• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.31 no.4
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• pp.251-257
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• 2013

Bathymetry sounding or water depth measurement is becoming more and more sophisticated with the increasing demand in accuracy, resolution and coverage in the recent years. Single beam echo sounding is still utilized to gather single line bathymetric profile in many surveys as ever, although there is an increasing demand for multi-beam echo sounding. Single beam echo sounder system acquires single line profiles of water depth as the vessel travel along the survey line. In this study, we performed single beam echo sounding with GNSS receiver for hydrographic survey at Namgang dam basin to calculate pure sediment. Unlike traditional research, we used not field reference station but NTRIP service of the reference station of DGNSS(Differential Global Navigation Satellite System) Central Office in this GNSS survey. The calculation results show that scouring volume is $603,650m^3$, sediment volume is $3,913,750m^3$ and so pure sediment volume is $3,310,100m^3$ at Namgang dam basin. And the availability of the NTRIP service of the DGNSS Central Office for echo sounding in land area has been confirmed in this study.

• Journal of the Korean Vacuum Society
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• v.15 no.6
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• pp.630-636
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• 2006

Scale down of semiconductor gate pattern will make progress centrally line width into transistor according to the high integration and high density of flash memory semiconductor. Recently, the many researchers are in the process of developing research for using the ONO(oxide-nitride-oxide) technology for the gate pattern give body to line breadth of less 100 nm. Therefore, etch rate and etch profile of the line width detail of less 100 nm affect important factor in a semiconductor process. In case of increasing of the platen power up to 50 W at the ICP etcher, etch rate and PR selectivity showed good result when the platen power of ICP etcher has 100 W. Also, in case of changing of HBr gas flux at the platen power of 100 W, etch rate was decreasing and PR selectivity is increasing. We founded terms that have etch rate 320 nm/min, PR selectivity 3.5:1 and etch slope have vertical in the case of giving the platen power 100 W and HBr gas 35 sccm at the ICP etcher. Also notch was not formed.

• Korean Journal of Clinical Pharmacy
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• v.29 no.2
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• pp.89-100
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• 2019

Background: Invasive aspergillosis (IA) is associated with high morbidity and mortality, particularly among immunocompromised patients, such as lung transplant recipients. Voriconazole, the first-line therapy for IA, shows a non-linear pharmacokinetic profile and has a narrow therapeutic range. Careful and appropriate administration is necessary, primarily because it is used for critically ill patients; however, the clinical usefulness of therapeutic drug monitoring (TDM) has not been sufficiently verified. Therefore, in this study, we validated the safety and efficacy of voriconazole TDM in lung transplant recipients receiving only voriconazole for IA treatment. Methods: The electronic medical records of lung transplant recipients (${\geq}19$ years of age) administered only voriconazole for > 7 days for treatment of IA from June 1, 2013 to May 31, 2018 were analyzed retrospectively. Results: Among the 54 patients, 27 each were allocated to TDM and non-TDM groups, respectively. There were no significant differences in patient characteristics between the two groups except for ICU-hospitalization status. Of the TDM group patients, 81.5% needed adjustment of voriconazole dosage because the levels were out of target range. Comparison of two groups showed that treatment response was higher throughout treatment and switching rates of second-line agents were significantly lower in the TDM group, but it was insufficient to confirm safety improvements through voriconazole TDM. Conclusions: Considering that the treatment response tended to be higher and the rates of switching to second-line antifungal agents were lower in the TDM group, voriconazole TDM may increase the therapeutic effect on IA in lung transplant patients.

• The Journal of Korean Academy of Sensory Integration
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• v.21 no.3
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• pp.39-53
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• 2023

Objective : The purpose was the effect of sensory integration therapy combined with an eye tracker on the sensory processing and visual perception of children with developmental disabilities. Methods : It was a single-subject study with a multiple baseline design between subjects, and the intervention applied sensory integration therapy combined with an eye tracker. Visual-motor speed and saccadic eye movements were assessed at each session of baseline and intervention periods. As pre- and post-evaluation, sensory profile, Korean-Developmental Test of Visual Perception and Trail Making Test were conducted. The results of each session evaluation and pre- and post-evaluation researched the effectiveness of the intervention through visual analysis and trend line analysis. Results : As a result of the evaluation for each session, the slope of the trend line for all children in visual-motor speed and saccadic eye movement increased sharply during the intervention compared to the baseline. As a result of the pre- and post-evaluation, the sensory processing of movement, body position, and visual changed from more than that of peers to a level similar to that of peers. In visual perception, all children's ability of Visual Closure increased. As a result of Trail Making Test conducted to confirm the improvement of children's visual tracking and visual-motor abilities, all children showed a decrease in performance time after the test compared to before. Conclusion : It was confirmed that sensory integration therapy combined with an eye tracker for developmental disabilities has effect on sensory processing and visual perception. It is expected to play an important role clinically as it can stimulate children's interest and motivation in line with recent technological improvements and the spread of smart devices.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.57 no.2
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• pp.171-181
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• 2012

