• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10339-10343
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• 2015

Breast cancer is the most common cancer among females worldwide and a most prevalent malignancy in Iranian women. Chronic stress may make an important contribution to cancer, especially in the breast. Numerous studies showed roles of neurotransmitters in the occurrence and progression of cancers which are mediated by their various types of receptors. This study was conducted to evaluate alterations in the expression profile of dopamine receptor genes in peripheral blood mononuclear cells (PBMC) as stress factors in breast cancer patients and the human breast cancer cell line (MCF-7). Peripheral blood samples were obtained from 30 patients and 30 healthy individuals. Total mRNA was extracted from PBMC and MCF-7 cells and RT-PCR was performed to confirm the presence of five dopamine receptors (DRD1-DRD5). Expression changes of dopamine receptor genes were evaluated by real time PCR. We observed that DRD2-DRD4 in PBMCs of breast cancer patients were increased compared to healthy individuals. In addition, all dopamine receptor subtypes but DRD1 were expressed in MCF-7 cells. Therefore, alterations of these receptors as stress factors should be assessed for selecting appropriate drugs such as D2-like agonists for treatment of breast cancer after performing complimentary tests. Determining the expression profile of dopamine receptor genes thus seems promising.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1996년도 한국자동제어학술회의논문집(국내학술편); 포항공과대학교, 포항; 24-26 Oct. 1996
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• pp.1476-1479
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• 1996

발전설비나 자동차 그리고 항공우주분야에 사용되는 각종 bearing, 원형부품들에 사용되는 ring을 생산하는 방법중, 가장 효과적이고 경제적인 방법은 ring rolling (ring 압연)이다. 이 방법은 직경 50cm에서 2m이상의 원형 ring을 연속적으로 짧은 시간내에 (한 ring당 약 1분) 생산 가능하다. 이제까지의 수학적 모델을 사용한 제어시스템은 ring의 단면적이 사각형인 제품에는 최소한의 오차로 생산 가능하였으나, plant의 생산성과 제품의 다양성을 위하여 ring의 단면적이 복잡한 것을 생산시에는 문제점이 노출되었다. 왜냐하면 기존의 수학적모델이 roll gap 또는 metal forming zone에 근거하여 modelling하였기 때문이다. 본 논문에서는, 이러한 문제점을 고전적인 수학적 모델을 기초로한 adaptive control system의 방법대신에, 축적된 control system설계와 운용 경험을 이용하여 설계한 퍼지제어기 및 그것의 실적용 그리고 그 결과를 소개한다. 실적용 결과는, 제조된 단면적이 상대적으로 복잡한 bearing의 형상이 (filling grad)이 제어기의 제어정도 판단기준이었는데, 99.5%의 형상도를 보임으로서 industry에서 요구하는 제품기준을 만족시켰다. 또한 짧은 제어기 설계 및 on-line optimization 기간 또한 이 제어기의 장점이었다.

• 치과방사선
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• 제27권1호
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• pp.73-86
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• 1997

This study was performed to assess the analyzing methods developed to detect clinically and quantitatively longitudinal bone changes. Through preliminary experiment, accuracy of Cu-Eq value conversion to the mass of HA was examined. For main experiment, 15 intraoral radiograms taken at soon, 1st, 2nd, 4th, and 6th week after implantation of mixture in extracted sites of 3 cases were used. We took the radiograms with copper step wedge as test object and HA phantom X -ray taking was standardized by using Rinn XCP device customized directly to the individual dentition with resin bite block. The images inputted by Quick scanner into computer were digitized and analyzed by NIH image program. The stability of the copper equivalent transformation and the usefulness of two analyzing methods by ROI and Reslice were examined. Obtained results as follows: 1) On the Cu equivalent images, the coefficient of variation in the measurement of Cu-Eq. value of ROI ranged from 0.05 to 0.24 and showed high reproducibility. 2) All results obtained by resliced contiguous image were coincident with those obtained from the assessment by ROI and formation of plot profile. 3) On the stacked and resliced image at the line of interest, we could analyze directly and quantitatively the longitudinal changes at several portions by plot profile and qualitatively by surface plot. 4) Implant area showed marked resorption till 2 weeks after implantation and showed significant increase in Cu-Eq. value at 6th week(p<0.01) and periapical area showed increase in Cu-Eq. value at 6th week compared to after-operation's.

