• Explosives and Blasting
• /
• v.41 no.4
• /
• pp.9-16
• /
• 2023

To compare the global warming impact of the TBM and NATM method, which are representative tunnel excavation methods, a life cycle assessment was performed for each method. Life cycle assessment should compare the sum of carbon emissions by considering the pre-manufacturing stage, product manufacturing stage, usage stage, and disposal stage. However, access to TBM (Tunnel Boring Machine) manufacturing and disposal data is limited, so I had no choice but to focus on the analysis for the usage stage. In general, carbon emissions during the pre-product manufacturing stage and product manufacturing stage often exceed 90% of carbon emissions throughout the entire process. Therefore, since it is difficult to achieve the analysis goal only by comparing the usage stage, the analysis scope was expanded, and carbon emissions for the process were calculated for the NATM method with access to manufacturing data. As a result of comparing the relative impact on global warming, the carbon emissions of the TBM method were found to be higher than those of the NATM method even though TBM method was only considered for the usage stage. So there it is, the NATM method can be seen as environmentally friendly in the future when considering the impact of climate change (global warming), which has recently attracted attention among environmental impact fields.

• Radiation Oncology Journal
• /
• v.24 no.2
• /
• pp.96-102
• /
• 2006

Purpose: A retrospective study was performed to evaluate the efficiency and feasibility of twice daily radiation therapy plus concurrent chemotherapy for limited-stage small cell lung cancer in terms of treatment response, survival, patterns of failure, and acute toxicities. Materials and Methods: Between February 1993 and October 2002, 76 patients of histologically proven limited-stage small cell lung cancer (LS-SCLC) were treated with twice daily radiation therapy and concurrent chemotherapy. Male was in 84% (64/76), and median age was 57 years (range, 32-75 years). Thoracic radiation therapy consisted of 120 or 150 cGy per fraction, twice a day at least 6 hours apart, 5 days a week. Median total dose was 50.4 Gy (range, 45-51 Gy). Concurrent chemotherapy consisted of CAV ($cytoxan\;1000mg/m^2,\;adriamycin\;40mg/m^2,\;vincristine\;1mg/m^2$) alternating with PE ($cisplatin\;60mg/m^2,\;etoposide\;100mg/m^2$) or PE alone, every 3 weeks. The median cycle of chemotherapy was six (range, 1-9 cycle). Prophylactic cranial irradiation (PCI) was recommended to the patients who achieved a complete response (CR). PCI scheme was 25 Gy/10 fractions. Median follow up was 18 months (range, 1-136 months). Results: Overall response rate was 86%; complete response in 39 (52%) and partial response in 26 (34%) patients. The median overall survival was 23 months. One, two, and three year overall survival rate was 72%, 50% and 30%, respectively. In univariate analysis, the treatment response was revealed as a significant favorable prognostic factor for survival (p<0.001). Grade 3 or worse acute toxicities were leukopenia in 46 (61%), anemia in 5 (6%), thrombocytopenia in 10 (13%), esophagitis in 5 (6%), and pulmonary toxicity in 2 (2%) patients. Of 73 evaluable patients, 40 (55%) patients subsequently had disease progression. The most frequent first site of distant metastasis was brain. Conclusion: Twice daily radiation therapy plus concurrent chemotherapy produced favorable response and survival for LS-SCLC patients with tolerable toxicities. To improve the treatment response, which proved as a significant prognostic factor for survival, there should be further investigations about fractionation scheme, chemotherapy regimens and compatible chemoradiotherapy schedule.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.28 no.4
• /
• pp.365-370
• /
• 2014

The intrinsic concepts of the three yin and three yang diseases in is unclear yet in spite of considerable controversy. In order to answer these problems, the structures of pathological transmission and anatomical terms used in the text were analyzed first. On these structural bases, the theoretical background and differential therapeutic principles of three yin and three yang disease classification. The organic structures frequently used in the text were heart, stomach, pancreas, blood chamber and urinary bladder, and the important regions in the transmission were chest, flank, epigastrium, abdomen, hypogastrium, groin on the other hand. When a host is invaded by extrinsic pathogen, an affinity is formed between the two based on the similarity of epidermal density condition and nutrient-defense features and existing disorders in the body. And then the symptoms show in 3 stages with 6 patterns in the general infective diseases. The initial stage is the period that the syndrome is limited in the external flesh area, and it mainly corresponds with taiyang bing besides the other exterior patterns of 3 yang and 2 yin bing. The middle stage is to the climax after the end of initial stage and it corresponds with mainly yangming bing including shaoyang and taiyin bing. In the terminal stage, the host gradually falls into exhaustive step or recovery phase, corresponding with shaoyin and jueyin bing. Conclusively, these dual meanings of three yang and yin should be a first guide and principle of treatment against various infective diseases.