Lysine is the first limiting essential amino acid in cereals for humans and monogastric animals, although its content is generally low. A chemically induced high-lysine barley mutant, M98, has an agronomically undesirable shrunken endosperm trait. In order to obtain detailed insight into the atypical traits of M98 grains, we characterized amino acid composition and protein profiles of M98 and its parent cultivar Chalssalbori. Among a total of 16 amino acids, the percentage of each of the 7 amino acids, including lysine, was 1.2~1.8 times higher in M98, comparing to Chalssalbori. The percentage of proline and its precursor, glutamic acid, in M98 was about the half of that of the amino acids in Chalssalbori, but arginine synthesized from glutamic acid was 1.8 times higher in M98, compared that in the parent cultivar. Theses results indicated that the mutation in M98 grains might alter the proportion of amino acids linked to each other in a biosynthetic pathway. A comparison of grain proteome profiles between Chalssalbori and M98 revealed 70 differentially expressed protein spots, where 45 protein spots were up-regulated and 25 protein spots down-regulated in M98 compared to those in Chalssalbori. Of these changed protein spots, 53 were identified using nano-electrospray ionization liquid chromatography mass spectrometry. Most of these identified proteins were involved in various biological processes. In particular, 28 protein spots such as ${\beta}$-amylase, serpins and B3-hordein were identified as proteins associated with the atypical traits of M98. It was thought that a genetic study on the unique protein profile of M98 would be needed to develop an agronomically feasible barley cultivar with high-lysine trait.

• Korean Journal of Community Nutrition
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• v.11 no.1
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• pp.133-142
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• 2006

Antioxidant vitamin supplementation focuses one's attention on the prevention of age-related diseases. This study was conducted to investigate the antioxidant status and lipid profiles and to look into the antioxidant vitamin supplementation that affects lipid metabolism in 20 elderly non-smoking Korean women (placebo group: n = 6, vitC suppl: n = 7, vitE suppl: n = 7). Age, height, weight, muscle, percent of fat and WHR were not significantly different among the groups, however $\%$ of fat was above $33\%$ and WHR was above 0.9. And blood pressure of the placebo group was 131.7/81.7 (border line hypertension), that of vitamin C supplement was 141.4/87.1 (hypertension) and that of vitamin E supplement was 151.4/92.9 (hypertension). Although nutrient intakes of all groups were poor, antioxidant status (blood vitamins C, E, A, and beta-carotene) and lipid profile (TG, total-cholesterol, VLDL-cholesterol, LDL-cholesterol, HDL-cholesterol) were normal. For nutritional intervention, the vitamin C supplement group received L-ascorbic acid 1,000 mg, and vitamin E supplement group received d-alpha-tocopherol 400IU for 4 weeks, showing the effects of vitamin E supplementation. Response total cholesterol of HDL-cholesterol (T-Chol/HDL) in vitamin E supplement group was significantly decreased from 4.3 to 3.2. And response LDL-cholesterol of HDL-cholesterol (LDL/HDL) in the vitamin E supplement group was also significantly decreased from 2.6 to 1.7. In addition, after the adjustment for plasma lipids (TG, total cholesterol), plasma vitamin A levels in vitamin E supplement group were significantly increased from 7.89 mg/g to 14.91 mg/g. And systolic blood pressure in vitamin E supplement group was significantly reduced. These results suggested that vitamin E supplementation affects the lipid profiles and blood pressure in elderly non-smoking women. So various nutrition programs must be implemented against age-related diseases and further studies are needed regarding sorts and amounts of antioxidant nutrients and supplementation periods.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.9 no.3
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• pp.83-92
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• 2004

A continuous monitoring of textural characteristics of surface sediments, sedimentation rates and beach profile was carried out to investigate the seasonal variations of sedimentary processes in the Imjado beach, southwestern coast of Korea for two years. The beach profiles consist of steep beach face and relatively flat middle and low tide beaches. The slope of the beach face increases in summer and decreases in winter, in good accordance with the standard beach cycle. Ridge and runnel systems are well developed in the middle and low tide beaches during the summer, but these structures are replaced by mega-ripples during the winter. The sediments are fining southward as well as landward. The mean grain-size tends to be increasingly coarser during seasons of autumn and winter on the north beach and during seasons of winter and spring on the south one. In addition, the sediments are eroded on the north beach and accumulated on the south one as a whole. These are probably due to southward transportation of the sediments as long-shore current (NE-SW) runs around the coastal line of the beach. However, the seasonal variations in accumulation rates are very complex and irregular. It is considered that the Imjado beach represents in non-equilibrium state, as a result of coastal and submarine topographic changes by artificial agents and sea-level uprising associated with global warming.

