use 'Danta PR', NGS (Next Generation Sequencing) technology for genome resequencing to develop polymorphic makers between Chinese oriental melon, 'Hyangseo 1' and Korean oriental melon. From the resequencing data that covered about 81 times of the genome size, 104,357 of SSR motifs and Indel, and 1,092,436 of SNPs were identified. 299 SSR and 307 Indel markers were chosen to cover each chromosome with 25 markers. These markers were subsequently used to identify genotypes of 'Danta PR' BC1 (F1 x 'Danta PR') population and a genetic linkage map was constructed. SSR, Indel, and SNPs identified in this study would be useful as a breeding tool to develop new oriental melon varieties.