• KIEAE Journal
• /
• v.13 no.6
• /
• pp.99-104
• /
• 2013

Many activities associated with the construction and habitation of buildings are connected with issues affecting the environment such as global warming, climate change, and consumption of valuable natural resources such as fossil fuels. To minimize negative impacts on the environment, the building industry worldwide has implemented green building practices in many countries. One of the main green strategies is to reduce greenhouse gas emissions caused by residential structures because they are most substantially connected with global warming and climate change. To determine the actual quantity of green house gas emissions caused by the construction and use of a building, it is important to analyze total greenhouse gas emissions over the life cycle of buildings including construction, operation & maintenance(O&M) and demolition stages. Many studies suggest methods to calculate greenhouse gas emissions at the construction stage, but the literature addressing greenhouse gas emissions at the O & M stage is limited. A year-long study was conducted utilizing the deterioration method to calculate greenhouse gas emissions at the O & M stage of building life for condominium types of buildings in South Korea. Through this research, it is possible to analyze greenhouse gas emissions of buildings at the O & M stage, the longest span of the life cycle, and eventually help to calculate total greenhouse gas emissions over the life cycle of the building.

• Korea Journal of Hospital Management
• /
• v.8 no.1
• /
• pp.1-23
• /
• 2003

General drug prices involve three stages: shipment stage, wholesaler stage and retail stage. Policies on drug price differ from country to country. Shipment stage prices are tightly regulated in countries like France and Netherlands. They are free in only a minority of advanced countries, even if these include some major players such as the US, Germany and, in a very limited sense, Japan. The situation in the UK is very complex with a semi-free system, where drug companies are free to set their own prices but cannot exceed a predetermined profit ceiling. Mark-up at both wholesaler and retail stages is formally admitted in most countries observed. Apart from the general drug prices, reimbursement price of insured drugs has been major policy concerns. Most countries reviewed in this study has exerted some control over reimbursement prices, but differ both in the way how and in the extent to which prices are admitted or fixed. Price fixing has been used in France and Japan. Some countries have transformed their system over time, particularly to move to reference pricing in the last decade. This mechanism has empowered the customer, and improved price competition on the market. Referring to the drug price policies in the advanced countries, this study makes some suggestions for the redirection of Korean price policy for reimbursement drug in health insurance as follows: to match appropriate policy tools to each policy goal; to maximize market mechanism through effective reimbursement price fixing which admits mark-ups in wholesaler and retail prices; to introduce reference pricing system in order to redirect patient's demand with a financial incentive to choose the best-priced drugs and to save the finance of health insurance; and to strengthen surveillance and monitoring mechanism in the drug market.

• Archives of Pharmacal Research
• /
• v.17 no.4
• /
• pp.209-212
• /
• 1994

Mophological normal of unfertilized oocytes, which was collected 12-14 hours after human Chorionic Gonadotropin(jCG) injection, was not influenced by chronically adiministration of cocaine for 2 weeks in mice. Proportion of normal unfertilized oocytes in non-cocaine treated group (control), `0 mg/kg and 20 mg/kg cocaine treated group based on body weight with subcutaneous(s.c.) daily injection of cocaine for 2 weeks were 92.9%, 85.6% and 90.9%, respectively. There is no significant difference between control and cocaine treated groups. Two to 8 cell stage embryos collected 24-48 hours post hCG in control group were 66.7%, whereas, 10 mg/kg and 20 mg/kg groups treated with cocaine was 12.5% and 27.3% respectively. Although control and treated groups are significantly different (p<0.05) the developmental score of 2 to 8 cell stage embryos collected at 24-48 hours post HCG, there is no difference between 10 mg/kg and 20 mg/kg treated with cocaine groups. These results indicated that the normal embryos of the roups of cocaine administration were significantly amested when compared with that of control group. The proportion of 2 to 8 cell stage embryo reaching the blastocyst stage, which were cultured 48-52 hours with 5% $Co_2$ in air at $37^{\circ}C$, were 93.9% in control group and, 70.4% and 71.9% in each 10 mg/kg and to blastocyst in vitro culture was significantly limited embryos obtained from cocanized mice compared with those of control mice. These results suggest that episode of cocaine intoxication can cause impaiment of early embrygenesis in the mouse.

