• Applied Biological Chemistry
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• 제33권3호
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• pp.239-246
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• 1990

유기 용매에 추출되는 유리형의 홍국 색소를 보다 많이 얻기 위하여 Monascus anka의 균주를 자연 및 자외선 변이균주에서 선발하고 배양 조건을 탐색하였다. 균주 N3를 Lin's medium에서 진탕 배양, Nishikawa's medium에서 정치 배양 및 진탕 배양하여 균체성장과 색소생성에 소요되는 시간, 유기용매에 추출되는 색소의 양을 비교하여 보았다. Lin's medium에서의 액침 배양에서는 수용성 색소가 우세하게 생성되는 반면 Nishikawa's medium에서의 정치 배양에서는 보다 많은 유기용매 가용성의 색소를 얻을 수 있었다. 한편 탄소원으로는 자당외에 에탄올이 가장 효과적이었다. Sterol 합성저해제를 처리하였을 때는 상당한 색소 형성의 증가를 볼 수 있었다. 이차원 TLC로써 아직 보고된 바 없는 색소들이 존재함을 알 수 있었다. 이 균주의 색소중 가장 다량으로 존재하는 황색소의 하나를 분리하였고 분광학적 방법으로 ankaflavin으로 동정하였다.

• Applied Biological Chemistry
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• 제35권6호
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• pp.443-448
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• 1992

현탁배양에 의한 박하 세포의 생장 특성을 살펴보기 위하여 박하 잎으로부터 캘러스를 유기하고 이 캘러스 중 쉽게 퇴화되지 않고 생육 속도가 빠른 우수 세포주를 선발하였으며 선발된 세포주를 현탁 배양하였다. 현탁 배양중 배지의 조성, 식물 생장 호르몬, 배지의 pH가 생육에 미치는 영향을 조사하였다. 배지로서 사용한 Lin-Staba 배지, B5 배지, MS 배지 중 에서는 Lin-Staba 배지에서 세포의 생육이 가장 좋았으며 특히 이 배지에 100 mg/l yeast extract를 첨가했을 때 생육은 크게 저해되었다. 식물 생장 호르몬의 경우는 cytokinin류가 auxin류를 첨가했을 때보다 생장 속도가 더 빨라졌다. 배지의 초기 pH는 생장에 큰 영향을 주지 못하였다.

• 대한음성학회:학술대회논문집
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• 대한음성학회 1996년도 10월 학술대회지
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• pp.207-207
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• 1996

The neutral tone is one of the most important distinguishing features in Beijing Mandarin, but there are two completely different views on its linguistic function: a special tone(Xu, 1980) versus weak stress(Chao, 1968). In this paper, the acoustic manifestation of the neutral tone will be explored to show that it is closely related to weak stress. 122 disyllabic words in which the second syllable carries the neutral tone, including 22 stress pairs, were uttered by a native male speaker of Beijing dialect and analysed by Kay Digital Sonagraph 5500-1. The results of the acoustic analysis are presented as follows: 1) The first two formants of the medial and the syllabic vowel moves towards that of central vowel with a greater magnitude in the syllable with the neutral tone than in the syllable with any of the four normal tones. Also the vowel ending, and nasal coda /n/ and / / in the syllable with the neutral tone tends to be deleted. 2) In the syllables with the neutral tone, there are strong carryover coarticulations between the medial and syllabic vowel and the preceding unvoiced consonant. In general, the vowel is affected to move towards the position of the central vowel with more greater magnitude by coronal consonant than by labial or velar consonant. 3) In the syllable with the neutral tone, when and only when it precedes a syllable with tone-4, the high vowel following [f], [ts'], [s], [ts'], [s], [tc'] or [c] tends to be voiceless. 4) It can be seen from the acoustical results of 22 stress pairs that the duration of the syllable with the neutral tone is on the average reduced to 55% of that of the syllable with the four normal tones, and the duration of the final in the syllable with neutral tone is on the average reduced to 45% of that of the final in the syllable with the four normal tones(Lin & Yan 1980). 5) The FO contour of the neutral tone is highly dependent on the preceding normal tone(Lin & Yan 1993). For a number of languages it has been found that the vowel space is reduced as the level of stress placed upon the vowel is reduced(Nord 1986). Therefore we reach the conclusion that the syllable with neutral tone is related to weak stress(Lin & Yan 1990). The neutral tone is not a special tone because the preceding normal tone.

