• The Korean Journal of Physiology and Pharmacology
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• v.26 no.3
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• pp.175-182
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• 2022

Translocation of azurophil granules is pivotal for bactericidal activity of neutrophils, the first-line defense cells against pathogens. Previously, we reported that lysophosphatidylcholine (LPC), an endogenous lipid, enhances bactericidal activity of human neutrophils via increasing translocation of azurophil granules. However, the precise mechanism of LPC-induced azurophil granule translocation was not fully understood. Treatment of neutrophil with LPC significantly increased CD63 (an azurophil granule marker) surface expression. Interestingly, cytochalasin B, an inhibitor of action polymerization, blocked LPC-induced CD63 surface expression. LPC increased F-actin polymerization. LPC-induced CD63 surface expression was inhibited by both a Rho specific inhibitor, Tat-C3 exoenzyme, and a Rho kinase (ROCK) inhibitor, Y27632 which also inhibited LPC-induced F-actin polymerization. LPC induced Rho-GTP activation. NSC23766, a Rac inhibitor, however, did not affect LPC-induced CD63 surface expression. Theses results suggest a novel regulatory mechanism for azurophil granule translocation where LPC induces translocation of azurophil granules via Rho/ROCK/F-actin polymerization pathway.

• Journal of Pharmacopuncture
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• v.13 no.1
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• pp.37-43
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• 2010

Objective : Ginseng is one of most widely used herbal medicine. Ginseng showed anti-metastasis activities. However, its molecular mechanisms of action are unknown. So we want to report the wild ginseng repress which plays key roles in neoplastic epithelial-mesenchymal transition process. Methods : Treatment of the human colorectal carcinoma LOVO cells and human gastric carcinoma SNU601 cells with the increased concentrations of cultivated wild ginseng extracts resulted in a gradual decrease in the AXIN2 gene expression. Results : Metastasis-suppressor genes, maspin and nm23 was not affected by the treatment of ginseng extracts in LOVO cells. Moreover, the mountain cultivated wild ginseng or mountain wild ginseng are similar in their inhibitory effects on the expression of AXIN2 gene, but are substantially stronger than cultivated ginseng. Conclusion : We described the novel mechanism of wild ginseng-induced anti-metastasis activity by repressing the expression of AXIN2 gene that plays key roles in epithelial-mesenchymal transition process.

• International Journal of Control, Automation, and Systems
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• v.3 no.spc2
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• pp.302-307
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• 2005

A novel neuro controller based simple neuro-structure with modified error function is introduced in this paper. This controller consists of two independent controllers, known as the voltage regulator and the angular controller. The voltage regulator is used to modify terminal voltage for the purpose of tracking a reference voltage. The angular controller is utilized to guarantee the stability of the system. In this structure each neuron uses a linear hard limit activation function that depends on the controlled variable and its derivatives. There is no need for parameter identification or any off-line training data. Two proposed controllers are merged by a smooth switch to build a complete controller. The effectiveness of the proposed novel control action is demonstrated through some computer simulations on a Single-Machine Infinite-Bus (SMIB) power system.

• Journal of Biomedical Engineering Research
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• v.21 no.2
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• pp.189-201
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• 2000

Mechanical factors in the human body are considered to play a dominant role in low back problems. Various spinal structures. including muscles, act in unison to resist the external load. An estimation of the muscle forces in this structure requires a knowledge of the orientation, location and area of cross-section of the muscles to complete the formulation of a truly three-dimensional mathematical model of the spine. The geometric parameters which are calculated were the line of action, the centroid and physiologic area of cross-section of each muscle as a function of the spinal level. This geometric data were obtained from CT scans of 11 subjects participating in this study.

• Journal of the Korean Society of Industry Convergence
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• v.9 no.4
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• pp.285-291
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• 2006

A traffic accident is occurred by unbalance of reciprocal action of driver, vehicle and road conditions. To prevent the traffic accident, rapid and perfect road improvement is needed. But most of road improvement plans have insufficient budget. So decision maker has to determine the priority to invest. A model in this study, analyzing the effect of road conditions to the traffic accident, helps to decide the priority in road improvement. This study considered five danger indices ; 1) traffic volume, 2) speed variance, 3) vehicle mixing rate, 4) curved line radius, and 5) difference between design speed and running speed. Danger rate composed by five indices can be a scale of priority of improvement. The model in this study didn't consider all of factors about traffic accident. But this study can propose the methodology for traffic safety policy. For deriving the model, this study used data from highways in Korea and United States. Therefore the model has to apply the highways only.