• Progress in Medical Physics
• /
• v.29 no.4
• /
• pp.123-136
• /
• 2018

The complex dose distribution and dose transfer characteristics of intensity-modulated radiotherapy increase the importance of precise beam data measurement and review in the acceptance inspection and preparation stages. In this study, we propose a process map for the introduction and installation of high-precision radiotherapy devices and present items and guidelines for risk management at the acceptance test procedure (ATP) and commissioning stages. Based on the ATP of the Varian and Elekta linear accelerators, the ATP items were checked step by step and compared with the quality assurance (QA) test items of the AAPM TG-142 described for the medical accelerator QA. Based on the commissioning procedure, dose quality control protocol, and mechanical quality control protocol presented at international conferences, step-by-step check items and commissioning guidelines were derived. The risk management items at each stage were (1) 21 ionization chamber performance test items and 9 electrometer, cable, and connector inspection items related to the dosimetry system; (2) 34 mechanical and dose-checking items during ATP, 22 multileaf collimator (MLC) items, and 36 imaging system items; and (3) 28 items in the measurement preparation stage and 32 items in the measurement stage after commissioning. Because the items presented in these guidelines are limited in terms of special treatment, items and practitioners can be modified to reflect the clinical needs of the institution. During the system installation, it is recommended that at least two clinically qualified medical physicists (CQMP) perform a double check in compliance with the two-person rule. We expect that this result will be useful as a radiation safety management tool that can prevent radiation accidents at each stage during the introduction of radiotherapy and the system installation process.

• The Journal of the Korea Contents Association
• /
• v.21 no.2
• /
• pp.140-147
• /
• 2021

EEG(electroencephalogram) are measured to accurately determine the level of sleep in various sleep examinations. In general, measurements are more accurate as the number of sensor channels increases. EEG can interfere with sleep by attaching electrodes to the skin when measuring. It is necessary for self sleep care to select the minimum number of EEG channels that take into account both the user's discomfort and the accuracy of the measurement data. In this paper, we proposed a sleep stage analysis model based on machine learning and conducted experiments for using from one channel to four channels. We obtained estimation accuracy for sleep stage as following 82.28% for one channel, 85.77% for two channels, 80.33% for three channels and 68.87% for four channels. Although the measurement location is limited, the results of this study compare the accuracy according to the number of channels and provide information on the selection of channel numbers in the EEG sleep analysis.

• Smart Structures and Systems
• /
• v.31 no.5
• /
• pp.485-500
• /
• 2023

Machine learning-based structural health monitoring (ML-based SHM) methods are researched extensively in the recent decade due to the availability of advanced information and sensing technology. ML methods are well-known for their pattern recognition capability for complex problems. However, the main obstacle of ML-based SHM is that it often requires pre-collected historical data for model training. In most actual scenarios, damage presence can be detected using the unsupervised learning method through anomaly detection, but to further identify the damage types would require prior knowledge or historical events as references. This creates the cold-start problem, especially for new and unobserved structures. Modal-based methods identify damages based on the changes in the structural global properties but often require dense measurements for accurate results. Therefore, a two-stage hybrid modal-machine learning damage detection scheme is proposed. The first stage detects damage presence using Principal Component Analysis-Frequency Response Function (PCA-FRF) in an unsupervised manner, whereas the second stage further identifies the damage. To solve the cold-start problem, mode shape assessment using the first mode is initiated when no trained model is available yet in the second stage. The damage identified by the modal-based method would be stored for future training. This work highlights the performance of the scheme in alleviating the cold-start issue as it transitions through different phases, starting from zero damage sample available. Results showed that single and multiple damages can be identified at an acceptable accuracy level even when training samples are limited.

• The Journal of Economics, Marketing and Management
• /
• v.6 no.1
• /
• pp.17-24
• /
• 2018

Purpose - Major countries in the world continue to grow up without employment by the economy opening, more investment in foreign countries and technical innovation. Nevertheless, SMEs have job creation continuously. As this result, support for SMEs that is the source of job creation has increased attention. However, previous research between SMEs and job-creating is limited to the job creation effect of comparing with large companies, and R&D investment effect including government support. Also, many research provides the different result of correlation with technology innovation and job creation. Therefore, previous research has insufficient to explain job creation by which in the technology commercialization stage and the job-specific workforce. Research design, data, and Methodology - This study investigated the impact of customized R&D support upon job creation by using questionnaires of SMEs R&D service of K-Institution from 2009 to 2013. In detail, we analyzed the relationship between the technology commercialization stage and the usefulness of customized R&D support. Also, we added the analyzed the relationship between the usefulness of customized R&D support and the job-specific workforce. Results - Research result, Job creation had a significant relation to the usefulness of customized R&D support in product design stage and mass production stage. Also, R&D worker and production worker correlated with the usefulness of customized R&D support. These results indicate the importance of hiring R&D workers and production workers at the higher technology readiness. Conclusions -Therefore, this study suggests some implications for the government's SMEs support policy and the solve employment problems such as youth unemployment.