• Title/Summary/Keyword: Linkage Method

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Comparison of Principal Component Regression and Nonparametric Multivariate Trend Test for Multivariate Linkage (다변량 형질의 유전연관성에 대한 주성분을 이용한 회귀방법와 다변량 비모수 추세검정법의 비교)

  • Kim, Su-Young;Song, Hae-Hiang
    • The Korean Journal of Applied Statistics
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    • v.21 no.1
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    • pp.19-33
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    • 2008
  • Linear regression method, proposed by Haseman and Elston(1972), for detecting linkage to a quantitative trait of sib pairs is a linkage testing method for a single locus and a single trait. However, multivariate methods for detecting linkage are needed, when information from each of several traits that are affected by the same major gene are available on each individual. Amos et al. (1990) extended the regression method of Haseman and Elston(1972) to incorporate observations of two or more traits by estimating the principal component linear function that results in the strongest correlation between the squared pair differences in the trait measurements and identity by descent at a marker locus. But, it is impossible to control the probability of type I errors with this method at present, since the exact distribution of the statistic that they use is yet unknown. In this paper, we propose a multivariate nonparametric trend test for detecting linkage to multiple traits. We compared with a simulation study the efficiencies of multivariate nonparametric trend test with those of the method developed by Amos et al. (1990) for quantitative traits data. For multivariate nonparametric trend test, the results of the simulation study reveal that the Type I error rates are close to the predetermined significance levels, and have in general high powers.

An Alternative Way of Constructing Ancestral Graphs Using Marker Allele Ages from Population Linkage Disequilibrium Information

  • Park, Lee-Young
    • Genomics & Informatics
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    • v.7 no.1
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    • pp.1-12
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    • 2009
  • An alternative way of constructing ancestral graphs, which is different from the coalescent-based approach, is proposed using population linkage disequilibrium (LD) data. The main difference from the existing method is the construction of the ancestral graphs based on variants instead of individual sequences. Therefore, the key of the proposed method is to use the order of allele ages in the graphs. Distinct from the previous age-estimation methods, allele ages are estimated from full haplotype information by examining the number of generations from the initial complete LD to the current decayed state for each two variants depending on the direction of LD decay between variants. Using a simple algorithmic procedure, an ancestral graph can be derived from the expected allele ages and current LD decay status. This method is different in many ways from previous methods, and, with further improvement, it might be a good replacement for the current approaches.

Development of Field Current ripple Compensating Method by d-axis Flux-linkage in WRSM (권선계자형 동기전동기의 d축 쇄교자속에 의한 계자전류리플 보상 기법 개발)

  • Hwang, Dae-Yeon;Gu, Bon-Gwan
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.67 no.9
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    • pp.1165-1173
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    • 2018
  • Recently, owing to environmental problems and instability of rare earth resources market, non-rare earth electric motors are attracting attention. As a non-rare earth motor type, a wound rotor synchronous motor(WRSM) has high power density and wide driving range further it can reduce loss by field current control during field weakening control at high speed. However, since the d-axis flux of the WRSM is coupled with the rotor circuit, the fluctuation in the d-axis flux linkage affects the rotor circuit, which causes ripple of the field current and torque. In this paper, we propose the field current ripple compensation method by injecting the feedforward voltage. the proposed compensating method was demonstrated by simulation and experiments.

Virtual Signal Injected MTPA Control for DTC Five-Phase IPMSM Drives

  • Liu, Guohai;Yang, Yuqi;Chen, Qian
    • Journal of Power Electronics
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    • v.19 no.4
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    • pp.956-967
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    • 2019
  • This paper introduces a virtual signal injected maximum torque per ampere (MTPA) control strategy for direct-torque-controlled five-phase interior permanent magnet synchronous motor (IPMSM) drives. The key of the proposed method is that a high frequency signal is injected virtually into the stator flux linkage. Then the responding stator current is calculated and regulated to compensate the amplitude of the flux linkage. This is done according to the relationship between the stator current and the stator flux linkage. Since the proposed method does not inject any real signals into the motor, it does not cause any of the problems associated with high-frequency signals, such as additional copper loss and extra torque ripple. Simulation and experimental results are offered to verify the effectiveness of the proposed method.

A Sensorless Switched Reluctance Drive System Based on the Improved Simplified Flux Method

  • Li, Zhenguo;Song, Andong;Ahn, Jin-Woo
    • Journal of international Conference on Electrical Machines and Systems
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    • v.1 no.4
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    • pp.477-482
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    • 2012
  • This paper describes a new rotor position sensorless control method for SRM drives based on an improved simplified flux linkage method. In the traditional simplified flux linkage method, every phases take turns conduction and current chopping control method is used. Every phases take turns conduction means turning on the incoming working phase while turning off the working phase. This conduction mode causes coupling between turn-on and turn-off angles, which goes against optimal efficiency or torque ripple minimization with sensorless speed control. In the improved simplified flux linkage method, turn-off angle is calculated by flux loop, the turn-on angle can be given arbitrarily and has no relations with the turn-off angle, and the current chopping control method is used. The speed and rotor position can be estimated then. Finally, a sensorless SRM speed control system and an experiment platform with DSP are built and validity of this method is confirmed.