• 대한수의학회지
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• 제40권1호
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• pp.187-195
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• 2000

The ejaculates from 67 HanWoo prove bull, bred in Livestock Improvement Main center of NLCF, were used to determine the correlation between the sperm motional characteristics and the pregnancy rate of artificial insemination(AI). The motional characteristics of sperm were analysed by Computer-assisted sperm analyser(CASA), thereafter inseminated equally 1,256 heads of cow regarding to parity, age, and live weight. There were no significant difference(p>0.05) in the pregnancy rate according to year from 1996 to 1998, but the LIN, ALH, STR, BCF, MAD and WOB of sperm in the year 1997, were highest pregnancy rate, were higher than those of sperm in the year 1998, were lowest pregnancy rate(p<0.05). The semen had no significant effect on pregnancy rate according to season(p>0.05). However spring, had a little higher pregnancy rate than that of autumn, were higher than autumn in VSL, VAP, LIN, ALH, BCF, MAD and WOB, but in DNM. The pregnancy rates of spring in the year 1996 and 1997 were higher than that of autumn in the year 1998(p<0.05). The spring in the year 1997, highest in pregnancy rate, were higher than the autumn in the year 1998 in VSL, VAP, LIN, STR, BCF, MAD and WOB, but in DNM(p<0.05). There were no the motion characteristic of sperm that was significant correlate with pregnancy rate of AI as the semen were analysed before artificial insemination and those, had some degree characteristics in motility, viability and abnormality, were used to AI. However there were a tendency that the higher the VSL, VAP, ALH, LIN, STR, BCF, MAD and WOB and the lower the DNM were, the higher the pregnancy rate of AI were.

• Journal of Ginseng Research
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• 제42권3호
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• pp.298-303
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• 2018

Background: Panax ginseng is one of the most commonly used medicinal herbs worldwide for a variety of therapeutic properties including neurocognitive effects. Ginsenoside Rg1 is one of the most abundant active chemical constituents of this herb with known neuroprotective, anxiolytic, and cognition improving effects. Methods: We investigated the effects of Rg1 on the medial prefrontal cortex (mPFC), a key brain region involved in cognition, information processing, working memory, and decision making. In this study, the effects of systemic administration of Rg1 (1 mg/kg, 3 mg/kg, or 10 mg/kg) on (1) spontaneous firing of the medial prefrontal cortical neurons and (2) long-term potentiation (LTP) in the hippocampal-medial prefrontal cortical (HP-mPFC) pathway were investigated in male Sprague-Dawley rats. Results: The spontaneous neuronal activity of approximately 50% the recorded pyramidal cells in the mPFC was suppressed by Rg1. In addition, Rg1 attenuated LTP in the HP-mPFC pathway. These effects were not dose-dependent. Conclusion: This report suggests that acute treatment of Rg1 impairs LTP in the HP-mPFC pathway, perhaps by suppressing the firing of a subset of mPFC neurons that may contribute to the neurocognitive effects of Rg1.

• 비교문화연구
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• 제25권
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• pp.363-389
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• 2011

Modern Chinese Literature, the so-called 'feminist' is a very modern and the traditional criticism and took an important position in the double action. Because a woman's freedom from the bondage of traditional ethics of restoring the social status equal to men but to women does not give, that compared to men and women just the dimension of the problem of isolation is not just. It is dominated by yugajeok worldview by streamlining the whole Chinese society to build a modern society and the country was a critical task. However, multi-cultural life of Lin, Hui-yin and Ling, Shu-hua in the history of the world's attention to the shrine was worried attention to soils, rather than East-West dualism law by taking a mixture of both women in modern Chinese literature and Western literature from the center of efforts to overcome the traditional point hayeotdaneun feminist literature that may be different. Lin, Hui-yin and Ling, Shu-hua to overcome the Western-oriented culture really the true dream of China's globalization and localization could be regarded. She naesewotdeon the banner of feminist literature in the traditional 'anti feudal', 'free personality' silcheondoen under such slogans as well as women's liberation from traditional, male-oriented perspective away from the women's unique experiences and new understanding of the value of the superiority the concept of a woman, and was to create. In particular, the femininity of these women who traditionally associated with women and the unique culture - the creation of a new consciousness, a re-evaluation of traditional feminine skills and talents was to try to.