• 한국전자파학회논문지
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• 제21권2호
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• pp.143-151
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• 2010

본 논문에서는 Metamaterial CRLH 구조 기반의 0차 공진현상이 발생되는 새로운 직각 패치 안테나가 제안된다. 일반 마이크로스트립 패치 구조의 기본 공진 모드인 반파장 공진이나 반파장 공진의 양의 정수배가 아닌 구조 전체에 전계가 같은 위상을 갖게 하면서, 기존에 발표된 다수의 금속 쎌들이 일렬 연결된 1차원 0차 공진 안테나의 구조와 달리 금속 패치 주위에 하나의 용량성 결합 직각 링만을 부착하는 구조를 제안하는 것이다. 2.4 GHz에서 0차 공진 특성을 갖도록 설계된 등가회로에 따른 물리 구조의 치수들이 입력된 3차원 전자장 분석기에서 안테나의 성능에 대한 모의시험을 수행한다. 설계 결과 2.4 GHz에서 공진점을, 그리고 이득과 효율은 각각 5 dB와 98%를 얻었다. 또한 본 논문이 제안하는 안테나가 마이크로스트립 패치 안테나의 장점인 low-profile과 모노폴 안테나의 장점인 전방향 패턴을 동시에 가지는 특징이 논의된다.

• 한국정밀공학회지
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• 제29권3호
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• pp.279-288
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• 2012

The material removal mechanism in machining is significantly affected by the cutting edge geometry. Its effect becomes even more substantial when the depth of cut is relatively small as compared to the characteristic length which represents the shape and size of the cutting edge. Conventionally, radius or focal length has been employed as the characteristic length with the assumption that the shape of cutting edge is round or parabolic. However, in reality, there could be various ways to determine the radius or focal length even for the same tool edge profile, depending on the region to be considered as cutting edge in the measured profile and the constraints to be set in constructing the best fitted circle or parabola. In this regard, the present study proposes various models to determine the characteristic length in terms of radius or focal length. Their physical compatibility are validated by carrying out 2D orthogonal cutting experiments using inserts with a wide range of characteristic length ($30{\sim}180\;{\mu}m$ in terms of radius) and then by investigating the correlation between the characteristic length and the cutting forces. Such validation is based on the common belief that the larger the characteristic length is, the blunter the cutting edge is and the higher the cutting forces are. Interestingly, the results showed that the correlation is higher for the radius or focal length obtained with a constraint that the center of best fitted circle or the focus of the best fitted parabola should be on the bisectional line of the wedge angle of tool.

• Preventive Nutrition and Food Science
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• 제22권2호
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• pp.124-130
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• 2017

This paper describes in detail proximate composition, nutritional profile, phytochemical constituents, antioxidant activities, antimicrobial potential, and antihemolytic activity (towards human erythrocytes) of various fractions of wild Ganoderma lucidum. Proximate analysis established that wild G. lucidum comprises about $87.02{\pm}5.45%$ of moisture, and the remaining part is a rich source of proteins ($8.59{\pm}0.37%$), crude fiber ($54.21{\pm}1.2%$), and carbohydrate (35.16%) with smaller fat content (3.33 %). Similarly, phytochemical screening revealed the presence of flavonoids ($217.51{\pm}0.30mg/g$), ascorbic acid ($116{\pm}7.32mg/g$), phenolics ($360.72{\pm}34.07mg/g$), ${\beta}$-carotenes ($0.42{\pm}0.04{\mu}g/g$), and lycopene ($0.05{\pm}0.00{\mu}g/g$). Extracts of wild G. lucidum in various solvents provided first line protection against Escherichia coli and Pasteurella multocida in the order of ethyl acetate> ethanol> methanol> n-hexane> water. Furthermore, aqueous and methanolic extracts of wild G. lucidum were found to be safe towards human erythrocytes. Overall, wild mushroom (G. lucidum) was found to be a good source of dietary supplements, antimicrobial and antioxidant agents in the pursuance of its commercial utilization in food and pharmaceutical industries.

• 한국정밀공학회지
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• 제23권5호
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• pp.37-43
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• 2006

Fitting process carried out in automobile transmission assembly line is classified into three classes; heat fitting, press fitting, and their combined fitting. Heat fitting is a method that heats gear to a suitable range under the tempering temperature and squeezes it toward the outer diameter of shaft. Its stress depends on the yield strength of gear. Press fitting is a method that generally squeezes gear toward that of shaft at room temperature by press. Another method heats warmly gear and safely squeezes it toward that of shaft. Warm shrink fitting process for automobile transmission part is now gradually increased, but the parts (shaft/gear) assembled by this process produced dimensional change in both outer diameter and profile of the gear. So that it may cause noise and vibration between gears. In order to solve these problems, we need an analysis of warm shrink fitting process, in which design parameters are involved; contact pressure according to fitting interference between outer diameter of shaft and inner diameter of gear, fitting temperature, and profile tolerance of gear. In this study, an closed form equation to predict contact pressure and fitting load was proposed in order to develop optimization technique of warm shrink fitting process and verified its reliability through the experimental results measured in the field and FEM, that is, thermal-structural coupled field analysis. Actual loads measured in the field have a good agreement with the results obtained by theoretical and finite element analysis and also the expanded amounts of the outer diameters of the gears have a good agreement with results.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제42회 동계 정기 학술대회 초록집
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• pp.436-437
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• 2012