QTL Identification Using Combined Linkage and Linkage Disequilibrium Mapping for Milk Production Traits on BTA6 in Chinese Holstein Population

  • Hu, F.;Liu, J.F.;Zeng, Z.B.;Ding, X.D.;Yin, C.C.;Gong, Y.Z.;Zhang, Q.
    • Asian-Australasian Journal of Animal Sciences
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    • v.23 no.10
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    • pp.1261-1267
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    • 2010
  • Milk production traits are important economic traits for dairy cattle. The aim of the present study was to refine the position of previously detected quantitative trait loci (QTL) on bovine chromosome 6 affecting milk production traits in Chinese Holstein dairy cattle. A daughter design with 918 daughters from 8 elite sire families and 14 markers spanning the previously identified QTL region were used in the analysis. We employed a combined linkage and linkage disequilibrium analysis (LDLA) approach with two options for calculating the IBD probabilities, one was based on haplotypes of all 14 markers (named Method 1) and the other based on haplotypes with sliding windows of 5 markers (named Method 2). For milk fat yield, the two methods revealed a highly significant QTL located within a 6.5 cM interval (Method 1) and a 4.0 cM interval (Method 2), respectively. For milk protein yield, a highly significant QTL was detected within a 3.0 cM interval (Method 1) or a 2.5 cM interval (Method 2). These results confirmed the findings of our previous study and other studies, and greatly narrowed down the QTL positions.

Detection of QTL on Bovine X Chromosome by Exploiting Linkage Disequilibrium

  • Kim, Jong-Joo
    • Asian-Australasian Journal of Animal Sciences
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    • v.21 no.5
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    • pp.617-623
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    • 2008
  • A fine-mapping method exploiting linkage disequilibrium was used to detect quantitative trait loci (QTL) on the X chromosome affecting milk production, body conformation and productivity traits. The pedigree comprised 22 paternal half-sib families of Black-and-White Holstein bulls in the Netherlands in a grand-daughter design for a total of 955 sons. Twenty-five microsatellite markers were genotyped to construct a linkage map on the chromosome X spanning 170 Haldane cM with an average inter-marker distance of 7.1 cM. A covariance matrix including elements about identical-by-descent probabilities between haplotypes regarding QTL allele effects was incorporated into the animal model, and a restricted maximum-likelihood method was applied for the presence of QTL using the LDVCM program. Significance thresholds were obtained by permuting haplotypes to phenotypes and by using a false discovery rate procedure. Seven QTL responsible for conformation types (teat length, rump width, rear leg set, angularity and fore udder attachment), behavior (temperament) and a mixture of production and health (durable prestation) were detected at the suggestive level. Some QTL affecting teat length, rump width, durable prestation and rear leg set had small numbers of haplotype clusters, which may indicate good classification of alleles for causal genes or markers that are tightly associated with the causal mutation. However, higher maker density is required to better refine the QTL position and to better characterize functionally distinct haplotypes which will provide information to find causal genes for the traits.

Design of a Spring-Actuated Linkage for Specified Dynamic Responses (규정된 동적응답을 위한 스프링구동 링크기구의 설계)

  • Ahn, K.Y.;Cho, S.S.;Park, W.J.;Kim, S.H.
    • Proceedings of the KSME Conference
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    • 2001.06c
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    • pp.476-481
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    • 2001
  • In a vacuum circuit breaker mechanism, a spring-actuated linkage system is used to satisfy the desired opening and closing characteristics of electric contacts. Because the opening dynamics of electric contacts is determined by such a linkage system, the stiffness, free length and attachment points of a spring become the important design parameters. In this paper, based on the energy conservation that the total system energy is constant throughout the operating range of a mechanism, a systematic design procedure of determining the spring design parameters is presented. The proposed procedure is applied to the design of an opening spring for satisfying the specified opening characteristics.

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Walking Apparatus Design through Jansen Mechanism (얀센 메커니즘을 통한 보행 기구 설계)

  • Nam, Ungsig
    • Proceeding of EDISON Challenge
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    • 2016.03a
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    • pp.473-476
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    • 2016
  • In this study, important design factors in Jansen leg mechanism by which two legs can be driven by only one input like a motor are considered through method of transmitting motion in three-bar linkage and Grashof law in four-bar linkage. In preliminary design, by using EDISON m-sketch and its simulation which can observe trace of feet, two identical four-bar linkages are initially designed and two three-bar linkages are added to four-bar linkages sequentially. By analyzing GL(Ground Length) and GAC(Ground Angle Coefficient), the adequacy of the preliminary design was estimated. Final design of walking apparatus is implemented using CAD software, Assembly2 of EDISON Designer. Finally, proposals to improve software used in this study are suggested.

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