• Journal of the Korean housing association
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• v.14 no.3
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• pp.127-136
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• 2003

The purpose of this study is to establish concept about a plan direction of preschooler's library, and provide a design type of preschooler's library. As a result, the following findings were obtained: 1) For the preschooler's reading area, it should be segregated between schooler and preschooler. Because there is a difference between a library use action and a development characteristic, it needs to be segregated to avoid conflict using library for both of those groups. 2) The space composition of preschooler's library stands up, and of a tube considers a traffic line of a user according to the function and systematizes a child, and to cause an interest of preschoolers. 3) Furnitures and equipment of preschooler's library must arrange in consideration of human body size of a user in a tube.

• Journal of Power Electronics
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• v.11 no.3
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• pp.375-380
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• 2011

A STATic synchronous COMpensator (STATCOM) is a shunt connected voltage source converter (VSC) based FACTS controller using Gate Turn Off (GTO) power semiconductor devices employed for reactive power control. The operation principal is similar to that of a synchronous condenser. A typical application of a STATCOM is voltage regulation at the midpoint of a long transmission line for the enhancement of power transfer capability and/or reactive power control at the load centre. This paper presents the modeling of STATCOM with twenty four pulse three level VSC and Type-1 controller to regulate the reactive current or the bus voltage. The performance is evaluated by transient simulation. It is observed that, the STATCOM shows excellent transient response to step change in the reactive current reference. While the eigenvalue analysis is based on D-Q model, the transient simulation is based on both D-Q and 3 phase models of STATCOM (which considers switching action of VSC).

• The Korean Journal of Physiology and Pharmacology
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• v.6 no.3
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• pp.139-142
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• 2002

To examine intracellular signaling of human $S1P_3\;(hS1P_3),$ a sphingosine 1-phosphate (S1P) receptor in plasma membrane, $hS1P_3$ DNA was transfected into RH7777 rat hepatoma cell line, and the inhibition of forskolin-induced cAMP accumulation and activation of MAP kinases by S1P were tested. In $hS1P_3$ transformants, S1P inhibited forskolin-induced activation of adenylyl cyclase activity by about 80% and activated MAP kinases in dose-dependent and pertussis-toxin (PTX) sensitive manners. In oocytes expressing $hS1P_3$ receptor, S1P evoked $Cl^-$ conductance. These data suggested that PTX-sensitive G proteins are involved in $hS1P_3-mediated$ signaling, especially the positive action of S1P in cell proliferation. The potential advantages of rat hepatoma cells for the research of sphingosine 1-phosphate receptor are discussed.

• Transactions on Electrical and Electronic Materials
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• v.17 no.1
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• pp.7-12
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• 2016

This paper proposes a metal contact RF MEMS switch which utilizes a see-saw mechanism to acquire a switching action. The switch was built on a quartz substrate and involves vertical deflection of the beam under an applied actuation voltage of 5.46 volts over a signal line. The see-saw mechanism relieves much of the operation voltage required to actuate the switch. The switch has a stiff beam eliminating any stray mechanical forces. The switch has an excellent isolation of −90.9 dB (compared to − 58 dB in conventional designs ), the insertion of −0.2 dB, and a wide bandwidth of 88 GHz (compared to 40 GHz in conventional design ) making the switch suitable for wide band applications.

• Korean Journal of Human Ecology
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• v.8 no.1
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• pp.193-210
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• 1999

The purpose of this study is to compare the similarity of clothing between Modern and Gothic, and between Post-Modern and Renaissance Period. The results are as followes: The beauty of ideal body was changed from unemphasis of body line to emphasis of the erotic espects of body. The style of clothing was changed from simple and functional in order to give freedom in action, to various and complicated in from, and even uncomfortable in order to emphasize individuality. Decoration on clothing like details, trimmings, and various accessories were not prefered in Gothic and Modem Period, but very popular in Post-Modern and Renaissance Period.