• Asian-Australasian Journal of Animal Sciences
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• v.28 no.8
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• pp.1163-1170
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• 2015

Two probiotic strains, Lactobacillus johnsonii x-1d-2 and Lactobacillus mucosae x-4w-1, originally isolated from piglet feces, have been demonstrated to possess antimicrobial activities, antibiotic resistances and interleukin-6 induction ability in RAW 267.4 macrophages in our previous study. These characteristics make L. johnsonii x-1d-2 and L. mucosae x-4w-1 good candidates for application in feed probiotics. In this study, soybeal meal, molasses and sodium acetate were selected to optimize the growth medium for cultivation of L. johnsonii x-1d-2 and L. mucosae x-4w-1. These two strains were then freeze-dried and mixed into the basal diet to feed the weaned piglets. The effects of L. johnsonii x-1d-2 and L. mucosae x-4w-1 on the growth performance and fecal microflora of weaned piglets were investigated. The results showed that the bacterial numbers of L. johnsonii x-1d-2 and L. mucosae x-4w-1 reached a maximum of 8.90 and 9.30 log CFU/mL, respectively, when growing in optimal medium consisting of 5.5% (wt/vol) soybean meal, 1.0% (wt/vol) molasses and 1.0% (wt/vol) sodium acetate. The medium cost was 96% lower than the commercial de Man, Rogosa and Sharpe medium. In a further feeding study, the weaned piglets fed basal diet supplemented with freeze-dried probiotic cultures exhibited higher (p<0.05) body weight gain, feed intake, and gain/feed ratio than weaned piglets fed basal diet. Probiotic feeding also increased the numbers of lactobacilli and decreased the numbers of E. coli in the feces of weaned piglets. This study demonstrates that L. johnsonii x-1d-2 and L. mucosae x-4w-1 have high potential to be used as feed additives in the pig industry.

• Clinical and Experimental Pediatrics
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• v.55 no.1
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• pp.6-10
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• 2012

Human puberty is a complex, coordinated biological process with multiple levels of regulations. The timing of puberty varies greatly in children and is influenced by both environmental and genetic factors. The key genes of pubertal onset, $KISS1$, $GPR54$, $GNRH1$ and $GNRHR$, may be major causal factors underlying gonadotropin-releasing hormone-dependent precocious puberty (GDPP). Two gain-of-function mutations in $KISS1$ and $GPR54$ have been identified recently as genetic causes of GDPP. $GNRH1$ and $GNRHR$ are also gene candidates for GDPP; however no mutations have been identified in these genes. Presently potential genetic causes like $LIN28B$ continues to appear; many areas of research await exploration in this context. In this review, I focus primarily on the genetic causes of GDPP.

• Archives of Pharmacal Research
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• v.28 no.8
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• pp.889-891
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• 2005

Two ergosterins and two triterpenoids were isolated from the dried fruit bodies of Ascomyce Bulgaria inquinans. By means of chemical (hydrolysis) and spectroscopic methods (NMR, EIMS), their structures were established as betuinic acid (1), cerevisterol (2), (24R)ergosta-7, $22E­diene-3\beta,\;5\alpha,\;6\beta-triol-3-O-palmitate$ (3) and ursolic acid (4). Compound 3 is a new compound.

• Korean Journal of Clinical Pharmacy
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• v.28 no.1
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• pp.57-64
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• 2018

Background: Patients experience significant differences in aspects of mortality, quality of life, and costs between during the year of receiving liver transplant (LT) and the subsequent years (post-LT). This study aimed to estimate the medical utilization and cost of LT for patients compared to post-LT patients by using a recent National Patient Sample (NPS) data provided by the Korean Health Insurance Review and Assessment Service (HIRA). Methods: This study used a subset of the 2015 HIRA-NPS. Patient claims data that included Z944 (Korean Standard Classification of Diseases code for LT status) were selected. Within the selected data, LT patients were identified based on whether the national health insurance number code of Q80 (procedure code for LT surgery) was included, and they were compared to post-LT patients. Results: In the analysis, 330 patients were included. The average cost per patient was $90,066{\pm}36,959$ thousand KRW and $10,557{\pm}9,668$ thousand KRW for LT and post-LT patients, respectively. Especially, LT patients' costs for injection/procedure, surgery/treatment, and examination were higher than other costs, being $35,983{\pm}18,115$ thousand KRW, $28,246{\pm}9,408$ thousand KRW, and $12,131{\pm}6,604$ thousand KRW, respectively. For inpatients, the average number of hospitalized days was $63.5{\pm}66.0$ days for LT patients and $22.3{\pm}35.1$ days for post-LT patients. Conclusion: Compared to post-LT patients, LT patients had higher costs, especially for injection/procedure, surgery/treatment, and examination. Additionally, the LT group had longer hospitalization duration and higher costs for their hospital admission, whereas they did not show a significant difference in number of visits and medical costs for outpatient-care.

• Structural Engineering and Mechanics
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• v.77 no.1
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• pp.1-17
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• 2021

The influence of prestress force on the fundamental frequency and static deflection shape of uncracked Prestressed Concrete (PC) beams with a parabolic bonded tendon was examined in this paper. Due to the conflicts among existing theories, the analytical solutions for properly considering the dynamic and static behavior of these members is not straightforward. A series of experiments were conducted for a total period of approximately 2.5 months on a PC beam made with high strength concrete, subsequently and closely to the 28 days of age of concrete. Specifically, the simply supported PC member was short term subjected to free transverse vibration and three-point bending tests during its early-age. Subsequently, the experimental data were compared with a model that describes the dynamic behavior of PC girders as a combination of two substructures interconnected, i.e., a compressed Euler-Bernoulli beam and a tensioned parabolic cable. It was established that the fundamental frequency of uncracked PC beams with a parabolic bonded tendon is sensitive to the variation of the initial elastic modulus of concrete in the early-age curing. Furthermore, the small variation in experimental frequency with time makes doubtful its use in inverse problem identifications. Conversely, the relationship between prestress force and static deflection shape is well described by the magnification factor formula of the "compression-softening" theory by assuming the variation of the chord elastic modulus of concrete with time.