• Korean journal of medical education
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• 제30권4호
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• pp.295-308
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• 2018

Purpose: Although medical curricula are now better structured for integration of biomedical sciences and clinical training, most teaching and learning activities still follow the older teacher-centric discipline-specific formats. A newer pedagogical approach, known as Collaborative Learning Cases (CLCs), was adopted in the medical school to facilitate integration and collaborative learning. Before incorporating CLCs into the curriculum of year 1 students, two pilot runs using the action research method was carried out to improve the design of CLCs. Methods: We employed the four-phase Kemmis and McTaggart's action research spiral in two cycles to improve the design of CLCs. A class of 300 first-year medical students (for both cycles), 11 tutors (first cycle), and 16 tutors (second cycle) were involved in this research. Data was collected using the 5-points Likert scale survey, open-ended questionnaire, and observation. Results: From the data collected, we learned that more effort was required to train the tutors to understand the principles of CLCs and their role in the CLCs sessions. Although action research enables the faculty to improve the design of CLCs, finding the right technology tools to support collaboration and enhance learning during the CLCs remains a challenge. Conclusion: The two cycles of action research was effective in helping us design a better learning environment during the CLCs by clarifying tutors' roles, improving group and time management, and meaningful use of technology.

• 한국콘텐츠학회논문지
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• 제22권9호
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• pp.147-155
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• 2022

이 글은 홍콩 출신 감독 린차오셴(林超賢)이 중국의 주선율 영화에 어떤 변화를 가져왔는지, 그리고 이러한 변화에 영향을 미친 요소들을 분석하기 위한 것이다. 분석의 대상은 린차오셴(林超賢)의 영화 <오퍼레이션 메콩>(湄公河行動, 2016), <오퍼레이션 레드 씨>(紅海行動, 2018), <긴급구원>(緊急救援, 2020)이다. 린차오셴은 중국 대륙 감독들에 비해 정치적 부담이 크지 않아 상업영화의 모델을 이용해 주선율 영화를 만들고 홍콩영화의 요소를 주선율 영화에 최대한 활용하고 있다. 그 결과 주선율 영화의 이데올로기는 딱딱한 표현이 아니라 관객의 공감을 불러일으킬 수 있는 다원화된 가치를 보여준다. 사실적이고 복합적인 인물은 과거 고정 천편일률적이며 비현실적이었던 영웅의 이미지를 대체한다. 스펙터클한 액션 장면과 폭력적인 장면의 응용이 시각적 진풍경을 만들어낸다. 그 결과 주선율 영화는 더 높은 상업적 가치를 얻었다. 린차오센의 영화는 새롭게 변화하는 관객의 취향이 영화산업에서 중요한 요인임을 확인시켜주었으며 높아진 제작비와 더불어 민영영화사의 역할을 키우고 있다.

• IMMUNE NETWORK
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• 제23권4호
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• pp.34.1-34.15
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• 2023

Lung cancer, particularly non-small cell lung cancer (NSCLC) which contributes more than 80% to totally lung cancer cases, remains the leading cause of cancer death and the 5-year survival is less than 20%. Continuous understanding on the mechanisms underlying the pathogenesis of this disease and identification of biomarkers for therapeutic application and response to treatment will help to improve patient survival. Here we found that a molecule known as DUSP10 (also known as MAPK phosphatase 5) is oncogenic in NSCLC. Overexpression of DUSP10 in NSCLC cells resulted in reduced activation of ERK and JNK, but increased activation of p38, which was associated with increased cellular growth and migration. When inoculated in immunodeficient mice, the DUSP10-overexpression NSCLC cells formed larger tumors compared to control cells. The increased growth of DUSP10-overexpression NSCLC cells was associated with increased expression of tumor-promoting cytokines including IL-6 and TGFβ. Importantly, higher DUSP10 expression was associated with poorer prognosis of NSCLC patients. Therefore, DUSP10 could severe as a biomarker for NSCLC prognosis and could be a target for development of therapeutic method for lung cancer treatment.

• 유통과학연구
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• 제11권9호
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• pp.35-42
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• 2013

Purpose - The objective of this paper is to identify how different incentive factors influence teachers with different ages and professional titles at LinYi University, China. Research design, data, and methodology - A total of 435 university teachers participated in the study, and the Grey Correlation Degree Analysis method was used to analyze the sample data. Results - The results indicated that teachers with different professional titles and ages have different levels of preference on various incentive factors. Young and assistant-level teachers seem to place more importance on incentives than associate and senior-level teachers. Conclusions - This study has some practical implications. First, the principal and school administrators should pay more attention to young and middle-aged teachers and to how these teachers are motivated through monetary incentives as compared to associate or senior-level teachers. Second, school administrators should pay more attention to teachers' opportunities for career growth and should provide more opportunity for academic promotion. In order to stimulate positivity in teachers, school administrators should adopt various incentive systems.