Double patterning technology (DPT) has been suggested as a promising candidates of the next generation lithography technology in FLASH and DRAM manufacturing in sub-40nm technology node. DPT enables to overcome the physical limitation of optical lithography, and it is expected to be continued as long as e-beam lithography takes place in manufacturing. Several different processes for DPT are currently available in practice, and they are litho-litho-etch (LLE), litho-etch-litho-etch (LELE), litho-freeze-litho-etch (LFLE), and self-aligned double patterning (SADP) [1]. The self-aligned approach is regarded as more suitable for mass production, but it requires precise control of sidewall space etch profile for the exact definition of hard mask layer. In this paper, we propose etch end point detection (EPD) in spacer etching to precisely control sidewall profile in SADP. Conventional etch EPD notify the end point after or on-set of a layer being etched is removed, but the EPD in spacer etch should land-off exactly after surface removal while the spacer is still remained. Precise control of real-time in-situ EPD may help to control the size of spacer to realize desired pattern geometry. To demonstrate the capability of spacer-etch EPD, we fabricated metal line structure on silicon dioxide layer and spacer deposition layer with silicon nitride. While blanket etch of the spacer layer takes place in inductively coupled plasma-reactive ion etching (ICP-RIE), in-situ monitoring of plasma chemistry is performed using optical emission spectroscopy (OES), and the acquired data is stored in a local computer. Through offline analysis of the acquired OES data with respect to etch gas and by-product chemistry, a representative EPD time traces signal is derived. We found that the SE-EPD is useful for precise control of spacer etching in DPT, and we are continuously developing real-time SE-EPD methodology employing cumulative sum (CUSUM) control chart [2].

• 한국농공학회논문집
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• 제50권5호
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• pp.3-15
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• 2008

This study aims to simulate the 3 dimensional (3D) model of Keum-man connection canal using geographic information system (GIS) as well as considering design in viewpoint of engineering. The canal connects from Keumkang to Mangyungkang in order to supply fresh water into Saemankeum lake. This study used 3 dimensional spatial planning model (3DSPLAM) process to generate the 3D model, which has not only several planning layers in actual process, but also their corresponding layers in modeling process to simulate 3D space of rural villages. The discharge of the canal is $20m^3/s$ on slope of 1/28,400 in the canal length of 14.2km, which consists of pipe line and open channel. This study surveyed the route of the canal and its surrounding environment for facilities to make images in the 3D graphic model. Besides, the present study developed data set in GIS for geogrphical surface modeling as well as parameters in hydraulic analysis for water surface profile on the canal using HEC-RAS model. From the data set constructed, this study performed analysis of water surface profile with HEC-RAS, generation of digital elevation model (DEM) and 3D objects, design of the canal section and route on DEM in AutoCAD, and 3D canal model and its surrounding 3D space in 3DMAX with virtual reality. The study result showed that the process making 3D canal model tried in this study is very useful to generate computer graphic model with the designed canal on the surface of DEM. The generated 3D canal can be used to assist decision support for the canal policy.

• 한국자동차공학회논문집
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• 제5권3호
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• pp.54-65
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• 1997

To quantify the LII signals from soot particle of flames in diesel engine cylinder, a new method has been proposed for correcting LII signal attenuated by soot particles between the measuring point and the detector. It has been verified by an experiment on a laminar jet ethylene-air diffusion flame. Being proportional to the attenuation, the ratio of LII signal at two different detection wavelengths can be used to correct the measured LIIsignal and obtain the unattenuated LII signal, from which the soot volume fraction in the flame can be estimated. Both the 1064-nm and frequency-doubled 532-nm beams from the Nd : YAG laser are used. Single-shot, one-dimensional(1-D) line images are recorded on the intensified CCD camera, with the rectangular-profile laser beam using 1-mm-diameter pinhole. Two broadband optical interference filters having the center wavelengths of 647 nm and 400 nm respectively and a bandwidth of 10 nm are used. This two-wavelength correction has been applied to the ethylene-air coannular laminar diffusion flame, previously studied on soot formation by the laser extinction method in this laboratory. The results by the LII measurement technique and the conventional laser extinction method at the height of 40 nm above the jet exit agreed well with each other except around outside of the peaks of soot concentration, where the soot concentration was relatively high and resulting attenuation of the LII signal was large. The radial profile shape of soot concentration was not changed a lot, but the absolute value of the soot volume fraction around outside edge changed from 4ppm to 6.5 ppm at r=2.8mm after correction. This means that the attenuation of LII signal was approximately 40% at this point, which is higher than the average attenuation rate of this flame, 10~15%.