• Journal of the Korean Institute of Rural Architecture
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• v.8 no.3
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• pp.83-90
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• 2006

1) Lee-Su village is located in a riverside of an upper Tu-men river. Since an upper stream of Tu-men river is narrow and easy to pilot a boat, early in the past, it facilitated the form of the village near to the North Korean. 2) The form of the village is parabolic from the founding period. That is, increasing the number of houses in the time of the Cultural Revilution Campaign, and the Japanese colony, the village has transformed into the bigger size about 72 families from the small town. After the cultural revolution, due to private asset allowed in accordance with the Chinese Reform and Open Policy, the number of families in the town and the population have been decreased. As a result, 28 families live in the village currently. 3) The town which was well-ordered in the Japanese colonial period has been changed to a very disordered and agricultural town, owing to the decrease of the families A road system has been also ruined naturally in accordance with the decline of the number of the families.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.4
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• pp.2591-2594
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• 2013

Aim: To compare the efficacy and safety of paclitaxel liposome (Lipusu$^{(R)}$) with paclitaxel in combination with tegafur and oxaliplatin in treating patients with advanced gastric cancer. Materials and Methods: Patients with advanced gastric cancer receiving chemotherapy were retrospectively collected, and divided into two groups. Patients in group A received paclitaxel liposomes at a dose of 135 $mg/m^2$ on day 1 of each cycle, and patients in group B were given paclitaxel at the same dose with the same timing. All patients received tegafur at a dose of 500 $mg/m^2$ on days 1-5, and oxaliplatin at a dose of 80-100 $mg/m^2$ on day 1 for 2 cycles (each cycle was 21 d in total). Results: Fifty-eight patients could be evaluated for efficacy. The overall response rate was 47% in group A (14/30), and 46% in group B (13/28). Disease control rate was 73% in group A (22/30), and 71% in group B (20/28) (P>0.05). No significant differences were detected in hematologic and neurologic toxicities between the two groups (P>0.05). However, nausea, vomiting and hypersensitive reactions were significantly lower in group A than in group B (P<0.05). Conclusion: Paclitaxel liposomes are as effective as paclitaxel when combined with tegafur and oxaliplation in treating patients with advanced gastric cancer, but adverse reactions with paclitaxel liposomes are less common.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.5 no.3 s.11
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• pp.24-28
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• 2006

This paper proposed design and implementation of automation system that recognize device module boards automatically that are connected on main control board. The system of this paper is divided to main board and device module boards, and the main board is designed a board by slot structure. The slot structure is possible a extension for upgrade and addition of board ability. Besides, it is easier a establishment and disjointing because it recognizes automatically a device board. The proposed system in this paper compares with K10S1 PLC. The result shows an advantage of extensibility and ability, and it is reduced expense and period for development.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2009.11a
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• pp.11-16
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• 2009

Public rental apartment has suffered social exclusion problem, stemmed from its closed planing for a very specific range of the disadvantaged population. Thereby, it has been recognized as a disliked residential facility. To alleviate this problem, various approaches have been tried such as ownership-tenant mixture, and different unit size mixture. The purpose of this study is to grasp the expected social relation among neighboring residents according to socially integrative planing elements such as ownership, unit size and family life cycle match. Thirty eight graduate students in architecture and housing field responded to the questionnaire which was specifically made to identify relations of 28 neighboring situations based on $2{\times}2{\times}2$ variable composition. Frequency, percentage and MDS(multidimensional scaling) were used to analyze data. As a result, the order of preferred matchy were identified. The match between rental/small/children group and ownership/middle/children group was turned out to be the most desirable while the match between rental/small/children family group and rental/small/elderly group was found the least desirable. Spatial representations of the relationships among 8 household types were delineated. In conclusion, the definite patterns of the favorable and unfavorable match were found. This result is expected to be used as a reference in developing a strategic match to promote the rental apartments social integration in Korea.

• Restorative Dentistry and Endodontics
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• v.28 no.1
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• pp.72-79
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• 2003

The objective of this in vitro study was to evaluate the efficacy of a Ca(OH)$_2$removal before and after early coronal flaring using different types of instruments. 100 plastic blocks with 30$^{\circ}$artificial curved canals were used in this study and randomly divided into a control group and 4 experimental groups(GG, OS, GT, PT Group) 20 teeth each. The canals were instrumented, and Ca(OH)$_2$was temporary filled into the each canal. Irrigation was peformed with Max-i-Probe 25- 30-gauge probes before and after recapitulation. The results of this study were as follows 1. There were no significant difference among the groups in size of irrigating needle(p<0.05). 2. There was a significant difference between before and after recapitulation regardless size of irrigating needle(p<0.05). 3. Before recapitulation, there was a significant difference between 25- and 30-gauge needle in all groups(P<0.05). 4. After recapitulation, there was a significant difference between 25- and 30-gauge needle in the control group(p<0.05). But there were no significant difference among the experimental groups. It is concluded that the effectiveness of canal irrigation was decided to the depth of irrigating needle into the canal. The effect of canal irrigation tend to facilitate by the early coronal flaring. The recapitulation was the most effective during canal irrigation regardless the size of irrigating needle. Therefore, the recapitulation is a mandatory way to facilitate the effectiveness of canal irrigation during canal enlargement.