• Journal of Acupuncture Research
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• v.19 no.6
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• pp.111-124
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• 2002

A line of study reported that electroacupuncture(EA) modulate natural killer cell(NK Cell) activities. One report suggested that EA enhanced splenic interferon-gamma($IFN-{\gamma}$), interleukin-2(IL-2), and NK cell activity in Sprague-Dawley rats. Another study suggested that $IFN-{\gamma}$ mediates the up-regulation of NK cell activity, and endogenous ${\beta}$-endorphin secretion also play a role in the up-regulation of NK cell activity induced by EA stimulation. In order to better understand the molecular regulation underlying the activation of NK cell induced by EA, we have utilized cDNA microarray to elucidate how EA alters program of gene expression of spleen in rats. First, we divided three groups, group I was EA group treated with EA in restriction holder, group II was sham group with only holder stress, and last group III was control group with no treatment. We measured NK cell activity after EA stimulation three times for 2 days using $^{51}Cr$ release assay. Second, Biotin-labeled cDNA probes synthesized from EA group and sham group, were competitively hybridized to the microarray that contained variable genes. Such high-throughput screening has identified a number of EA-responsive gene candidates. Of these, we found that EA induced a subset of genes of genes that functionally could modulatory effects on NK cell activity. Genes(vascular cell adhesion molecule-1, protein-tyrosine kinase, CD94 mRNA) related to boost NK cell activity, were increased by EA And, genes(protein-tyrosine-phospatase mRNA, protein-tyrosine phosphatase(SHP-1) mRNA) related to inhibit NK cell activity, were decreased by EA. These EA-responsive genes may provide key insights from which to understand mechanisms of activation of NK cell induced by EA.

• The korean journal of orthodontics
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• v.27 no.1
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• pp.45-54
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• 1997

The purpose of this study was to evaluate the indications of bionator in Class II division 1 malocclusion, The 48 subjects were classified into good result group(group1) and poor result group(group2) in reference to posttreatment molar relation, posttreatment overbite and overjet, posttreatment profile, and relapse. Pretreatment lateral cephalograms were calculated and evaluated by t-test stepwise discriminant analysis. The results were as follows ; 1. In jaw bone relationship, ANB, facial convexity angle, AB to facial plane angle were significantly different between two treatment groups. In denture pattern, L1 to facial plane, L1 to A-Pog, FMIA, and U1 to facial plane were significantly different and m soft tissue profile, protuberance of lower lip and upper lip were significantly different between tw o treatment groups. 2. The results in according to discriminant analysis stated that L1 to facial plane, ANB, FMIA and protuberance of lower lip help prediction of treatment result of bionator. 3. 3 major influential variables were obtained by stepwise discriminant analysis - L1 to facial plane, articular angle and ANB difference. And Fisher discriminant function was made by these three major variables.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.11
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• pp.561-567
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• 2018

This study was carried out to improve the ride quality of high-speed electric multiple unit. Through dynamic analysis of the HEMU-430X, the range of the equivalent conicity with a critical speed of 300 km/h was between 0.05 and 0.25. The initial adopted wheel profile of HEMU-430X was S1002. The equivalent conicity of S1002 with the mileage of more than 40,000 km was about 0.033 and it was confirmed that XP55 is more suitable for stable operation because XP55 has the equivalent conicity of over 0.061. In order to improve ride quality of high-speed electric multiple unit, the change of installation angle of the yaw damper was suggested from $7.35^{\circ}$ to $0^{\circ}$. From sensitivity analysis and optimization, the air spring lateral and vertical stiffness was suggested to be reduced by 30% and the secondary vertical and lateral damper damping coefficient was increased by 50%. By applying this, it was expected that the car body acceleration could be improved by about 20% on average. The HEMU-430X's yaw damper installation angle was changed to $0^{\circ}$ and the damping coefficient of the lateral damper was increased by 30%. When the test run was carried out at the speed of 300 km/h on the Kyungbu high-speed line, the vehicle lateral acceleration had improved by 34.3%. The effect of additional improvement measures proposed in this paper will be tested in the on track test. The riding quality improvement process used in this study can be used to solve ride quality problems that can occur in commercial operation of high-speed electric multiple unit in the future.